87 research outputs found
Fracturing ranked surfaces
- Author
- A Coniglio
- A Coniglio
- A Maritan
- A-L Barabási
- B Kerr
- BB Mandelbrot
- CL Knecht
- CM Fortuin
- CM Newman
- CP Stark
- E Fehr
- EA Oliveira
- FY Wu
- HA Makse
- I Chang
- J Mathiesen
- J Yan
- JC Wierman
- JS Andrade Jr
- K Çiftçi
- KJ Schrenk
- M Cieplak
- M Cieplak
- M Hubbe
- M Porto
- M Porto
- M Sahimi
- M Sahimi
- ME Fisher
- NAM Araújo
- O Scholder
- PH Poole
- R Dobrin
- S Goyal
- S Havlin
- S Prakash
- SR Broadbent
- SS Manna
- TS Jackson
- Y Deng
- Y Ikedo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 02/04/2012
- Field of study
Discretized landscapes can be mapped onto ranked surfaces, where every
element (site or bond) has a unique rank associated with its corresponding
relative height. By sequentially allocating these elements according to their
ranks and systematically preventing the occupation of bridges, namely elements
that, if occupied, would provide global connectivity, we disclose that bridges
hide a new tricritical point at an occupation fraction p=pc, where pc
is the percolation threshold of random percolation. For any value of p in the
interval pc<p≤1, our results show that the set of bridges has a
fractal dimension dBB≈1.22 in two dimensions. In the limit p→1, a self-similar fracture is revealed as a singly connected line
that divides the system in two domains. We then unveil how several seemingly
unrelated physical models tumble into the same universality class and also
present results for higher dimensions
Cone rod dystrophies
- Author
- A Hameed
- A Kipioti
- A Kobayashi
- A Maugeri
- A Swaroop
- BA Walters
- BJ Klevering
- CE Briggs
- Christian P Hamel
- CL Freund
- CP Hamel
- D Ducroq
- D Samra
- E Sprecher
- FB Porto
- FM Meire
- FY Demirci
- G Clarke
- GA Fishman
- GM Sarra
- I Perrault
- I Perrault
- IK Jalili
- J Zernant
- JA Kylstra
- JM Rozet
- LM Downey
- M Danciger
- M Michaelides
- M Nakazawa
- M Papaioannou
- M Warburg
- MG Ausems
- MM Sohocki
- PK Swain
- PL Beales
- RE Kelsell
- S Johnson
- S Khaliq
- SM Downes
- TS Aleman
- Publication venue
- BioMed Central
- Publication date
- 01/01/2007
- Field of study
Cone rod dystrophies (CRDs) (prevalence 1/40,000) are inherited retinal dystrophies that belong to the group of pigmentary retinopathies. CRDs are characterized by retinal pigment deposits visible on fundus examination, predominantly localized to the macular region. In contrast to typical retinitis pigmentosa (RP), also called the rod cone dystrophies (RCDs) resulting from the primary loss in rod photoreceptors and later followed by the secondary loss in cone photoreceptors, CRDs reflect the opposite sequence of events. CRD is characterized by primary cone involvement, or, sometimes, by concomitant loss of both cones and rods that explains the predominant symptoms of CRDs: decreased visual acuity, color vision defects, photoaversion and decreased sensitivity in the central visual field, later followed by progressive loss in peripheral vision and night blindness. The clinical course of CRDs is generally more severe and rapid than that of RCDs, leading to earlier legal blindness and disability. At end stage, however, CRDs do not differ from RCDs. CRDs are most frequently non syndromic, but they may also be part of several syndromes, such as Bardet Biedl syndrome and Spinocerebellar Ataxia Type 7 (SCA7). Non syndromic CRDs are genetically heterogeneous (ten cloned genes and three loci have been identified so far). The four major causative genes involved in the pathogenesis of CRDs are ABCA4 (which causes Stargardt disease and also 30 to 60% of