86 research outputs found

    Remote sensing applied to litho-structural and regolith mapping of the SW of Angola (PLANAGEO Project)

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    ABSTRACT: IGEO (Geological Institute of Angola) has developed the sosubprograms was focused on the remote sensing survey of the country. The main objective of the study is the use of satellite Earth Observation data in order to support preliminary geological and regolith mapping. This allows us to obtain a first approximation to cartography 1:250.000. Litho-structural and regolith maps are elaborated over eight blocks, covering one-third of the country area and including different geological contexts.info:eu-repo/semantics/publishedVersio

    Estimating Age-Dependent Extinction: Contrasting Evidence from Fossils and Phylogenies.

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    The estimation of diversification rates is one of the most vividly debated topics in modern systematics, with considerable controversy surrounding the power of phylogenetic and fossil-based approaches in estimating extinction. Van Valen's seminal work from 1973 proposed the "Law of constant extinction," which states that the probability of extinction of taxa is not dependent on their age. This assumption of age-independent extinction has prevailed for decades with its assessment based on survivorship curves, which, however, do not directly account for the incompleteness of the fossil record, and have rarely been applied at the species level. Here, we present a Bayesian framework to estimate extinction rates from the fossil record accounting for age-dependent extinction (ADE). Our approach, unlike previous implementations, explicitly models unobserved species and accounts for the effects of fossil preservation on the observed longevity of sampled lineages. We assess the performance and robustness of our method through extensive simulations and apply it to a fossil data set of terrestrial Carnivora spanning the past 40 myr. We find strong evidence of ADE, as we detect the extinction rate to be highest in young species and declining with increasing species age. For comparison, we apply a recently developed analogous ADE model to a dated phylogeny of extant Carnivora. Although the phylogeny-based analysis also infers ADE, it indicates that the extinction rate, instead, increases with increasing taxon age. The estimated mean species longevity also differs substantially, with the fossil-based analyses estimating 2.0 myr, in contrast to 9.8 myr derived from the phylogeny-based inference. Scrutinizing these discrepancies, we find that both fossil and phylogeny-based ADE models are prone to high error rates when speciation and extinction rates increase or decrease through time. However, analyses of simulated and empirical data show that fossil-based inferences are more robust. This study shows that an accurate estimation of ADE from incomplete fossil data is possible when the effects of preservation are jointly modeled, thus allowing for a reassessment of Van Valen's model as a general rule in macroevolution

    MINEO Southern Europe environment test site : contamination impact mapping and modelling : final Report

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    Relatório final do projeto MINEO: Assessing and monitoring the environmental impact of mining activities in Europe using advanced Earth Observation techniques. Project funded by the European Community under the “Information Society Technology” Programme (1998-2002)ABSTRACT: Under the framework of the MINEO project, the abandoned S.Domingos mining area as been selected as representative of Southern Europe Environment to test methods and tools for assessing and monitoring the environmental impact of mining activities using hyperspectral data and other relevant data sets. The S.Domingos mining area, is characterised by a long-term mining activity, since pre-roman times till the 1960’s, and is included in the group of Volcanogenic Massive Sulphide deposits of the Iberian Pyrite Belt. The orebody contained Cu, and also Zn and Pb. Several facilities were developed for mining works and ore transportation, covering an area of 50km2, facilitating dispersion of related pollutants. The main environmental problems can be summarised as related to waste material and their pollutant content (Zn, Pb, Sb, Cu, As, Hg and Cd), acid waters (minimum pH value of 1.7) and associated dispersion, as well as landscape disruption. Hyperspectral images were able to identify mineralogical/chemical dispersion of waste material related to Acid Mine Drainage (AMD) following two approaches: one related to AMD waste material field spectra and the other based on AMD minerals, using standard spectral libraries. The processing techniques used were mainly based on the Spectral Angle Mapper classifier and Mixture Tunned Matched Filtering. Globally, both mapping results obtained, either in AMD waste material either in AMD minerals, were able to detect mineralogical/chemical characteristics of imaged ground data, which were validated by field data. The GIS geochemical modelling allowed the determination of effective AMD area of influence, based in water pH values, using geostatistical methods. The Indicator “Collocate-Cokriging” of the water pH using the distance to the highest correlated AMD waste material (mixed sulphur materials from hyperspectral classification) predicts the AMD dispersion in the area related to that material. This methodology achieved good results and could be applied in new areas using waste material hyperspectral image classification for AMD delimitation area.N/

