The effect of schooling and ability on achievement test scores

This paper develops two methods for estimating the effect of schooling on achievement test scores that control for endogeneity of schooling by postulating that both schooling and test scores are generated by a common unobserved latent ability. These methods are applied to data on schooling and test scores. Estimates from the two methods are in close agreement. We find that the effects of schooling on test scores are roughly linear across schooling levels. The effects of schooling on measured test scores are slightly larger for lower latent ability levels. We find that schooling increases the AFQT score on average between 2 and 4 percentage points, roughly twice as large as the effect claimed by Herrnstein and Murray (1994) but in agreement with estimates produced by Neal and Johnson (1996) and Winship and Korenman (1997). We extend the previous literature by estimating the impact of schooling on measured test scores at various quantiles of the latent ability distribution.Education; ability; latent variables; selection; MCMC

Bonneville basin analogues for large lake processes & chronologies of geomorphic development on Mars

Journal ArticlePleistocene Lake Bonneville was a large (~50,000 sq km) terrestrial closed lake system in Utah, USA that developed during the Last Glacial Maximum (~20 ka BP), and persisted at highstand until a catastrophic outburst flood event ~17.4 ka cal BP and warming climate significantly lowered its volume [1]. Lake Bonneville and its modern relict Great Salt Lake (fig. 1) is one of the most extensive, well preserved, and best dated lake systems on Earth and can serve as an analogue for deducing the style of development and age of similar features imaged on Mars [2]. Lake Bonneville exhibits prominent shorelines, spits, bay mouth barriers, deltas, gullies, outburst channels, and playa lake features, including patterned grounds and downwind aeolian systems, all of which are features inferred from imagery of Mars landforms

Facies Architecture and Provenance of a Boulder-Conglomerate Submarine Channel System, Panoche Formation, Great Valley Group: A Forearc Basin Response to Middle Cretaceous Tectonism in the California Convergent Margin

Tectonic reorganization induced by a rapid increase in plate motion ­obliquity and rate beginning at ca. 100 Ma affected California’s Andean-style convergent margin, with concomitant changes in the accretionary prism of the Franciscan Complex, the Great Valley forearc basin, and the Sierran continental arc. Using facies analysis and a combined provenance approach, we suggest that this ca. 100 Ma tectonic signal is preserved in a Cenomanian (Upper Cretaceous) boulder-conglomerate outcrop along the San Luis Reservoir (SLR) in the southern Great Valley, which represents the thickest and coarsest deep-water deposit ever described in the Great Valley Group (GVG). We document a 1.8-km-thick by 4-km-long depositional-dip profile of an interpreted SE-directed (axial) submarine channel system that is part of a conglomeratic package that stretches 20 km along the east-central Diablo Range. Our facies analysis of the SLR area documents five facies associations within four aggradational channel complex sets, followed by regional abandonment. Sandstone petrography and mudrock geochemical data suggest a dissected continental Sierra Nevadan arc source. Conglomerate clast counts show abundant ophiolitic-type clasts that may be derived from the Coast Range Ophiolite and/or the Western Sierra Nevada Metamorphic Belt. Detrital-­zircon geochronology data also indicate western and central Sierra Nevadan sources; however, we interpret an anomalous (relative to other Cenomanian localities) 105–95 Ma zircon population to indicate the initial erosional products from the volcanic carapace associated with the Late Cretaceous magmatic flare-up within the eastern Sierran arc. This flare-up has been linked to an increase in arc-parallel plate motion that induced deformation along shear zones in the eastern Sierra Nevada, allowing for widespread plutonism. Our provenance interpretation makes the SLR area the earliest Upper Cretaceous GVG locality to receive significant detritus from the flare-up, effectively linking tectonic plate motion changes and coarse-grained, deep-water forearc sedimentation

Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults.

A variety of age-related differences in the innate and adaptive immune systems have been proposed to contribute to the increased susceptibility to infection of human neonates and older adults. The emergence of RNA sequencing (RNA-seq) provides an opportunity to obtain an unbiased, comprehensive, and quantitative view of gene expression differences in defined cell types from different age groups. An examination of ex vivo human monocyte responses to lipopolysaccharide stimulation or Listeria monocytogenes infection by RNA-seq revealed extensive similarities between neonates, young adults, and older adults, with an unexpectedly small number of genes exhibiting statistically significant age-dependent differences. By examining the differentially induced genes in the context of transcription factor binding motifs and RNA-seq data sets from mutant mouse strains, a previously described deficiency in interferon response factor-3 activity could be implicated in most of the differences between newborns and young adults. Contrary to these observations, older adults exhibited elevated expression of inflammatory genes at baseline, yet the responses following stimulation correlated more closely with those observed in younger adults. Notably, major differences in the expression of constitutively expressed genes were not observed, suggesting that the age-related differences are driven by environmental influences rather than cell-autonomous differences in monocyte development

"Caring for Insiderness": Phenomenologically informed insights that can guide practice.

