99 research outputs found
List Decoding of Matrix-Product Codes from nested codes: an application to Quasi-Cyclic codes
A list decoding algorithm for matrix-product codes is provided when are nested linear codes and is a non-singular by columns matrix. We
estimate the probability of getting more than one codeword as output when the
constituent codes are Reed-Solomon codes. We extend this list decoding
algorithm for matrix-product codes with polynomial units, which are
quasi-cyclic codes. Furthermore, it allows us to consider unique decoding for
matrix-product codes with polynomial units
Processing and Transmission of Information
Contains research objectives and reports on three research projects.National Science Foundation (Grant G-16526)National Institutes of Health (Grant MH-04737-03)National Aeronautics and Space Administration (Grant NsG-496)Lincoln Laboratory, Purchase Order DDL BB-107U.S. Air Force under Contract AF 19(628)-50
Processing and Transmission of Information
Contains research objectives and reports on four research projects.Lincoln Laboratory, Purchase Order DDL B-00306U. S. ArmyU. S. NavyU. S. Air Force under Air Force Contract AF19(604)-7400National Science Foundation (Grant B-16526)National Institutes of Health (Grant MP-4737
Processing and Transmission of Information
Contains research objectives and reports on seven research projects.Lincoln Laboratory, Purchase Order DDL-B222Air Force under Air Force Contract AF19(604)-5200Office of Naval Research under Contract Nonr-1841(57
Convergence and divergence in the evolution of cat skulls: temporal and spatial patterns of morphological diversity
Background: Studies of biological shape evolution are greatly enhanced when framed in a phylogenetic perspective.
Inclusion of fossils amplifies the scope of macroevolutionary research, offers a deep-time perspective on tempo and mode
of radiations, and elucidates life-trait changes. We explore the evolution of skull shape in felids (cats) through morphometric
analyses of linear variables, phylogenetic comparative methods, and a new cladistic study of saber-toothed cats.
Methodology/Principal Findings: A new phylogenetic analysis supports the monophyly of saber-toothed cats
(Machairodontinae) exclusive of Felinae and some basal felids, but does not support the monophyly of various sabertoothed
tribes and genera. We quantified skull shape variation in 34 extant and 18 extinct species using size-adjusted linear
variables. These distinguish taxonomic group membership with high accuracy. Patterns of morphospace occupation are
consistent with previous analyses, for example, in showing a size gradient along the primary axis of shape variation and a
separation between large and small-medium cats. By combining the new phylogeny with a molecular tree of extant Felinae,
we built a chronophylomorphospace (a phylogeny superimposed onto a two-dimensional morphospace through time). The
evolutionary history of cats was characterized by two major episodes of morphological divergence, one marking the
separation between saber-toothed and modern cats, the other marking the split between large and small-medium cats.
Conclusions/Significance: Ancestors of large cats in the ‘Panthera’ lineage tend to occupy, at a much later stage,
morphospace regions previously occupied by saber-toothed cats. The latter radiated out into new morphospace regions
peripheral to those of extant large cats. The separation between large and small-medium cats was marked by considerable
morphologically divergent trajectories early in feline evolution. A chronophylomorphospace has wider applications in
reconstructing temporal transitions across two-dimensional trait spaces, can be used in ecophenotypical and functional
diversity studies, and may reveal novel patterns of morphospace occupation
Stage-Specific Pathways of Leishmania infantum chagasi Entry and Phagosome Maturation in Macrophages
The life stages of Leishmania spp. include the infectious promastigote and the replicative intracellular amastigote. Each stage is phagocytosed by macrophages during the parasite life cycle. We previously showed that caveolae, a subset of cholesterol-rich membrane lipid rafts, facilitate uptake and intracellular survival of virulent promastigotes by macrophages, at least in part, by delaying parasitophorous vacuole (PV)-lysosome fusion. We hypothesized that amastigotes and promastigotes would differ in their route of macrophage entry and mechanism of PV maturation. Indeed, transient disruption of macrophage lipid rafts decreased the entry of promastigotes, but not amastigotes, into macrophages (P<0.001). Promastigote-containing PVs were positive for caveolin-1, and co-localized transiently with EEA-1 and Rab5 at 5 minutes. Amastigote-generated PVs lacked caveolin-1 but retained Rab5 and EEA-1 for at least 30 minutes or 2 hours, respectively. Coinciding with their conversion into amastigotes, the number of