ВНУТРІШНЬОПЕЧІНКОВИЙ ХОЛЕСТАЗ ВАГІТНИХ ПІСЛЯ ЗАСТОСУВАННЯ ДОПОМІЖНИХ РЕПРОДУКТИВНИХ ТЕХНОЛОГІЙ: КЛІНІЧНІ ОСОБЛИВОСТІ

80 pregnant women were examined after assisted reproductive technology (ART) programs: 40 women with manifestations of intrahepatic cholestasis of pregnant women (IHP) - the main group and 40 women without manifestations of IHP (comparison group).In the majority (62.5%) of patients after ART, the diagnosis of IHP established after 30 weeks of pregnancy. Some patients (27.5%) reported short-term episodes of IHP up to 24 weeks of gestation. In 17.5% of women, IHP had a severe course. Almost a third (27.5%) of women are over 35 years old. Women with IHP have a significantly higher frequency of allergies in the anamnesis (35.0%), liver pathology (20.0%) and diseases of the gastrointestinal tract (25.0%). In one third of women, IHP developed repeatedly, 42.5% of the main patients indicated a family history burdened with IHP. Almost a third of women (27.5% vs. 12.5%, p<0.05) had a history of polycystic ovary syndrome.The current pregnancy characterized by a high frequency of complications. A quarter of patients (25.0%) had early preeclampsia. In the second half of pregnancy, the threat of preterm birth noted in most women during the manifestation of IHP (60.0%). The incidence of fetal distress in women with IHP was almost 2 times higher than in patients without this complication (47.5% vs. 25.0%, respectively, p <0.05). The frequency of preeclampsia is also higher (40.0%).The vast majority of women in the main group were born by cesarean section (70.0%). Almost half of patients with IHP were premature (45.0%). A third of women (35.0%) had fetal distress in childbirth. In 27.5%, childbirth complicated by bleeding of more than 5% of body weight. The postpartum period was characterized by a 4-fold increase in the frequency of late bleeding (20.0% vs. 5.0%, p <0.05).One case of antenatal mortality noted in pregnant women after ART with IHP. Almost half of the children were born with asphyxia of varying severity (48.7%), with 10.3% diagnosed with severe asphyxia. One third of children were born with a body weight below 2500 g (30.8%). In 74.4% of newborns from mothers of the main group, various disorders of the period of early neonatal adaptation were noted, among which the most prominent were: RDS (35.9%), jaundice (43.6%) and gastrointestinal syndrome (30.8%). The 2-fold increased incidence of hemorrhagic syndrome (17.9%) is noteworthy.80 pregnant women were examined after assisted reproductive technology (ART) programs: 40 women with manifestations of intrahepatic cholestasis of pregnant women (IHP) - the main group and 40 women without manifestations of IHP (comparison group).In the majority (62.5%) of patients after ART, the diagnosis of IHP established after 30 weeks of pregnancy. Some patients (27.5%) reported short-term episodes of IHP up to 24 weeks of gestation. In 17.5% of women, IHP had a severe course. Almost a third (27.5%) of women are over 35 years old. Women with IHP have a significantly higher frequency of allergies in the anamnesis (35.0%), liver pathology (20.0%) and diseases of the gastrointestinal tract (25.0%). In one third of women, IHP developed repeatedly, 42.5% of the main patients indicated a family history burdened with IHP. Almost a third of women (27.5% vs. 12.5%, p<0.05) had a history of polycystic ovary syndrome.The current pregnancy characterized by a high frequency of complications. A quarter of patients (25.0%) had early preeclampsia. In the second half of pregnancy, the threat of preterm birth noted in most women during the manifestation of IHP (60.0%). The incidence of fetal distress in women with IHP was almost 2 times higher than in patients without this complication (47.5% vs. 25.0%, respectively, p <0.05). The frequency of preeclampsia is also higher (40.0%).The vast majority of women in the main group were born by cesarean section (70.0%). Almost half of patients with IHP were premature (45.0%). A third of women (35.0%) had fetal distress in childbirth. In 27.5%, childbirth complicated by bleeding of more than 5% of body weight. The postpartum period was characterized by a 4-fold increase in the frequency of late bleeding (20.0% vs. 5.0%, p <0.05).One case of antenatal mortality noted in pregnant women after ART with IHP. Almost half of the children were born with asphyxia of varying severity (48.7%), with 10.3% diagnosed with severe asphyxia. One third of children were born with a body weight below 2500 g (30.8%). In 74.4% of newborns from mothers of the main group, various disorders of the period of early neonatal adaptation were noted, among which the most prominent were: RDS (35.9%), jaundice (43.6%) and gastrointestinal syndrome (30.8%). The 2-fold increased incidence of hemorrhagic syndrome (17.9%) is noteworthy

The generality of inflation in some closed FRW models with a scalar field

The generality of inflation in closed FRW Universe is studied for the models with a scalar field on a brane and with a complex scalar field. The results obtained are compared with the previously known results for the model with a scalar field and a perfect fluid. The influence of the measure chosen in the initial condition space on the ratio of inflationary solution is described.Comment: 15 pages with 5 eps figures; small corrections in text; final version to appear in Int. J. Mod. Phys.