Understanding the ‘‘insider’’ perspective has been a pivotal strength of qualitative research. Further than this, within the more applied fields in which the human activity of ‘‘caring’’ takes place, such understanding of ‘‘what it is like’’ for people from within their lifeworlds has also been acknowledged as the foundational starting point in order for ‘‘care’’ to be caring. But we believe that more attention needs to be paid to this foundational generic phenomenon: what it means to understand the ‘‘insiderness’’ of another, but more importantly, how to act on this in caring ways. We call this human phenomenon ‘‘caring for insiderness.’’ Drawing on existing phenomenological studies of marginal caring situations at the limits of caring capability, and through a process of phenomenologically oriented reflection, we interrogated some existential themes implicit in these publications that could lead to deeper insights for both theoretical and applied purposes. The paper provides direction for practices of caring by highlighting some dangers as well as some remedies along this path

Easily fabricated ion source for characterizing mixtures of organic compounds by direct analysis in real time mass spectrometry

The increasing use of atmospheric pressure mass spectrometry has led to the development of many ambient ionization sources, for which sampling versatility and low cost are desired features. One such recent ambient ionization method is direct analysis in real time mass spectrometry (DART-MS), which has proven to be well suited to the analysis of native samples of both simple and complex natures. We describe a home-built DART source (EZ-DART) with versatile sampling capabilities, low power requirements, and low assembly cost which can be easily interfaced to mass spectrometers equipped with an atmospheric pressure inlet. The operating temperature range (22–250 °C) enables the acquisition of both temperature programmed desorption-based DART mass spectra and the collection of multistep collision-induced dissociation (CID) mass spectra. We present here the validation of the EZ-DART source and a demonstration of its performance in a number of relevant applications. Additionally, we introduce the new DART application of reagent assisted desorption ionization (RADI) for the targeting of specific chemical functionality in complex organic mixtures through a host–guest chemical system

Adipose Tissue Distribution and Survival Among Women with Nonmetastatic Breast Cancer.

ObjectivePrevious studies of breast cancer survival have not considered specific depots of adipose tissue such as subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT).MethodsThis study assessed these relationships among 3,235 women with stage II and III breast cancer diagnosed between 2005 and 2013 at Kaiser Permanente Northern California and between 2000 and 2012 at Dana Farber Cancer Institute. SAT and VAT areas (in centimeters squared) were calculated from routine computed tomography scans within 6 (median: 1.2) months of diagnosis, covariates were collected from electronic health records, and vital status was assessed by death records. Hazard ratios (HRs) and 95% CIs were estimated using Cox regression.ResultsSAT and VAT ranged from 19.0 to 891 cm2 and from 0.484 to 454 cm2 , respectively. SAT was related to increased risk of death (127-cm2 increase; HR [95% CI]: 1.13 [1.02-1.26]), but no relationship was found with VAT (78.18-cm2 increase; HR [95% CI]: 1.02 [0.91-1.14]). An association with VAT was noted among women with stage II cancer (stage II: HR: 1.17 [95% CI: 0.99-1.39]; stage III: HR: 0.90 [95% CI: 0.76-1.07]; P interaction < 0.01). Joint increases in SAT and VAT were associated with mortality above either alone (simultaneous 1-SD increase: HR 1.19 [95% CI: 1.05-1.34]).ConclusionsSAT may be an underappreciated risk factor for breast cancer-related death

Mathematical Modelling of Metabolic Regulation in Aging

The underlying cellular mechanisms that characterize aging are complex and multifaceted. However, it is emerging that aging could be regulated by two distinct metabolic hubs. These hubs are the pathway defined by the mammalian target of rapamycin (mTOR) and that defined by the NAD+-dependent deacetylase enzyme, SIRT1. Recent experimental evidence suggests that there is crosstalk between these two important pathways; however, the mechanisms underpinning their interaction(s) remains poorly understood. In this review, we propose using computational modelling in tandem with experimentation to delineate the mechanism(s). We briefly discuss the main modelling frameworks that could be used to disentangle this relationship and present a reduced reaction pathway that could be modelled. We conclude by outlining the limitations of computational modelling and by discussing opportunities for future progress in this area