promastigote PVs positive for LAMP-1 increased from 20% at 1 hour, to 46% by 24 hours, (P<0.001, Chi square). In contrast, more than 80% of amastigote-initiated PVs were LAMP-1+ at both 1 and 24 hours. Furthermore, lipid raft disruption increased LAMP-1 recruitment to promastigote, but not to amastigote-containing compartments. Overall, our data showed that promastigotes enter macrophages through cholesterol-rich domains like caveolae to delay fusion with lysosomes. In contrast, amastigotes enter through a non-caveolae pathway, and their PVs rapidly fuse with late endosomes but prolong their association with early endosome markers. These results suggest a model in which promastigotes and amastigotes use different mechanisms to enter macrophages, modulate the kinetics of phagosome maturation, and facilitate their intracellular survival
Multigene phylogeny of the Mustelidae: Resolving relationships, tempo and biogeographic history of a mammalian adaptive radiation
<p>Abstract</p> <p>Background</p> <p>Adaptive radiation, the evolution of ecological and phenotypic diversity from a common ancestor, is a central concept in evolutionary biology and characterizes the evolutionary histories of many groups of organisms. One such group is the Mustelidae, the most species-rich family within the mammalian order Carnivora, encompassing 59 species classified into 22 genera. Extant mustelids display extensive ecomorphological diversity, with different lineages having evolved into an array of adaptive zones, from fossorial badgers to semi-aquatic otters. Mustelids are also widely distributed, with multiple genera found on different continents. As with other groups that have undergone adaptive radiation, resolving the phylogenetic history of mustelids presents a number of challenges because ecomorphological convergence may potentially confound morphologically based phylogenetic inferences, and because adaptive radiations often include one or more periods of rapid cladogenesis that require a large amount of data to resolve.</p> <p>Results</p> <p>We constructed a nearly complete generic-level phylogeny of the Mustelidae using a data matrix comprising 22 gene segments (~12,000 base pairs) analyzed with maximum parsimony, maximum likelihood and Bayesian inference methods. We show that mustelids are consistently resolved with high nodal support into four major clades and three monotypic lineages. Using Bayesian dating techniques, we provide evidence that mustelids underwent two bursts of diversification that coincide with major paleoenvironmental and biotic changes that occurred during the Neogene and correspond with similar bursts of cladogenesis in other vertebrate groups. Biogeographical analyses indicate that most of the extant diversity of mustelids originated in Eurasia and mustelids have colonized Africa, North America and South America on multiple occasions.</p> <p>Conclusion</p> <p>Combined with information from the fossil record, our phylogenetic and dating analyses suggest that mustelid diversification may have been spurred by a combination of faunal turnover events and diversification at lower trophic levels, ultimately caused by climatically driven environmental changes. Our biogeographic analyses show Eurasia as the center of origin of mustelid diversity and that mustelids in Africa, North America and South America have been assembled over time largely via dispersal, which has important implications for understanding the ecology of mustelid communities.</p
The mammals of Angola
Scientific investigations on the mammals of Angola started over 150 years
ago, but information remains scarce and scattered, with only one recent published
account. Here we provide a synthesis of the mammals of Angola based on a thorough
survey of primary and grey literature, as well as recent unpublished records. We present
a short history of mammal research, and provide brief information on each species
known to occur in the country. Particular attention is given to endemic and near endemic
species. We also provide a zoogeographic outline and information on the conservation
of Angolan mammals. We found confirmed records for 291 native species, most of
which from the orders Rodentia (85), Chiroptera (73), Carnivora (39), and
Cetartiodactyla (33). There is a large number of endemic and near endemic species,
most of which are rodents or bats. The large diversity of species is favoured by the wide range of habitats with contrasting environmental conditions, while endemism tends to
be associated with unique physiographic settings such as the Angolan Escarpment. The
mammal fauna of Angola includes 2 Critically Endangered, 2 Endangered, 11
Vulnerable, and 14 Near-Threatened species at the global scale. There are also 12 data
deficient species, most of which are endemics or near endemics to the countryinfo:eu-repo/semantics/publishedVersio
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