International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS

Characterization of the Ejecta from the NASA/DART Impact on Dimorphos: Observations and Monte Carlo Models

The NASA Double Asteroid Redirection Test (DART) spacecraft successfully crashed on Dimorphos, the secondary component of the binary (65803) Didymos system. Following the impact, a large dust cloud was released, and a long-lasting dust tail developed. We have extensively monitored the dust tail from the ground and the Hubble Space Telescope. We provide a characterization of the ejecta dust properties, i.e., particle size distribution and ejection speeds, ejection geometric parameters, and mass, by combining both observational data sets and using Monte Carlo models of the observed dust tail. The size distribution function that best fits the imaging data is a broken power law having a power index of -2.5 for particles of r & LE; 3 mm and -3.7 for larger particles. The particles range in size from 1 & mu;m up to 5 cm. The ejecta is characterized by two components, depending on velocity and ejection direction. The northern component of the double tail, observed since 2022 October 8, might be associated with a secondary ejection event from impacting debris on Didymos, although is also possible that this feature results from the binary system dynamics alone. The lower limit to the total dust mass ejected is estimated at & SIM;6 x 10(6) kg, half of this mass being ejected to interplanetary space

C-peptide, IGF-I, sex-steroid hormones and adiposity: a cross-sectional study in healthy women within the European Prospective Investigation into Cancer and Nutrition (EPIC)

Objectives: The risk of some cancers is positively associated with body weight, which may influence circulating levels of sex-steroid hormones, insulin and IGF-I. Interrelationships between these hormones and the associations with adiposity were evaluated in healthy women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: A cross-sectional analysis was performed on anthropometric and hormonal data from 743 pre- and 1217 postmenopausal women. Body mass index (BMI) and waist circumference were used as indicators of adiposity. C-peptide, Insulin Growth Factor (IGF)-I, Insulin Growth Factor binding protein (IGFBP)-3, androgens, estrogens and sex hormone binding globulin (SHBG) were measured by immunoassays; free sex steroid concentrations were calculated. Results: BMI and waist circumference were positively correlated with estrogens in postmenopausal women and with C-peptide, free testosterone and inversely with SHBG in all women. C-peptide and IGF-I were inversely correlated with SHBG, and positively with free sex steroids in postmenopausal women. IGF-I was positively associated with postmenopausal estrogens and androgen concentrations in all women. Conclusions: Sex-steroid concentrations appear to be regulated along several axes. Adiposity correlated directly with estrogens in postmenopausal women and with insulin, resulting in lower SHBG and increased levels of free sex steroids. Independent of adiposity and insulin, IGF-I was associated with decreased SHBG levels, and increased concentrations of androgens and postmenopausal estrogens