Dental erosion: In vitro model of wine assessor's erosion

The document attached has been archived with permission from the Australian Dental Association. An external link to the publisher’s copy is included.Background: Wine makers and assessors frequently experience severe dental erosion. The objectives of this study were to develop an in vitro model of dental erosion caused by frequent wine contact with teeth, and to use this model to assess the effectiveness of a variety of methods which might protect against this form of erosion. Methods: An initial pilot study found that riesling style wine was more erosive than champagne style, and both more than claret. Wine tasting was simulated by subjecting exposed windows of enamel and root surfaces on 50 intact, extracted human teeth to 1400 one minute exposures to white wine (pH 3.2). A variety of dental materials were applied to the exposed windows on groups of teeth prior to erosive challenge, to assess their protective ability. Results: Protective resin coatings and fluoride varnishes protected both enamel and roots against wine induced erosion. A high degree of protection was provided by APF gel, with less by NaF gel. Conclusions: It was concluded that dentists may be able to help minimise erosion resulting from frequent wine-tasting in their patients by the clinical application of one or a combination of these agents at times prior to prolonged assessment periods.Tong Bee Mok, J McIntyre and D Hun

Review study and evaluation of possible flight experiments relating to cloud physics experiments in space

The general objectives of the Zero-Gravity Atmospheric Cloud Physics Laboratory Program are to improve the level of knowledge in atmospheric cloud research by placing at the disposal of the terrestrial-bound atmospheric cloud physicist a laboratory that can be operated in the environment of zero-gravity or near zero-gravity. This laboratory will allow studies to be performed without mechanical, aerodynamic, electrical, or other techniques to support the object under study. The inhouse analysis of the Skylab 3 and 4 experiments in dynamics of oscillations, rotations, collisions and coalescence of water droplets under low gravity-environment is presented

Proceedings of an ESA-NASA Workshop on a Joint Solid Earth Program

The NASA geodynamics program; spaceborne magnetometry; spaceborne gravity gradiometry (characterizing the data type); terrestrial gravity data and comparisons with satellite data; GRADIO three-axis electrostatic accelerometers; gradiometer accommodation on board a drag-free satellite; gradiometer mission spectral analysis and simulation studies; and an opto-electronic accelerometer system were discussed

Multilayered folding with voids

In the deformation of layered materials such as geological strata, or stacks of paper, mechanical properties compete with the geometry of layering. Smooth, rounded corners lead to voids between the layers, while close packing of the layers results in geometrically-induced curvature singularities. When voids are penalized by external pressure, the system is forced to trade off these competing effects, leading to sometimes striking periodic patterns. In this paper we construct a simple model of geometrically nonlinear multi-layered structures under axial loading and pressure confinement, with non-interpenetration conditions separating the layers. Energy minimizers are characterized as solutions of a set of fourth-order nonlinear differential equations with contact-force Lagrange multipliers, or equivalently of a fourth-order free-boundary problem. We numerically investigate the solutions of this free boundary problem, and compare them with the periodic solutions observed experimentally

PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation.

Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate. One recently identified susceptibility loci for human GCT is PR (PRDI-BF1 and RIZ) domain proteins 14 (PRDM14). PRDM14 is expressed in early primate PGCs and is repressed as PGCs differentiate. To examine PRDM14 in human GCTs we profiled human GCT cell lines and patient samples and discovered that PRDM14 is expressed in embryonal carcinoma cell lines, embryonal carcinomas, seminomas, intracranial germinomas and yolk sac tumors, but is not expressed in teratomas. To model constitutive overexpression in human PGCs, we generated PGC-like cells (PGCLCs) from human pluripotent stem cells (PSCs) and discovered that elevated expression of PRDM14 does not block early PGC formation. Instead, we show that elevated PRDM14 in PGCLCs causes proliferation and differentiation defects in the germline

A Qualitative Investigation Into the Impact of the Basketball Learning Intervention Programme (BLIP) on Disengaged Secondary School Students in the United Kingdom

This paper will evaluate the longitudinal effects of a basketball based intervention programme that targeted ten disengaged male secondary school students at a school in the Kent, England. The programme aimed to improve the behaviour and academic performance of the participants through a weekly intervention carried out by an external basketball player and coach providing academic support, mentoring and specially designed basketball sessions. Sports interventions have been deemed to provide a positive short-term impact on young people. However, researchers have identified the need for a longitudinal approach in order to examine the effects of such interventions post involvement as supported. This study involved five former Basketball Learning Intervention Programme (BLIP) members (with a mean age of 16.4 SD± 0.55 years) that were interviewed using semi-structured interview approach, 12 months after completing the intervention. Interpretative Phenomenological Analysis (IPA) revealed four superordinate and eleven subordinate themes. The four superordinate themes were; ‘baseline behaviours pre-intervention’, ‘immediate outcomes of the BLIP’, ‘impact of the coach’ and ‘long standing transferable outcomes’. The results revealed an immediate impact in comparison to the baseline behaviours of the participants pre-intervention. The data suggested that one of the most effective aspects of the programme was the positive impact of the coach on the participants. More importantly, this is the only study to report long-term improvements amongst the participants in terms of behaviour and academics as a result of engagement in a sports based intervention

