Cortometraje de ficción “Memento Mori”

El presente proyecto busca contar una historia que gira en torno a las consecuencias de la culpa y sus efectos a largo plazo, explorando formas poco convencionales y menos habituales para exponerla y abordarla. Para esto, se optó por la selección de tópicos puntuales y útiles que sirvieran como ejes para guiar la narrativa de manera en que ninguno de estos elementos se sintiera débil o colocado por una conveniencia representativa, buscando siempre que estos se encuentren estrechamente entrelazados entre ellos mismos y con el propio guión del proyecto. Los procesos de escritura empleados para la elaboración del guión siguen la propuesta de Panizza Montanari (2018), entendiendo al producto audiovisual como algo más que la realización de una historia escrita en papel, dando pase a la creación del cortometraje mediante el apoyo de imágenes y sonidos que remiten a los tópicos principales del proyecto. Sobre esto giran los procesos de investigación y las referencias históricas que fueron asociadas en beneficio de la historia, las cuales se detallan dentro de este trabajo escrito. Con la conclusión de este proyecto, se han explorado algunos métodos menos usuales que comprenden al guión como una herramienta flexible a la disposición del realizador más que un proceso fijo, inamovible y necesario para la realización de un proyecto audiovisual. Las imágenes, los sonidos y las metáforas visuales pueden muchas veces devenir en los elementos indispensables para una narración más sútil y interesante, nutriendo a su vez no solo al producto final, sino también el proceso de su concepción y desarrollo.This project seeks to tell a story that revolves around the consequences of guilt and its long-term effects, exploring unconventional and less common ways to expose and address this illness. For this, we opted for the selection of specific and useful topics that would serve as axes to guide the narrative process so that none of these elements felt weak or placed in order to fulfill a flat convenience for representation, always seeking that they are closely intertwined with each other and with the project's own script. The writing processes used for the elaboration of the script follow the proposal of Panizza Montanari (2018), understanding the audiovisual product as something more than the realization of a story written on paper, giving way to the creation of the short film through the support of images and sounds that refer to the main topics of the project. On this revolve the research processes and the historical references that were associated for the benefit of history, which are detailed within this written work. With the conclusion of this project, some less usual methods have been explored that understand the script as a flexible tool at the disposal of the filmmaker rather than a fixed one, immovable and necessary process for the realization of an audiovisual project. Images, sounds and visual metaphors can often become the indispensable elements for a more subtle and interesting narrative, nourishing in turn not only the final product, but also the process of its conception and development.Trabajo de investigació

Performance evaluation of a real time OFDM radio over fiber system at 2.5 GHz using software defined radio SDR

This paper presents the implementation of an OFDM radio over fiber (RoF) system at 2.5 GHz using software defined radio (SDR). In this work, first we present an introduction of the main concepts about radio over fiber and an orthogonal frequency-division multiplexing (OFDM) system at 2.5 GHz, then we present a comparison of an OFDM RoF system in three scenarios, modifying the wireless distances and the optical fiber distance in order to evaluate the performance of the system taking into account the symbol error rate (SER) vs signal to noise ratio (SNR) curves

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up

Coronavirus disease 2019 (COVID-19), a viral respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may predispose patients to thrombotic disease, both in the venous and arterial circulations, due to excessive inflammation, platelet activation, endothelial dysfunction, and stasis. In addition, many patients receiving antithrombotic therapy for thrombotic disease may develop COVID-19, which can have implications for choice, dosing, and laboratory monitoring of antithrombotic therapy. Moreover, during a time with much focus on COVID-19, it is critical to consider how to optimize the available technology to care for patients without COVID-19 who have thrombotic disease. Herein, we review the current understanding of the pathogenesis, epidemiology, management and outcomes of patients with COVID-19 who develop venous or arterial thrombosis, and of those with preexisting thrombotic disease who develop COVID-19, or those who need prevention or care for their thrombotic disease during the COVID-19 pandemic.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155446/1/Bikdeli-2020-COVID-19 and Thrombotic or Thromb.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155446/3/DeepBluepermissions_agreement-CCBYandCCBY-NC_ORCID_Barnes.docxhttps://deepblue.lib.umich.edu/bitstream/2027.42/155446/4/license_rdf.rdfDescription of Bikdeli-2020-COVID-19 and Thrombotic or Thromb.pdf : ArticleDescription of DeepBluepermissions_agreement-CCBYandCCBY-NC_ORCID_Barnes.docx : Deep Blue sharing agreemen

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

Introduction: More than 70 common alleles are known to be involved in breast cancer (BC) susceptibility, and several exhibit significant heterogeneity in their associations with different BC subtypes. Although there are differences in the association patterns between BRCA1 and BRCA2 mutation carriers and the general population for several loci, no study has comprehensively evaluated the associations of all known BC susceptibility alleles with risk of BC subtypes in BRCA1 and BRCA2 carriers. Methods: We used data from 15,252 BRCA1 and 8,211 BRCA2 carriers to analyze the associations between approximately 200,000 genetic variants on the iCOGS array and risk of BC subtypes defined by estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and triple-negative- (TN) status; morphologic subtypes; histological grade; and nodal involvement. Results: The estimated BC hazard ratios (HRs) for the 74 known BC alleles in BRCA1 carriers exhibited moderate correlations with the corresponding odds ratios from the general population. However, their associations with ER-positive BC in BRCA1 carriers were more consistent with the ER-positive as

