33,431 research outputs found

    The Joint Airport Weather Studies (JAWS) project

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    A block diagram of the joint airport weather studies program is presented. Background leading to the development of the program is reviewed. Basic studies, aircraft performance, and detection and warning techniques used to develop fine scale structure of thunderstorm dynamics and kinematics in the vicinity of a major airport; effect of thunderstorm low level wind shear on aircraft performance; and development of real time testing of flow level wind shear detection and warning techniques and displays are described

    miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development

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    MicroRNAs play a crucial role in the regulation of cell growth and differentiation. Mice with genetic deletion of miR-375 exhibit impaired glycemic control due to decreased β-cell and increased α-cell mass and function. The relative importance of these processes for the overall phenotype of miR-375KO mice is unknown. Here, we show that mice overexpressing miR-375 exhibit normal β-cell mass and function. Selective re-expression of miR-375 in β-cells of miR-375KO mice normalizes both, α- and β-cell phenotypes as well as glucose metabolism. Using this model, we also analyzed the contribution of β-cells to the total plasma miR-375 levels. Only a small proportion (≈1 %) of circulating miR-375 originates from β-cells. Furthermore, acute and profound β-cell destruction is sufficient to detect elevations of miR-375 levels in the blood. These findings are supported by higher miR-375 levels in the circulation of type 1 diabetes (T1D) subjects but not mature onset diabetes of the young (MODY) and type 2 diabetes (T2D) patients. Together, our data support an essential role for miR-375 in the maintenance of β-cell mass and provide in vivo evidence for release of miRNAs from pancreatic β-cells. The small contribution of β-cells to total plasma miR-375 levels make this miRNA an unlikely biomarker for β-cell function but suggests a utility for the detection of acute β-cell death for autoimmune diabetes

    The Penguin: a Low Reynolds Number Powered Glider for Station Keeping Missions

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    The Penguin is a low Reynolds number (approx. 100,000) remotely piloted vehicle (RPV). It was designed to fly three laps indoors around two pylons in a figure-eight course while maximizing loiter time. The Penguin's low Reynolds number mission is an important one currently being studied for possible future flights in the atmospheres of other planets and for specialized military missions. Although the Penguin's mission seemed quite simple at first, the challenges of such low Reynolds number flight have proven to be quite unique. In addition to the constraint of low Reynolds number flight, the aircraft had to be robust in its control, highly durable, and it had to carry a small instrument package. The Penguin's flight plan, concept, performance, aerodynamic design, weight estimation, structural design, propulsion, stability and control, and cost estimate is detailed

    A mathematical morphology approach for a qualitative exploration of drought events in space and time

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    Drought events occur worldwide and possibly incur severe consequences. Trying to understand and characterize drought events is of considerable importance in order to improve the preparedness for coping with future events. In this paper, we present a methodology that allows for the delineation of drought events by exploiting their spatiotemporal nature. To that end, we apply operators borrowed from mathematical morphology to represent drought events as connected components in space and time. As an illustration, we identify drought events on the basis of a 35-year data set of daily soil moisture values covering mainland Australia. We then extract characteristics reflecting the affected area, duration and intensity from the proposed representation of a drought event in order to illustrate the impact of tuning parameters in the methodology presented. Yet, this paper we refrain from comparing with other drought delineation methods

    What Are They Doing Anyway?: Library as Place and Student Use of a University Library

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    Objective - To determine student use of library spaces, the authors recorded student location and behaviors within the Library, to inform future space design. Methods - The case study method was used with both quantitative and qualitative measures. The authors had two objectives to guide this assessment of library spaces: 1) To determine what library spaces are being used by students and whether students are working individually, communally, or collaboratively and 2) To determine whether students use these spaces for learning activities and/or social engagement. Results - After data collection and analysis, the authors determined students are using individual or communal spaces almost equally as compared with collaborative group spaces. Data also revealed peak area usage and times. Conclusion - Observed student individual and social work habits indicate further need for spaces with ample electrical outlets and moveable tables. Further study is recommended to see whether additional seating and renovated spaces continue to enhance informal learning communities at URI and whether the Library is becoming a “third place” on campus
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