44,287 research outputs found
Chemical structure matching using correlation matrix memories
This paper describes the application of the Relaxation By Elimination (RBE) method to matching the 3D structure of molecules in chemical databases within the frame work of binary correlation matrix memories. The paper illustrates that, when combined with distributed representations, the method maps well onto these networks, allowing high performance implementation in parallel systems. It outlines the motivation, the neural architecture, the RBE method and presents some results of matching small molecules against a database of 100,000 models
Abelian homotopy Dijkgraaf-Witten theory
We construct a version of Dijkgraaf-Witten theory based on a compact abelian
Lie group within the formalism of Turaev's homotopy quantum field theory. As an
application we show that the 2+1-dimensional theory based on U(1) classifies
lens spaces up to homotopy type.Comment: 23 pages, 1 figur
The impact of General Dental Council registration and continuing professional development on UK dental care professionals:(2) dental technicians.
The XMM-Newton Iron Line Profile of NGC 3783
We report on observations of the iron K line in the nearby Seyfert 1 galaxy,
NGC 3783, obtained in a long, 2 orbit (240 ks) XMM-Newton observation. The line
profile obtained exhibits two strong narrow peaks at 6.4 keV and at 7.0 keV,
with measured line equivalent widths of 120 and 35 eV respectively. The 6.4 keV
emission is the K-alpha line from near neutral Fe, whilst the 7.0 keV feature
probably originates from a blend of the neutral Fe K-beta line and the H-like
line of Fe at 6.97 keV. The relatively narrow velocity width of the K-alpha
line (<5000 km/s), its lack of response to the continuum emission on short
timescales and the detection of a neutral Compton reflection component are all
consistent with a distant origin in Compton-thick matter such as the putative
molecular torus. A strong absorption line from highly ionized iron (at 6.67
keV) is detected in the time-averaged iron line profile, whilst the depth of
the feature appears to vary with time, being strongest when the continuum flux
is higher. The iron absorption line probably arises from the highest ionization
component of the known warm absorber in NGC 3783, with an ionization of logxi=3
and column density of 5x10^{22}cm{-2} and may originate from within 0.1pc of
the nucleus. A weak red-wing to the iron K line profile is also detected below
6.4 keV. However when the effect of the highly ionized warm absorber on the
underlying continuum is taken into account, the requirement for a relativistic
iron line component from the inner disk is reduced.Comment: 34 pages, including 11 figures. Accepted for publication in Ap
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Introducing creativity techniques and software apps to the care of people with dementia
This poster reports research to introduce creative problem solving techniques and software to the care for people with dementia in residential homes
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What is the impact of psychiatric decision units on mental health crisis care pathways? Protocol for an interrupted time series analysis with a synthetic control study
Background
The UK mental health system is stretched to breaking point. Individuals presenting with mental health problems wait longer at the ED than those presenting with physical concerns and finding a bed when needed is difficult – 91% of psychiatric wards are operating at above the recommended occupancy rate. To address the pressure, a new type of facility – psychiatric decision units (also known as mental health decision units) – have been introduced in some areas. These are short-stay facilities, available upon referral, targeted to help individuals who may be able to avoid an inpatient admission or lengthy ED visit. To advance knowledge about the effectiveness of this service for this purpose, we will examine the effect of the service on the mental health crisis care pathway over a 4-year time period; the 2 years proceeding and following the introduction of the service. We use aggregate service level data of key indicators of the performance of this pathway.
Methods
Data from four mental health Trusts in England will be analysed using an interrupted time series (ITS) design with the primary outcomes of the rate of (i) ED psychiatric presentations and (ii) voluntary admissions to mental health wards. This will be supplemented with a synthetic control study with the same primary outcomes, in which a comparable control group is generated for each outcome using a donor pool of suitable National Health Service Trusts in England. The methods are well suited to an evaluation of an intervention at a service delivery level targeting population-level health outcome and the randomisation or ‘trialability’ of the intervention is limited. The synthetic control study controls for national trends over time, increasing our confidence in the results. The study has been designed and will be carried out with the involvement of service users and carers.
Discussion
This will be the first formal evaluation of psychiatric decision units in England. The analysis will provide estimates of the effect of the decision units on a number of important service use indicators, providing much-needed information for those designing service pathways
ASCA observations of type-2 Seyfert galaxies: II. The Importance of X-ray Scattering and Reflection
We discuss the importance of X-ray scattering and Compton reflection in
type-2 Seyfert galaxies, based upon the analysis of ASCA observations of 25
such sources. Consideration of the iron Kalpha, [O III] line and X-ray
variability suggest that NGC 1068, NGC 4945, NGC 2992, Mrk 3, Mrk 463E and Mrk
273 are dominated by reprocessed X-rays. We examine the properties of these
sources in more detail.
We find that the iron Kalpha complex contains significant contributions from
neutral and high-ionization species of iron. Compton reflection, hot gas and
starburst emission all appear to make significant contributions to the observed
X-ray spectra.
Mrk 3 is the only source in this subsample which does not have a significant
starburst contamination. The ASCA spectrum below 3 keV is dominated by hot
scattering gas with U_X ~ 5, N_H ~ 4 x 10^23 cm^-2. This material is more
highly ionized than the zone of material comprising the warm absorber seen in
Seyfert~1 galaxies, but may contain a contribution from shock-heated gas
associated with the jet. Estimates of the X-ray scattering fraction cover 0.25
- 5%. The spectrum above 3 keV appears to be dominated by a Compton reflection
component although there is evidence that the primary continuum component
becomes visible close to 10 keV.Comment: 27 pages, 6 figures. LaTeX with encapsulated postscript. To appear in
the Astrophysical Journal. Also available via
http://lheawww.gsfc.nasa.gov/~george/papers/gnt_s2p2/abstract.htm
SHEEP: The Search for the High Energy Extragalactic Population
We present the SHEEP survey for serendipitously-detected hard X-ray sources
in ASCA GIS images. In a survey area of deg, 69 sources were
detected in the 5-10 keV band to a limiting flux of erg
cm s. The number counts agree with those obtained by the similar
BeppoSAX HELLAS survey, and both are in close agreement with ASCA and BeppoSAX
2-10 keV surveys. Spectral analysis of the SHEEP sample reveals that the 2-10
and 5-10 keV surveys do not sample the same populations, however, as we find
considerably harder spectra, with an average assuming no
absorption. The implication is that the agreement in the number counts is
coincidental, with the 5-10 keV surveys gaining approximately as many hard
sources as they lose soft ones, when compared to the 2-10 keV surveys. This is
hard to reconcile with standard AGN ``population synthesis'' models for the
X-ray background, which posit the existence of a large population of absorbed
sources. We find no evidence of the population hardening at faint fluxes, with
the exception that the few very brightest objects are anomalously soft. 53 of
the SHEEP sources have been covered by ROSAT in the pointed phase. Of these 32
were detected. An additional 3 were detected in the RASS. As expected the
sources detected with ROSAT are systematically softer than those detected with
ASCA alone, and of the sample as a whole (truncated).Comment: 36 pages, 7 figs, to appear in Ap
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