1,162 research outputs found

    Platinized counter-electrodes for dye-sensitised solar cells from waste thermocouples: A case study for resource efficiency, industrial symbiosis and circular economy

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    A study of a local industrial symbiosis involving the recovery of platinum from waste thermocouples which is then used for the preparation of catalytic electrodes suitable for dye-sensitized solar cell production is reported. The small quantity of platinum in the filaments of used thermocouples, thousands of which are discarded each year by metal foundries, can be economically recovered by conversion to chloroplatinic acid hydrate, an ‘added value’ product, which can then be used in the fabrication of dye-sensitized solar cell counter-electrodes. 91% recovery of platinum from filaments as chloroplatinic acid hydrate has been achieved by aqua regia digestion of manually isolated filaments. Cost-benefit analysis shows the proposed process derives sufficient value to cover landfill costs for what is left of the waste thermocouples after platinum removal; provide ∼5 days employment; and provide 63% materials cost savings for electrode preparation in comparison to purchasing commercially available chloroplatinic acid hydrate. The proposed local industrial symbiosis would, per year, divert ∼50  g of platinum from landfill, avoid up to 1400 kg of CO2 emissions associated with primary production of an equivalent quantity of platinum, and give enough platinum to produce catalytic electrodes for ∼500 m2 of dye-sensitized solar cells, which could supply clean energy for 12 homes in the locality. The process exemplifies the environmental, economic and social benefits available through adoption of circular practices, which make use of secondary materials available within the local economy by valorizing wastes. The process also overcomes economic barriers to critical raw materials (CRMs) recovery from dissipative applications

    Evaluating the Application of Microbial Induced Calcite Precipitation Technique to Stabilize Expansive Soils

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    Expansive soils, also known as swell-shrink soils have been a problem for civil infrastructures including roads and foundations from ancient times. The use of chemical additives such as cement and lime to stabilize expansive soils is a common practice among geotechnical engineers, especially for lightly loaded structures. However, several occurrences of subgrade failures have been observed after stabilizing with chemical additives. Hence, engineers are in search of sustainable stabilization alternatives. Microbial Induced Calcite Precipitation (MICP) is gaining attention as an environmentally friendly soil improvement technique. Several researchers have successfully tested its feasibility in mitigating liquefaction-induced problems in sandy soils. In this research, the authors are evaluating its effectiveness in stabilizing expansive soils. For this purpose two natural expansive soils with high and low plasticity properties were subjected to MICP treatments. The soil samples were first augmented with bacterium Sporosarcina Pasteurii and then treated with Calcium Chloride and Urea. Variables such as microbial concentrations and curing times were studied in this research. Geotechnical testing including Atterberg limits and unconfined compression strength were performed to evaluate the efficacy of MICP treatments. Preliminary results indicate that there is a reduction in plasticity and swelling characteristics of the soils and increase in the unconfined compression strength

    Moral enhancement: do means matter morally?

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    One of the reasons why moral enhancement may be controversial, is because the advantages of moral enhancement may fall upon society rather than on those who are enhanced. If directed at individuals with certain counter-moral traits it may have direct societal benefits by lowering immoral behavior and increasing public safety, but it is not directly clear if this also benefits the individual in question. In this paper, we will discuss what we consider to be moral enhancement, how different means may be used to achieve it and whether the means we employ to reach moral enhancement matter morally. Are certain means to achieve moral enhancement wrong in themselves? Are certain means to achieve moral enhancement better than others, and if so, why? More specifically, we will investigate whether the difference between direct and indirect moral enhancement matters morally. Is it the case that indirect means are morally preferable to direct means of moral enhancement and can we indeed pinpoint relevant intrinsic, moral differences between both? We argue that the distinction between direct and indirect means is indeed morally relevant, but only insofar as it tracks an underlying distinction between active and passive interventions. Although passive interventions can be ethical provided specific safeguards are put in place, these interventions exhibit a greater potential to compromise autonomy and disrupt identity

