Multi-walled Carbon Nanotubes, NM-400, NM-401, NM-402, NM-403: Characterisation and Physico-Chemical Properties

In 2011 the JRC launched a Repository for Representative Test Materials that supports both EU and international research projects, and especially the OECD Working Party on Manufactured Nanomaterials' (WPMN) exploratory testing programme "Testing a Representative set of Manufactured Nanomaterials" for the development and collection of data on characterisation, toxicological and ecotoxicological properties, as well as risk assessment and safety evaluation of nanomaterials. The JRC Repository responds to a need for availability of nanomaterial from a single production batch to enhance the comparability of results between different research laboratories and projects. The present report presents the physico-chemical characterisation of the multi-walled carbon nanotubes (MWCNT) from the JRC Repository: NM-400, NM-401, NM-402 and NM-403. NM-400 was selected as principal material for the OECD WPMN testing programme. They are produced by catalytic chemical vapour deposition. Each of these NMs originates from one respective batch of commercially manufactured MWCNT. They are nanostructured, i.e. they consist of more than one graphene layer stacked on each other and rolled together as concentric tubes. The MWCNT NMs may be used as a representative material in the measurement and testing with regard to hazard identification, risk and exposure assessment studies. The results are based on studies by several European laboratories participating to the NANOGENOTOX Joint Action.JRC.I.4-Nanobioscience

Synthetic Amorphous Silicon Dioxide (NM-200, NM-201, NM-202, NM-203, NM-204): Characterisation and Physico-Chemical Properties

The European Commission's Joint Research Centre (JRC) provides scientific support to European Union policy including nanotechnology. Within this context, the JRC launched, in February 2011, a repository for Representative Test Materials (RTMs), based on preparatory work started in 2008. It supports both EU and international research projects, and especially the OECD Working Party on Manufactured Nanomaterials (WPMN). The WPMN leads an exploratory testing programme "Testing a Representative set of Manufactured Nanomaterials" for the development and collection of data on characterisation, toxicological and ecotoxicological properties, as well as risk assessment and safety evaluation of nanomaterials. The purpose is to understand the applicability of the OECD Test Guidelines for the testing of nanomaterials as well as end-points relevant for such materials. The Repository responds to a need for nanosafety research purposes: availability of nanomaterial from a single production batch to enhance the comparability of results between different research laboratories and projects. The availability of representative nanomaterials to the international scientific community furthermore enhances and enables development of safe materials and products. The present report presents the physico-chemical characterisation of the synthetic amorphous silicon dioxide (SiO2, SAS) from the JRC repository: NM-200, NM-201, NM-202, NM-203 and NM-204. NM-200 was selected as principal material for the OECD test programme "Testing a representative set of manufactured nanomaterials". NM-200, NM-201 and NM-204 (precipitated SAS) are produced via the precipitation process, whereas NM-202 and NM-203 (fumed or pyrogenic SAS) are produced via a high temperature process. Each of these NMs originates from one respective batch of commercially manufactured SAS. They are nanostructured, i.e. they consist of aggregated primary particles. The SAS NMs may be used as a representative material in the measurement and testing with regard to hazard identification, risk and exposure assessment studies. The results for more than 15 endpoints are addressed in the present report, including physical-chemical properties, such as size and size distribution, crystallite size and electron microscopy images. Sample and test item preparation procedures are addressed. The results are based on studies by several European laboratories participating to the NANOGENOTOX Joint Action, as well as the JRC.JRC.I.4-Nanobioscience

Titanium Dioxide, NM-100, NM-101, NM-102, NM-103, NM-104, NM-105: Characterisation and Physico-Chemical Properties

The European Commission's Joint Research Centre (JRC) provides scientific support to European Union policy including nanotechnology. Within this context, the JRC launched, in February 2011, a repository for Representative Test Materials (RTMs), based on preparatory work started in 2008. It supports both EU and international research projects, and especially the OECD Working Party on Manufactured Nanomaterials (WPMN). The WPMN leads an exploratory testing programme "Testing a Representative set of Manufactured Nanomaterials" for the development and collection of data on characterisation, toxicological and ecotoxicological properties, as well as risk assessment and safety evaluation of nanomaterials. The purpose is to understand the applicability of the OECD Test Guidelines for the testing of nanomaterials as well as end-points relevant for such materials. The Repository responds to a need for nanosafety research purposes: availability of nanomaterial from a single production batch to enhance the comparability of results between different research laboratories and projects. The availability of representative nanomaterials to the international scientific community furthermore enhances and enables development of safe materials and products. The present report presents the physico-chemical characterisation of the Titanium dioxide series from the JRC repository: NM-100, NM-101, NM-102, NM-103, NM-104 and NM-105. NM-105 was selected as principal material for the OECD test programme "Testing a representative set of manufactured nanomaterials". NM-100 is included in the series as a bulk comparator. Each of these NMs originates from one batch of commercially manufactured TiO2. The TiO2 NMs may be used as representative material in the measurement and testing with regard to hazard identification, risk and exposure assessment studies. The results for more than 15 endpoints are addressed in the present report, including physico-chemical properties, such as size and size distribution, crystallite size and electron microscopy images. Sample and test item preparation procedures are addressed. The results are based on studies by several European laboratories participating to the NANOGENOTOX Joint Action, as well as by the JRC.JRC.I.4-Nanobioscience