Development of bioceramic material for spinal surgery implants

Highly porous zirconia-based ceramics were prepared. The ceramic samples sintered at 1600°C had porosities from 40% to 43%, with pore size ranges as follows: "big pore" 100-220 pm and "small pore" 0.8-8 pm. This makes the ceramic structure to be very similar to the structure of the natural spinal bone. The level of mechanical properties of the synthesized zirconia-based ceramics is determined by the pore sizes. The values of the compressive strength and the effective Young's modulus are very similar to those characteristics of the natural spinal bone

THE ENZYMATIC STATUS FEATURES IN BLOOD LYMPHOCYTES IN CHILDREN WITH DYSFUNCTIONAL DISORDERS OF BILIARY TRACT AND THEIR ASSOCIATION WITH GIARDIASIS

N the study of NAD(P)-dependent dehydrogenases activity in blood lymphocytes in children with dysfunctional disorders of the biliary tract (DDBT) and. DDBT in association with giardiasis detected significant changes in the intracellular metabolism. In children with DDBT in blood lymphocytes the levels of substrate flow decreased at the terminal reactions of glycolysis and. the tricarboxylic acid cycle, which determines the inhibition, respectively, anaerobic and aerobic cellular respiration. It's been established that in blood lymphocytes of children with DDBT, associated with giardiasis, the activity of enzymes determining the state of aerobic respiration is reduced, while maintaining the normal level of intensity of the terminal reactions of anaerobic glycolysis. Regardless of the presence or absence of giardiasis in children with DDBT the activity of pentose phosphate cycle is reduced which characterizes the inhibition of the reactions of macromolecular synthesis

Anisotropy and inflation in Bianchi I brane worlds

After a more general assumption on the influence of the bulk on the brane, we extend some conclusions by Maartens et al. and Santos et al. on the asymptotic behavior of Bianchi I brane worlds. As a consequence of the nonlocal anisotropic stresses induced by the bulk, in most of our models, the brane does not isotropize and the nonlocal energy does not vanish in the limit in which the mean radius goes to infinity. We have also found the intriguing possibility that the inflation due to the cosmological constant might be prevented by the interaction with the bulk. We show that the problem for the mean radius can be completely solved in our models, which include as particular cases those in the references above.Comment: 10 pages, improved discussion on the likeliness of non-isotropization, completed list of references, matches version to appear in Class. Quantum Gra

ИССЛЕДОВАНИЕ ИЗНОСА РАДИАЛЬНО-УПОРНЫХ ШАРИКОПОДШИПНИКОВ

Wearing process of balls in an angular ball bearing has been investigated in the paper. Force affecting a separator from the side of balls is determined theoretically. Wear rate may be calculated with a formula for abrasive wear while substituting numerical parameter values of the investigated ball bearing for formula symbols.Рассматривается износ шариков в радиально-упорном шарикоподшипнике. Теоретически определяется усилие, действующее на сепаратор со стороны шариков. Интенсивность изнашивания можно определить по формуле для абразивного изнашивания при подстановке в нее числовых значений параметров рассматриваемого подшипника

Millikelvin de Haas-van Alphen and magnetotransport studies of graphite

Copyright © 2011 American Physical SocietyRecent studies of the electronic properties of graphite have produced conflicting results regarding the positions of the different carrier types within the Brillouin zone, and the possible presence of Dirac fermions. In this paper we report a comprehensive study of the de Haas–van Alphen, Shubnikov–de Haas, and Hall effects in a sample of highly orientated pyrolytic graphite, at temperatures in the range 30 mK to 4 K and magnetic fields up to 12 T. The transport measurements confirm the Brillouin-zone locations of the different carrier types assigned by Schroeder, Dresselhaus and Javan Phys. Rev. Lett. 20 1292 (1968): electrons are at the K point, and holes are near the H points. We extract the cyclotron masses and scattering times for both carrier types from the temperature- and magnetic-field-dependences of the magneto-oscillations. Our results indicate that the holes experience stronger scattering and hence have lower mobility than the electrons. We utilize phase-frequency analysis and intercept analysis of the 1/B positions of magneto-oscillation extrema to identify the nature of the carriers in graphite, whether they are Dirac or normal (Schrödinger) fermions. These analyses indicate normal holes and electrons of indeterminate natur

