143 research outputs found
Dynamics and statistics of heavy particles in turbulent flows
We present the results of Direct Numerical Simulations (DNS) of turbulent
flows seeded with millions of passive inertial particles. The maximum Taylor's
Reynolds number is around 200. We consider particles much heavier than the
carrier flow in the limit when the Stokes drag force dominates their dynamical
evolution. We discuss both the transient and the stationary regimes. In the
transient regime, we study the growt of inhomogeneities in the particle spatial
distribution driven by the preferential concentration out of intense vortex
filaments. In the stationary regime, we study the acceleration fluctuations as
a function of the Stokes number in the range [0.16:3.3]. We also compare our
results with those of pure fluid tracers (St=0) and we find a critical behavior
of inertia for small Stokes values. Starting from the pure monodisperse
statistics we also characterize polydisperse suspensions with a given mean
Stokes.Comment: 13 pages, 10 figures, 2 table
Lichen planus of uterine cervix - the first report of a novel site of occurrence: a case report
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Inflammatory myopathy and severe rhabdomyolysis induced by leuprolide acetate therapy for prostate cancer: a case report
<p>Abstract</p> <p>Introduction</p> <p>Leuprolide acetate is a synthetic analog of gonadotropin-releasing hormone used for the treatment of prostate cancer. Its side effects are hot flashes, nausea, and fatigue. We report a case of a patient with proximal inflammatory myopathy accompanied by severe rhabdomyolysis and renal failure following the second application of leuprolide acetate. Drug withdrawal and steroid therapy resulted in remission within six weeks of the diagnosis. To the best of our knowledge, our case report describes the second case of leuprolide acetate-induced inflammatory myopathy and the first case of severe leuprolide acetate-induced rhabdomyolysis and renal failure in the literature.</p> <p>Case presentation</p> <p>A 64-year-old Swiss Caucasian man was admitted to the hospital because of progressive proximal muscle weakness, dyspnea, and oliguria. He had been treated twice with leuprolide acetate in monthly doses. We performed a muscle biopsy, which excluded other causes of myopathy. The patient's renal failure and rhabdomyolysis were treated with rehydration and steroid therapy.</p> <p>Conclusion</p> <p>The aim of our case report is to highlight the rare but severe side effects associated with leuprolide acetate therapy used to treat patients with inflammatory myopathy: severe rhabdomyolysis and renal failure.</p
Perturbation theory for large Stokes number particles in random velocity fields
We derive a perturbative approach to study, in the large inertia limit, the
dynamics of solid particles in a smooth, incompressible and finite-time
correlated random velocity field. We carry on an expansion in powers of the
inverse square root of the Stokes number, defined as the ratio of the
relaxation time for the particle velocities and the correlation time of the
velocity field. We describe in this limit the residual concentration
fluctuations of the particle suspension, and determine the contribution to the
collision statistics produced by clustering. For both concentration
fluctuations and collision velocities, we analyze the differences with the
compressible one-dimensional case.Comment: Latex, 12 pages, 2 eps figures include
Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.To search for new sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conducted a genome-wide association study of 38.5 million single nucleotide polymorphisms (SNPs) and small indels identified through whole-genome sequencing of 2230 Icelanders. We imputed genotypes for 4208 BCC patients and 109 408 controls using Illumina SNP chip typing data, carried out association tests and replicated the findings in independent population samples. We found new BCC susceptibility loci at TGM3 (rs214782[G], P = 5.5 × 10(-17), OR = 1.29) and RGS22 (rs7006527[C], P = 8.7 × 10(-13), OR = 0.77). TGM3 encodes transglutaminase type 3, which plays a key role in production of the cornified envelope during epidermal differentiation.Red Tematica de Investigacion Cooperative en Cancer RD06/0020/1054
Danish Cancer Society
"Europe Against Cancer": European Prospective Investigation into Cancer and Nutrition (EPIC)
deCODE Genetics/AMGE
New basal cell carcinoma susceptibility loci.
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files.
This article is open access.In an ongoing screen for DNA sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conduct a genome-wide association study (GWAS) of 24,988,228 SNPs and small indels detected through whole-genome sequencing of 2,636 Icelanders and imputed into 4,572 BCC patients and 266,358 controls. Here we show the discovery of four new BCC susceptibility loci: 2p24 MYCN (rs57244888[C], OR=0.76, P=4.7 × 10(-12)), 2q33 CASP8-ALS2CR12 (rs13014235[C], OR=1.15, P=1.5 × 10(-9)), 8q21 ZFHX4 (rs28727938[G], OR=0.70, P=3.5 × 10(-12)) and 10p14 GATA3 (rs73635312[A], OR=0.74, P=2.4 × 10(-16)). Fine mapping reveals that two variants correlated with rs73635312[A] occur in conserved binding sites for the GATA3 transcription factor. In addition, expression microarrays and RNA-seq show that rs13014235[C] and a related SNP rs700635[C] are associated with expression of CASP8 splice variants in which sequences from intron 8 are retained.NCI\SAIC-Frederick, Inc. (SAIC-F) 10XS170
Roswell Park Cancer Institute 10XS171
Science Care Inc. X10S172
Laboratory, Data Analysis and Coordinating Center (LDACC)
HHSN268201000029C
SAIC-F
10ST1035
HHSN261200800001E
Brain Bank
DA006227
DA033684
N01MH000028
University of Geneva
MH090941
MH101814
University of Chicago
MH090951
MH090937
MH101820
MH101825
University of North Carolina-Chapel Hill
MH090936
MH101819
Harvard University
MH090948
Stanford University
MH101782
Washington University St Louis
MH101810
University of Pennsylvania
MH10182
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations
A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple sclerosis, not reported previously. Using polygenic risk scores based on public summary statistics of variants outside the major histocompatibility complex region we quantified genetic overlap between common autoimmune diseases in Icelanders and identified disease clusters characterized by autoantibody presence/absence. As multiple sclerosis-polygenic risk scores captures the risk of primary biliary cirrhosis and vice versa (P = 1.6 x 10(-7), 4.3 x 10(-9)) we used primary biliary cirrhosis as a proxy-phenotype for multiple sclerosis, the idea being that variants conferring risk of primary biliary cirrhosis have a prior probability of conferring risk of multiple sclerosis. We tested 255 variants forming the primary biliary cirrhosis-polygenic risk score and found seven multiple sclerosis-associating variants not correlated with any previously established multiple sclerosis variants. Most of the variants discovered are close to or within immune-related genes. One is a low-frequency missense variant in TYK2, another is a missense variant in MTHFR that reduces the function of the encoded enzyme affecting methionine metabolism, reported to be dysregulated in multiple sclerosis brain.publishedVersio
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