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

Abstract Introduction More than 70 common alleles are known to be involved in breast cancer (BC) susceptibility, and several exhibit significant heterogeneity in their associations with different BC subtypes. Although there are differences in the association patterns between BRCA1 and BRCA2 mutation carriers and the general population for several loci, no study has comprehensively evaluated the associations of all known BC susceptibility alleles with risk of BC subtypes in BRCA1 and BRCA2 carriers. Methods We used data from 15,252 BRCA1 and 8,211 BRCA2 carriers to analyze the associations between approximately 200,000 genetic variants on the iCOGS array and risk of BC subtypes defined by estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and triple-negative- (TN) status; morphologic subtypes; histological grade; and nodal involvement. Results The estimated BC hazard ratios (HRs) for the 74 known BC alleles in BRCA1 carriers exhibited moderate correlations with the corresponding odds ratios from the general population. However, their associations with ER-positive BC in BRCA1 carriers were more consistent with the ER-positive associations in the general population (intraclass correlation (ICC) = 0.61, 95% confidence interval (CI): 0.45 to 0.74), and the same was true when considering ER-negative associations in both groups (ICC = 0.59, 95% CI: 0.42 to 0.72). Similarly, there was strong correlation between the ER-positive associations for BRCA1 and BRCA2 carriers (ICC = 0.67, 95% CI: 0.52 to 0.78), whereas ER-positive associations in any one of the groups were generally inconsistent with ER-negative associations in any of the others. After stratifying by ER status in mutation carriers, additional significant associations were observed. Several previously unreported variants exhibited associations at P <10−6 in the analyses by PR status, HER2 status, TN phenotype, morphologic subtypes, histological grade and nodal involvement. Conclusions Differences in associations of common BC susceptibility alleles between BRCA1 and BRCA2 carriers and the general population are explained to a large extent by differences in the prevalence of ER-positive and ER-negative tumors. Estimates of the risks associated with these variants based on population-based studies are likely to be applicable to mutation carriers after taking ER status into account, which has implications for risk prediction

Evaluación mediante indicadores del impacto ambiental de proyectos viales

Tesis (Ingeniero Civil) -- Universidad de Cartagena. Facultad de Ciencias Económicas E Ingeniería. Programa de Ingeniería Civil; año 1999.El presente estudio tiene por objeto proponer una metodología para la evaluación del impacto ambiental en proyectos viales, basada en indicadores de impacto ambiental

Comparison of performance between OFDM and GFDM in a 3.5GHz band 5G hybrid Fiber-Wireless link using SDR

This work presents a comparison between Orthogonal Frequency Division Multiplexing OFDM and Generalized Frequency Division Multiplexing GFDM to evaluate the latency and bit error rate in a Fiber-wireless link in 3.5 GHz band using Software Defined Radio SDR, taking into account its feasibility for the 5G networks in the future

Mechanical properties and X-ray diffraction analyses of clay/sand pellets for CO

In this work, we report the mechanical properties of an alternative material based on a mixture of natural clay and ferruginous sand in pellet form for CO2 capture. These raw materials were collected from Ecuador, and they contain iron and titanium oxides from volcanic origin. To evaluate the effect of the sand content on the mechanical properties of pellets, the samples were manually prepared with 0 (control sample), 15, and 25 wt.% sand contents and analyzed using free-fall drop impact and uniaxial compression tests. The uniaxial compression test was carried out under three conditions: using sieved sand, using sand without sieving, and under wet conditions. The sand contents caused the drop number to decrease in the free-fall drop impact test. From the uniaxial compression test, the compressive strength, elastic modulus, and toughness were calculated. The elastic modulus showed a better performance for samples with lower porosity. The compressive strength demonstrated higher values for samples with 15 wt.% sand contents than for samples with the other sand contents. The toughness values did not significantly change. It was evidenced that the porosity, mineral composition, and humidity exerted an influence during the mechanical tests. The mineral phases were analyzed by X-ray diffraction, and quantitative analysis based on whole-powder-pattern fitting revealed that the iron and titanium oxide contents increased as the concentration of sand in the pellets increased

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow

Coronavirus disease-2019 (COVID-19), a viral respiratory illness caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), may predispose patients to thrombotic disease, both in the venous and arterial circulations, because of excessive inflammation, platelet activation, endothelial dysfunction, and stasis. In addition, many patients receiving antithrombotic therapy for thrombotic disease may develop COVID-19, which can have implications for choice, dosing, and laboratory monitoring of antithrombotic therapy. Moreover, during a time with much focus on COVID-19, it is critical to consider how to optimize the available technology to care for patients without COVID-19 who have thrombotic disease. Herein, the authors review the current understanding of the pathogenesis, epidemiology, management, and outcomes of patients with COVID-19 who develop venous or arterial thrombosis, of those with pre-existing thrombotic disease who develop COVID-19, or those who need prevention or care for their thrombotic disease during the COVID-19 pandemic. (J Am Coll Cardiol 2020;75:2950-73) (c) 2020 by the American College of Cardiology Foundation