Comparative study of topical treatment in mild to moderate acne vulgaris

INTRODUCTION: Acne vulgaris is common among adolescent age group in either sex. The morbidity associated with acne is more severe. It affects 90% of people worldwide .Acne and resulting scaring can have a psychological impact including lowered self esteem, social impairment and anger. It has been shown that mild to moderate degrees of acne can be associated with higher rates of depression. Hence appropriate intervention is necessary to prevent complications such as scarring, psychological impacts and secondary impaired social function MATERIALS AND METHODS: This study was conducted at Rajiv Gandhi Government General Hospital attached to Madras Medical College, Chennai as Prospective Randomized follow up study. The patients satisfying the inclusion criteria were randomly allocated to three treatment groups 2.5% Benzoyl peroxide ,0.1% Adapalene and combination of above drugs. They were followed up for a period of 12 weeks and reduction in number of lesions were recorded and statistically analyzed. RESULTS: Among 90 patients male were 61 (67.7%) patients and females were 29 (32.3%). 13 to 18 years were commonly affected 76.67% in our study. In BPO group there were 57.72% reduction in number of lesions at the end of second week which is statistically significant with p value < 0.001. In Adapalene group statistical reduction in number of lesions were noted at 12 weeks with p value < 0.001. In combination group there was significant reduction at 2 weeks with 52.83 % from baseline. Also combination group showed consistent overall reduction in number of lesions at 12 weeks with 86.1 %. The patient acceptance and adherence was good among the combination group. CONCLUSION: Combination of Benzoyl peroxide with Adapalene was superior to individual drugs in reducing number of lesions in mild to moderate acne vulgaris

Nature and distribution of dark matter: 1. Dwarf spheroidals and Milky Way

We argue that observations on Milky Way and dwarf spheroidals imply existence of individual haloes around dwarf spheroidals. If neutrinos (or any other 'hot' particle) provide the dark matter then we show that: (i) Embedding of visible matter inside large (&#8764; few Mpc) dark matter islands is observationally untenable. (ii) Dwarf spheroidals possess dark matter haloes of about 10 kpc radius around them, and have an (M/L) ratio of about 104. (iii) The haloes of spiral galaxies (e.g. Milky Way) extend to about 100 kpc in radius. If 'cold' dark matter makes up the haloes, then no significant constraints are obtained. We discuss briefly the effect of these constraints on larger scales

Gravitational pertubation of homogeneous collisionless dark matter

The effect of a perturbing mass on a homogeneous collisionless cloud of dark matter is considered in the linear approximation. It is shown that gravitational potential can have turning points, in sharp contrast with gravitating systems of finite extent. The model offers a reasonable explanation for the observed secondary maxima in the density distribution of rich clusters. The relevance of the model to the flatness of the rotation curves of galaxies is also discussed

Laboratory evaluation of pesticides on oviposition, egg mortality and feeding deterrence on cashew stem and root borer, Plocaederus ferrugenius L. (Coleoptera: Cerambycidae)

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Constraints on unstable heavy neutrinos from cosmology

Cosmological scenarios with massive unstable neutrinos are discussed. Restrictions on the mass and the lifetime of the unstable neutrino are derived from (a) age and mass density of the universe and (b) the growth of primordial fluctuations. It will not be possible to accommodate unstable neutrinos with masses above &#8764; 1 ke V in standard cosmology unless they have exceedingly small lifetime: &#932; &lt;5 &#215; 108s

Efficacy of Vitamin C and Vitamin E as an add on therapy in diabetic foot ulcer and red blood cell morphology as a biomarker of oxidative stress: a randomized, open label, comparative pilot study

Background: Diabetes mellitus is a major cause of increased morbidity and mortality in developing countries. Foot ulcer is one of the long term complications of diabetes. Oxidative stress plays a major role in pathogenesis of diabetes mellitus and its long term complications. Impaired wound healing in diabetic individuals is due to ischemia and hypoxia occurring as a consequence of oxidative stress. Vitamin C and E have antioxidant property. This study aims to assess their efficacy in healing of diabetic ulcer. Objective of the study was to evaluate the efficacy of Vitamin C and E in healing diabetic foot ulcer.Methods: 60 adult patients with diabetic foot ulcer were randomized to test and control groups (30 in each). Treatment period was 12 weeks + 4 weeks follow up per patient. After obtaining written informed consent, patients in test group received Vitamin C (500mg BD) and Vitamin E (400mg BD) for 12 weeks along with standard treatment for diabetes and antibiotics for foot ulcer.Results: At the end of 12 weeks, increase in healing of foot ulcer assessed by percent reduction of ulcer area in study group 72.50% than control group 39.67% (p<0.001) was observed. There was a significant reduction of fasting blood glucose, Oxidative stress induced damage to RBCs and BP in the study group compared to control group. No serious adverse effects occurred.Conclusions: Vitamin C and E reverse oxidative stress induced morphological changes in RBCs, improve anemia and increase blood flow to ulcer area. Hence they are highly effective in healing diabetic foot ulcer along with standard therapy.

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.

Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells. The persister cell pool constitutes a reservoir from which drug-resistant tumours may emerge. Targeting persister cells therefore presents a therapeutic opportunity to impede tumour relapse. We previously found that cancer cells in a high mesenchymal therapy-resistant cell state are dependent on the lipid hydroperoxidase GPX4 for survival. Here we show that a similar therapy-resistant cell state underlies the behaviour of persister cells derived from a wide range of cancers and drug treatments. Consequently, we demonstrate that persister cells acquire a dependency on GPX4. Loss of GPX4 function results in selective persister cell ferroptotic death in vitro and prevents tumour relapse in mice. These findings suggest that targeting of GPX4 may represent a therapeutic strategy to prevent acquired drug resistance

EVALUATION OF SOLAR PHOTOVOLTAIC WATER PUMPING SYSTEM AND IMPROVING ITS EFFICIENCY FOR DEVELOPING AN ENERGY STORAGE DEVICE

An electricity demand in India is now at an all-time high. Agriculture accounts for 21.5 percent of total electricity use; according to sectoral demand patterns. Technology is becoming increasingly popular. PV cells are utilized to power electrical equipment because of their high energy output. Solar energy is a clean and inexpensive energy source. Solar powered water pumping is an important technology for conserving vital resources such as water and electricity. This experiment is to calculate the efficiency of solar pump and panel. It is evaluated by calculating the input and output energy of the pump and panel. By comparing the efficiencies of pump and panel we can be able to estimate the amount of loss of energy. For conserving the energy, we can also install battery and charge controller for the use of pump in dark without solar energy. It conserves energy even while the pump is working. At the time of 2-3pm the efficiency of solar panel is about 55-60% and for the pump is 50-55%. By installing the storage device, we can save 2-5% of the energy wastage. This proves to be a better implementation for conserving the energy and the use of pump at any time. View Article DOI: 10.47856/ijaast.2022.v09i08.00

Immunogenicity and safety of live attenuated hepatitis A Vaccine: a multicentric study

Objective: To evaluate immunogenicity and tolerability of single dose live attenuated injectable hepatitis A vaccine in four metropolitan cities of India. Methods: Live attenuated hepatitis A vaccine was administered to 505 children aged 18-60 months in four centers across India. Immunogenicity of the vaccine was assessed by estimation of anti-HAV antibody titer at 6 weeks and 6 months following administration of the vaccine. Safety evaluation of the vaccine was also done during the visits. Results: At 6 weeks, 480 subjects (95%) came for the follow-up and 411 (81.4%) subjects reported at the end of 6 months. The geometric mean titer (GMT) of anti-HAV antibody of the subjects who did not have the seroprotective titer at the baseline were assessed at 6 weeks and 6 months which was 81.04 mIU/ml and 150.66 mIU/ml respectively. At 6 weeks, 95.1% seroconverted and at the end of 6 months, 97.9% had seroconverted. Both solicited and unsolicited vaccine-induced local and systemic adverse events were insignificant at all the centers, except swelling and induration in a few. Conclusion: Live attenuated injectable hepatitis A vaccine was immunogenic and tolerable with minimal reactogenecity, in this study of single dose schedule. Safety profile was also satisfactory in the study population

Biallelic PDX1 (insulin promoter factor 1) mutations causing neonatal diabetes without exocrine pancreatic insufficiency

This is the final version. Available on open access from Wiley via the DOI in this recordAims: Recessive PDX1 (IPF1) mutations are a rare cause of pancreatic agenesis, with three cases reported worldwide. A recent report described two cousins with a homozygous hypomorphic PDX1 mutation causing permanent neonatal diabetes with subclinical exocrine insufficiency. The aim of our study was to investigate the possibility of hypomorphic PDX1 mutations in a large cohort of patients with permanent neonatal diabetes and no reported pancreatic hypoplasia or exocrine insufficiency. Methods: PDX1 was sequenced in 103 probands with isolated permanent neonatal diabetes in whom ABCC8, KCNJ11 and INS mutations had been excluded. Results: Sequencing analysis identified biallelic PDX1 mutations in three of the 103 probands with permanent neonatal diabetes (2.9%). One proband and his affected brother were compound heterozygotes for a frameshift and a novel missense mutation (p.A34fsX191; c.98dupC and p.P87L; c.260C>T). The other two probands were homozygous for novel PDX1 missense mutations (p.A152G; c.455C>G and p.R176Q; c.527G>A). Both mutations affect highly conserved residues located within the homeobox domain. None of the four cases showed any evidence of exocrine pancreatic insufficiency, either clinically, or, where data were available, biochemically. In addition a heterozygous nonsense mutation (p.C18X; c.54C>A) was identified in a fourth case. Conclusions: This study demonstrates that recessive PDX1 mutations are a rare but important cause of isolated permanent neonatal diabetes in patients without pancreatic hypoplasia/agenesis. Inclusion of the PDX1 gene in mutation screening for permanent neonatal diabetes is recommended as a genetic diagnosis reveals the mode of inheritance, allows accurate estimation of recurrence risks and confirms the requirement for insulin treatment. © 2013 The Authors. Diabetic Medicine © 2013 Diabetes UK.Diabetes UKEuropean Union FP