1,526 research outputs found
The PWWP domain and the evolution of unique DNA methylation toolkits in Hymenoptera.
DNMT3 in Hymenoptera has a unique duplication of the essential PWWP domain. Using GST-tagged PWWP fusion proteins and histone arrays we show that these domains have gained new properties and represent the first case of PWWP domains binding to H3K27 chromatin modifications, including H3K27me3, a key modification that is important during development. Phylogenetic analyses of 107 genomes indicate that the duplicated PWWP domains separated into two sister clades, and their distinct binding capacities are supported by 3D modeling. Other features of this unique DNA methylation system include variable copies, losses, and duplications of DNMT1 and DNMT3, and combinatorial generations of DNMT3 isoforms including variants missing the catalytic domain. Some of these losses and duplications of are found only in parasitic wasps. We discuss our findings in the context of the crosstalk between DNA methylation and histone methylation, and the expanded potential of epigenomic modifications in Hymenoptera to drive evolutionary novelties
Probing cosmic dawn with emission lines: predicting infrared and nebular line emission for ALMA and JWST
Infrared and nebular lines provide some of our best probes of the physics
regulating the properties of the interstellar medium (ISM) at high-redshift.
However, interpreting the physical conditions of high-redshift galaxies
directly from emission lines remains complicated due to inhomogeneities in
temperature, density, metallicity, ionisation parameter, and spectral hardness.
We present a new suite of cosmological, radiation-hydrodynamics simulations,
each centred on a massive Lyman-break galaxy that resolves such properties in
an inhomogeneous ISM. Many of the simulated systems exhibit transient but well
defined gaseous disks that appear as velocity gradients in [CII]~158.6m
emission. Spatial and spectral offsets between [CII]~158.6m and
[OIII]~88.33m are common, but not ubiquitous, as each line probes a
different phase of the ISM. These systems fall on the local [CII]-SFR relation,
consistent with newer observations that question previously observed
[CII]~158.6m deficits. Our galaxies are consistent with the nebular line
properties of observed galaxies and reproduce offsets on the BPT and
mass-excitation diagrams compared to local galaxies due to higher star
formation rate (SFR), excitation, and specific-SFR, as well as harder spectra
from young, metal-poor binaries. We predict that local calibrations between
H and [OII]~3727 luminosity and galaxy SFR apply up to , as
do the local relations between certain strong line diagnostics (R23 and
[OIII]~5007/H) and galaxy metallicity. Our new simulations are well
suited to interpret the observations of line emission from current (ALMA and
HST) and upcoming facilities (JWST and ngVLA)
Interplay of LFV and slepton mass splittings at the LHC as a probe of the SUSY seesaw
We study the impact of a type-I SUSY seesaw concerning lepton flavour
violation (LFV) both at low-energies and at the LHC. The study of the di-lepton
invariant mass distribution at the LHC allows to reconstruct some of the masses
of the different sparticles involved in a decay chain. In particular, the
combination with other observables renders feasible the reconstruction of the
masses of the intermediate sleptons involved in decays. Slepton mass splittings can be either
interpreted as a signal of non-universality in the SUSY soft breaking-terms
(signalling a deviation from constrained scenarios as the cMSSM) or as being
due to the violation of lepton flavour. In the latter case, in addition to
these high-energy processes, one expects further low-energy manifestations of
LFV such as radiative and three-body lepton decays. Under the assumption of a
type-I seesaw as the source of neutrino masses and mixings, all these LFV
observables are related. Working in the framework of the cMSSM extended by
three right-handed neutrino superfields, we conduct a systematic analysis
addressing the simultaneous implications of the SUSY seesaw for both high- and
low-energy lepton flavour violation. We discuss how the confrontation of
slepton mass splittings as observed at the LHC and low-energy LFV observables
may provide important information about the underlying mechanism of LFV.Comment: 50 pages, 42 eps Figures, typos correcte
Assessment of Yellow Fever Epidemic Risk: An Original Multi-criteria Modeling Approach
This article describes the use of an original modeling approach to assess the risk of yellow fever (YF) epidemics. YF is a viral hemorrhagic fever responsible in past centuries for devastating outbreaks. Since the 1930s, a vaccine has been available that protects the individual for at least 10 years, if not for life. However, immunization of populations in African countries was gradually discontinued after the 1960s. With the decrease in immunity against YF in African populations the disease reemerged in the 1980s. In 2005, WHO, UNICEF, and the GAVI Alliance decided to support preventive vaccination of at-risk populations in West African endemic countries in order to tackle the reemergence of YF and reduce the risk of urban YF outbreaks. Financial resources were made available to scale up a global YF vaccine stockpile and to support countries with limited resources in the management of preventive vaccination campaigns. This article describes the process we used to determine the most at-risk populations using a mathematical model to prioritize targeted immunization campaigns. We believe that this approach could be useful for other diseases for which decision making process is difficult because of limited data availability, complex risk variables, and a need for rapid decisions and implementation
Goldstone Fermion Dark Matter
We propose that the fermionic superpartner of a weak-scale Goldstone boson
can be a natural WIMP candidate. The p-wave annihilation of this `Goldstone
fermion' into pairs of Goldstone bosons automatically generates the correct
relic abundance, whereas the XENON100 direct detection bounds are evaded due to
suppressed couplings to the Standard Model. Further, it is able to avoid
indirect detection constraints because the relevant s-wave annihilations are
small. The interactions of the Goldstone supermultiplet can induce non-standard
Higgs decays and novel collider phenomenology.Comment: 25 pages, 6 figures. References added, minor typos corrected.
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BENEFIT RISK JUDGMENTS FOR PATIENTS RECEIVING RETINOIDS ON A SHORT-TERM AND LONG-TERM BASIS - PANEL DISCUSSION
Atomically dispersed Pt-N-4 sites as efficient and selective electrocatalysts for the chlorine evolution reaction
Chlorine evolution reaction (CER) is a critical anode reaction in chlor-alkali electrolysis. Although precious metal-based mixed metal oxides (MMOs) have been widely used as CER catalysts, they suffer from the concomitant generation of oxygen during the CER. Herein, we demonstrate that atomically dispersed Pt-N-4 sites doped on a carbon nanotube (Pt-1/CNT) can catalyse the CER with excellent activity and selectivity. The Pt-1/CNT catalyst shows superior CER activity to a Pt nanoparticle-based catalyst and a commercial Ru/Ir-based MMO catalyst. Notably, Pt-1/CNT exhibits near 100% CER selectivity even in acidic media, with low Cl- concentrations (0.1M), as well as in neutral media, whereas the MMO catalyst shows substantially lower CER selectivity. In situ electrochemical X-ray absorption spectroscopy reveals the direct adsorption of Cl- on Pt-N-4 sites during the CER. Density functional theory calculations suggest the PtN4C12 site as the most plausible active site structure for the CER
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