Functional kernel estimators of conditional extreme quantiles

We address the estimation of "extreme" conditional quantiles i.e. when their order converges to one as the sample size increases. Conditions on the rate of convergence of their order to one are provided to obtain asymptotically Gaussian distributed kernel estimators. A Weissman-type estimator and kernel estimators of the conditional tail-index are derived, permitting to estimate extreme conditional quantiles of arbitrary order.Comment: arXiv admin note: text overlap with arXiv:1107.226

Evidence of Martensitic Phase Transitions in Magnetic Ni-Mn-In Thin Films

Ni 50Mn35In15 Heusler alloy thin films (with thicknesses of about 10 nm) have been grown on single crystal MgO and SrTiO3 (STO) (100) substrates using a laser-assisted molecular beam epitaxy method. Films of mixed austenitic and martensitic phases and of pure martensitic phase have been detected for those grown on MgO and STO substrates, respectively. Thermomagnetic curves were measured using a SQUID magnetometer and are consistent with those of off-stoichiometric In-based bulk Heusler alloys, including a martensitic transition at T = 315 K for films grown on MgO. The differences in the properties of the films grown on MgO and STO are discussed

Search for long lived heaviest nuclei beyond the valley of stability

The existence of long lived superheavy nuclei (SHN) is controlled mainly by spontaneous fission and $\alpha$-decay processes. According to microscopic nuclear theory, spherical shell effects at Z=114, 120, 126 and N=184 provide the extra stability to such SHN to have long enough lifetime to be observed. To investigate whether the so-called "stability island" could really exist around the above Z, N values, the $\alpha$-decay half lives along with the spontaneous fission and $\beta$-decay half lives of such nuclei are studied. The $\alpha$-decay half lives of SHN with Z=102-120 are calculated in a quantum tunneling model with DDM3Y effective nuclear interaction using $Q_\alpha$ values from three different mass formulae prescribed by Koura, Uno, Tachibana, Yamada (KUTY), Myers, Swiatecki (MS) and Muntian, Hofmann, Patyk, Sobiczewski (MMM). Calculation of spontaneous fission (SF) half lives for the same SHN are carried out using a phenomenological formula and compared with SF half lives predicted by Smolanczuk {\it et al}. Possible source of discrepancy between the calculated $\alpha$-decay half lives of some nuclei and the experimental data of GSI, JINR-FLNR, RIKEN are discussed. In the region of Z=106-108 with N$\sim$ 160-164, the $\beta$-stable SHN $^{268}_{106}Sg_{162}$ is predicted to have highest $\alpha$-decay half life ($T_\alpha \sim 3.2hrs$) using $Q_\alpha$ value from MMM. Interestingly, it is much greater than the recently measured $T_\alpha$ ($\sim 22s$) of deformed doubly magic $^{270}_{108}Hs_{162}$ nucleus. A few fission-survived long-lived SHN which are either $\beta$-stable or having large $\beta$-decay half lives are predicted to exist near $^{294}110_{184}$, $^{293}110_{183}$, $^{296}112_{184}$ and $^{298}114_{184}$. These nuclei might decay predominantly through $\alpha$-particle emission.Comment: 14 pages, 6 figures, 1 tabl

Handbook of methods for risk-based analysis of technical specifications

Technical Specifications (TS) requirements for nuclear power plants define the Limiting Conditions for Operations (LCOs) and Surveillance Requirements (SRs) to assure safety during operation. In general, these requirements are based on deterministic analyses and engineering judgments. Improvements in these requirements are facilitated by the availability of plant-specific Probabilistic Risk Assessments (PRAs). The US Nuclear Regulatory Commission (USNRC) Office of Research sponsored research to develop systematic, risk-based methods to improve various aspects of TS requirements. A handbook of methods summarizing such risk-based approaches has been completed in 1994. It is expected that this handbook will provide valuable input to NRC`s present work in developing guidance for using PRA in risk-informed regulation. The handbook addresses reliability and risk-based methods for evaluating allowed outage times (AOTs), action statements requiring shutdown where shutdown risk may be substantial, surveillance test intervals (STIs), managing plant configurations, and scheduling maintenance

Berry curvature induced anomalous Hall conductivity in the magnetic topological oxide double perovskite Sr₂FeMoO₆

Oxide materials exhibit several structural, magnetic, and electronic properties. Their stability under ambient conditions, easy synthesis, and high transition temperatures provide such systems with an ideal ground for realizing topological properties and real-life technological applications. However, experimental evidence of topological states in oxide materials is rare. In this paper, we have synthesized single crystals of oxide double perovskite Sr2FeMoO6 and revealed its topological nature by investigating its structural, magnetic, and electronic properties. We observed that the system crystallized in the cubic space group Fm3¯m, which is a half-metallic ferromagnet. Transport measurements show an anomalous Hall effect (AHE), and it is evident that the Hall contribution originates from the Berry curvature. Assuming a shift of the Fermi energy toward the conduction band, the contribution of the AHE is enhanced owing to the presence of a gapped nodal line. This paper can be used to explore and realize the topological properties of bulk oxide systems. © 2022 authors. Published by the American Physical Society

