'The world is full of big bad wolves': investigating the experimental therapeutic spaces of R.D. Laing and Aaron Esterson

In conjunction with the recent critical assessments of the life and work of R.D. Laing, this paper seeks to demonstrate what is revealed when Laing’s work on families and created spaces of mental health care are examined through a geographical lens. The paper begins with an exploration of Laing’s time at the Tavistock Clinic in London during the 1960s, and of the co-authored text with Aaron Esterson entitled, Sanity, Madness and the Family (1964). The study then seeks to demonstrate the importance Laing and his colleague placed on the time-space situatedness of patients and their worlds. Finally, an account is provided of Laing’s and Esterson’s spatial thinking in relation to their creation of both real and imagined spaces of therapeutic care

The cytochrome P450 family in the parasitic nematode <i>Haemonchus contortus</i>

&lt;i&gt;Haemonchus contortus&lt;/i&gt;, a highly pathogenic and economically important parasitic nematode of sheep, is particularly adept at developing resistance to the anthelmintic drugs used in its treatment and control. The basis of anthelmintic resistance is poorly understood for many commonly used drugs with most research being focused on mechanisms involving drug targets or drug efflux. Altered or increased drug metabolism is a possible mechanism that has yet to receive much attention despite the clear role of xenobiotic metabolism in pesticide resistance in insects. The cytochrome P450s (CYPs) are a large family of drug-metabolising enzymes present in almost all living organisms, but for many years thought to be absent from parasitic nematodes. In this paper, we describe the CYP sequences encoded in the &lt;i&gt;H. Contortus&lt;/i&gt; genome and compare their expression in different parasite life-stages, sexes and tissues. We developed a novel real-time PCR approach based on partially assembled CYP sequences “tags” and confirmed findings in the subsequent draft genome with RNA-seq. Constitutive expression was highest in larval stages for the majority of CYPs, although higher expression was detected in the adult male or female for a small subset of genes. Many CYPs were expressed in the worm intestine. A number of &lt;i&gt;H. Contortus&lt;/i&gt; genes share high identity with &lt;i&gt;Caenorhabditis elegans&lt;/i&gt; CYPs and the similarity in their expression profiles supports their classification as putative orthologues. Notably, &lt;i&gt;H. Contortus&lt;/i&gt; appears to lack the dramatic CYP subfamily expansions seen in &lt;i&gt;C. elegans&lt;/i&gt; and other species, which are typical of CYPs with exogenous roles. However, a small group of &lt;i&gt;H. Contortus&lt;/i&gt; genes cluster with the &lt;i&gt;C. elegans&lt;/i&gt; CYP34 and CYP35 subfamilies and may represent candidate xenobiotic metabolising genes in the parasite

Analysing the Transverse Structure of the Relativistic Jets of AGN

This paper describes a method of fitting total intensity and polarization profiles in VLBI images of astrophysical jets to profiles predicted by a theoretical model. As an example, the method is used to fit profiles of the jet in the Active Galactic Nucleus Mrk501 with profiles predicted by a model in which a cylindrical jet of synchrotron plasma is threaded by a magnetic field with helical and disordered components. This fitting yields model Stokes Q profiles that agree with the observed profiles to within the 1-2 \sigma uncertainties; the I model and observed profiles are overall not in such good agreement, with the model I profiles being generally more symmetrical than the observed profiles. Consistent fitting results are obtained for profiles derived from 6cm VLBI images at two distances from the core, and also for profiles obtained for different wavelengths at a single location in the VLBI jet. The most striking success of the model is its ability to reproduce the spine-sheath polarization structure observed across the jet. Using the derived viewing angle in the jet rest frame, \delta' approximately 83 degrees, together with a superluminal speed reported in the literature, \beta apparent = 3.3, yields a solution for the viewing angle and velocity of the jet in the observer's frame \delta degrees and \beta approximately 0.96. Although these results for Mrk501 must be considered tentative, the combined analysis of polarization profiles and apparent component speeds holds promise as a means of further elucidating the magnetic field structures and other parameters of parsec-scale AGN jets

Low Carbon Electricity Investment: The Limitations of Traditional Approaches and a Radical Alternative

Moving to a very low carbon electricity system is central to meeting the goals of UK energy policy, and indeed to the wider global challenge of tackling climate change. This will require massive investment in low carbon electricity sources. This working paper identifies four key difficulties with the current mainstream approach of relying on the impact of a carbon price in the present liberalised electricity market, supplemented with additional incentive mechanisms like renewable obligation certificates and feed-in tariffs. We then summarise alternate mechanisms and propose a new approach, aimed at harnessing the potential interest and capital of electricity consumers, large and small, directly in funding low carbon electricity investments, in the form of longterm ‘Green Power’ contracts that operate in a separate, differentiated contract market

The impact of instrument choice on investment in abatement technologies: a case study of tax versus trade incentives for CCS and Biomass for electricity