autosomal recessive CRDs), CRX and GUCY2D (which are responsible for many reported cases of autosomal dominant CRDs), and RPGR (which causes about 2/3 of X-linked RP and also an undetermined percentage of X-linked CRDs). It is likely that highly deleterious mutations in genes that otherwise cause RP or macular dystrophy may also lead to CRDs. The diagnosis of CRDs is based on clinical history, fundus examination and electroretinogram. Molecular diagnosis can be made for some genes, genetic counseling is always advised. Currently, there is no therapy that stops the evolution of the disease or restores the vision, and the visual prognosis is poor. Management aims at slowing down the degenerative process, treating the complications and helping patients to cope with the social and psychological impact of blindness
HS1, a Lyn Kinase Substrate, Is Abnormally Expressed in B-Chronic Lymphocytic Leukemia and Correlates with Response to Fludarabine-Based Regimen
- Author
- A Contri
- AE Pugh-Bernard
- Alfons Navarro
- AM Brunati
- Anna Cabrelle
- Anna Maria Brunati
- Antonella Teramo
- AV Danilov
- C Scielzo
- C Scielzo
- Cristina Gattazzo
- D Kitamura
- E Meulmeester
- Elena Tibaldi
- Elisa Ave
- F Lee
- Federica Frezzato
- Gianpietro Semenzato
- H Dohner
- H He
- JM Dal Porto
- K Hussein
- L Trentin
- Livio Trentin
- M Crespo
- M Reth
- M Ruzzene
- M Ruzzene
- MC Frame
- Monica Facco
- MR Warr
- NE Harwood
- OO Onabajo
- Renato Zambello
- Samuela Carraro
- SJ Parsons
- T Fukuda
- T Uruno
- TJ Hamblin
- TJ Hamblin
- TJ Hamblin
- TS Gomez
- Valentina Trimarco
- Veronica Martini
- Y Suzuki
- Y Xu
- Y Yamanashi
- YP Chong
- YR Chen
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
In B-Chronic Lymphocytic Leukemia (B-CLL) kinase Lyn is overexpressed, active, abnormally distributed, and part of a cytosolic complex involving hematopoietic lineage cell-specific protein 1 (HS1). These aberrant properties of Lyn could partially explain leukemic cells’ defective apoptosis, directly or through its substrates, for example, HS1 that has been associated to apoptosis in different cell types. To verify the hypothesis of HS1 involvement in Lyn-mediated leukemic cell survival, we investigated HS1 protein in 71 untreated B-CLL patients and 26 healthy controls. We found HS1 overexpressed in leukemic as compared to normal B lymphocytes (1.38±0.54 vs 0.86±0.29, p<0.01), and when HS1 levels were correlated to clinical parameters we found a higher expression of HS1 in poor-prognosis patients. Moreover, HS1 levels significantly decreased in ex vivo leukemic cells of patients responding to a fludarabine-containing regimen. We also observed that HS1 is partially localized in the nucleus of neoplastic B cells. All these data add new information on HS1 study, hypothesizing a pivotal role of HS1 in Lyn-mediated modulation of leukemic cells’ survival and focusing, one more time, the attention on the BCR-Lyn axis as a putative target for new therapeutic strategies in this disorder
Potential application of waste from castor bean (Ricinus communis L.) for production for xylanase of interest in the industry
- Author
- A Glyk
- A Poorna
- AM Castro
- CHA Oliveira
- CS Sánchez-Trasviña
- CW Hasseltine
- D Garai
- DN Adhyaru
- FX Lu
- G Rahimpour Mamo
- G Suvarna Lakshmi
- GL Miller
- H Chen
- H Mutlu
- H Ogino
- HL Ho
- HM Soliman
- J Gao
- JJ Pandya
- JL Cleland
- M Irfan
- M Rito-Palomares
- MJ Bailey
- MM Bradford
- MR Spier
- MTH Cavalcanti
- MV Ramesh
- PG Mazzola
- PN Herculano
- PN Herculano
- RA Rodrigues
- RDPB Pirota
- RS Prakasham
- S Khammuang
- S Raja
- S Yang
- SK Ang
- SK Ang
- SM Pancera