    The Molecular Phylogenetic Signature of Clades in Decline

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    Molecular phylogenies have been used to study the diversification of many clades. However, current methods for inferring diversification dynamics from molecular phylogenies ignore the possibility that clades may be decreasing in diversity, despite the fact that the fossil record shows this to be the case for many groups. Here we investigate the molecular phylogenetic signature of decreasing diversity using the most widely used statistic for inferring diversity dynamics from molecular phylogenies, the γ statistic. We show that if a clade is in decline its molecular phylogeny may show evidence of the decrease in the diversification rate that occurred between its diversification and decline phases. The ability to detect the change in diversification rate depends largely on the ratio of the speciation rates of the diversification and decline phases, the higher the ratio the stronger the signal of the change in diversification rate. Consequently, molecular phylogenies of clades in relative rapid decline do not carry a signature of their decreasing diversification. Further, the signal of the change in diversification rate, if present, declines as the diversity drop. Unfortunately, the molecular signature of clades in decline is the same as the signature produced by diversity dependent diversification. Given this similarity, and the inability of current methods to detect declining diversity, it is likely that some of the extant clades that show a decrease in diversification rate, currently interpreted as evidence for diversity dependent diversification, are in fact in decline. Unless methods can be developed that can discriminate between the different modes of diversification, specifically diversity dependent diversification and declining diversity, we will need the fossil record, or data from some other source, to distinguish between these very different diversity trajectories

    Alu-Alu Recombination Underlying the First Large Genomic Deletion in GlcNAc-Phosphotransferase Alpha/Beta (GNPTAB) Gene in a MLII Alpha/Beta Patient

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    Mucolipidosis type II α/β is a severe, autosomal recessive lysosomal storage disorder, caused by a defect in the GNPTAB gene that codes for the α/β subunits of the GlcNAc-phosphotransferase. To date, over 100 different mutations have been identified in MLII α/β patients, but no large deletions have been reported. Here we present the first case of a large homozygous intragenic GNPTAB gene deletion (c.3435-386_3602 + 343del897) encompassing exon 19, identified in a ML II α/β patient. Long-range PCR and sequencing methodologies were used to refine the characterization of this rearrangement, leading to the identification of a 21 bp repetitive motif in introns 18 and 19. Further analysis revealed that both the 5' and 3' breakpoints were located within highly homologous Alu elements (Alu-Sz in intron 18 and Alu-Sq2, in intron 19), suggesting that this deletion has probably resulted from Alu-Alu unequal homologous recombination. RT-PCR methods were used to further evaluate the consequences of the alteration for the processing of the mutant pre mRNA GNPTAB, revealing the production of three abnormal transcripts: one without exon 19 (p.Lys1146_Trp1201del); another with an additional loss of exon 20 (p.Arg1145Serfs*2), and a third in which exon 19 was substituted by a pseudoexon inclusion consisting of a 62 bp fragment from intron 18 (p.Arg1145Serfs*16). Interestingly, this 62 bp fragment corresponds to the Alu-Sz element integrated in intron 18.This represents the first description of a large deletion identified in the GNPTAB gene and contributes to enrich the knowledge on the molecular mechanisms underlying causative mutations in ML II.This work was supported by FCT - project PIC/IC/83252/2007 (http://alfa.fct.mctes.pt/). Coutinho MF and Quental S received grants from the FCT (SFRH/BD/48103/2008; SFRH/BPD/64025/2009)

    The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure

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    We have recently discovered that the two tryptophans of human β2-microglobulin have distinctive roles within the structure and function of the protein. Deeply buried in the core, Trp95 is essential for folding stability, whereas Trp60, which is solvent-exposed, plays a crucial role in promoting the binding of β2-microglobulin to the heavy chain of the class I major histocompatibility complex (MHCI). We have previously shown that the thermodynamic disadvantage of having Trp60 exposed on the surface is counter-balanced by the perfect fit between it and a cavity within the MHCI heavy chain that contributes significantly to the functional stabilization of the MHCI. Therefore, based on the peculiar differences of the two tryptophans, we have analysed the evolution of β2-microglobulin with respect to these residues

    Relationship between spatial ability, visuospatial working memory and self-assessed spatial orientation ability: a study in older adults

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    This paper describes some novel spatial tasks and questionnaires designed to assess spatial and orientation abilities. The new tasks and questionnaires were administered to a sample of 90 older adults (41 males, age range 57–90), along with some other tests of spatial ability (Minnesota Paper Form Board, Mental Rotations Test, and Embedded Figures Test) and tests of visuospatial working memory (Corsi’s Block Test and Visual Pattern Test). The internal reliability of the new tasks and questionnaires was analyzed, as well as their relationship with the spatial and working memory tests. The results showed that the new spatial tasks are reliable, correlate with working memory and spatial ability tests and, compared with the latters, show stronger correlations with the self-report questionnaires referring to orientation abilities. A model was also tested (with reference to Allen et al. in Intelligence 22:327–355, 1996) in which the new tasks were assumed to relate to spatial ability and predict orientation abilities as assessed by the self-report measures
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