Development of a control banding tool for nanomaterials

Control banding (CB) can be a useful tool for managing the potential risks of nanomaterials. The here proposed CB, which should be part of an overall risk control strategy, groups materials by hazard and emission potential. The resulting decision matrix proposes control bands adapted to the risk potential levels and helps define an action plan. If this plan is not practical and financially feasible, a full risk assessment is launched. The hazard banding combines key concepts of nanomaterial toxicology: translocation across biological barriers, fibrous nature, solubility, and reactivity. Already existing classifications specific to the nanomaterial can be used "as is." Otherwise, the toxicity of bulk or analogous substances gives an initial hazard band, which is increased if the substance is not easily soluble or if it has a higher reactivity than the substance. The emission potential bands are defined by the nanomaterials' physical form and process characteristics. Quantities, frequencies, and existing control measures are taken into account during the definition of the action plan. Control strategies range from room ventilation to full containment with expert advice. This CB approach, once validated, can be easily embedded in risk management systems. It allows integrating new toxicity data and needs no exposure data. [Authors]]]> Nanoparticles ; Risk Assessment ; Occupational Exposure eng https://serval.unil.ch/resource/serval:BIB_89875793AD57.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_89875793AD579 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_89875793AD579 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_89877752F262 2022-02-19T02:25:47Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_89877752F262 PROSPECT guideline for rotator cuff repair surgery: systematic review and procedure‐specific postoperative pain management recommendations info:doi:10.1111/anae.14796 info:eu-repo/semantics/altIdentifier/doi/10.1111/anae.14796 info:eu-repo/semantics/altIdentifier/pmid/31392721 Toma, O. Persoons, B. Pogatzki-Zahn, E. Van de Velde, M. Joshi, G. P. Schug, S Kehlet, H Bonnet, F Rawal, N Delbos, A Lavand'homme, P Beloeil, H Raeder, J Sauter, A Albrecht, E Lirk, P info:eu-repo/semantics/article article 2019-10 Anaesthesia, vol. 74, no. 10, pp. 1320-1331 info:eu-repo/semantics/altIdentifier/pissn/0003-2409 info:eu-repo/semantics/altIdentifier/pissn/1365-2044 Anesthesiolog, Pain Medicine, Postoperative Pain, Rotator cuff repair eng https://serval.unil.ch/resource/serval:BIB_89877752F262.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_89877752F2629 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_89877752F2629 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/openAccess CC BY-NC 4.0 https://creativecommons.org/licenses/by-nc/4.0/ application/pdf oai:serval.unil.ch:BIB_89880A60EA7B 2022-02-19T02:25:47Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_89880A60EA7B Vitamins and carotenoids in human milk delivering preterm and term infants: Implications for preterm nutrient requirements and human milk fortification strategies. info:doi:10.1016/j.clnu.2020.05.012 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.clnu.2020.05.012 info:eu-repo/semantics/altIdentifier/pmid/32534950 Redeuil, K. Lévêques, A. Oberson, J.M. Bénet, S. Tissot, E. Longet, K. de Castro, A. Romagny, C. Beauport, L. Fischer Fumeaux, C.J. Tolsa, J.F. Affolter, M. Giménez, E.C. Garcia-Rodenas, C.L. Thakkar, S.K. info:eu-repo/semantics/article article 2021-01 Clinical nutrition, vol. 40, no. 1, pp. 222-228 info:eu-repo/semantics/altIdentifier/eissn/1532-1983 urn:issn:0261-5614 <![CDATA[Differences in vitamin and carotenoids content of human milk (HM) produced for infants born at term and preterm is poorly understood. In this study, HM was collected weekly for four and two months post-partum for preterm and term groups, respectively. Nutrients of interest, from single full breast expressions were measured by liquid chromatography coupled with mass spectrometry. Microbiological assay was employed for vitamin B &lt;sub&gt;12&lt;/sub&gt; . When compared at equivalent post-partum age, vitamins B &lt;sub&gt;1&lt;/sub&gt; , B &lt;sub&gt;2&lt;/sub&gt; , B &lt;sub&gt;6&lt;/sub&gt; , and B &lt;sub&gt;9&lt;/sub&gt; were significantly higher in preterm than in term HM, but only during the first two weeks. No significant differences were observed for A, E, B &lt;sub&gt;3&lt;/sub&gt; and B &lt;sub&gt;12&lt;/sub&gt; between groups. Lycopene was the only carotenoid exhibiting a significant higher concentration in term than in preterm HM between weeks 1 and 4 post-partum. When compared at equivalent post-menstrual age, preterm milk was significantly higher for vitamins B &lt;sub&gt;1&lt;/sub&gt; , B &lt;sub&gt;2&lt;/sub&gt; , B &lt;sub&gt;3&lt;/sub&gt; , B &lt;sub&gt;6&lt;/sub&gt; and B &lt;sub&gt;9&lt;/sub&gt; and lower levels of vitamins A, E, β-carotene, β-cryptoxanthin, lutein, zeaxanthin and lycopene compared to their term counterparts. These results suggest that preterm breastfed infants at term equivalent age may receive lower amounts of these micronutrients than breast-fed term neonates, possibly highlighting the need to supplement or fortify their nutritional intake with vitamins and carotenoids. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT #02052245