- T Collins
- T Ncube
- TS Porto
- ZDVL Mayerhoff
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A new enzymatic process for the treatment of phenolic pollutants
- Author
- Attilio Converti
- Ayranci K
- Britto JM
- Campeanu G
- Chaplin MF
- Colombié S
- Converti A
- Converti A
- Durán N
- Eaton HD
- Eidhin DMN
- Fang C
- Faria RO
- Freire RS
- Fuerst EP
- Gisele Pigatto
- Harald Horn
- Hasmann FA
- Ikehata K
- Ikehata K
- Jain AK
- Jiang H
- Jiang H
- Kameda E
- Kujawski W
- López-Molina D
- Mario Zilli
- Martin LB
- Mauri Sergio Alves Palma
- Mojović Z
- Neufeld RD
- Palma MSA
- Palma MSA
- Pastorino L
- Porto TS
- Quadros PA
- Quan D
- Romanovskaya II
- Rosatto SR
- Sellés-Marchart S
- Shibata CT
- Theodore L
- Toral MI
- Viana DA
- Wuyts N
- Yamada K
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Vulnerabilidade social e risco ambiental: uma abordagem metodológica para avaliação de injustiça ambiental
- Author
- Abreu MA
- Acselrad H
- Acselrad H
- Alvito M
- Bryant B
- Bullard RD
- Bullard RD
- Bullard RD
- Chakraborty J
- Christovam Barcellos
- Cristiane Hübner
- Cutter S
- Cutter S
- Dias R
- Feichas SAQ
- Freitas CM
- Glickman TS
- Gould KA
- Harner J
- Haughton G
- Herculano S
- Kumar CM
- Lester JP
- Marcelo Firpo Porto
- Marcondes MJA
- Martinez-Alier J
- Mennis J
- Mohai P
- Newmann CM
- Oliveira ACM
- Porto MFS
- Préteceille E
- Rego VS
- Ruy Cartier
- Sheppard E
- Stockwell JR
- Yandle T
- Zandberg PA
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
A relação entre professores com sofrimento psíquico e crianças escolares com problemas de comportamento
- Author
- Achenbach TM
- Ackermann R
- American Psychiatric Association
- Araujo TM
- Araujo TM
- Assis SG.
- Avanci JQ
- Bee H
- Beltrão IK
- Berg-Nielsen TS
- Bird HR
- Bordin IAS
- Boyle MH
- Chae PK
- Claro TS
- Codo W
- Coutinho ESF.
- Egyed CJ
- Ferdinand RF
- Fergusson DM
- Fleitlich-Bilyk B
- Franklin K
- Gabriela Franco Dias Lyra
- Gasparini SM
- Harding TW
- Iacoponi E
- Kathie Njaine
- Kolko DJ
- Lanier J
- Mari JJ
- Massola GM
- Minayo MCS
- Murray CJL
- Najman JM
- Porto LA
- Raquel de Vasconcellos Carvalhaes de Oliveira
- Reis EJFB
- Rutter M
- Santos PL
- Silva ATB.
- Simone Gonçalves de Assis
- Thiago de Oliveira Pires
- Verhulst FC
- Youngstrom E
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
- Auer P
- Avidan M
- Avila Sanchez FJ
- Avila EJD
- Avis J
- Awad H
- Axioti E
- Ayyaz H
- Azam UAA
- Azambuja P
- Azevedo C
- Aziz FZ
- Baas P
- Baghirzada L
- Bai H-P
- Bai Y
- Baillie S
- Baines D
- Baio TH
- Bairaktari A
- Baker G
- Baker K-A
- Baker P
- Balain B
- Balaji P
- Balajonda N
- Balanescu A
- Balasubramaniam M
- Baldisserotto S
- Baldwin J
- Baldwin M
- Balfoussia D
- Bali C
- Bandeira ME
- Banerjee R
- Bankewitz C
- Banner-Goodspeed V
- Bao Q
- Barcraft-Barnes H
- Barneto L
- Barnett A
- Baroselli A
- Barraclough J
- Barras J-P
- Barrett S
- Barrett WJ
- Basanth S
- Batchelor N
- Bateman B
- Bates A
- Bates S
- Batista HD
- Bauchmuller K
- Bauer M
- Baumgarten G
- Baxter L
- Beaton C
- Beattie S
- Beavis V
- Bechan S
- Bejia T
- Belciu I
- Belda MT
- Bell G
- Bell R
- Bell S
- Bellandi M
- Bello J
- Beloeil H
- Belskiy V
- Ben-Menachem E
- Benavent P
- Benevento A
- Bengeri S
- Bennett C
- Bennett M
- Bennett R
- Bennett V
- Bentley C
- Beretta L
- Berg A
- Bergin C
- Bernard A
- Berntsen E
- Bertram W
- Bester D
- Bester M
- Bettega F
- Bettinelli A
- Bhardwaj N
- Bhatia K
- Bhula C
- Bi Y
- Biais M
- Biccard BM
- Bidd H
- Bidgoli J
- Biffen A
- Bignami E
- Bilolikar A
- Bin Mustapha MT
- Birch J
- Bishop DG
- Biyase T
- Bizios C
- Blackwell C
- Blackwood D
