Clinical success of restorations with bioactive and non-bioactive materials: Systematic Review and Network Meta-Analysis

The oral cavity is a complex and dynamic environment with frequent pH and temperature changes that can affect the longevity of dental restorations. Consequently, bioactive restorative materials, capable of advantageous interactions with the oral environment and dental tissues, are promising alternatives. However, there is limited scientific evidence of their clinical performance. Therefore, we conducted this systematic review and network meta-analysis of clinical studies to address the research question: Does the clinical evaluation of restorations on permanent teeth with bioactive materials show greater success rates than those with non-bioactive materials

Seleção de modelos não lineares para a descriação das curvas de crescimento do fruto do cafeeiro

Coffee is one of the most important products of Brazilian agriculture, therefore studies aimed at improving the final quality of the coffee cherry has increasingly been the target of research. To know the growth curves of fruits allows a best crop management, as well as identify times of higher demand for nutrients. The aim of this work was to compare the nonlinear regression models Logistic e Gompertz in the description of the growth curves of coffee fruit, considering the heterogeneity of sampling variances, in the different faces of sunlight exposure. The data sets corresponds to the results of an experiment conducted in the College of Agriculture and Veterinary Sciences, UNESP, Jaboticabal-SP, with the cultivar Obatã IAC 1669-20, which belongs to the species Coffea arabica (CUNHA;VOLPE, 2011). We analyzed the data by using the nonlinear models Gompertz and Logistic, weighted (heterogeneous sample variance) and unweighted. We estimated the parameters by “gnls” function from library “nlme” from the statistical software R, which uses the least squares method and the Gauss-Newton algorithm for convergence. We compared the fit of the models by using the following criteria: adjustment coefficient of determination  (Ra2 ); Akaike information criterion (AIC) and measures Bates and Watts curvature. The nonlinear models described fairly the coffee fruit growth, providing parameters with practical interpretations. The icorporation of heteroscedasticity was effective because the parameters estimates become more reliable. The model that best described the growth of coffee fruit was weighted Gompertz model, in both faces of sunlight exposure.O café é um dos produtos mais importantes da agricultura brasileira, portanto estudos que visam uma melhor qualidade final do seu fruto têm sido, cada vez mais, objetivo de pesquisas. Conhecer as curvas de crescimento de frutos permite um melhor manejo da cultura, bem como identificar as épocas de maior demanda de nutrientes. Objetivou-se, neste trabalho, comparar o ajuste dos modelos de regressão não lineares Logístico e Gompertz, na descrição das curvas de crescimento do fruto do cafeeiro, considerando a heterogeneidade das variâncias amostrais, nas diferentes faces de exposição ao sol. Os dados analisados foram obtidos de Cunha e Volpe (2011) e correspondem aos resultados parciais de um experimento conduzido na Faculdade de Ciências Agrárias e Veterinárias, UNESP, Campus Jaboticabal, SP, com a cultivar Obatã IAC 1669-20, que pertence à espécie Coffea arabica. Foram utilizados os modelos não lineares Gompertz e Logístico, ponderados (variâncias amostrais heterogêneas) e não ponderados. A estimação dos parâmetros foi feita utilizando a função “gnls” da biblioteca “nlme” do software R, o método de mínimos quadrados e o algoritmo de convergência de Gauss-Newton. A qualidade dos ajustes foi comparada com base nos seguintes critérios: coeficiente de determinação ajustado (Ra2 ) ; critério de informação de Akaike e medidas de curvatura de Bates e Watts. Os modelos não lineares estudados descreveram de forma satisfatória a curva de crescimento do fruto do cafeeiro, fornecendo parâmetros com interpretações práticas. A incorporação da heterocedasticidade foi eficiente, pois tornou as estimativas dos parâmetros mais confiáveis. O modelo que melhor descreveu o crescimento do fruto do cafeeiro foi o modelo Gompertz ponderado, em ambas as faces de exposição ao sol.

