2,319 research outputs found

    A low cost treadmill for experimental animals

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    Psychosocial justice for students in custody

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    Availability to quality education is significantly beneficial to the life prospects of young people. In particular, for young people caught up in the justice system, it is argued that involvement in education reduces risk of further criminality and improves a person’s prospects for future community engagement. This paper overviews a recent study undertaken in the Australian state of Victoria. The study worked with project partner, Parkville College, the government school operating inside the state’s two detention centres, to examine what supports and hinders education for students in custody. Amongst other purposes, education should be about the pursuit of justice and if accepted as an ontological opportunity, education can invite the pursuit of a particular kind of justice – psychosocial justice. Subsequently, psychosocial theory applied to educational practice in youth detention is inextricably linked to issues concerning justice, both for how theory is invoked and ways in which practice is enacted. The paper first introduces the concept of psychosocial justice then hears from staff connected to Parkville College regarding issues and concerns related to their work. As shown, education for incarcerated young people, not just in Australia but internationally, is enhanced by contributions from psychosocial studies providing a means to pursuing justice informed by a politics of psychosocialism

    It Sounds like It Feels: Preliminary Exploration of an Aeroacoustic Diagnostic Protocol for Singers

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    To date, no established protocol exists for measuring functional voice changes in singers with subclinical singing-voice complaints. Hence, these may go undiagnosed until they progress into greater severity. This exploratory study sought to (1) determine which scale items in the self-perceptual Evaluation of Ability to Sing Easily (EASE) are associated with instrumental voice measures, and (2) construct as proof-of-concept an instrumental index related to singers’ perceptions of their vocal function and health status. Eighteen classical singers were acoustically recorded in a controlled environment singing an /a/ vowel using soft phonation. Aerodynamic data were collected during a softly sung /papapapapapapa/ task with the KayPENTAX Phonatory Aerodynamic System. Using multi and univariate linear regression techniques, CPPS, vibrato jitter, vibrato shimmer, and an efficiency ratio (SPL/PSub) were included in a significant model (p < 0.001) explaining 62.4% of variance in participants’ composite scores of three scale items related to vocal fatigue. The instrumental index showed a significant association (p = 0.001) with the EASE vocal fatigue subscale overall. Findings illustrate that an aeroacoustic instrumental index may be useful for monitoring functional changes in the singing voice as part of a multidimensional diagnostic approach to preventative and rehabilitative voice healthcare for professional singing-voice users

    Stoichiometrically driven disorder and local diffusion in NMC cathodes

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    Major structural differences in lithium nickel manganese cobalt oxides (NMC) prepared under identical conditions have been uncovered using neutron powder diffraction. Sample NMC-622 was obtained as a single R[3 with combining macron]m crystal structure with little defects, whereas NMC-811 showed significant Li deficiency and NMC-433 formed three distinct phases; ordered R[3 with combining macron]m, disordered R[3 with combining macron]m and a C2/m phase. Local diffusion behaviour was also studied by muon spin relaxation (ÎŒSR). It was observed that single phase R[3 with combining macron]m NMC-622 showed a higher lithium diffusion coefficient (4.4 × 10−11 cm2 s−1) compared to lithium deficient NMC-811 (2.9 × 10−11 cm2 s−1), or the highly disordered NMC-433 (3.4 × 10−11 cm2 s−1). Furthermore, activation energies for the Li diffusion process were estimated to be 58 meV, 61 meV and 28 meV for NMC-811, NMC-622 and NMC-433, respectively

    Multiple diffusion pathways in LixNi0.77Co0.14Al0.09O2 (NCA) Li-ion battery cathodes

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    Experimental evidence for the presence of two computationally theorised diffusion pathways, namely the oxygen dumbbell hop (ODH) and tetrahedral site hop (TSH), has been given for the first time by muon spin relaxation (”SR) on sub-stoichiometric LixNi0.77Co0.14Al0.09O2. ”SR has proven to be a powerful tool that is able to discriminate between diffusion pathways that occur on different timescales on a local level, where bulk electrochemical techniques cannot. Whereas the estimated values of DLi at lithium concentrations of 0.87 and 0.71 were found to be on the order of 10-11 by electrochemical impedance spectroscopy, contributions to diffusion from ODH and TSH were determined to be on the order of 10-11 and 10-10 cm2 s-1, and a factor of four decrease in Ea for both samples, in excellent agreement with theoretical calculations on related compounds. Rietveld refinement of both X-ray and neutron diffraction data was also used to interrogate the local structure of the materials where no contribution from Li+/Ni2+ cation mixing was observed