- Blaj M
- Blakemore SP
- Bland M
- Blunt M
- Blyth K
- Bocchino S
- Bodansky D
- Bodger P
- Boer C
- Boereboom C
- Boggiano V
- Bogner G
- Bolaji B
- Bolton D
- Boone M
- Boschi L
- Boshier P
- Botes M
- Botis I
- Bottini C
- Bottrill F
- Bouchez S
- Boulton K
- Bouris V
- Bourner L
- Boutsikos G
- Bouwman A
- Bouwman RA
- Bowrey S
- Boxall L
- Boyd C
- Bradburn M
- Bradley J
- Branagan G
- Branco T
- Brand B
- Brandsborg B
- Breitenstein S
- Brennan A
- Brennan E
- Brenner L
- Brincat M
- Briscoe R
- Bristogiannis S
- Brooke J
- Brookes J
- Brookes M
- Brooks C
- Broomby R
- Brotto AF
- Brown A
- Brown CW
- Brown G
- Brown J
- Brown J
- Brown L
- Brown R
- Brown R
- Browning J
- Bruma D
- Brunete T
- Brunswicker A
- Bryant H
- Bua E
- Buccimazza I
- Buckley S
- Buerkle C
- Buhre W
- Buhre W
- Buhrer T
- Builu PM
- Buise M
- Bullock C
- Bunwarie B
- Burns K
- Burrows L
- Burrows T
- Burston B
- Burtenshaw A
- Burton M
- Busuioc M
- Butryn I
- Butt G
- Byrne K
- Cabezuelo E
- Cabral R
- Cabral TDN
- Cabrini L
- Cacala S
- Cai F
- Cai Y
- Cain H
- Cairns C
- Cakova V
- Calderwood C
- Callaghan M
- Campbell D
- Campbell D
- Campbell D
- Campbell G
- Campbell G
- Campbell K
- Campbell M
- Campbell T
- Campey L
- Camsooksai J
- Cancho D
- Candido K
- Cang J
- Cannavo M
- Cao J
- Cao Y
- Cao Z
- Cardellino S
- Cardosa J
- Cardoso G
- Cardy J
- Carmino L
- Carp CP
- Carr A
- Carrera R
- Carroll C
- Carroll J
- Caser E
- Castano Moreira B
- Castano B
- Castle G
- Cavanagh S
- Cawthorn L
- Cernea DD
- Chaddock M
- Chaloulis P
- Chan A
- Chan HMH
- Chan M
- Chan P
- Chan V
- Chan WK
- Chan WKJ
- Chan YL
- Chande S
- Chandler B
- Chandra S
- Chandrasekharan S
- Chang YH
- Chaniotaki F
- Charitos E
- Charlalampidoy A
- Charles R
- Chatterjee D
- Chatterjee J
- Chatzimichali CA
- Chau S
- Chazova E
- Cheah C
- Cheah S
- Cheeseman M
- Cheing Y
- Chen C
- Chen C
- Chen F
- Chen F
- Chen H
- Chen J
- Chen J
- Chen L
- Chen L
- Chen L-L
- Chen P
- Chen Q
- Chen R
- Chen S
- Chen S
- Chen S
- Chen Y
- Chen Y
- Chen Y
- Chen Y
- Chen Z
- Cheng B
- Cheng KH
- Cheng Z
- Cheong E
- Cherian R
- Cherrett V
- Chetty RR
- Chew M
- Chhabra A
- Chicken D-W
- Chilinciuc I
- Chin II
- Chirkut S
- Chisbert Cuenca V
- Chlorou D
- Choi H-MD
- Choi S
- Chow L
- Christian R
- Christiansen IC
- Christmas N
- Christodoulidis G
- Christodoulopoulou T
- Christofaki M
- Christoforidis D
- Chronis C
- Chu HM
- Chu S
- Chua P
- Chukkambotla S
- Chung CKE
- Cifra E
- Ciobanu C
- Ciobotaru OR
- Cirstea E
- Clark R
- Clarkson A
- Clarkson R
- Claxton A
- Clemmons K
- Cloro LM
- Clyde A
- Cobzaru I
- Codita A
- Colangelo A
- Colangelo C
- Colling K
- Collins H
- Collins M
- Collins N
- Colvin C
- Commey T
- Comptaer N
- Conde C
- Conradie A
- Constantin K
- Cook T
- Cooper L
- Cooper L
- Cooper M
- Cooper R
- Cooper S
- Copaciu E
- Cope J
- Copetti E
- Copley E
- Copotoiu SM
- Coppens M
- Corneci D
- Cornell J
- Cornish J
- Correia da Silva RFM
- Corti D
- Costanzo E
- Costelloe H
- Cotter R
- Cotterell S
- Cotterill D
- Coughlan E
- Coulter I
- Coulter S
- Coutinho F
- Cowton A
- Cox H
- Cozar OI
- Craig J
- Craven R
- Craw N
- Craw S
- Creary T
- Cripps H
- Critchley R
- Cronje L
- Cruickshank R
- Cruikshanks A
- Cruz S
- Cueva A
- Cunha P
- Curley G
- Currow H
- Czepanski C
- Czeslick E
- D'Andrea R
- da Costa Fischer BF
- Dafnios N
- Dai H
- Dai Q
- Dai Q
- Dai SY
- Daikou P
- Dalamagka M
- Dalampini E
- Dali-Kemmery L
- Dalton E
- Damant R
- Daniel C
- Daniel GD
- Daniel H
- Daniel H
- Daniel S
- Dankl D
- Darko J
- Darwish S
- Das S
- Dasrath A
- Datson A
- Daubeny T
- Daugaard M
- Davari M
- Dave T
- Davies C
