Efficacy and safety of secukinumab administration by autoinjector in patients with psoriatic arthritis: results from a randomized, placebo-controlled trial (FUTURE 3)

Background: The study aimed to assess 52-week efficacy and safety of secukinumab self-administration by autoinjector in patients with active psoriatic arthritis (PsA) in the FUTURE 3 study (ClinicalTrials.gov NCT01989468). Methods: Patients (≥ 18 years of age; N = 414) with active PsA were randomized 1:1:1 to subcutaneous (s.c.) secukinumab 300 mg, 150 mg, or placebo at baseline, weeks 1, 2, 3, and 4, and every 4 weeks thereafter. Per clinical response, placebo-treated patients were re-randomized to s.c. secukinumab 300 or 150 mg at week 16 (nonresponders) or week 24 (responders) and stratified at randomization by prior anti-tumor necrosis factor (TNF) therapy (anti-TNF-naïve, 68.1%; intolerant/inadequate response (anti-TNF-IR), 31.9%). The primary endpoint was the proportion of patients achieving at least 20% improvement in American College of Rheumatology response criteria (ACR20) at week 24. Autoinjector usability was evaluated by Self-Injection Assessment Questionnaire (SIAQ). Results: Overall, 92.1% (300 mg), 91.3% (150 mg), and 93.4% (placebo) of patients completed 24 weeks, and 84.9% (300 mg) and 79.7% (150 mg) completed 52 weeks. In the overall population (combined anti-TNF-naïve and anti-TNF-IR), ACR20 response rate at week 24 was significantly higher in secukinumab groups (300 mg, 48.2% (p < 0.0001); 150 mg, 42% (p < 0.0001); placebo, 16.1%) and was sustained through 52 weeks. SIAQ results showed that more than 93% of patients were satisfied/very satisfied with autoinjector usage. Secukinumab was well tolerated with no new or unexpected safety signals reported. Conclusions: Secukinumab provided sustained improvements in signs and symptoms in active PsA patients through 52 weeks. High acceptability of autoinjector was observed. The safety profile was consistent with that reported previously

Ground State Properties of an Asymmetric Hubbard Model for Unbalanced Ultracold Fermionic Quantum Gases

In order to describe unbalanced ultracold fermionic quantum gases on optical lattices in a harmonic trap, we investigate an attractive ($U<0$) asymmetric ($t_\uparrow\neq t_\downarrow$) Hubbard model with a Zeeman-like magnetic field. In view of the model's spatial inhomogeneity, we focus in this paper on the solution at Hartree-Fock level. The Hartree-Fock Hamiltonian is diagonalized with particular emphasis on superfluid phases. For the special case of spin-independent hopping we analytically determine the number of solutions of the resulting self-consistency equations and the nature of the possible ground states at weak coupling. Numerical results for unbalanced Fermi-mixtures are presented within the local density approximation. In particular, we find a fascinating shell structure, involving normal and superfluid phases. For the general case of spin-dependent hopping we calculate the density of states and the possible superfluid phases in the ground state. In particular, we find a new magnetized superfluid phase.Comment: 9 pages, 5 figure

Wigner's DD-matrix elements for SU(3)SU(3) - A Generating Function Approach

A generating function for the Wigner's $D$-matrix elements of $SU(3)$ is derived. From this an explicit expression for the individual matrix elements is obtained in a closed form.Comment: RevTex 3.0, 22 pages, no figure

Informacija autoriams

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Fire analysis of steel frames with the use of artificial neural networks

The paper presents an alternative approach to the modelling of the mechanical behaviour of steel frame material when exposed to the high temperatures expected in fires. Based on a series of stress-strain curves obtained experimentally for various temperature levels, an artificial neural network (ANN) is employed in the material modelling of steel. Geometrically and materially, a non-linear analysis of plane frame structures subjected to fire is performed by FEM. The numerical results of a simply supported beam are compared with our measurements, and show a good agreement, although the temperature-displacement curves exhibit rather irregular shapes. It can be concluded that ANN is an efficient tool for modelling the material properties of steel frames in fire engineering design studies. (c) 2007 Elsevier Ltd. All rights reserved

Kronika

2013 metai Klasikinės filologijos katedrojeKlasikinės filologijos katedros dėstytojų 2013 metais išleistos knygo

Langkah Awal Perbaikan Produktivitas Berbasis Performans pada Kerbau Potong Jantan di Indonesia

Dikenal ada dua tipe kerbau yaitu potong dan perah yang berjumlah 195,4 juta ekor, dimana populasi terbesar adalah tipe perah, sedangkan kerbau potong berkembang pesat di Asia Tenggara dan China dengan jumlah populasi sekitar 24 juta ekor dan Indonesia memiliki 1,3 juta ekor. Ada tujuh rumpun kerbau potong di Indonesia dengan kemampuan adaptasi pada lingkungan yang berbeda. Walaupun demikian, Indonesia menghadapi persoalan pengembangan kerbau yaitu penurunan populasi yang cukup besar dalam dekade terakhir dengan penyebab yang sangat kompleks. Solusi mengurangi penurunan populasi yang sederhana salah satunya adalah melalui penggunaan pejantan unggul karena dapat memperbaiki performans produksi sejak lahir sampai dewasa, memperbaiki kinerja reproduksi dan mengurangi jumlah ternak inbred. Untuk mendapatkan pejantan unggul harus dilakukan melalui recording untuk pembibitan dan pemanfaatan data recording serta seleksi secara tepat. Hasil penelitian menunjukkan bahwa penggunaan pejantan inferior sudah lama berlangsung, performans kerbau jantan mempunyai variasi yang besar per satuan umur. Membangun kurva pertumbuhan akan memudahkan modifikasi untuk menetapkan target produktivitas keseluruhan yang ingin dicapai melalui penggunaan pejantan unggul

2014 metai (sausio–liepos mėn.) Klasikinės filologijos katedroje

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Chern-Simons theory and three-dimensional surfaces

There are two natural Chern-Simons theories associated with the embedding of a three-dimensional surface in Euclidean space; one is constructed using the induced metric connection -- it involves only the intrinsic geometry, the other is extrinsic and uses the connection associated with the gauging of normal rotations. As such, the two theories appear to describe very different aspects of the surface geometry. Remarkably, at a classical level, they are equivalent. In particular, it will be shown that their stress tensors differ only by a null contribution. Their Euler-Lagrange equations provide identical constraints on the normal curvature. A new identity for the Cotton tensor is associated with the triviality of the Chern-Simons theory for embedded hypersurfaces implied by this equivalence. The corresponding null surface stress capturing this information will be constructed explicitly.Comment: 10 pages, unnecessary details removed, typos fixed, references adde