The behaviour of copper in view of radiation damage in the LHC luminosity upgrade

In view of the safe operation of the quadrupoles in the luminosity upgrade of the LHC accelerator, the response of the copper stabilizer at low temperatures to the various high energy radiation sources is of primary importance. The present study takes into account the expected high energy spectrum of the simultaneous radiation by neutrons, protons, pions, electrons and photons, calculated using the FLUKA code by F. Cerutti (CERN) as well as on literature values. It was found that proton irradiation causes a considerably higher damage than neutron irradiation: in spite of a 3.8% proton fraction, the measured damage is of the order of 20%, which fits with the calculations of N. Mokhov (Fermilab) on the contribution of protons to the dpa. The same calculations indicate that the total effect of protons, pions and electrons is at least as high as that of neutrons. Since recent neutron experiments of Nakamoto et al. show that the RRR of Cu is reduced from 200 to 50-120 for a fluence of 10^{21} n/cm^{2}, it follows that the inclusion of all high energy sources would lead to RRR values well below 50, thus endangering stability and protection. This result confirms the necessity of including a tungsten shield inside the quadrupoles.Comment: 7 pages, Contribution to WAMSDO 2013: Workshop on Accelerator Magnet, Superconductor, Design and Optimization; 15 - 16 Jan 2013, CERN, Geneva, Switzerlan

Gaia DR2 view of the Lupus V-VI clouds: the candidate diskless young stellar objects are mainly background contaminants

Extensive surveys of star-forming regions with Spitzer have revealed populations of disk-bearing young stellar objects. These have provided crucial constraints, such as the timescale of dispersal of protoplanetary disks, obtained by carefully combining infrared data with spectroscopic or X-ray data. While observations in various regions agree with the general trend of decreasing disk fraction with age, the Lupus V and VI regions appeared to have been at odds, having an extremely low disk fraction. Here we show, using the recent Gaia data release 2 (DR2), that these extremely low disk fractions are actually due to a very high contamination by background giants. Out of the 83 candidate young stellar objects (YSOs) in these clouds observed by Gaia, only five have distances of 150 pc, similar to YSOs in the other Lupus clouds, and have similar proper motions to other members in this star-forming complex. Of these five targets, four have optically thick (Class II) disks. On the one hand, this result resolves the conundrum of the puzzling low disk fraction in these clouds, while, on the other hand, it further clarifies the need to confirm the Spitzer selected diskless population with other tracers, especially in regions at low galactic latitude like Lupus V and VI. The use of Gaia astrometry is now an independent and reliable way to further assess the membership of candidate YSOs in these, and potentially other, star-forming regions.Comment: Accepted for publication on Astronomy&Astrophysics Letter

The Solar Twin Planet Search II. A Jupiter twin around a solar twin

Through our HARPS radial velocity survey for planets around solar twin stars, we have identified a promising Jupiter twin candidate around the star HIP11915. We characterize this Keplerian signal and investigate its potential origins in stellar activity. Our analysis indicates that HIP11915 hosts a Jupiter-mass planet with a 3800-day orbital period and low eccentricity. Although we cannot definitively rule out an activity cycle interpretation, we find that a planet interpretation is more likely based on a joint analysis of RV and activity index data. The challenges of long-period radial velocity signals addressed in this paper are critical for the ongoing discovery of Jupiter-like exoplanets. If planetary in nature, the signal investigated here represents a very close analog to the solar system in terms of both Sun-like host star and Jupiter-like planet.Comment: 8 pages, 5 figures; A&A accepted; typos corrected in this versio

