Threshold detection in an on-off binary communications channel with atmospheric scintillation

The optimum detection threshold in an on-off binary optical communications system operating in the presence of atmospheric turbulence was investigated assuming a poisson detection process and log normal scintillation. The dependence of the probability of bit error on log amplitude variance and received signal strength was analyzed and semi-emperical relationships to predict the optimum detection threshold derived. On the basis of this analysis a piecewise linear model for an adaptive threshold detection system is presented. Bit error probabilities for non-optimum threshold detection system were also investigated

Unveiling Palomar 2: The Most Obscure Globular Cluster in the Outer Halo

We present the first color-magnitude study for Palomar 2, a distant and heavily obscured globular cluster near the Galactic anticenter. Our (V,V-I) color-magnitude diagram (CMD), obtained with the UH8K camera at the CFHT, reaches V(lim) = 24 and clearly shows the principal sequences of the cluster, though with substantial overall foreground absorption and differential reddening. The CMD morphology shows a well populated red horizontal branch with a sparser extension to the blue, similar to clusters such as NGC 1261, 1851, or 6229 with metallicities near [Fe/H] = -1.3$. From an average of several indicators, we estimate the foreground reddening at E(B-V) = 1.24 +- 0.07 and obtain a true distance modulus (m-M)_0 = 17.1 +- 0.3$, placing it about 34 kpc from the Galactic center. We use starcounts of the bright stars to measure the core radius, half-mass radius, and central concentration of the cluster. Its integrated luminosity is M_V = -7.9, making it clearly brighter and more massive than most other clusters in the outer halo.Comment: 25 pages, aastex, with 8 postscript figures; accepted for publication in AJ, September 1997. Also available by e-mail from [email protected]. Please consult Harris directly for (big) postscript files of Figures 1a,b (the images of the cluster

The Density Spike in Cosmic-Ray-Modified Shocks: Formation, Evolution, and Instability

We examine the formation and evolution of the density enhancement (density spike) that appears downstream of strong, cosmic-ray-modified shocks. This feature results from temporary overcompression of the flow by the combined cosmic-ray shock precursor/gas subshock. Formation of the density spike is expected whenever shock modification by cosmic-ray pressure increases strongly. That occurence may be anticipated for newly generated strong shocks or for cosmic-ray-modified shocks encountering a region of higher external density, for example. The predicted mass density within the spike increases with the shock Mach number and with shocks more dominated by cosmic-ray pressure. We find this spike to be linearly unstable under a modified Rayleigh-Taylor instability criterion at the early stage of its formation. We confirm this instability numerically using two independent codes based on the two-fluid model for cosmic-ray transport. These two-dimensional simulations show that the instability grows impulsively at early stages and then slows down as the gradients of total pressure and gas density decrease. Observational discovery of this unstable density spike behind shocks, possibly through radio emission enhanced by the amplified magnetic fields would provide evidence for the existence of strongly cosmic-ray modified shock structures.Comment: 26 pages in Latex and 6 figures. Accepted to Ap

Relativistic effects in Ni II and the search for variation of the fine structure constant

Theories unifying gravity and other interactions suggest the possibility of spatial and temporal variation of physical ``constants'' in the Universe. Detection of high redshift absorption systems intersecting the sight lines towards distant quasars provide a powerful tool for measuring these variations. In the present paper we demonstrate that high sensitivity to variation of the fine structure constant alpha can be obtained by comparing cosmic and laboratory spectra of the Ni II ion. Relativistic effects in Ni II reveal many interesting features. The Ni II spectrum exhibits avoided level crossing phenomenon under variation of alpha and the intervals between the levels have strong nonlinear dependencies on relativistic corrections. The values of the transition frequency shifts, due to the change of alpha, vary significantly from state to state including change of the sign. This enhances the sensitivity to the variation of alpha and reduces possible systematic errors. The calculations of alpha-dependence of the nickel ion spectral lines that are detectable in quasar absorption spectra have been performed using a relativistic configuration interaction method.Comment: 13 pages, 1 figure, accepted by Phys. Rev. A, typos corrected, acknowledgment adde

How well do antivirals shorten genital herpes pain duration?

Q: How well do antivirals shorten genital herpes pain duration? Evidence-based answer: Oral and intravenous (IV) acyclovir each shorten the duration of pain for a first primary outbreak of herpes by about 50%; topical acyclovir shortens it by about 25% (strength of recommendation [SOR]: B, small randomized controlled trials [RCTs] with some methodological flaws). Oral valacyclovir and famcyclovir are equivalent to oral acyclovir. Adding topical acyclovir to oral acyclovir doesn't produce additional benefit (SOR: B, RCTs). Patients with severe disease may require IV acyclovir (SOR: C, expert opinion). General treatment measures that may improve patient comfort include keeping lesions clean and dry, avoiding tight clothing, taking analgesics, and using ice packs or taking warm baths (SOR: C, expert opinion). Evidence for using complementary and alternative medicine to treat genital herpes is lacking or conflicting [SOR: C, narrative review of clinical trials]

GTF2IRD1 regulates transcription by binding an evolutionarily conserved DNA motif ‘GUCE’

AbstractGTF2IRD1 is a member of a family of transcription factors whose defining characteristic is varying numbers of a helix–loop–helix like motif, the I-repeat. Here, we present functional analysis of human GTF2IRD1 in regulation of three genes (HOXC8, GOOSECOID and TROPONIN ISLOW). We define a regulatory motif (GUCE–GTF2IRD1 Upstream Control Element) common to all three genes. GUCE is bound in vitro by domain I-4 of GTF2IRD1 and mediates transcriptional regulation by GTF2IRD1 in vivo. Definition of this site will assist in identification of other downstream targets of GTF2IRD1 and elucidation of its role in the human developmental disorder Williams–Beuren syndrome

Possible evidence for a variable fine structure constant from QSO absorption lines: systematic errors

Comparison of quasar absorption spectra with laboratory spectra allow us to probe possible variations in the fundamental constants over cosmological time-scales. In a companion paper we present an analysis of Keck/HIRES spectra and report possible evidence suggesting that the fine structure constant, alpha, may have been smaller in the past: da/a = (-0.72 +/- 0.18) * 10^{-5} over the redshift range 0.5 < z < 3.5. In this paper we describe a comprehensive investigation into possible systematic effects. Most of these do not significantly influence our results. When we correct for those which do produce a significant systematic effect in the data, the deviation of da/a from zero becomes more significant. We are lead increasingly to the interpretation that alpha was slightly smaller in the past.Comment: 15 pages, 8 figures, Accepted by MNRAS, small changes after referee's comments, accepted versio

A Search for Time Variation of the Fine Structure Constant

A method offering an order of magnitude sensitivity gain is described for using quasar spectra to investigate possible time or space variation in the fine structure constant, alpha. Applying the technique to a sample of 30 absorption systems, spanning redshifts 0.5 < z< 1.6, obtained with the Keck I telescope, we derive limits on variations in alpha over a wide range of epochs. For the whole sample Delta(alpha)/alpha = -1.1 +/- 0.4 x 10^{-5}. This deviation is dominated by measurements at z > 1, where Delta(alpha)/alpha = -1.9 +/- 0.5 x 10^{-5}. For z < 1, Delta(alpha)/alpha = -0.2 +/- 0.4 x 10^{-5}, consistent with other known constraints. Whilst these results are consistent with a time-varying alpha, further work is required to explore possible systematic errors in the data, although careful searches have so far not revealed any.Comment: 4 pages, 1 figure, accepted for publication in Physical Review Letter