The potential of the adaptive thermal comfort concept in longterm actively conditioned buildings for improved energy performance and user wellbeing

Technological progress in conditioning practice combined with prevailing thermal comfort criteria, created stable, tightly controlled indoor temperature bands. Research shows indoor temperatures to be increasing in the heating period, leading to higher building energy use than planned. Field studies provide proof that occupants not in control of their indoor climate are more dissatisfied and report problems in wellbeing. Widening temperature bands could be an effective measure leading to energy conservation, increasing satisfaction and, as shown recently, helping to mitigate health problems related to our way of life. The adaptive approach to thermal comfort postulates that people\u27s thermal comfort perception adapts to the indoor and outdoor climatic conditions they normally experience. However, according to standards, the adaptive model is applicable only to passively conditioned (free-running) buildings, even though the adaptive principles may well apply also to actively conditioned buildings. Our review found studies demonstrating positive health effects and energy conservation potential in permanently or seasonally conditioned buildings. On this basis, the potential of the adaptive approach and translations into concrete design or operation solutions for actively conditioned buildings are discussed in this paper. We conclude that the adaptive concept offers a potential for indoor climate control in actively conditioned buildings in the temperate and cold climates

Study of endometriosis in women of reproductive age, laparoscopic management and its outcome

Background: The prevalence of endometriosis is seen to be from 10% to 20% in the reproductive age group. The prevalence of endometriosis is 30% to 70% among women presenting with infertility. In our study the incidence of endometriosis appears to be on the higher side. The objective is to find out the prevalence of endometriosis in the female population in the reproductive age and to study the outcome after laparoscopic surgery in infertile women with endometriosisMethods: A total of 200 patients who presented with symptoms of dysmenorrhoea, dyspareunia, chronic pelvic pain with or/without infertility were studied in the women of reproductive age group. The diagnostic/operative laparoscopy was performed in 75 patients. Endometriosis was identified by laparoscopy in 50 cases and confirmed by histopathological examination.Results: Out of the above 200 patients, 25% (50 cases) were diagnosed as cases of endometriosis. Out of which, 50% (25 cases) patients had moderate to severe endometriosis. The prevalence of infertility was 22.5% (45cases out of 200). Endometriosis was the cause of infertility in 33 patients. 25 patients had moderate to severe endometriosis and remaining 8 cases minimal to mild disease. The prevalence of endometriosis was 73.33% in infertile women. The fertility rate after surgery, during the 2 years follow up is 36.36% (12 cases conceived out of 33 cases).Conclusions: The prevalence of endometriosis in infertile women is higher and the outcome after laparoscopic surgery is encouraging. The symptoms and clinical signs should raise the suspicion of pelvic endometriosis

Guidelines to bridge the gap between adaptive thermal comfort theory and building design and operation practice

Adaptive thermal comfort guidelines have been developed within the work of Annex 69: “Strategy and practice of adaptive thermal comfort in low energy buildings”. The guidelines have been established based on a framework for adopting adaptive thermal comfort principles in building design and operation developed by the authors. The guidelines target building practitioners, addressing the critical interrelated role building planners, building operators and occupants play. A successful adaptive thermal comfort design, in which design for human thermal adaptation is foreseen, planned, and carefully embedded in the design and operation intent, is based on broad knowledge and understanding of the multiple quantifiable and non-quantifiable factors influencing human perception, as well as human building interaction. Adaptive building design follows a user-centric integrated design approach and therefore it is critical to consider the occupants’ and the operators’ role in buildings already in the design phase. This paper focuses on three main challenges identified earlier and how these are addressed in the guidelines, i.e. i) updating prevailing knowledge about human thermophysiology and adaptation, ii) developing a procedure for design of adaptive opportunities, and iii) providing guidance for operational planning and operation of adaptive buildings. The challenge for future research remains to assess the magnitude of how specific design decisions affect particular adaptive mechanisms

Application of nanotechnology in antimicrobial finishing of biomedical textiles

In recent years, the antimicrobial nanofinishing of biomedical textiles has become a very active, high-growth research field, assuming great importance among all available material surface modifications in the textile industry. This review offers the opportunity to update and critically discuss the latest advances and applications in this field. The survey suggests an emerging new paradigm in the production and distribution of nanoparticles for biomedical textile applications based on non-toxic renewable biopolymers such as chitosan, alginate and starch. Moreover, a relationship among metal and metal oxide nanoparticle (NP) size, its concentration on the fabric, and the antimicrobial activity exists, allowing the optimization of antimicrobial functionality.Andrea Zille (C2011-UMINHO-2C2T-01) acknowledges funding from Programa Compromisso para a Ciencia 2008, Portugal

Evaluating assumptions of scales for subjective assessment of thermal environments – Do laypersons perceive them the way, we researchers believe?

International audienc

In Vivo Quantitative Study of Sized-Dependent Transport and Toxicity of Single Silver Nanoparticles Using Zebrafish Embryos