Nano 2030 – Manufactured Nanomaterials by 2030 – Workplace health and safety consequences in small business in France

International audienc

Food-grade TiO 2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

International audienceFood-grade titanium dioxide (TiO 2) containing a nanoscale particle fraction (TiO 2-NPs) is approved as a white pigment (E171 in Europe) in common foodstuffs, including confectionary. There are growing concerns that daily oral TiO 2-NP intake is associated with an increased risk of chronic intestinal inflammation and carcinogenesis. In rats orally exposed for one week to E171 at human relevant levels, titanium was detected in the immune cells of Peyer's patches (PP) as observed with the TiO 2-NP model NM-105. Dendritic cell frequency increased in PP regardless of the TiO 2 treatment, while regulatory T cells involved in dampening inflammatory responses decreased with E171 only, an effect still observed after 100 days of treatment. In all TiO 2-treated rats, stimulation of immune cells isolated from PP showed a decrease in Thelper (Th)-1 IFN-γ secretion, while splenic Th1/Th17 inflammatory responses sharply increased. E171 or NM-105 for one week did not initiate intestinal inflammation, while a 100-day E171 treatment promoted colon microinflammation and initiated preneoplastic lesions while also fostering the growth of aberrant crypt foci in a chemically induced carcinogenesis model. These data should be considered for risk assessments of the susceptibility to Th17-driven autoimmune diseases and to colorectal cancer in humans exposed to TiO 2 from dietary sources

: Conséquences en santé et sécurité au travail dans les petites entreprises en France

rapport édité par l'INVS - co produit par les experts1er scénario : Un engagement fort et fructueux de l’État et des entreprises : un développement massifLes expert se placent en 2030 en imaginant que les années 2020 ont été marquées par une succession d’innovations scientifiques et techniques majeures dans différents domaines. Au cours de cette période, les investissements publics et privés alloués à des technologies nouvelles et prometteuses se sont ainsi très fortement accrus.Conséquences : On dispose à la fois des outils et de l’argent pour innover, produire et prévenir les risques. Les nouveaux produits sont correctement catégorisés ce qui permet la mise en place de moyens de prévention des risques professionnels adaptés.2ème scénario : Un rejet éclairé de la part de la société : un développement dans quelques rares filières stratégiquesConséquences : Dans un contexte d’opacité, les systèmes publics de prévention des risques professionnels ne sont pas les bienvenus dans les entreprises. Pour ces dernières, les interventions de l’Etat, à travers une application sans nuance du principe de précaution, peuvent peser gravement. 3ème scénario : Une mainmise industrielle : un développement dans des secteurs porteursConséquences : Le contrat individuel entre l’entreprise et le travailleur est devenu la règle. La prévention est strictement du ressort des entreprises et s’exprime majoritairement en termes de réparation et non pas en termes de prévention primaire. 4ème scénario : Une volonté régionale soutenue : un développement en fonction des compétences localesConséquences : La protection de la santé des travailleurs répond à des exigences très générales définies au niveau européen, mais elle est pilotée par les instances régionales

: Conséquences en santé et sécurité au travail dans les petites entreprises en France

rapport édité par l'INVS - co produit par les experts1er scénario : Un engagement fort et fructueux de l’État et des entreprises : un développement massifLes expert se placent en 2030 en imaginant que les années 2020 ont été marquées par une succession d’innovations scientifiques et techniques majeures dans différents domaines. Au cours de cette période, les investissements publics et privés alloués à des technologies nouvelles et prometteuses se sont ainsi très fortement accrus.Conséquences : On dispose à la fois des outils et de l’argent pour innover, produire et prévenir les risques. Les nouveaux produits sont correctement catégorisés ce qui permet la mise en place de moyens de prévention des risques professionnels adaptés.2ème scénario : Un rejet éclairé de la part de la société : un développement dans quelques rares filières stratégiquesConséquences : Dans un contexte d’opacité, les systèmes publics de prévention des risques professionnels ne sont pas les bienvenus dans les entreprises. Pour ces dernières, les interventions de l’Etat, à travers une application sans nuance du principe de précaution, peuvent peser gravement. 3ème scénario : Une mainmise industrielle : un développement dans des secteurs porteursConséquences : Le contrat individuel entre l’entreprise et le travailleur est devenu la règle. La prévention est strictement du ressort des entreprises et s’exprime majoritairement en termes de réparation et non pas en termes de prévention primaire. 4ème scénario : Une volonté régionale soutenue : un développement en fonction des compétences localesConséquences : La protection de la santé des travailleurs répond à des exigences très générales définies au niveau européen, mais elle est pilotée par les instances régionales