Forbidden Ca 2 in the sun unmasked by way of Venus

Eleven high-dispersion spectra of Venus, taken with blue Doppler shifts have permitted the unmasking of the 7323.88A forbidden line of Ca II from terrestrial absorption. An equivalent width is obtained of 7.4 + or - 0.4mA for this line in integrated sunlight. Our value of W sub lambda is smaller than previous values and much more accurate. The HSRA solar model gives a solar calcium abundance of A sub Ca = 6.21

Non-Uniqueness of Quantized Yang-Mills Theories

We consider quantized Yang-Mills theories in the framework of causal perturbation theory which goes back to Epstein and Glaser. In this approach gauge invariance is expressed by a simple commutator relation for the S-matrix. The most general coupling which is gauge invariant in first order contains a two-parametric ambiguity in the ghost sector - a divergence- and a coboundary-coupling may be added. We prove (not completely) that the higher orders with these two additional couplings are gauge invariant, too. Moreover we show that the ambiguities of the n-point distributions restricted to the physical subspace are only a sum of divergences (in the sense of vector analysis). It turns out that the theory without divergence- and coboundary-coupling is the most simple one in a quite technical sense. The proofs for the n-point distributions containing coboundary-couplings are given up to third or fourth order only, whereas the statements about the divergence-coupling are proven in all orders.Comment: 22 pages. The paper is written in TEX. The necessary macros are include

Scalar Matter Coupled to Quantum Gravity in the Causal Approach: Finite One-Loop Calculations and Perturbative Gauge Invariance

Quantum gravity coupled to scalar massive matter fields is investigated within the framework of causal perturbation theory. One-loop calculations include matter loop graviton self-energy and matter self-energy and yield ultraviolet finite and cutoff-free expressions. Perturbative gauge invariance to second order implies the usual Slavnov-Ward identities for the graviton self-energy in the loop graph sector and generates the correct quartic graviton-matter interaction in the tree graph sector. The mass zero case is also discussed.Comment: 37 pages, latex, no figures, some typos corrected, section 3 modifie

The effect of e-learning on the quality of orthodontic appliances

Purpose: The effect of e-learning on practical skills in medicine has not yet been thoroughly investigated. Today’s multimedia learning environment and access to e-books provide students with more knowledge than ever before. The aim of this study is to evaluate the effect of online demonstrations concerning the quality of orthodontic appliances manufactured by undergraduate dental students. Materials and methods: The study design was a parallel-group randomized clinical trial. Fifty-four participants were randomly assigned to one of the three groups: 1) conventional lectures, 2) conventional lectures plus written online material, and 3) access to resources of groups one and two plus access to online video material. Three orthodontic appliances (Schwarz Plate, U-Bow Activator, and Fränkel Regulator) were manufactured during the course and scored by two independent raters blinded to the participants. A 15-point scale index was used to evaluate the outcome quality of the appliances. Results: In general, no significant differences were found between the groups. Concerning the appliances, the Schwarz Plate obtained the highest scores, whereas the Fränkel Regulator had the lowest scores; however, these results were independent of the groups. Females showed better outcome scores than males in groups two and three, but the difference was insignificant. Age of the participants also had no significant effect. Conclusion: The offer that students could use additional time and course-independent e-learning resources did not increase the outcome quality of the orthodontic appliances. The advantages of e-learning observed in the theoretical fields of medicine were not achieved in the educational procedures for manual skills. Factors other than e-learning may have a higher impact on manual skills, and this should be investigated in further studies

Massive gravity as a quantum gauge theory

We present a new point of view on the quantization of the massive gravitational field, namely we use exclusively the quantum framework of the second quantization. The Hilbert space of the many-gravitons system is a Fock space ${\cal F}^{+}({\sf H}_{\rm graviton})$ where the one-particle Hilbert space ${\sf H}_{graviton}$ carries the direct sum of two unitary irreducible representations of the Poincar\'e group corresponding to two particles of mass $m > 0$ and spins 2 and 0, respectively. This Hilbert space is canonically isomorphic to a space of the type $Ker(Q)/Im(Q)$ where $Q$ is a gauge charge defined in an extension of the Hilbert space ${\cal H}_{\rm graviton}$ generated by the gravitational field $h_{\mu\nu}$ and some ghosts fields $u_{\mu}, \tilde{u}_{\mu}$ (which are vector Fermi fields) and $v_{\mu}$ (which are vector field Bose fields.) Then we study the self interaction of massive gravity in the causal framework. We obtain a solution which goes smoothly to the zero-mass solution of linear quantum gravity up to a term depending on the bosonic ghost field. This solution depends on two real constants as it should be; these constants are related to the gravitational constant and the cosmological constant. In the second order of the perturbation theory we do not need a Higgs field, in sharp contrast to Yang-Mills theory.Comment: 35 pages, no figur

HMGXB4 targets Sleeping Beauty transposition to vertebrate germinal stem sells

Transposons are parasitic genetic elements that frequently hijack key cellular processes of the host. HMGXB4 is a Wnt signalling-associated HMG-box protein, previously identified as a transcriptional regulating host factor of Sleeping Beauty (SB) transposition. Here, we establish that HMGXB4 is highly expressed from the zygote stage, and declines after transcriptional genome activation. Nevertheless, HMGXB4 is activated by its own promoter at 4-cell stage, responding to the parental-to-zygotic transition, marks stemness, and maintains its expression during germ cell specification. The HMGXB4 promoter is located at an active chromatin domain boundary. As a vertebrate-specific modulator of SETD1A and NuRF complexes, HMGXB4 links histone H3K4 methyltransferase- and ATP-dependent nucleosome remodelling activities. The expression of HMGXB4 is regulated by the KRAB-ZNF/TRIM28 epigenetic repression machinery. A post-transcriptional modification by SUMOylation diminishes its transcriptional activator function and regulates its nucleolar trafficking. Collectively, HMGXB4 positions SB transposition into an elaborate stem cell-specific transcriptional regulatory mechanism that is active during early embryogenesis and germline development, thereby potentiating heritable transposon insertions in the germline

Nanoscale Study of Calcium Handling Remodeling in Right Ventricular Cardiomyocytes Following Pulmonary Hypertension

Pulmonary hypertension is a complex disorder characterized by pulmonary vascular remodeling and right ventricular hypertrophy, leading to right heart failure. The mechanisms underlying this process are not well understood. We hypothesize that the structural remodeling occurring in the cardiomyocytes of the right ventricle affects the cytosolic Ca2+ handling leading to arrhythmias. After 12 days of monocrotaline-induced pulmonary hypertension in rats, epicardial mapping showed electrical remodeling in both ventricles. In myocytes isolated from the hypertensive rats, a combination of high-speed camera and confocal line-scan documented a prolongation of Ca2+ transients along with a higher local Ca2+-release activity. These Ca2+ transients were less synchronous than in controls, likely due to disorganized transverse-axial tubular system. In fact, following pulmonary hypertension, hypertrophied right ventricular myocytes showed significantly reduced number of transverse tubules and increased number of axial tubules; however, Stimulation Emission Depletion microscopy demonstrated that the colocalization of L-type Ca2+ channels and RyR2 (ryanodine receptor 2) remained unchanged. Finally, Stimulation Emission Depletion microscopy and super-resolution scanning patch-clamp analysis uncovered a decrease in the density of active L-type Ca2+ channels in right ventricular myocytes with an elevated open probability of the T-tubule anchored channels. This may represent a general mechanism of how nanoscale structural changes at the early stage of pulmonary hypertension impact on the development of the end stage failing phenotype in the right ventricle