Nanomaterials possess distinctive physicochemical properties (e.g., small sizes and high surface area-to-volume ratios) and promise a wide variety of applications, ranging from the design of high quality consumer products to effective disease diagnosis and therapy. These properties can lead to toxic effects, potentially hindering advances in nanotechnology. In this study, we have synthesized and characterized purified and stable (nonaggregation) silver nanoparticles (Ag NPs, 41.6 ± 9.1 nm in average diameter) and utilized early developing (cleavage-stage) zebrafish embryos (critical aquatic and eco- species) as in vivo model organisms to probe the diffusion and toxicity of Ag NPs. We found that single Ag NPs (30-72 nm diameters) passively diffused into the embryos through chorionic pores via random Brownian motion and stayed inside the embryos throughout their entire development (120 hours-post-fertilization, hpf). Dose-and size-dependent toxic effects of the NPs on embryonic development were observed, showing the possibility of tuning biocompatibility and toxicity of the NPs. At lower concentrations of the NPs (≤0.02 nM), 75-91% of embryos developed into normal zebrafish. At the higher concentrations of NPs (≥0.20 nM), 100% of embryos became dead. At the concentrations in between (0.02-0.2 nM), embryos developed into various deformed zebrafish. Number and sizes of individual Ag NPs embedded in tissues of normal and deformed zebrafish at 120 hpf were quantitatively analyzed, showing deformed zebrafish with higher number of larger NPs than normal zebrafish and size-dependent nanotoxicity. By comparing with our previous studies of smaller Ag NPs (11.6 ± 3.5 nm), we found striking size-dependent nanotoxicity that, at the same molar concentration, the larger Ag NPs (41.6 ± 9.1 nm) are more toxic than the smaller Ag NPs (11.6 ± 3.5 nm)

Timing and minimal access surgery for sciatica: a summary of two randomized trials

Scientific Assessment and Innovation in Neurosurgical Treatment Strategie

Study of Charge-Dependent Transport and Toxicity of Peptide-Functionalized Silver Nanoparticles Using Zebrafish Embryos and Single Nanoparticle Plasmonic Spectroscopy

Nanomaterials possess unusually high surface area-to-volume ratios and surface-determined physicochemical properties. It is essential to understand their surface-dependent toxicity in order to rationally design biocompatible nanomaterials for a wide variety of applications. In this study, we have functionalized the surfaces of silver nanoparticles (Ag NPs, 11.7 ±+2.7 nm in diameter) with three biocompatible peptides (CALNNK, CALNNS, CALNNE) to prepare positively (Ag-CALNNK NPs+ζ), negatively (Ag-CALNNS NPs−2ζ), and more negatively charged NPs (Ag-CALNNE NPs−4ζ), respectively. Each peptide differs in a single amino acid at its C-terminus, which minimizes the effects of peptide sequences and serves as a model molecule to create positive, neutral, and negative charges on the surface of the NPs at pH 4-10. We have studied their charge-dependent transport into early developing (cleavage-stage) zebrafish embryos and their effects on embryonic development using dark-field optical microscopy and spectroscopy (DFOMS). We found that all three Ag-peptide NPs passively diffused into the embryos via their chorionic pore canals, and stayed inside the embryos throughout their entire development (120 h), showing charge-independent diffusion modes and charge-dependent diffusion coefficients. Notably, the NPs create chargedependent toxic effects on embryonic development, showing that the Ag-CALNNK NPs+ζ (positively charged) are the most biocompatible while the Ag-CALNNE NPs−4ζ (more negatively charged) are the most toxic. By comparing with our previous studies of the same sized citrated Ag and Au NPs, the Ag-peptide NPs are much more biocompatible than the citrated Ag NPs, and nearly as biocompatible as the Au NPs, showing the dependence of nanotoxicity upon the surface charges, surface functional groups, and chemical compositions of the NPs. This study also demonstrates powerful applications of single NP plasmonic spectroscopy for quantitative analysis of single NPs in vivo and in tissues, and reveals the possibility of rational design of biocompatible NPs

Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

<p>Abstract</p> <p>Background</p> <p>In a genome-wide association scan, the single-nucleotide polymorphism (SNP) rs738409 in the patatin-like phospholipase 3 gene (<it>PNPLA3</it>) was strongly associated with increased liver fat content. We investigated whether this SNP is associated with the occurrence and progression of nonalcoholic fatty liver disease (NAFLD) in the Japanese population.</p> <p>Methods</p> <p>SNP rs738409 was genotyped by the Taqman assay in 253 patients with NAFLD (189 with nonalcoholic steatohepatitis [NASH] and 64 with simple steatosis) and 578 control subjects. All patients with NAFLD underwent liver biopsy. Control subjects had no metabolic disorders. For a case-control study, the <it>χ</it>²-test (additive model) was performed. Odds ratios (ORs) were adjusted for age, gender, and body mass index (BMI) by using multiple logistic regression analysis with genotypes (additive model), age, gender, and BMI as the independent variables. Multiple linear regression analysis was performed to test the independent effect of risk allele on clinical parameters while considering the effects of other variables (age, gender, and BMI), which were assumed to be independent of the effect of the SNP.</p> <p>Results</p> <p>The risk allele (G-allele) frequency of rs738409 was 0.44 in the control subjects and 0.60 in patients with NAFLD; this shows a strong association with NAFLD (additive model, <it>P </it>= 9.4 × 10^-10). The OR (95% confidence interval) adjusted for age, gender, and BMI was 1.73 (1.25-2.38). Multiple linear regression analysis indicated that the G-allele of rs738409 was significantly associated with increases in aspartate transaminase (AST) (<it>P </it>= 0.00013), alanine transaminase (ALT) (<it>P </it>= 9.1 × 10^-6), and ferritin levels (<it>P </it>= 0.014), and the fibrosis stage (<it>P </it>= 0.011) in the patients with NAFLD, even after adjustment for age, gender, and BMI. The steatosis grade was not associated with rs738409.</p> <p>Conclusions</p> <p>We found that in the Japanese population, individuals harboring the G-allele of rs738409 were susceptible to NAFLD, and that rs738409 was associated with plasma levels of ALT, AST, and ferritin, and the histological fibrosis stage. Our study suggests that <it>PNPLA3 </it>may be involved in the progression of fibrosis in NAFLD.</p