Atuação, concepções e saberes de profissionais da Educação Infantil: um olhar sobre um processo de formação inicial em serviço

Este texto resulta de uma pesquisa realizada no âmbito do Programa Proinfantil, em Mato Grosso. Objetiva-se, por meio deste recorte, identificar continuidades/descontinuidades nas práticas pedagógicas das profissionais a partir da participação no Programa. Os fundamentos teóricos das análises se pautam na legislação específica e literatura pertinente à formação de professores da Educação Infantil. A amostra abarcou 37 cursistas, contatados mediante questionário, observação das práticas pedagógicas e entrevistas. Os resultados indicam que o processo de formação vivenciado atingiu o objetivo de problematização da prática das profissionais possibilitando-lhes interlocução com a teoria e ressignificação dos papéis dos sujeitos envolvidos

Participação nos lucros e resultados (PLR): um estudo dos bancos de crédito consignado de Belo Horizonte, Minas Gerais/ Profit and Result Sharing (PLR): a study of consigned credit banks in Belo Horizonte, Minas Gerais

As transformações contemporâneas nas relações de trabalho têm ocorrido de maneira cada vez mais explícita no cenário global, desencadeando um movimento de modernização dos sistemas produtivos e de gestão das empresas. Neste contexto, as empresas brasileiras têm incorporado importantes ferramentas de incentivo à participação dos trabalhadores no processo produtivo, como os programas de Participação nos Lucros e Resultados (PLR), de modo a favorecer a gestão compartilhada da organização e a partilha dos resultados positivos obtidos com sua atuação. O presente artigo tem como objetivo analisar a normatização e as práticas de pagamento da PLR, no âmbito das Instituições Financeiras de empréstimo consignado de Belo Horizonte/MG, sob a vigência da Lei nº 10.101/2000. De forma específica, buscou-se identificar os elementos que caracterizam a PLR como ferramenta de gestão empresarial participativa; verificar a regulamentação da PLR no Brasil e as condições impostas pela legislação trabalhista para o pagamento dessa verba aos empregados. Para tanto, no presente estudo foram utilizadas pesquisa bibliográfica, documental e de levantamento. A partir da análise dos instrumentos coletivos de trabalho firmados entre os bancos e o sindicato representativo da categoria obreira, homologados entre os anos de 2008 e 2018, foi possível identificar os parâmetros de regulação, aplicação e condições de pagamento da PLR no setor. Avaliou-se, também, a atuação e a percepção das lideranças sindicais em face dos programas de PLR. A pesquisa concluiu que a PLR, aplicada assertivamente, é uma importante ferramenta de estratégia dos empregadores e um grande meio de recompensar a produtividade de seu pessoal

Hepatic Lipidosis in Banded Armadillos (Euphractus sexcinctus) Bred in Captivity

Background: Wild animals bred in captivity may develop steatosis due to unbalanced dietary intake and obesity caused by sedentary behaviour. In some rural areas, six-banded armadillos are raised in captivity inside some metal barrels, with restricted space, and are often overfeed. After getting fattening, armadillos they are slaughtered and used as food. Theunfavorable conditions may somehow contribute to likely underlie the development of many diseases, among them we can including hepatic steatosis. The present report aims to describe the pathological fndings of hepatic lipidosis in banded armadillos (Euphractus sexcinctus), bred in captivity.Case: The animals were three female adult six-banded armadillos (Euphractus sexcinctus), caught in the native forest of the city of Natal, Rio Grande do Norte, Brazil and raised in domestic environment in a small enclosure and fed with human food leftovers. After eight months kept in these conditions armadillos had severe obesity and then were donated to the city zoo, where they were quarantined and presented clinical symptoms of anorexia for two weeks, weight loss and exhaustion. After being found dead during daily inspection carried out by the veterinarian zoo, the six-banded armadillos were sent to the Animal Pathology Laboratory of Federal Rural University of the Semi-Arid (UFERSA) for pathological examination.The animals presented with a history of anorexia were extremely obese and the autopsy detected had extensive deposits of fat in the carcass and liver. Histopathologically, the liver cells hepatocytes showed marked intracytoplasmic vacuolization and with peripheral displacement of the nucleus to the periphery, with and positive staining for lipids using scarlet Sudan III. To our knowledge, this is the frst report of hepatic lipidosis in banded.Discussion: Hepatic lipidosis can be categorized into normal liver and mild, moderate, or severe fatty liver. In severe cases, it is estimated that 80% of the hepatocytes are affected. Therefore, we classifed the hepatic lipidosis of the three studied female six-banded armadillos as severe, since the lipids were deposited diffusely. Based on the severity of the lesions and absence of other fndings, we concluded here that hepatic lipidosis contributed to the cause of the six-banded armadil los death. The weight of the animals in this report may be associated with innapropriate enclosure dimensions and a diet based on human food leftovers. Such diet was reportedly composed of rice, beens, spaghetti, and bread, which are food with high levels of carbohydrate. The armadillos of the Euphractus sexcinctus species usually weigh between 3 and 6 kg and hence, the animals of this report showed twice the normal weight. The occurrence of hepatic lipidosis associated with anorexia triggered by a stressful event such as a change of environment and diet armadillos observed in the present study is in agreement with literature data pointing anorexia in obese animals as a major predisposing factors for the occurrence of hepatic lipidosis by promoting energy restriction, peripheral lipolysis and large intake of fatty acids to the liver.Keywords: Euphractus sexcinctus, armadillos, anatomopathology, liver, lipidosis