Disposition kinetics of ceftizoxime in acute mastitis in Murrah buffaloes

Acute mastitis was induced by inoculation of Staphylococcus aureus in 6 buffaloes. Ceftizoxime was administrated intravenously @25 mg/kg to evaluate pharmacokinetics of ceftizoxime in mastitic buffaloes. The maximum mean plasma concentration of ceftizoxime was recorded at 0.08 h in healthy buffaloes which was followed by decreased plasma concentration of 23.53 ± 0.84 µg/ml at 1 h and persisted up to 24 h. Mean values of t½ß were 5.86 ± 0.18 and 8.42 ± 0.58 h in healthy and induced mastitic buffaloes, respectively. Mean Vdarea value of 1.10 ± 0.06 L/kg in healthy buffaloes was increased significantly. The maximum mean milk concentration of ceftizoxime at 2 h (73.34 ± 4.35 µg/ml) in lactating buffaloes decreased gradually till 12 h (31.31 ± 5.66 µg/ml) and persisted up to 96 h (1.57 ± 0.20 µg/ml). So, ceftizoxime can be used for treatment of staphylococcal mastitis in buffaloes

Quantum inelastic conductance through molecular wires

We calculate non-perturbatively the inelastic effects on the conductance through a conjugated molecular wire-metal heterojunction, including realistic electron-phonon coupling. We show that at sub-band-gap energies the current is dominated by quantum coherent transport of virtual polarons through the molecule. In this regime, the tunneling current is strongly increased relative to the case of elastic scattering. It is essential to describe the full quantum coherence of the polaron formation and transport in order to obtain correct physics. Our results are generally applicable to one-dimensional atomic or molecular wires.Comment: 4 pages, 4 figures, accepted for publication in Physical Review Letter

Improved dd+4^4He potentials by inversion, the tensor force and validity of the double folding model

Improved potential solutions are presented for the inverse scattering problem for $d$+$^4$He data. The input for the inversions includes both the data of recent phase shift analyses and phase shifts from RGM coupled-channel calculations based on the NN Minnesota force. The combined calculations provide a more reliable estimate of the odd-even splitting of the potentials than previously found, suggesting a rather moderate role for this splitting in deuteron-nucleus scattering generally. The approximate parity-independence of the deuteron optical potentials is shown to arise from the nontrivial interference between antisymmetrization and channel coupling to the deuteron breakup channels. A further comparison of the empirical potentials established here and the double folding potential derived from the M3Y effective NN force (with the appropriate normalisation factor) reveals strong similarities. This result supports the application of the double folding model, combined with a small Majorana component, to the description even of such a loosely bound projectile as the deuteron. In turn, support is given for the application of iterative-perturbative inversion in combination with the double folding model to study fine details of the nucleus-nucleus potential. A $d$-$^4$He tensor potential is also derived to reproduce correctly the negative $^6$Li quadrupole moment and the D-state asymptotic constant.Comment: 22 pages, 12 figures, in Revte

Rationalizing the permeation of polar antibiotics into Gram-negative bacteria

The increasing level of antibiotic resistance in Gram-negative bacteria, together with the lack of new potential drug scaffolds in the pipeline, make the problem of infectious diseases a global challenge for modern medicine. The main reason that Gram-negative bacteria are particularly challenging is the presence of an outer cell-protecting membrane, which is not present in Gram-positive species. Such an asymmetric bilayer is a highly effective barrier for polar molecules. Several protein systems are expressed in the outer membrane to control the internal concentration of both nutrients and noxious species, in particular: (i) water-filled channels that modulate the permeation of polar molecules and ions according to concentration gradients, and (ii) efflux pumps to actively expel toxic compounds. Thus, besides expressing specific enzymes for drugs degradation, Gram-negative bacteria can also resist by modulating the influx and efflux of antibiotics, keeping the internal concentration low. However, there are no direct and robust experimental methods capable of measuring the permeability of small molecules, thus severely limiting our knowledge of the molecular mechanisms that ultimately control the permeation of antibiotics through the outer membrane. This is the innovation gap to be filled for Gram-negative bacteria. This review is focused on the permeation of small molecules through porins, considered the main path for the entry of polar antibiotics into Gram-negative bacteria. A fundamental understanding of how these proteins are able to filter small molecules is a prerequisite to design/optimize antibacterials with improved permeation. The level of sophistication of modern molecular modeling algorithms and the advances in new computer hardware has made the simulation of such complex processes possible at the molecular level. In this work we aim to share our experience and perspectives in the context of a multidisciplinary extended collaboration within the IMI-Translocation consortium. The synergistic combination of structural data, in vitro assays and computer simulations has proven to give new insights towards the identification and description of physico–chemical properties modulating permeation. Once similar general rules are identified, we believe that the use of virtual screening techniques will be very helpful in searching for new molecular scaffolds with enhanced permeation, and that molecular modeling will be of fundamental assistance to the optimization stage