    Solving the Simplest Theory of Quantum Gravity

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    We solve what is quite likely the simplest model of quantum gravity, the worldsheet theory of an infinitely long, free bosonic string in Minkowski space. Contrary to naive expectations, this theory is non-trivial. We illustrate this by constructing its exact factorizable S-matrix. Despite its simplicity, the theory exhibits many of the salient features expected from more mature quantum gravity models, including the absence of local off-shell observables, a minimal length, a maximum achievable (Hagedorn) temperature, as well as (integrable relatives of) black holes. All these properties follow from the exact S-matrix. We show that the complete finite volume spectrum can be reconstructed analytically from this S-matrix with the help of the thermodynamic Bethe Ansatz. We argue that considered as a UV complete relativistic two-dimensional quantum field theory the model exhibits a new type of renormalization group flow behavior, "asymptotic fragility". Asymptotically fragile flows do not originate from a UV fixed point.Comment: 32+4 pages, 1 figure, v2: typos fixed, published versio

    Mapping of Mycobacterium tuberculosis Complex Genetic Diversity Profiles in Tanzania and Other African Countries

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    The aim of this study was to assess and characterize Mycobacterium tuberculosis complex (MTBC) genotypic diversity in Tanzania, as well as in neighbouring East and other several African countries. We used spoligotyping to identify a total of 293 M. tuberculosis clinical isolates (one isolate per patient) collected in the Bunda, Dar es Salaam, Ngorongoro and Serengeti areas in Tanzania. The results were compared with results in the SITVIT2 international database of the Pasteur Institute of Guadeloupe. Genotyping and phylogeographical analyses highlighted the predominance of the CAS, T, EAI, and LAM MTBC lineages in Tanzania. The three most frequent Spoligotype International Types (SITs) were: SIT21/CAS1-Kili (n = 76; 25.94%), SIT59/LAM11-ZWE (n = 22; 7.51%), and SIT126/EAI5 tentatively reclassified as EAI3-TZA (n = 18; 6.14%). Furthermore, three SITs were newly created in this study (SIT4056/EAI5 n = 2, SIT4057/T1 n = 1, and SIT4058/EAI5 n = 1). We noted that the East-African-Indian (EAI) lineage was more predominant in Bunda, the Manu lineage was more common among strains isolated in Ngorongoro, and the Central-Asian (CAS) lineage was more predominant in Dar es Salaam (p-value<0.0001). No statistically significant differences were noted when comparing HIV status of patients vs. major lineages (p-value = 0.103). However, when grouping lineages as Principal Genetic Groups (PGG), we noticed that PGG2/3 group (Haarlem, LAM, S, T, and X) was more associated with HIV-positive patients as compared to PGG1 group (Beijing, CAS, EAI, and Manu) (p-value = 0.03). This study provided mapping of MTBC genetic diversity in Tanzania (containing information on isolates from different cities) and neighbouring East African and other several African countries highlighting differences as regards to MTBC genotypic distribution between Tanzania and other African countries. This work also allowed underlining of spoligotyping patterns tentatively grouped within the newly designated EAI3-TZA lineage (remarkable by absence of spacers 2 and 3, and represented by SIT126) which seems to be specific to Tanzania. However, further genotyping information would be needed to confirm this specificity

    Design and testing of hydrophobic core/hydrophilic shell nano/micro particles for drug-eluting stent coating

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    In this study, we designed a novel drug-eluting coating for vascular implants consisting of a core coating of the anti-proliferative drug docetaxel (DTX) and a shell coating of the platelet glycoprotein IIb/IIIa receptor monoclonal antibody SZ-21. The core/shell structure was sprayed onto the surface of 316L stainless steel stents using a coaxial electrospray process with the aim of creating a coating that exhibited a differential release of the two drugs. The prepared stents displayed a uniform coating consisting of nano/micro particles. In vitro drug release experiments were performed, and we demonstrated that a biphasic mathematical model was capable of capturing the data, indicating that the release of the two drugs conformed to a diffusion-controlled release system. We demonstrated that our coating was capable of inhibiting the adhesion and activation of platelets, as well as the proliferation and migration of smooth muscle cells (SMCs), indicating its good biocompatibility and anti-proliferation qualities. In an in vivo porcine coronary artery model, the SZ-21/DTX drug-loaded hydrophobic core/hydrophilic shell particle coating stents were observed to promote re-endothelialization and inhibit neointimal hyperplasia. This core/shell particle-coated stent may serve as part of a new strategy for the differential release of different functional drugs to sequentially target thrombosis and in-stent restenosis during the vascular repair process and ensure rapid re-endothelialization in the field of cardiovascular disease