Generic dynamics of 4-dimensional C2 Hamiltonian systems

We study the dynamical behaviour of Hamiltonian flows defined on 4-dimensional compact symplectic manifolds. We find the existence of a C2-residual set of Hamiltonians for which every regular energy surface is either Anosov or it is in the closure of energy surfaces with zero Lyapunov exponents a.e. This is in the spirit of the Bochi-Mane dichotomy for area-preserving diffeomorphisms on compact surfaces and its continuous-time version for 3-dimensional volume-preserving flows

Online identification and nonlinear control of the electrically stimulated quadriceps muscle

A new approach for estimating nonlinear models of the electrically stimulated quadriceps muscle group under nonisometric conditions is investigated. The model can be used for designing controlled neuro-prostheses. In order to identify the muscle dynamics (stimulation pulsewidth-active knee moment relation) from discrete-time angle measurements only, a hybrid model structure is postulated for the shank-quadriceps dynamics. The model consists of a relatively well known time-invariant passive component and an uncertain time-variant active component. Rigid body dynamics, described by the Equation of Motion (EoM), and passive joint properties form the time-invariant part. The actuator, i.e. the electrically stimulated muscle group, represents the uncertain time-varying section. A recursive algorithm is outlined for identifying online the stimulated quadriceps muscle group. The algorithm requires EoM and passive joint characteristics to be known a priori. The muscle dynamics represent the product of a continuous-time nonlinear activation dynamics and a nonlinear static contraction function described by a Normalised Radial Basis Function (NRBF) network which has knee-joint angle and angular velocity as input arguments. An Extended Kalman Filter (EKF) approach is chosen to estimate muscle dynamics parameters and to obtain full state estimates of the shank-quadriceps dynamics simultaneously. The latter is important for implementing state feedback controllers. A nonlinear state feedback controller using the backstepping method is explicitly designed whereas the model was identified a priori using the developed identification procedure

The HI content of extremely metal-deficient blue compact dwarf galaxies

We have obtained new HI observations with the 100m Green Bank Telescope (GBT) for a sample of 29 extremely metal-deficient star-forming Blue Compact Dwarf (BCD) galaxies, selected from the Sloan Digital Sky Survey spectral data base to be extremely metal-deficient (12+logO/H<7.6). Neutral hydrogen was detected in 28 galaxies, a 97% detection rate. Combining the HI data with SDSS optical spectra for the BCD sample and adding complementary galaxy samples from the literature to extend the metallicity and mass ranges, we have studied how the HI content of a galaxy varies with various global galaxian properties. There is a clear trend of increasing gas mass fraction with decreasing metallicity, mass and luminosity. We obtain the relation M(HI)/L(g)~L(g)^{-0.3}, in agreement with previous studies based on samples with a smaller luminosity range. The median gas mass fraction f(gas) for the GBT sample is equal to 0.94 while the mean gas mass fraction is 0.90+/-0.15, with a lower limit of ~0.65. The HI depletion time is independent of metallicity, with a large scatter around the median value of 3.4 Gyr. The ratio of the baryonic mass to the dynamical mass of the metal-deficient BCDs varies from 0.05 to 0.80, with a median value of ~0.2. About 65% of the BCDs in our sample have an effective yield larger than the true yield, implying that the neutral gas envelope in BCDs is more metal-deficient by a factor of 1.5-20, as compared to the ionized gas.Comment: 21 pages, 13 figures, accepted for publication in MNRA

Glimmers: Resolving the Privacy/Trust Quagmire

Many successful services rely on trustworthy contributions from users. To establish that trust, such services often require access to privacy-sensitive information from users, thus creating a conflict between privacy and trust. Although it is likely impractical to expect both absolute privacy and trustworthiness at the same time, we argue that the current state of things, where individual privacy is usually sacrificed at the altar of trustworthy services, can be improved with a pragmatic $Glimmer$ $of$ $Trust$, which allows services to validate user contributions in a trustworthy way without forfeiting user privacy. We describe how trustworthy hardware such as Intel's SGX can be used client-side -- in contrast to much recent work exploring SGX in cloud services -- to realize the Glimmer architecture, and demonstrate how this realization is able to resolve the tension between privacy and trust in a variety of cases