- Davies H
- Davies K
- Davies K
- Davies L
- Davies Z
- Davis E
- Davis F
- Davis S
- Daya B
- De Andres Ibanez JA
- de Araujo DM
- De Baerdemaeker L
- de Beer J
- de Boer HD
- De Bruyne A
- de Campos Ferreira MF
- de Fretes J
- de Gasperi J
- De Hert S
- De Jongh K
- De Kegel D
- De Meyer JN
- De Oliveira MC
- de Rudnicki S
- de Swardt M
- de Vasconcellos K
- de Villiers M
- de Wet J
- Deacon M
- Deblaere I
- Dedemadi G
- Deen T
- Deepak S
- Deighton K
- Deja M
- Delgado Garcia DR
- Delgado Navarro C
- Della Rocca G
- Dempsey G
- Dempster A
- den Hoedt M
- Denham S
- Dent K
- Dermitzaki D
- Desbordes J
- Despotidis V
- Diaconescu C
- Dias F
- Dias S
- Dickson J
- Ditai J
- Divatia J
- Dixon L
- do Nascimento Junior P
- Dobson G
- Docherty P
- Dodiyi-Manuel A
- Dodsworth K
- Dolan R
- Dong B
- Donohue R
- Donovan A
- Douglas J
- Doumos R
- Downes C
- Doyle D
- Dragnea D
- Dragoescu NA
- Drake M
- Drimala M
- Drinkwater Z
- Drummond L
- Du F
- Du F
- Du X
- Duarte C
- Dube NZ
- Duca A
- Dudgeon L
- Dudson R
- Duenser M
- Dumitrascu CO
- Dumitrescu A
- Dunay A
- Dunk N
- Durant E
- Durodola A
- Dursin AN
- Durst A
- Duttchen K
- Dutu M
- Dwyer H
- Dylst D
- Dzhamullaev P
- Dzulkipli N
- Echem R
- Edmond H
- Edwards J
- Edwards M
- Edwards M
- Efthymiadi A
- Egan T
- Eggleston C
- Eichwalder A
- Eikman J
- Ekelund K
- el Manser D
- El-Sayed A
- Elabib A
- Elena G
- Elferink-Vonk R
- Elgasim M
- Ellis J
- Ellis K
- Elna C
- Emma T
- Endersby S
- Eneje P
- Eng K
- English D
- English R
- Epodoi J
- Eskildsen KZ
- Esteves S
- Ethgen S
- Evans A
- Evans C
- Everingham K
- Ewe R
- Ezekiel E
- Ezike H
- Fagerlund MJ
- Faina L
- Falk E
- Fan H
- Fan L
- Fan Y
- Fanfani LC
- Faponle F
- Faria e Maia D
- Faria F
- Farid N
- Farina Z
- Farrell H
- Farrow M
- Fasina O
- Fatungase OM
- Faulds M
- Fei Y
- Fellinger P
- Feng Y
- Fengas L
- Fergey L
- Ferguson M
- Fernandez S
- Ferrando C
- Filipescu D
- Filippopoulos A
- Finch A
- Fiorentza K
- Fischbach N
- Flatt J
- Fleischer A
- Fleisher L
- Fleisher LA
- Flores Risco S
- Flores AAA
- Flores K
- Flossos A
- Foers W
- Foglia J
- Foley J
- Fonck K
- Foord D
- Foot H
- Foot J
- Ford D
- Forget P
- Forsans E
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
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- AKI Research Group
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- de Wilde W
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- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
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- Escórcio S
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- FINNRESUSCI Study Group
- Fischer G
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- Fromentin M
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- Huang WC
- Huang WC
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- Hung WT
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- Ignacio ML
- Iida A
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- Imanaka H
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- Ince C
- Iotti GA
- Iotti GA
- Iotti GA
- IPREA Study Group
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- Janotka M
- Janotka M
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
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- Jeong IY
- Jeong WY
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- Jiao LR
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- Jiménez GJ
- Jo YH
- Joachim J
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- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
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- Juliarena A