There has been a wide discussion on the different properties between carbon taxes, cap-and-trade schemes and hybrid instruments such as cap-and-trade schemes with price floors and ceilings. There has been less discussion on the incentives to investment that each of these instruments may provide. We build a three-period model to investigate the incentives offered to a large firm with diversified abatement options from such instruments when facing a choice between investing in lowcarbon technologies with potential learning benefits. We parameterise our model for a system similar to the EUETS and for two sample technologies, biomass for electricity and coal with carbon capture and storage. For both technologies we find that cap-and-trade schemes generate greater mean returns to such an investment than taxes, but with a wider distribution. We find that introducing price floors increase such mean returns while reducing the distribution, while ceilings further reduce the distribution, but also the mean and thus the overall incentives they offer will depend on the risk preference of the firm and scale of investment in relation to overall compliance costs

Boson Sampling from Gaussian States

We pose a generalized Boson Sampling problem. Strong evidence exists that such a problem becomes intractable on a classical computer as a function of the number of Bosons. We describe a quantum optical processor that can solve this problem efficiently based on Gaussian input states, a linear optical network and non-adaptive photon counting measurements. All the elements required to build such a processor currently exist. The demonstration of such a device would provide the first empirical evidence that quantum computers can indeed outperform classical computers and could lead to applications

Relativistic Landau damping of longitudinal waves in isotropic pair plasmas

Landau damping is described in relativistic electron-positron plasmas. Relativistic electron-positron plasma theory contains important new effects when compared with classical plasmas. For example, there are undamped superluminal wave modes arising from both a continuous and discrete mode structure, the former even in the classical limit. We present here a comprehensive analytical treatment of the general case resulting in a compact and useful form for the dispersion relation. The classical pair-plasma case is addressed, for completeness, in an appendix

Factors affecting metal mobilisation during oxidation of sulphidic, sandy wetland substrates

Most metals accumulate as sulphides under anoxic conditions in wetland substrates, reducing their bioavailability due to the solubility of metal sulphides. However, upon oxidation of these sulphides when the substrate is occasionally oxidised, metals can be released from the solid phase to the pore water or overlaying surface water. This release can be affected by the presence of carbonates, organic matter and clay. We compared changes of Cd, Cu and Zn mobility (CaCl2 extraction) during oxidation of a carbonate-rich and a carbonate-poor sulphidic, sandy wetland substrate. In addition, we studied how clay with low and high cation sorption capacity (bentonite and kaolinite, respectively) and organic matter (peat) can counteract Cd, Cu and Zn release during oxidation of both carbonate-rich and carbonate-poor sulphidic sediments. CaCl2-extractability of Cu, a measure for its availability, is low in both carbonate-poor and carbonate-rich substrates, whereas its variability is high. The availability of Cd and Zn is much higher and increases when peat is supplied to carbonate-poor substrates. A strong reduction of Cd and Zn extractability is observed when clay is added to carbonate-poor substrates. This reduction depends on the clay type. Most observations could be explained taking into account pH differences between treatments, with kaolinite resulting in a lower pH in comparison to bentonite. These pH differences affect the presence and characteristics of dissolved organic carbon and the metal speciation, which in turns affects the interaction of metals with the solid soil phase. In carbonate-rich substrates, Cd and Zn availability is lower and the effects of peat and clay amendment are less clear. The latter can also be attributed to the high pH and lack of pH differences between treatments

The IRAS Revised Bright Galaxy Sample (RBGS)

IRAS flux densities, redshifts, and infrared luminosities are reported for all sources identified in the IRAS Revised Bright Galaxy Sample (RBGS), a complete flux-limited survey of all extragalactic objects with total 60 micron flux density greater than 5.24 Jy, covering the entire sky surveyed by IRAS at Galactic latitude |b| > 5 degrees. The RBGS includes 629 objects, with a median (mean) sample redshift of 0.0082 (0.0126) and a maximum redshift of 0.0876. The RBGS supersedes the previous two-part IRAS Bright Galaxy Samples, which were compiled before the final ("Pass 3") calibration of the IRAS Level 1 Archive in May 1990. The RBGS also makes use of more accurate and consistent automated methods to measure the flux of objects with extended emission. Basic properties of the RBGS sources are summarized, including estimated total infrared luminosities, as well as updates to cross-identifications with sources from optical galaxy catalogs established using the NASA/IPAC Extragalactic Database (NED). In addition, an atlas of images from the Digitized Sky Survey with overlays of the IRAS position uncertainty ellipse and annotated scale bars is provided for ease in visualizing the optical morphology in context with the angular and metric size of each object. The revised bolometric infrared luminosity function, phi(L_ir), for infrared bright galaxies in the local Universe remains best fit by a double power law, phi(L_ir) ~ L_ir^alpha, with alpha = -0.6 (+/- 0.1), and alpha = -2.2 (+/- 0.1) below and above the "characteristic" infrared luminosity L_ir ~ 10^{10.5} L_solar, respectively. (Abridged)Comment: Accepted for publication in the Astronomical Journal. Contains 50 pages, 7 tables, 16 figures. Due to astro-ph space limits, only 1 of 26 pages of Figure 1, and 1 of 11 pages of Table 7, are included; full resolution Postscript files are available at http://nedwww.ipac.caltech.edu/level5/March03/IRAS_RBGS/Figures/ . Replacement: Corrected insertion of Fig. 15 (MethodCodes.ps) in LaTe