The Brazilian Portuguese version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)

The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the Brazilian Portuguese language. The reading comprehension of the questionnaire was tested in 10 JIA parents and patients. Each participating centre was asked to collect demographic, clinical data and the JAMAR in 100 consecutive JIA patients or all consecutive patients seen in a 6-month period and to administer the JAMAR to 100 healthy children and their parents. The statistical validation phase explored descriptive statistics and the psychometric issues of the JAMAR: the three Likert assumptions, floor/ceiling effects, internal consistency, Cronbach\u2019s alpha, interscale correlations, test\u2013retest reliability, and construct validity (convergent and discriminant validity). A total of 231 JIA patients (14.7% systemic, 43.3% oligoarticular, 22.5% RF negative polyarthritis, 19.5% other categories) and 72 healthy children, were enrolled in three centres. The JAMAR components discriminated well healthy subjects from JIA patients. All JAMAR components revealed good psychometric performances. In conclusion, the Brazilian Portuguese version of the JAMAR is a valid tool for the assessment of children with JIA and is suitable for use both in routine clinical practice and clinical research

Morphometric Alteration of Intestinal Epithelium of Rats (Rattus norvegicus) Submitted to the Technique of Enteropexy

Background: Due to the numerous complications that enteropexy may cause in domestic animals and humans, this study aimed at investigating the microscopic level, the damage generated by this technique in mice, in order to investigate the morphometric changes caused by enteropexy technique in rats.Materials, Methods & Results: Eighteen Wistar rats were submitted to surgical technique of enteropexy. To evaluate intestinal disorders they were euthanized at 30 (Group I), 60 (group II) and 90 (group III) days after the procedure. The animals were perfused with 2.5% glutaraldehyde and 4% paraformaldehyde for the removal of intestinal fragments for analysis in conventional microscopy and scanning electron microscopy. In classical histopathology, group I presented mild lesions with necrosis of the epithelium and infiltration of mononuclear cells. After 60 days, extensive ischemic necrosis area was observed, characterized by the denudation of epithelium cells and cellular debris in the lumen surface and loss of intestinal crypts. After 90 days (group III) lesions were evident and were characterized by strong coagulative necrosis of epithelial cells and intestinal crypts. Under electron microscopy, group I showed early fusion of the adjacent intestinal walls. After 60 days there was adherence of luminal stenosis and intestinal walls. In group III loss of epithelium and substitution of necrotic tissue were identified.Discussion: In the current study it was noticed microscopically that the groups had inflammatory reactions to foreign bodies. It is known that the sutures, independent of manufacture, behave as foreign bodies that induce tissue inflammation of the recipient organism and could harm the scar repair. Among the surgical threads, the nylon type (which was chosen for the current experiment) is indicated in the approach tissues in general and bandages, including cardiovascular, ophthalmic and neurological procedures. This category wire induces minimal inflammation of the receptor tissue. In studies of the histopathological analysis of the tissue reactions produced by the wire implant or nylon thread clamp in rats, it was observed that when the local action of two implants were compared, inflammation showed qualitatively similar responses, although they had different characteristics regarding their course. Inflammation is proportional to the proliferation of fibroblasts and the presence of fibrous tissue around the suture. This quote confirms the analyzed samples, in which, in all postoperative times showed inflammatory process, although at different magnitudes. Surgical research in laboratory animals has expanded in recent decades, mainly due to better anesthetic support, the sophistication of infrastructure, material for perioperative continuous monitoring and an incessant search for species that reproduce human morbid conditions. The main focus of these studies have been improving the knowledge about the pathophysiological mechanisms of disease, undertake therapeutic trials with new drugs, studying biomarkers and evaluate new techniques to be applied prospects in man. The most common sites of occurrence of intestinal are ileocolic intussusception junction and jejunojejunal segment. The enteroplication has been used to reduce the occurrence of intussusception, promoting the adhesion of the adjacent serosa layers of intestinal segments and thereby decreasing intestinal motility, their applicability is reported in humans, dogs and cats. The enteropexy technique causes morphological changes in intestinal epithelium of rats, evidenced in conventional and electron microscopy, progress with the passing of time the procedure