BIOMECHANIC OF BALANCE:PARADIGMS AND PROCEDURES

Balance, like coordination, is understood by virtually everyone to be a critical component of skillful movement. Yet there exists very little biomechanical research into how balance is employed and improved by performers of disparate abilities in different sports. The purpose of this symposium is to open a dialogue on the biomechanics of balance. The first part of the symposium will be an exposition of definitions and conceptions of balance from the literature. While most of the traditional approaches provide clarity on some aspect of balance, not one is broad enough to encompass the diversity of contexts and proficiencies in sport. By combining features of many approaches and elaborating on the false dichotomies (e.g., static vs. dynamic), we propose a more contemporary conception of balance which deals with the interplay of stability and mobility of the body with respect to its base of support. Depending on the sporting context, more stability than mobility may be desired, and depending on the skill level of the performer, more instability than stability may be apparent. There are many ways to operationalize stability and mobility: for example, using video, we can measure the position and movement of the line of gravity with respect to the base of support, and using a force plate, we can assess the A/P and M/L forces and the center of pressure. The second part of the symposium will be an exploration of balance using the stability/mobility paradigm and procedures. Specifically we will compare intermediate and advanced performers in four sports skills: In the basketball jump shot, which requires great A/P stability over a small base of support, higher skill was associated with less in stability. In the volleyball spike, which requires arrested mobility as the horizontal approach is transformed into the vertical jump, higher skill was associated with greater reduction in mobility. In the golf pitch shot, which requires little mobility in either the A/P or M/L directions, higher skill was associated with less mobility. In the weight lifting snatch, which requires an early horizontal movement of the bar followed by relative stability, lower skill was associated with greater stability. Given that the snatch also has a perceptible risk of injury, this finding is not surprising. Following a summary, the audience will be invited to participate in a discussion on the biomechanics of balance

Nucleosynthetic history of elements in the Galactic disk [X/Fe]-age relations from high-precision spectroscopy

Context. The chemical composition of stars is intimately linked to the formation and evolution of the Galaxy. Aims. We aim to trace the chemical evolution of the Galactic disk through the inspection of the [X/Fe]–age relations of 24 species from C to Eu. Methods. Using high-resolution and high signal-to-noise UVES spectra of nine solar twins, we obtained precise estimates of stellar ages and chemical abundances. These determinations have been integrated with additional accurate age and abundance determinations from recent spectroscopic studies of solar twins existing in the literature, comprising superb abundances with 0.01 dex precision. Based on this data set, we outlined the [X/Fe]–age relations over a time interval of 10 Gyr. Results. We present the [X/Fe] – age relations for 24 elements (C, O, Na, Mg, Al, Si, S, K, Ca, Sc, Ti, V, Cr, Mn, Co, Ni, Cu, Zn, Y, Ba, La, Ce, Nd, and Eu). Each different class of elements showed a distinct evolution with time that relies on the different characteristics, rates, and timescales of the nucleosynthesis sites from which they are produced. The α-elements are characterized by a [X/Fe] decrease with time. Strikingly, the opposite behavior is observed for Ca. The iron-peak elements show an early [X/Fe] increase followed by a decrease towards the youngest stars. The [X/Fe] for the n-capture elements decrease with age. We also found that both [Mg/Y] and [Al/Y] are precise stellar clocks, with [Al/Y] showing the steepest dependence on age. Conclusions. Knowledge of the [X/Fe]-age relations is a gold mine from which we can achieve a great understanding of the processes that governed the formation and evolution of the Milky Way. Through the reverse engineering of these relations we will be able to put strong constraints on the nature of the stellar formation history, the SNe rates, the stellar yields, and the variety of the SNe progenitors

New insights into volcanic processes at Stromboli from Cerberus, a remote-controlled open-path FTIR scanner system

The ordinary, low intensity, activity of Stromboli volcano is sporadically interrupted by more energetic events termed, depending on their intensity, “major explosions” and “paroxysms”. These short-lived energetic episodes represent a potential risk to visitors to the highly accessible summit of Stromboli. Observations made at Stromboli over the last decade have shown that the composition of gas emitted from the summit craters may change prior to such explosions, allowing the possibility that such changes may be used to forecast these potentially dangerous events. In 2008 we installed a novel, remote-controlled, open-path FTIR scanning system called Cerberus at the summit of Stromboli, with the objective of measuring gas compositions from individual vents within the summit crater terrace of the volcano with high temporal resolution and for extended periods. In this work we report the first results from the Cerberus system, collected in August-September 2009, November 2009 and May-June 2010. We find significant, fairly consistent, intra-crater variability for CO2/SO2 and H2O/CO2 ratios, and relatively homogeneous SO2/HCl ratios. In general, the southwest crater is richest in CO2, and the northeast crater poorest, while the central crater is richest in H2O. It thus appears that during the measurement period the southwest crater had a somewhat more direct connection to a primary, deep degassing system; whilst the central and northeast craters reflect a slightly more secondary degassing nature, with a supplementary, shallow H2O source for the central crater, probably related to puffing activity. Such water-rich emissions from the central crater can account for the lower crystal content of its eruption products, and emphasise the role of continual magma supply to the shallowest levels of Stromboli's plumbing system. Our observations of heterogeneous crater gas emissions and high H2O/CO2 ratios do not agree with models of CO2-flushing, and we show that simple depressurisation during magma ascent to the surface is a more likely model for H2O loss at Stromboli. We highlight that alternative explanations other than CO2 flushing are required to explain distributions of H2O and CO2 amounts dissolved in melt inclusions. We detected fairly systematic increases in CO2/SO2 ratio some weeks prior to major explosions, and some evidence of a decrease in this ratio in the days immediately preceding the explosions, with periods of low, stable CO2/SO2 ratios between explosions otherwise. Our measurements, therefore, confirm the medium term (~ weeks) precursory increases previously observed with MultiGas instruments, and, in addition, reveal new, short-term precursory decreases in CO2/SO2 ratios. immediately prior to the major explosions. Such patterns, if shown to be systematic, may be of great utility for hazard management at Stromboli's summit. Our results suggest that intra-crater CO2/SO2 variability may produce short-term peaks and troughs in CO2/SO2 time series measured with in-situ MultiGas instruments, due simply to variations in wind direction

Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.

Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia. Most pathogenic GRN mutations result in progranulin haploinsufficiency, which is thought to cause frontotemporal dementia in GRN mutation carriers. Progranulin haploinsufficiency may drive frontotemporal dementia pathogenesis by disrupting lysosomal function, as patients with GRN mutations on both alleles develop the lysosomal storage disorder neuronal ceroid lipofuscinosis, and frontotemporal dementia patients with GRN mutations (FTD-GRN) also accumulate lipofuscin. The specific lysosomal deficits caused by progranulin insufficiency remain unclear, but emerging data indicate that progranulin insufficiency may impair lysosomal sphingolipid-metabolizing enzymes. We investigated the effects of progranulin insufficiency on sphingolipid-metabolizing enzymes in the inferior frontal gyrus of FTD-GRN patients using fluorogenic activity assays, biochemical profiling of enzyme levels and posttranslational modifications, and quantitative neuropathology. Of the enzymes studied, only β-glucocerebrosidase exhibited impairment in FTD-GRN patients. Brains from FTD-GRN patients had lower activity than controls, which was associated with lower levels of mature β-glucocerebrosidase protein and accumulation of insoluble, incompletely glycosylated β-glucocerebrosidase. Immunostaining revealed loss of neuronal β-glucocerebrosidase in FTD-GRN patients. To investigate the effects of progranulin insufficiency on β-glucocerebrosidase outside of the context of neurodegeneration, we investigated β-glucocerebrosidase activity in progranulin-insufficient mice. Brains from Grn-/- mice had lower β-glucocerebrosidase activity than wild-type littermates, which was corrected by AAV-progranulin gene therapy. These data show that progranulin insufficiency impairs β-glucocerebrosidase activity in the brain. This effect is strongest in neurons and may be caused by impaired β-glucocerebrosidase processing

Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.

Tau aggregation is a hallmark feature in a subset of patients with frontotemporal dementia (FTD). Early and selective loss of von Economo neurons (VENs) and fork cells within the frontoinsular (FI) and anterior cingulate cortices (ACC) is observed in patients with sporadic behavioral variant FTD (bvFTD) due to frontotemporal lobar degeneration (FTLD), including FTLD with tau inclusions (FTLD-tau). Recently, we further showed that these specialized neurons show preferential aggregation of TDP-43 in FTLD-TDP. Whether VENs and fork cells are prone to tau accumulation in FTLD-tau remains unclear, and no previous studies of these neurons have focused on patients with pathogenic variants in the gene encoding microtubule-associated protein tau (FTLD-tau/MAPT). Here, we examined regional profiles of tau aggregation and neurodegeneration in 40 brain regions in 8 patients with FTLD-tau/MAPT and 7 with Pick's disease (PiD), a sporadic form of FTLD-tau that often presents with bvFTD. We further qualitatively assessed the cellular patterns of frontoinsular tau aggregation in FTLD-tau/MAPT using antibodies specific for tau hyperphosphorylation, acetylation, or conformational change. ACC and mid-insula were among the regions most affected by neurodegeneration and tau aggregation in FTLD-tau/MAPT and PiD. In these two forms of FTLD-tau, severity of regional neurodegeneration and tau protein aggregation were highly correlated across regions. In FTLD-tau/MAPT, VENs and fork cells showed disproportionate tau protein aggregation in patients with V337 M, A152T, and IVS10 + 16 variants, but not in patients with the P301L variant. As seen in FTLD-TDP, our data suggest that VENs and fork cells represent preferentially vulnerable neuron types in most, but not all of the MAPT variants we studied