Design and Synthesis of Some New Quinoline Based 1,2,3-Triazoles as Antimicrobial and Antimalarial Agents

A series of novel 6-bromo-2-chloro-3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-quinoline and its derivatives (5a-j) were synthesized in good yields from the intermediates (6-bromo-2-chloro-quinolin-3-yl)-methanol (2), methanesulfonic acid (6-bromo-2-chloroquinolin-3-yl)methyl methanesulfonate (3) and 3-azidomethyl-6-bromo-2-chloro-quinoline (4). The synthetic route leading to the title compounds is commenced from commercially available 6-bromo-2-chloro-quinolin-3-carbaldehyde (1). The chemical structures of the newly synthesized compounds were elucidated by their IR, 1H and 13C NMR, mass spectral data and elemental analysis. Further, all the target compounds were screened for their antimicrobial activity against various microorganisms and antimalarial activity towards P. falciparum. DOI: http://dx.doi.org/10.17807/orbital.v7i3.69

Design and Synthesis of Some New Quinoline Based 1,2,3-Triazoles as Antimicrobial and Antimalarial Agents

A series of novel 6-bromo-2-chloro-3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-quinoline and its derivatives (5a-j) were synthesized in good yields from the intermediates (6-bromo-2-chloro-quinolin-3-yl)-methanol (2), methanesulfonic acid (6-bromo-2-chloroquinolin-3-yl)methyl methanesulfonate (3) and 3-azidomethyl-6-bromo-2-chloro-quinoline (4). The synthetic route leading to the title compounds is commenced from commercially available 6-bromo-2-chloro-quinolin-3-carbaldehyde (1). The chemical structures of the newly synthesized compounds were elucidated by their IR, 1H and 13C NMR, mass spectral data and elemental analysis. Further, all the target compounds were screened for their antimicrobial activity against various microorganisms and antimalarial activity towards P. falciparum. DOI: http://dx.doi.org/10.17807/orbital.v7i3.69

Ultrasonic studies on binary mixtures of some aromatic ketones with acrylonitrile at 308.15 K

591-595The densities and sound speeds of mixtures of acetophenone, propiophenone, paramethyl acetophenone and parachloro acetophenone with acrylonitrile, over the entire range of composition, have been measured at a temperature of 308.15 K. The deviations in speed u, isentropic compressibility kS, intermolecular free-length LF and relative association RA have been computed using speed and density values. The u values are positive whereas kS and LF values are negative for all the systems, which indicate the specific interactions between unlike molecules. The results are discussed in the light of intermolecular interactions occurring in the solutions. The computed results of kS, have been fitted to a Redlich-Kister type polynomial equation

Densities and viscosities of binary liquid systems of acetonitrile with aromatic ketones at 308.15 K

1365-1371The densities and viscosities for the binary mixtures of acetonitrile + aromatic ketones (acetophenone,  propiophenone, paramethyl acetophenone and parachloro acetophenone) at 308.15 K over the entire range of composition are reported here. The densities and viscosities have been used to calculate the excess molar volumes and deviations in viscosity. The excess molar volumes and deviations in viscosity are fitted to a Redlich-Kister type equation. Other parameters like excess Gibbs free energy of activation of viscous flow and Grunberg-Nissan interaction constant are also utilized in the qualitative analysis to elicit the information on the nature of the bulk molecular interactions of acetonitrile + aromatic ketone binary mixtures

Acoustic studies of binary mixtures of N-methylacetamide with some chloroethanes and chloroethenes at 308.15 K

587-591The densities and speeds of sound of mixtures of 1,2 dichloroethane, 1,1,2 trichloroethane, 1,1,2,2 tetrachloroethane, trichloroethene and tetrachloroethene with N-methylacetamide, over the entire range of composition, have been measured at a temperature of 308.15 K. The deviations in speed Δu, isentropic compressibility ΔkS, intermolecular free-length ΔLF and relative association RA have been computed using speed and density values. The Δu values are negative whereas ΔkS and ΔLF values are positive for all the systems, which indicate the non-specific interactions between unlike molecules. The results are discussed in the light of intermolecular interactions occurring in the solutions. The computed results of ΔkS, have been fitted to a Redlich-Kister type polynomial equation

Volumetric and transport properties of binary liquid mixtures of aromatic hydrocarbons with N-methylacetamide at 308.15 K

511-516Experimental data on density, viscosity and speed of sound values at 308.15 K are presented for the binary mixtures of N-methylacetamide with benzene, toluene, mesitylene and phenylacetonitrile. From these experimental data, excess molar volumes, deviations in viscosity and isentropic compressibility of aromatic hydrocarbons with N-methylacetamide have been calculated. The computed values have been fitted to Redlich-Kister polynomial equation using multiparametric non-linear regression analysis to estimate the coefficients and standard errors. The variations in the calculated excess quantities for these mixtures have been studied in terms of molecular interactions between the component liquids and the effects of methyl and cyanomethylene substitution on benzene ring