11,006 research outputs found
Thermodynamics of Decaying Vacuum Cosmologies
The thermodynamic behavior of vacuum decaying cosmologies is investigated
within a manifestly covariant formulation. Such a process corresponds to a
continuous irreversible energy flow from the vacuum component to the created
matter constituents. It is shown that if the specific entropy per particle
remains constant during the process, the equilibrium relations are preserved.
In particular, if the vacuum decays into photons, the energy density and
average number density of photons scale with the temperature as and . The temperature law is determined and a generalized
Planckian type form of the spectrum, which is preserved in the course of the
evolution, is also proposed. Some consequences of these results for decaying
vacuum FRW type cosmologies as well as for models with ``adiabatic'' photon
creation are discussed.Comment: 21 pages, uses LATE
[autosomal Chronic Granulomatous Disease: Case Report And Mutation Analysis Of Two Brazilian Siblings].
To report the case of two siblings with chronic granulomatous disease. Chronic granulomatous disease is a primary immunodeficiency disorder characterized by abnormal microbicidal activity. Mutations in the p47-phox gene (NCF-1) are present in about 30% of the patients with chronic granulomatous disease; this group presents a better prognosis and later onset of recurrent infections as compared with the X-linked variant, present in about 56% of patients. Case 1 is a female presenting repeat infections since age 10, starting with impetigo followed by severe pneumonia six months later. The severity of the lung infection associated with liver abscess and the patient's resistance to treatment prompted laboratory investigation for immunodeficiency. The results of the nitroblue tetrazolium and superoxide release tests were consistent with a diagnosis of chronic granulomatous disease. The parents and siblings were assessed, revealing the presence of granulomatous disease in a brother (Case 2). He also presented repeat infections with impetigo at age 10, followed by pneumonia six months later, however in a non severe form. Single-strand conformational polymorphism analysis detected abnormal electrophoretic mobility of exon 2 of the NCF-1 gene. Sequence DNA analysis revealed a dinucleotide GT deletion in exon 2. It is important to evaluate the relatives of chronic granulomatous disease patients, even in the absence of typical clinical signs. Defining the mutation and its correlation with phenotype is important to provide appropriate genetic counseling and clinical prognosis.80425-
Test of CPT Symmetry and Quantum Mechanics with Experimental data from CPLEAR
We use fits to recent published CPLEAR data on neutral kaon decays to
and to constrain the CPT--violation parameters
appearing in a formulation of the neutral kaon system as an open
quantum-mechanical system. The obtained upper limits of the CPT--violation
parameters are approaching the range suggested by certain ideas concerning
quantum gravity.Comment: 9 pages of uuencoded postscript (includes 3 figures
The Transcription Factor NFAT5 Is Required for Cyclin Expression and Cell Cycle Progression in Cells Exposed to Hypertonic Stress
Background: Hypertonicity can perturb cellular functions, induce DNA damage-like responses and inhibit proliferation. The transcription factor NFAT5 induces osmoprotective gene products that allow cells to adapt to sustained hypertonic conditions. Although it is known that NFAT5-deficient lymphocytes and renal medullary cells have reduced proliferative capacity and viability under hypertonic stress, less is understood about the contribution of this factor to DNA damage responses and cell cycle regulation. Methodology/Principal Findings: We have generated conditional knockout mice to obtain NFAT5−/− T lymphocytes, which we used as a model of proliferating cells to study NFAT5-dependent responses. We show that hypertonicity triggered an early, NFAT5-independent, genotoxic stress-like response with induction of p53, p21 and GADD45, downregulation of cyclins, and cell cycle arrest. This was followed by an NFAT5-dependent adaptive phase in wild-type cells, which induced an osmoprotective gene expression program, downregulated stress markers, resumed cyclin expression and proliferation, and displayed enhanced NFAT5 transcriptional activity in S and G2/M. In contrast, NFAT5−/− cells failed to induce osmoprotective genes and exhibited poorer viability. Although surviving NFAT5−/− cells downregulated genotoxic stress markers, they underwent cell cycle arrest in G1/S and G2/M, which was associated with reduced expression of cyclins E1, A2 and B1. We also show that pathologic hypertonicity levels, as occurring in plasma of patients and animal models of osmoregulatory disorders, inhibited the induction of cyclins and aurora B kinase in response to T cell receptor stimulation in fresh NFAT5−/− lymphocytes. Conclusions/Significance: We conclude that NFAT5 facilitates cell proliferation under hypertonic conditions by inducing an osmoadaptive response that enables cells to express fundamental regulators needed for cell cycle progression.Molecular and Cellular Biolog
Author correction : a global database for metacommunity ecology, integrating species, traits, environment and space
Correction to: Scientific Data https://doi.org/10.1038/s41597-019-0344-7, published online 08 January 202
Author correction : a global database for metacommunity ecology, integrating species, traits, environment and space
Correction to: Scientific Data https://doi.org/10.1038/s41597-019-0344-7, published online 08 January 202
Two Loop Scalar Self-Mass during Inflation
We work in the locally de Sitter background of an inflating universe and
consider a massless, minimally coupled scalar with a quartic self-interaction.
We use dimensional regularization to compute the fully renormalized scalar
self-mass-squared at one and two loop order for a state which is released in
Bunch-Davies vacuum at t=0. Although the field strength and coupling constant
renormalizations are identical to those of lfat space, the geometry induces a
non-zero mass renormalization. The finite part also shows a sort of growing
mass that competes with the classical force in eventually turning off this
system's super-acceleration.Comment: 31 pages, 5 figures, revtex4, revised for publication with extended
list of reference
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