The synthesis of potential antimalarials. Derivatives of pantoyltaurine

The general hypothesis as to the mode of action of chemotherapeutic agents, which has been formulated by Fildes, Woods, McIlwain, and others (2), offers a rational and useful guide to the design of new drugs. Thus, bacteriostasis is pictured as caused by the blocking of reactions essential to growth by an inhibiting substance which has a structure similar to that of one of the normal enzymes or metabolites essential to the growth of the organism

A study of the flow field surrounding interacting line fires

The interaction of converging fires often leads to significant changes in fire behavior, including increased flame length, angle, and intensity. In this paper, the fluid mechanics of two adjacent line fires are studied both theoretically and experimentally. A simple potential flow model is used to explain the tilting of interacting flames towards each other, which results from a momentum imbalance triggered by fire geometry. The model was validated by measuring the velocity field surrounding stationary alcohol pool fires. The flow field was seeded with high-contrast colored smoke, and the motion of smoke structures was analyzed using a cross-correlation optical flow technique. The measured velocities and flame angles are found to compare reasonably with the predicted values, and an analogy between merging fires and wind-blown flames is proposed

Altruistic Contents of Quantum Prisoner's Dilemma

We examine the classical contents of quantum games. It is shown that a quantum strategy can be interpreted as a classical strategies with effective density-dependent game matrices composed of transposed matrix elements. In particular, successful quantum strategies in dilemma games are interpreted in terms of a symmetrized game matrix that corresponds to an altruistic game plan.Comment: Revised according to publisher's request: 4 pgs, 2 fgs, ReVTeX4. For more info, go to http://www.mech.kochi-tech.ac.jp/cheon

Equation of state in 2+1 flavor QCD with improved Wilson quarks by the fixed scale approach

We study the equation of state in 2+1 flavor QCD with nonperturbatively improved Wilson quarks coupled with the RG-improved Iwasaki glue. We apply the $T$-integration method to nonperturbatively calculate the equation of state by the fixed-scale approach. With the fixed-scale approach, we can purely vary the temperature on a line of constant physics without changing the system size and renormalization constants. Unlike the conventional fixed-$N_t$ approach, it is easy to keep scaling violations small at low temperature in the fixed scale approach. We study 2+1 flavor QCD at light quark mass corresponding to $m_\pi/m_\rho \simeq 0.63$, while the strange quark mass is chosen around the physical point. Although the light quark masses are heavier than the physical values yet, our equation of state is roughly consistent with recent results with highly improved staggered quarks at large $N_t$.Comment: 14 pages, 12 figures, v2: Table I and Figure 3 are corrected, reference updated. Main discussions and conclusions are unchanged, v3: version to appear in PRD, v4: reference adde

Co-evolution of strategy and structure in complex networks with dynamical linking

Here we introduce a model in which individuals differ in the rate at which they seek new interactions with others, making rational decisions modeled as general symmetric two-player games. Once a link between two individuals has formed, the productivity of this link is evaluated. Links can be broken off at different rates. We provide analytic results for the limiting cases where linking dynamics is much faster than evolutionary dynamics and vice-versa, and show how the individual capacity of forming new links or severing inconvenient ones maps into the problem of strategy evolution in a well-mixed population under a different game. For intermediate ranges, we investigate numerically the detailed interplay determined by these two time-scales and show that the scope of validity of the analytical results extends to a much wider ratio of time scales than expected

Two-population replicator dynamics and number of Nash equilibria in random matrix games

We study the connection between the evolutionary replicator dynamics and the number of Nash equilibria in large random bi-matrix games. Using techniques of disordered systems theory we compute the statistical properties of both, the fixed points of the dynamics and the Nash equilibria. Except for the special case of zero-sum games one finds a transition as a function of the so-called co-operation pressure between a phase in which there is a unique stable fixed point of the dynamics coinciding with a unique Nash equilibrium, and an unstable phase in which there are exponentially many Nash equilibria with statistical properties different from the stationary state of the replicator equations. Our analytical results are confirmed by numerical simulations of the replicator dynamics, and by explicit enumeration of Nash equilibria.Comment: 9 pages, 2x2 figure

Microwave power transmission system studies. Volume 2: Introduction, organization, environmental and spaceborne systems analyses

Introduction, organization, analyses, conclusions, and recommendations for each of the spaceborne subsystems are presented. Environmental effects - propagation analyses are presented with appendices covering radio wave diffraction by random ionospheric irregularities, self-focusing plasma instabilities and ohmic heating of the D-region. Analyses of dc to rf conversion subsystems and system considerations for both the amplitron and the klystron are included with appendices for the klystron covering cavity circuit calculations, output power of the solenoid-focused klystron, thermal control system, and confined flow focusing of a relativistic beam. The photovoltaic power source characteristics are discussed as they apply to interfacing with the power distribution flow paths, magnetic field interaction, dc to rf converter protection, power distribution including estimates for the power budget, weights, and costs. Analyses for the transmitting antenna consider the aperture illumination and size, with associated efficiencies and ground power distributions. Analyses of subarray types and dimensions, attitude error, flatness, phase error, subarray layout, frequency tolerance, attenuation, waveguide dimensional tolerances, mechanical including thermal considerations are included. Implications associated with transportation, assembly and packaging, attitude control and alignment are discussed. The phase front control subsystem, including both ground based pilot signal driven adaptive and ground command approaches with their associated phase errors, are analyzed

Microwave Power Transmission System Studies. Volume 1: Executive Summary

A study of microwave power generation, transmission, reception and control was conducted as a part of a program to demonstrate the feasibility of power transmission from geosynchronous orbit. A summary is presented of results concerning design approaches, estimated costs (ROM), critical technology, associated ground and orbital test programs with emphasis on dc to rf conversion, transmitting antenna, phase control, mechanical systems, flight operations, ground power receiving-rectifying antenna with systems analysis, and evaluation. Recommendations for early further in-depth studies complementing the technology program are included

Selection of dynamical rules in spatial Prisoner's Dilemma games

We study co-evolutionary Prisoner's Dilemma games where each player can imitate both the strategy and imitation rule from a randomly chosen neighbor with a probability dependent on the payoff difference when the player's income is collected from games with the neighbors. The players, located on the sites of a two-dimensional lattice, follow unconditional cooperation or defection and use individual strategy adoption rule described by a parameter. If the system is started from a random initial state then the present co-evolutionary rule drives the system towards a state where only one evolutionary rule remains alive even in the coexistence of cooperative and defective behaviors. The final rule is related to the optimum providing the highest level of cooperation and affected by the topology of the connectivity structure.Comment: 5 two-column pages, 3 figure