254 research outputs found
Letter from T.A. Jaggar, Jr., Chicago, Illinois, to Anne Whitney, 1912 June 2
https://repository.wellesley.edu/whitney_correspondence/2665/thumbnail.jp
Letter from T.A. Jaggar, Jr., Volcano House, Hawaii, to Anne Whitney, Boston, Massachusetts, 1912 September 18
https://repository.wellesley.edu/whitney_correspondence/2663/thumbnail.jp
Compassion Stress and the Qualitative Researcher
Human subjects are carefully protected in the research process. However, the same consideration is not currently being given to the qualitative researcher, even those investigating topics that are likely to elicit powerful emotions. The role of researcherās emotional responses and the self-care strategies that, in some circumstances, are appropriate for the researcher and other research support personnel have not received the attention they deserve in qualitative research literature. Based on experience in conducting research on the topic of self-directed learning and breast cancer, and on the limited literature available, the author makes the case for the use of strategies such as counseling, peer debriefing, and journal writing as means of dealing with the potential for ācompassion stressā as experienced by the researcher and other research support personnel. She also suggests that the preparation of social science researchers should include information on appropriate self-care strategies.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline
An Alternative Ethics? Justice and Care as Guiding Principles for Qualitative Research
The dominant conception of social research ethics is centred on deontological and consequentialist principles. In place of this, some qualitative researchers have proposed a very different approach. This appeals to a range of commitments that transform the goal of research as well as framing how it is pursued. This new ethics demands a participatory form of inquiry, one in which the relationship between researchers and researched is equalized. In this paper we examine this alternative approach, focusing in particular on two of the principles that are central to it: justice and care. We argue that there are some significant defects and dangers associated with this new conception of research ethics
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Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels
Induction of the antioxidant enzyme heme oxygenase-1 (HO-1) affords cellular protection and suppresses proliferation of vascular smooth muscle cells (VSMCs) associated with a variety of pathological cardiovascular conditions including myocardial infarction and vascular injury. However, the underlying mechanisms are not fully understood. Over-expression of Cav3.2 T-type Ca2+ channels in HEK293 cells raised basal [Ca2+]i and increased proliferation as compared with non-transfected cells. Proliferation and [Ca2+]i levels were reduced to levels seen in non-transfected cells either by induction of HO-1 or exposure of cells to the HO-1 product, carbon monoxide (CO) (applied as the CO releasing molecule, CORM-3). In the aortic VSMC line A7r5, proliferation was also inhibited by induction of HO-1 or by exposure of cells to CO, and patch-clamp recordings indicated that CO inhibited T-type (as well as L-type) Ca2+ currents in these cells. Finally, in human saphenous vein smooth muscle cells, proliferation was reduced by T-type channel inhibition or by HO-1 induction or CO exposure. The effects of T-type channel blockade and HO-1 induction were non-additive. Collectively, these data indicate that HO-1 regulates proliferation via CO-mediated inhibition of T-type Ca2+ channels. This signalling pathway provides a novel means by which proliferation of VSMCs (and other cells) may be regulated therapeutically
An exploration of secondary students' mental states when learning about acids and bases
This study explored factors of studentsā mental states, including emotion, intention, internal mental representation, and external mental representation, which can affect their learning performance. In evaluating studentsā mental states during the science learning process and the relationship between mental states and learning achievement, valid, reliable, and scalable measures of studentsā mental states and learning achievement are needed. This paper presents the development of the Mental State Conceptual Learning Inventory (MSCLI) to identify studentsā mental states before and after learning about acids and bases. This instrument is time efficient and convenient and can be administered to large student samples so that teachers and researchers can gain profound insights into their studentsā learning of acids and bases in science class. The results of this study indicate that studentsā mental states are highly correlated with their achievement. As a whole, low-achieving students tended to have negative emotions and low intentions, were not good at internal visualization, and were unable to interpret graphics and draw pictures. In contrast, high-achieving students had positive emotions and intentions when learning life-related topics about acids and bases, and were good at internal visualization and drawing and interpreting graphics
Enhancement Effects of Martentoxin on Glioma BK Channel and BK Channel (Ī±+Ī²1) Subtypes
BACKGROUND: BK channels are usually activated by membrane depolarization and cytoplasmic Ca(2+). Especially,the activity of BK channel (Ī±+Ī²4) can be modulated by martentoxin, a 37 residues peptide, with Ca(2+)-dependent manner. gBK channel (glioma BK channel) and BK channel (Ī±+Ī²1) possessed higher Ca(2+) sensitivity than other known BK channel subtypes. METHODOLOGY AND PRINCIPAL FINDINGS: The present study investigated the modulatory characteristics of martentoxin on these two BK channel subtypes by electrophysiological recordings, cell proliferation and Ca(2+) imaging. In the presence of cytoplasmic Ca(2+), martentoxin could enhance the activities of both gBK and BK channel (Ī±+Ī²1) subtypes in dose-dependent manner with EC(50) of 46.7 nM and 495 nM respectively, while not shift the steady-state activation of these channels. The enhancement ratio of martentoxin on gBK and BK channel (Ī±+Ī²1) was unrelated to the quantitative change of cytoplasmic Ca(2+) concentrations though the interaction between martentoxin and BK channel (Ī±+Ī²1) was accelerated under higher cytoplasmic Ca(2+). The selective BK pore blocker iberiotoxin could fully abolish the enhancement of these two BK subtypes induced by martentoxin, suggesting that the auxiliary Ī² subunit might contribute to the docking for martentoxin. However, in the absence of cytoplasmic Ca(2+), the activity of gBK channel would be surprisingly inhibited by martentoxin while BK channel (Ī±+Ī²1) couldn't be affected by the toxin. CONCLUSIONS AND SIGNIFICANCE: Thus, the results shown here provide the novel evidence that martentoxin could increase the two Ca(2+)-hypersensitive BK channel subtypes activities in a new manner and indicate that Ī² subunit of these BK channels plays a vital role in this enhancement by martentoxin
Whose domain and whose ontology?:Preserving human radical reflexivity over the efficiency of automatically generated feedback alone
In this chapter, we challenge an increase in the uncritical application of algorithmic processes for providing automatically generated feedback for students, within a neoliberal framing of contemporary higher education. Initially, we discuss our concerns alongside networked learning principles, which developed as a critical pedagogical response to new online learning programmes and platforms. These principles now overlap too, with the notion that we are living in āpostdigitalā times, where automatically generated feedback never stands alone, but is contested and supplemented by physical encounters and human feedback. First, we make observations on the e-marking platform Turnitin, alongside other rapidly developing artificial intelligence (AI) systems. When generic (but power-laden) maps are incorporated into both student and staff āperceivedā spaces through AI, we surface the aspects of feedback that risk being lost. Second, we draw on autoethnographic understandings of our own lived experience of performing radically reflexive feedback within a Masterās in Education programme. A radically reflexive form of feedback may not follow a pre-defined map, but it does offer a vehicle to restore individual student and staff voices and critical self-navigation of both physical and virtual learning spaces. This needs to be preserved in the ongoing shaping of the contemporary āpostdigitalā university
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