    Exceptional sperm cooperation in the wood mouse

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    Spermatozoa from a single male will compete for fertilization of ova with spermatozoa from another male when present in the female reproductive tract at the same time. Close genetic relatedness predisposes individuals towards altruism, and as haploid germ cells of an ejaculate will have genotypic similarity of 50%, it is predicted that spermatozoa may display cooperation and altruism to gain an advantage when inter-male sperm competition is intense. We report here the probable altruistic behaviour of spermatozoa in an eutherian mammal. Spermatozoa of the common wood mouse, Apodemus sylvaticus, displayed a unique morphological transformation resulting in cooperation in distinctive aggregations or 'trains' of hundreds or thousands of cells, which significantly increased sperm progressive motility. Eventual dispersal of sperm trains was associated with most of the spermatozoa undergoing a premature acrosome reaction. Cells undergoing an acrosome reaction in aggregations remote from the egg are altruistic in that they help sperm transport to the egg but compromise their own fertilizing ability

    Performance Evaluation of an Infrared Thermocouple

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    The measurement of the leaf temperature of forests or agricultural plants is an important technique for the monitoring of the physiological state of crops. The infrared thermometer is a convenient device due to its fast response and nondestructive measurement technique. Nowadays, a novel infrared thermocouple, developed with the same measurement principle of the infrared thermometer but using a different detector, has been commercialized for non-contact temperature measurement. The performances of two-kinds of infrared thermocouples were evaluated in this study. The standard temperature was maintained by a temperature calibrator and a special black cavity device. The results indicated that both types of infrared thermocouples had good precision. The error distribution ranged from −1.8 °C to 18 °C as the reading values served as the true values. Within the range from 13 °C to 37 °C, the adequate calibration equations were the high-order polynomial equations. Within the narrower range from 20 °C to 35 °C, the adequate equation was a linear equation for one sensor and a two-order polynomial equation for the other sensor. The accuracy of the two kinds of infrared thermocouple was improved by nearly 0.4 °C with the calibration equations. These devices could serve as mobile monitoring tools for in situ and real time routine estimation of leaf temperatures

    'Food hates' over the life course : an analysis of food narratives from the UK Mass Observation Archive

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    This article presents data from the UK Mass Observation Archive drawn from the 1982 Winter Food Directive, which focuses on memories of childhood food ‘hates’. Through our analysis of these data, we identify three main findings: (a) there is a discrepancy between individual-level and collective aggregate level food hates, which problematises the notion of commensality; (b) a small but powerful ‘outlier’ group of respondents, which we refer to as ‘visceral repulsors’, show relatively extreme reactions to certain foods throughout their lives; and (c) the duration and temporalities of food hates can be used to sketch a rough model of change and continuity of food hates over the life course. Finally, the discussion focuses on the food hate trajectories through the life course, situated in a social context, to explore the implications the findings may have for food and health policy more generally

    Big conductance calcium-activated potassium channel openers control spasticity without sedation.

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    BACKGROUND AND PURPOSE: Our initial aim was to generate cannabinoid agents that control spasticity, occurring as a consequence of multiple sclerosis (MS), whilst avoiding the sedative side effects associated with cannabis. VSN16R was synthesized as an anandamide (endocannabinoid) analogue in an anti-metabolite approach to identify drugs that target spasticity. EXPERIMENTAL APPROACH: Following the initial chemistry, a variety of biochemical, pharmacological and electrophysiological approaches, using isolated cells, tissue-based assays and in vivo animal models, were used to demonstrate the activity, efficacy, pharmacokinetics and mechanism of action of VSN16R. Toxicological and safety studies were performed in animals and humans. KEY RESULTS: VSN16R had nanomolar activity in tissue-based, functional assays and dose-dependently inhibited spasticity in a mouse experimental encephalomyelitis model of MS. This effect occurred with over 1000-fold therapeutic window, without affecting normal muscle tone. Efficacy was achieved at plasma levels that are feasible and safe in humans. VSN16R did not bind to known CB1 /CB2 /GPPR55 cannabinoid-related receptors in receptor-based assays but acted on a vascular cannabinoid target. This was identified as the major neuronal form of the big conductance, calcium-activated potassium (BKCa ) channel. Drug-induced opening of neuronal BKCa channels induced membrane hyperpolarization, limiting excessive neural-excitability and controlling spasticity. CONCLUSIONS AND IMPLICATIONS: We identified the neuronal form of the BKCa channel as the target for VSN16R and demonstrated that its activation alleviates neuronal excitability and spasticity in an experimental model of MS, revealing a novel mechanism to control spasticity. VSN16R is a potential, safe and selective ligand for controlling neural hyper-excitability in spasticity
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