IMPLANTAÇÃO DE PROTOCOLO DE QUALIDADE ASSISTENCIAL BASEADO EM CUIDADOS CENTRADOS NO PACIENTE CRÍTICO: RELATO DE EXPERIÊNCIA

RESUMO Objetivo: descrever as etapas da construção e implantação de um protocolo de qualidade assistencial, baseado no bundle ABCDEF, adaptado às necessidades locais, integrando-o à visão de cuidado centrado no paciente, vivenciadas pelo grupo multiprofissional pelo olhar dos enfermeiros. Método: trata-se de relato de experiência da construção e implantação parcial de um protocolo de qualidade assistencial, baseado nas orientações do PAD inserido no Programa de Qualidade Assistencial “ABCDEF”, que aborda o manejo da analgesia, da sedação e do delirium, englobando os protocolos de desmame de ventilação mecânica, mobilização precoce, higiene do sono e humanização desde a admissão na UTI. Resultados: foram implantados, até o momento, os protocolos de sedoanalgesia, desmame da ventilação mecânica e mobilização precoce. Estes passaram por ampla discussão com a equipe assistencial multiprofissional antes da implantação. Conclusão: inúmeros são os fatores que facilitam e dificultam a implantação do bundle ABCDEF em nossa realidade. A proposta de mudança é bem aceita pelo grupo, mas a adesão não é constante. Esforços intensos com educação permanente, encontros com equipe multiprofissional e valorização do trabalho pelos gestores parecem melhorar o engajamento

PREVALÊNCIA E FATORES ASSOCIADOS À INFECÇÃO POR LENTIVÍRUS DE PEQUENOS RUMINANTES EM CAPRINOS NO ESTADO DO TOCANTINS

Objetivando estimar a prevalência de caprinos soror­reagentes aos lentivírus de pequenos ruminantes (LVPR), através de uma amostragem não probabilística em rebanhos no Estado do Tocantins, analisaram-se 843 amostras de soros, mediante a utilização do teste de imunodifusão em gel de agarose (MICRO-IDGA) para a detecção de anticorpos anti-LVPR, sendo verificada uma frequência de animais sororreagentes de 2,7% (23/843). Identificaram-se cinco focos: dois no município de Araguaína e um em cada um desses municípios: Babaçulândia, Filadélfia e Miracema do Tocantins. De acordo com a região, os resultados foram os seguintes: 10,0% (20/200) e 1,4% (3/207) para as microrregiões Norte e Miracema, respectivamente. Entre as raças, a Saanen se apresentou com o maior percentual de animais sororreagentes, 11,7% (7/60). Para os animais sem raça definida, o percentual foi de 0,6% (2/310), e para a Anglo-Nubiana, de 3,0% (14/466). De acordo com a idade, os animais com idade inferior e superior a 24 meses apresentaram 1,9% (6/314) 3,2% (17/529), respectivamente. Os machos apresentaram 2,4% (4/166) de positivos e as fêmeas 2,8% (19/677). Os resultados indicam que os LVPR ocorrem com baixa prevalência no Estado do Tocantins, afetando principalmente animais da raça Saanen e da região norte. PALAVRAS-CHAVES: Brasil, CAEV, epidemiologia, microimunodifusão