Bearing the Cost of Stored Carbon Leakage

Carbon capture and sequestration (CCS) is considered a key technology for stabilizing climate change. However, leakage of CO2 from stored carbon can potentially undermine the value of carbon storage as a mitigation option. Thus, monitoring and verifiability of CO2 storage should be encouraged through policy provisions such as accounting and pricing of leaked emissions. Here we assess different institutional and economic mechanisms for accounting for carbon leakage. Using an integrated assessment model we quantify the impacts on the climate, the economy and the mitigation strategies. Results show that carbon leakage can reduce the share of fossil based CCS by up to 35%, if it is controlled and correctly priced. Biomass based CCS is less affected. Accounting for leakage leads to an increase of climate policy costs of up to 0.4 percentage points due to increased emissions

An inter-model assessment of the role of direct air capture in deep mitigation pathways

The feasibility of large-scale biological CO2 removal to achieve stringent climate targets remains unclear. Direct Air Carbon Capture and Storage (DACCS) offers an alternative negative emissions technology (NET) option. Here we conduct the first inter-model comparison on the role of DACCS in 1.5 and 2°C scenarios, under a variety of techno-economic assumptions. Deploying DACCS significantly reduces mitigation costs, and it complements rather than substitutes other NETs. The key factor limiting DACCS deployment is the rate at which it can be scaled up. Our scenarios’ average DACCS scale-up rates of 1.5 GtCO2/yr would require considerable sorbent production and up to 300 EJ/yr of energy input by 2100. The risk of assuming that DACCS can be deployed at scale, and finding it to be subsequently unavailable, leads to a global temperature overshoot of up to 0.8°C. DACCS should therefore be developed and deployed alongside, rather than instead of, other mitigation options

A risk-seeking future

The 2014 IPCC Assessment expresses doubt that the global surface temperature increase will remain within the 2 °C target without deploying risky carbon-capturing or solar radiation-deflecting technologies. New behavioural research suggests that, if the IPCC is right, citizens and policymakers will support such risk-taking

Insulin and GLP-1 infusions demonstrate the onset of adipose-specific insulin resistance in a large fasting mammal: potential glucogenic role for GLP-1.

Prolonged food deprivation increases lipid oxidation and utilization, which may contribute to the onset of the insulin resistance associated with fasting. Because insulin resistance promotes the preservation of glucose and oxidation of fat, it has been suggested to be an adaptive response to food deprivation. However, fasting mammals exhibit hypoinsulinemia, suggesting that the insulin resistance-like conditions they experience may actually result from reduced pancreatic sensitivity to glucose/capacity to secrete insulin. To determine whether fasting results in insulin resistance or in pancreatic dysfunction, we infused early- and late-fasted seals (naturally adapted to prolonged fasting) with insulin (0.065 U/kg), and a separate group of late-fasted seals with low (10 pM/kg) or high (100 pM/kg) dosages of glucagon-like peptide-1 (GLP-1) immediately following a glucose bolus (0.5g/kg), and measured the systemic and cellular responses. Because GLP-1 facilitates glucose-stimulated insulin secretion, these infusions provide a method to assess pancreatic insulin-secreting capacity. Insulin infusions increased the phosphorylation of insulin receptor and Akt in adipose and muscle of early and late fasted seals; however the timing of the signaling response was blunted in adipose of late fasted seals. Despite the dose-dependent increases in insulin and increased glucose clearance (high dose), both GLP-1 dosages produced increases in plasma cortisol and glucagon, which may have contributed to the glucogenic role of GLP-1. Results suggest that fasting induces adipose-specific insulin resistance in elephant seal pups, while maintaining skeletal muscle insulin sensitivity, and therefore suggests that the onset of insulin resistance in fasting mammals is an evolved response to cope with prolonged food deprivation

The role of carbon capture and storage electricity in attaining 1.5 and 2 °C

The climate targets defined under the Paris agreement of limiting global temperature increase below 1.5 or 2 °C require massive deployment of low-carbon options in the energy mix, which is currently dominated by fossil fuels. Scenarios suggest that Carbon Capture and Storage (CCS) might play a central role in this transformation, but CCS deployment is stagnating and doubts remain about its techno-economic feasibility. In this article, we carry out a throughout assessment of the role of CCS electricity for a variety of temperature targets, from 1.5 to above 4 °C, with particular attention to the lower end of this range. We collect the latest data on CCS economic and technological future prospects to accurately represent several types of CCS plants in the WITCH energy-economy model, We capture uncertainties by means of extensive sensitivity analysis in parameters regarding plants technical aspects, as well as costs and technological progress. Our research suggests that stringent temperature scenarios constrain fossil fuel CCS based deployment, which is maximum for medium policy targets. On the other hand, Biomass CCS, along with renewables, increases with the temperature stringency. Moreover, the relative importance of cost and performance parameters change with the climate target. Cost uncertainty matters in less stringent policy cases, whereas performance matters for lower temperature targets

Churg-Strauss syndrome: outcome and long-term follow-up of 38 patients from a single Italian centre

Objective: This study was aimed at verifying any potential correlation between anti-myeloperoxidase antineutrophil cytoplasmic antibodies (ANCA-MPO) and clinical features and outcome indices in Churg-Strauss Syndrome (CSS). Methods: Thirhty-eight Churg-Strauss syndrome patients were selected from the medical records of all vasculitis patients attending the Rheumatology and Immunology Unit at the Department of Internal Medicine of the University of Pisa in the decades between 1989 and 2008. Data were analysed retrospectively. Statistical analyses of the results were carried out using the Mann-Whitney test to determine the correlations between the clinical and serological parameters. Qualitative variables were compared using contingency table analysis and Fisher's exact test. Results: ANCA-MPO were detected in15/38 (39%) patients. Positive ANCA status was associated with peripheral neuropathy (p=0.0006), whereas negative ANCA status was associated with lung involvement (p=0.002). Relapses were strongly associated with positive ANCA status (p=0.01) and with an increase in- or a reappearence of ANCA-MPO levels (p=0.006). Finally, ANCA-MPO were significantly associated with neurological damage (p=0.003). Conclusions: The presence or absence of ANCA-MPO identify different clinical subsets in CSS. Overall, ANCA-MPO appears as a useful tool in the monitoring of CSS and in particular a good predictor of CSS relapse