    A New Approach to Evaluate and Reduce Uncertainty of Model-Based Biodiversity Projections for Conservation Policy Formulation

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    Biodiversity projections with uncertainty estimates under different climate, land-use, and policy scenarios are essential to setting and achieving international targets to mitigate biodiversity loss. Evaluating and improving biodiversity predictions to better inform policy decisions remains a central conservation goal and challenge. A comprehensive strategy to evaluate and reduce uncertainty of model outputs against observed measurements and multiple models would help to produce more robust biodiversity predictions. We propose an approach that integrates biodiversity models and emerging remote sensing and in-situ data streams to evaluate and reduce uncertainty with the goal of improving policy-relevant biodiversity predictions. In this article, we describe a multivariate approach to directly and indirectly evaluate and constrain model uncertainty, demonstrate a proof of concept of this approach, embed the concept within the broader context of model evaluation and scenario analysis for conservation policy, and highlight lessons from other modeling communities

    Toward Human-Carnivore Coexistence: Understanding Tolerance for Tigers in Bangladesh

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    Fostering local community tolerance for endangered carnivores, such as tigers (Panthera tigris), is a core component of many conservation strategies. Identification of antecedents of tolerance will facilitate the development of effective tolerance-building conservation action and secure local community support for, and involvement in, conservation initiatives. We use a stated preference approach for measuring tolerance, based on the ‘Wildlife Stakeholder Acceptance Capacity’ concept, to explore villagers’ tolerance levels for tigers in the Bangladesh Sundarbans, an area where, at the time of the research, human-tiger conflict was severe. We apply structural equation modeling to test an a priori defined theoretical model of tolerance and identify the experiential and psychological basis of tolerance in this community. Our results indicate that beliefs about tigers and about the perceived current tiger population trend are predictors of tolerance for tigers. Positive beliefs about tigers and a belief that the tiger population is not currently increasing are both associated with greater stated tolerance for the species. Contrary to commonly-held notions, negative experiences with tigers do not directly affect tolerance levels; instead, their effect is mediated by villagers’ beliefs about tigers and risk perceptions concerning human-tiger conflict incidents. These findings highlight a need to explore and understand the socio-psychological factors that encourage tolerance towards endangered species. Our research also demonstrates the applicability of this approach to tolerance research to a wide range of socio-economic and cultural contexts and reveals its capacity to enhance carnivore conservation efforts worldwide

    Cytochrome 450 1B1 (CYP1B1) polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC) patients

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    BACKGROUND: The selection of patients according to key genetic characteristics may help to tailor chemotherapy and optimize the treatment in Castration-Resistant Prostate Cancer (CRPC) patients. Functional polymorphisms within the cytochrome P450 1B1 (CYP1B1) gene have been associated with alterations in enzymatic expression and activity and may change sensitivity to the widely used docetaxel regimen. METHODS: CYP1B1 genotyping was performed on blood samples of 60 CRPC patients treated with docetaxel, using TaqMan probes-based assays. Association between CYP1B1-142C>G (leading to the 48ArgGly transition), 4326C>G (432LeuVal), and 4390A>G (453AsnSer) polymorphisms and treatment response, progression-free-survival (PFS) and overall-survival (OS) was estimated using Pearson χ2 test, Kaplan-Meier curves and Log-rank test. RESULTS: Patients carrying the CYP1B1-432ValVal genotype experienced a significantly lower response-rate (P = 0.014), shorter progression-free-survival (P = 0.032) and overall-survival (P < 0.001). Multivariate analyses and correction for multiple comparisons confirmed its prognostic significance for OS. No significant associations were found among other polymorphisms and both response and clinical outcome. CONCLUSIONS: CYP1B1-4326C>G (432LeuVal) polymorphism emerged as possible predictive marker of response and clinical outcome to docetaxel in CRPC patients and may represent a potential new tool for treatment optimization. Larger prospective trials are warranted to validate these findings, which might be applied to the future practice of CRPC treatment
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