213 research outputs found
Forcing and Velocity Correlations in a Vibrated Granular Monolayer
The role of forcing on the dynamics of a vertically shaken granular monolayer
is investigated. Using a flat plate, surprising negative velocity correlations
are measured. A mechanism for this anti-correlation is proposed with support
from both experimental results and molecular dynamics simulations. Using a
rough plate, velocity correlations are positive, and the velocity distribution
evolves from a gaussian at very low densities to a broader distribution at high
densities. These results are interpreted as a balance between stochastic
forcing, interparticle collisions, and friction with the plate.Comment: 4 pages, 5 figure
Two-dimensional Granular Gas of Inelastic Spheres with Multiplicative Driving
We study a two-dimensional granular gas of inelastic spheres subject to
multiplicative driving proportional to a power of the
local particle velocity . The steady state properties of the model
are examined for different values of , and compared with the
homogeneous case . A driving linearly proportional to
seems to reproduce some experimental observations which could not be reproduced
by a homogeneous driving. Furthermore, we obtain that the system can be
homogenized even for strong dissipation, if a driving inversely proportional toComment: 4 pages, 5 figures (accepted as Phys. Rev. Lett.
Evaluation of Two Internalizing Carcinoembryonic Antigen Reporter Genes for Molecular Imaging
PurposeThe objective of this article is to develop internalizing positron emission tomography (PET) reporter genes for tracking genetically modified T cells in vivo.ProceduresThe transmembrane and cytoplasmic domains of the human transferrin receptor (TfR) and CD5 were each fused to the carcinoembryonic (CEA) minigene N-A3 and expressed in Jurkat T cells. Internalization was evaluated by confocal microscopy or by intracellular uptake of ¹²⁵I-labeled anti-CEA scFv-Fc. Reporter gene-transfected Jurkat xenografts in mice were analyzed by immunohistochemistry (IHC) and imaged by PET using ¹²⁴I- or ⁶⁴Cu-scFv-Fc as tracers.ResultsSurface expression of TR(1-99)-NA3 was lower than that of NA3-CD5. Both reporter genes were internalized following binding of the anti-CEA antibody fragment. IHC of tumors showed strong staining of NA3-CD5, whereas TR(1-99)-NA3 stained weakly. Specific targeting of TR(1-99)-NA3 or NA3-CD5 was shown by PET in xenografted mice.ConclusionsThe in vivo imaging studies suggest a potential application of the internalizing form of CEA (N-A3) as a PET reporter gene
Marine Biotechnology: A New Vision and Strategy for Europe
Marine Board-ESF The Marine Board provides a pan-European platform for its member organisations to develop common priorities, to advance marine research, and to bridge the gap between science and policy in order to meet future marine science challenges and opportunities. The Marine Board was established in 1995 to facilitate enhanced cooperation between European marine science organisations (both research institutes and research funding agencies) towards the development of a common vision on the research priorities and strategies for marine science in Europe. In 2010, the Marine Board represents 30 Member Organisations from 19 countries. The Marine Board provides the essential components for transferring knowledge for leadership in marine research in Europe. Adopting a strategic role, the Marine Board serves its Member Organisations by providing a forum within which marine research policy advice to national agencies and to the European Commission is developed, with the objective of promoting the establishment of the European Marine Research Area
Model of coarsening and vortex formation in vibrated granular rods
Neicu and Kudrolli observed experimentally spontaneous formation of the
long-range orientational order and large-scale vortices in a system of vibrated
macroscopic rods. We propose a phenomenological theory of this phenomenon,
based on a coupled system of equations for local rods density and tilt. The
density evolution is described by modified Cahn-Hilliard equation, while the
tilt is described by the Ginzburg-Landau type equation. Our analysis shows
that, in accordance to the Cahn-Hilliard dynamics, the islands of the ordered
phase appear spontaneously and grow due to coarsening. The generic vortex
solutions of the Ginzburg-Landau equation for the tilt correspond to the
vortical motion of the rods around the cores which are located near the centers
of the islands.Comment: 4 pages, 5 figures, submitted to Phys. Rev. Let
Опыт применения золадекса у больных эндометриозом и рецидивирующими гиперпластическими процессами эндометрия
ЭНДОМЕТРИОЗ /ЛЕК ТЕРЭНДОМЕТРИЯ ГИПЕРПЛАЗИЯ /ЛЕК ТЕРЗОЛАДЕК
Identification of miRNA signatures associated with radiation-induced late lung injury in mice.