ОЦЕНКА МЕХАНИЧЕСКИХ ХАРАКТЕРИСТИК ЭНДОПРОТЕЗОВ СОСУДОВ

Titanium nickelide (nitinol) is one of prospective materials for production of special endo-prostheses and other parts and characterized with effect of shape memory. A specific feature of vascular endo-prostheses is the necessity to provide the required rigidity within the temperature interval from 15 to 42 оС. It has been established that titanium nickelide is able to provide the required rigidity but it depends on preliminary heat treatment parameters. So, it is important to determine rela-tions between rigidity of titanium nickelide wire and its preliminary heat treatment parameters for the given temperature in-terval. The aim of the work is to create devices that allow to estimate radial and flexural rigidity of elements made of flexible nitinol wire for manufacturing various medical products, including endo-prostheses of vessels – stents and stent grafts, filter traps. Laboratory digital scales and a specially developed dynamometer based on a cylindrical slotted spring and inductive displacement transducer have been used for measuring a load. The paper proposes possible variants of device designs used to monitor radial rigidity of blood vessel endo-prostheses, as well as to control flexural rigidity of endo-prosthesis elements and wire for their manufacture. The developed devices allow us to evaluate mechanical characteristics of samples under the desired temperature conditions. An introduction of the developed devices has permitted to carry out an operative control on radial and flexural stiffness of intravascular endo-prostheses elements both under conditions of research investigations and during technological process of their manufacture. Currently, the devices are used to specify heat treatment regimes for nitin-ol wire from various manufacturers while manufacturing vascular endo-prostheses. Один из перспективных материалов для изготовления специальных эндопротезов и других изделий – нике- лид титана, обладающий эффектом памяти формы. Особенностью эндопротезов сосудов является необходимость обеспечения требуемой жесткости при температуре от 15 до 42 оС. Установлено, что никелид титана способен обес- печить требуемую жесткость, но она зависит от режимов предварительной термообработки. Поэтому важно устано- вить связь между жесткостью проволоки из никелида титана и режимами его предварительной термообработки для заданного температурного интервала. Целью работы является создание устройств, позволяющих оценивать радиаль- ную и изгибную жесткость элементов, получаемых гибкой из нитиноловой проволоки для изготовления различных изделий медицинского назначения, в том числе эндопротезов сосудов – стентов и стент-графтов, фильтров-ловушек. Для измерения нагрузки использованы лабораторные цифровые весы и специально разработанный динамометр на основе цилиндрической прорезной пружины и индуктивного преобразователя перемещения. Предложены варианты устройств для контроля радиальной жесткости эндопротезов кровеносных сосудов, а также для контроля изгибной жесткости элементов эндопротезов и проволоки для их изготовления. Разработанные устройства позволяют оцени- вать механические характеристики образцов в нужных температурных условиях. Внедрение разработанных средств позволило выполнять оперативный контроль радиальной и изгибной жесткости элементов внутрисосудистых эндо- протезов как в условиях научных исследований, так и в ходе технологического процесса их изготовления. В настоя- щее время устройства используются для уточнения режимов термообработки нитиноловой проволоки различных производителей при изготовлении эндопротезов сосудов.

Anisotropy in Bianchi-type brane cosmologies

The behavior near the initial singular state of the anisotropy parameter of the arbitrary type, homogeneous and anisotropic Bianchi models is considered in the framework of the brane world cosmological models. The matter content on the brane is assumed to be an isotropic perfect cosmological fluid, obeying a barotropic equation of state. To obtain the value of the anisotropy parameter at an arbitrary moment an evolution equation is derived, describing the dynamics of the anisotropy as a function of the volume scale factor of the Universe. The general solution of this equation can be obtained in an exact analytical form for the Bianchi I and V types and in a closed form for all other homogeneous and anisotropic geometries. The study of the values of the anisotropy in the limit of small times shows that for all Bianchi type space-times filled with a non-zero pressure cosmological fluid, obeying a linear barotropic equation of state, the initial singular state on the brane is isotropic. This result is obtained by assuming that in the limit of small times the asymptotic behavior of the scale factors is of Kasner-type. For brane worlds filled with dust, the initial values of the anisotropy coincide in both brane world and standard four-dimensional general relativistic cosmologies.Comment: 12 pages, no figures, to appear in Class. Quantum Gra

Brane-world Cosmologies with non-local bulk effects

It is very common to ignore the non-local bulk effects in the study of brane-world cosmologies using the brane-world approach. However, we shall illustrate through the use of three different scenarios, that the non-local bulk-effect ${\cal P}_{\mu\nu}$ does indeed have significant impact on both the initial and future behaviour of brane-world cosmologies.Comment: 17 pages, no figures, iopart.cls, submitted to CQ