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- Jun IG
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- Junior JM
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- Kaminsky GE
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- Kolnikova I
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- Kouatchet A
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- Kulkarni AP
- Kumari BK
- Kumbamu A
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- Kurmukov IA
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- Kwon HM
- Kwon WY
- Kwon WY
- Kwon WY
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- Kyle UG
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- Labra C
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- Lafuente E
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- Lai CH
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- Lapteva K
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- Latini R
- Latini R
- Latini R
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- Lombardo MD
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- MacKay A
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- Maghsoudi B
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- Marcos-Zambrano LJ
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- Martín-Loeches I
- Martín-Loeches I
- Martínez F
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- Martínez L
- Martínez M
- Martínez MP
- Martínez MV
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- Martínez-Carmona JF
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- Menendez R
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- Mercat A
- Mercat A
- Mergulhão PJ
- Merino-Vega D
- Messenger D
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- Midwinter MJ
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- Miguelena PR
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- Mora-Ordóñez JM
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- Morimoto T
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- Morán I
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- Okayama Research Investigation Organizing Network (ORION)investigators
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- Pastor EE
- Patel B
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- Rutherford WB
- Rutten AM
- Rydingsward JE
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- St George’s University of London
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- Yılmaz G
- Yilmazer F
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- Yonis H
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- Yoshida T
- Yoshida T
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- Yoshitake E
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- Zabini D
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- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Contribution to the evaluation of language disturbances in subcortical lesions: a piloty study
- Author
- Alexander GE
- Alexander MP
- Allain P
- Benton AL
- Cláudia Sellitto Porto
- Crosson B
- Crowe SF
- Cummings JL
- D'Esposito M
- Damasio AR
- DeRenzi E
- Démonet JF
- Fisher CM
- Goodglass H
- Grant DA
- Grossman M
- Kaplan E
- Kimberg DY
- Letícia Lessa Mansur
- Mariana Jardim Azambuja
- McFarling D
- Mega MS
- Mesulam M-M
- Mesulam M-M
- Milberto Scaff
- Márcia Radanovic
- Nadeau SE
- Naeser MA
- Naeser MA
- Ojemann G
- Olsen TS
- Radanovic M
- Radanovic M
- Reitan RM
- Riklan M
- Shallice T
- Sirigu A
- Swain SA
- Wallesch C-W
- Waters G
- Weiller C
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
- …