Acute radiation exposure of the thorax can lead to late serious, and even life-threatening, pulmonary and cardiac damage. Sporadic in nature, late complications tend to be difficult to predict, which prompted this investigation into identifying non-invasive, tissue-specific biomarkers for the early detection of late radiation injury. Levels of circulating microRNA (miRNA) were measured in C3H and C57Bl/6 mice after whole thorax irradiation at doses yielding approximately 70% mortality in 120 or 180 days, respectively (LD70/120 or 180). Within the first two weeks after exposure, weight gain slowed compared to sham treated mice along with a temporary drop in white blood cell counts. 52% of C3H (33 of 64) and 72% of C57Bl/6 (46 of 64) irradiated mice died due to late radiation injury. Lung and heart damage, as assessed by computed tomography (CT) and histology at 150 (C3H mice) and 180 (C57Bl/6 mice) days, correlated well with the appearance of a local, miRNA signature in the lung and heart tissue of irradiated animals, consistent with inherent differences in the C3H and C57Bl/6 strains in their propensity for developing radiation-induced pneumonitis or fibrosis, respectively. Radiation-induced changes in the circulating miRNA profile were most prominent within the first 30 days after exposure and included miRNA known to regulate inflammation and fibrosis. Importantly, early changes in plasma miRNA expression predicted survival with reasonable accuracy (88-92%). The miRNA signature that predicted survival in C3H mice, including miR-34a-5p, -100-5p, and -150-5p, were associated with pro-inflammatory NF-κB-mediated signaling pathways, whereas the signature identified in C57Bl/6 mice (miR-34b-3p, -96-5p, and -802-5p) was associated with TGF-β/SMAD signaling. This study supports the hypothesis that plasma miRNA profiles could be used to identify individuals at high risk of organ-specific late radiation damage, with applications for radiation oncology clinical practice or in the context of a radiological incident
Shocks in supersonic sand
We measure time-averaged velocity, density, and temperature fields for steady
granular flow past a wedge and calculate a speed of granular pressure
disturbances (sound speed) equal to 10% of the flow speed. The flow is
supersonic, forming shocks nearly identical to those in a supersonic gas.
Molecular dynamics simulations of Newton's laws and Monte Carlo simulations of
the Boltzmann equation yield fields in quantitative agreement with experiment.
A numerical solution of Navier-Stokes-like equations agrees with a molecular
dynamics simulation for experimental conditions excluding wall friction.Comment: 4 pages, 5 figure
Coarsening of granular clusters: two types of scaling behaviors
We report on an experimental study of small cluster dynamics during the
coarsening process in driven granular submonolayers of 120mkm bronze particles.
The techniques of electrostatic and vertical mechanical vibration were employed
to excite the granular gas. We measure the scaling exponent for the evaporation
of small clusters during coarsening. It was found that the surface area of
small clusters S vs time t behaves as S ~ (t_0-t)^(2/3) for lower frequencies
and S ~ (t_0-t) for higher frequencies. We argue that the change in the scaling
exponent is related to the transition from three dimensional to two dimensional
character of motion in the granular gas.Comment: 4 pages,5 figures, submitted to Phys.Rev.
Granular Collapse as a Percolation Transition
Inelastic collapse is found in a two-dimensional system of inelastic hard
disks confined between two walls which act as an energy source. As the
coefficient of restitution is lowered, there is a transition between a state
containing small collapsed clusters and a state dominated by a large collapsed
cluster. The transition is analogous to that of a percolation transition. At
the transition the number of clusters n_s of size s scales as with .Comment: 10 pages revtex, 5 figures, accepted by Phys Rev E many changes and
corrections from previous submissio
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