Mechanical and corrosion properties of aluminium alloy EN AW 6082 after severe plastic deformation (SPD)

The aim had been to study changes in the properties of aluminium alloy AlSiMgMn. Influence of SPD of the mechanical properties had increased (Rm by 86 MPa, Ro0,2 by 175 MPa, while A had decreased to 20 %). The corrosion potentials had been evaluated in the environment of H2O and in SARS. After SPD was observed in the environment of H2O, that resistance had increased by -218 mV and after exposure up to 1 000 min there was a slight deterioration of resistance in SARS. On the surface specimens after SPD were observed higher quantities of corrosion products. After SPD was observed fatigue characteristics in torsional stress in the oblique branches Wohler curves showed favourable characteristics of about 35 %

Extension of the Measurement Capabilities of the Quadrupole Resonator

The Quadrupole Resonator, designed to measure the surface resistance of superconducting samples at 400 MHz has been refurbished. The accuracy of its RF-DC compensation measurement technique is tested by an independent method. It is shown that the device enables also measurements at 800 and 1200 MHz and is capable to probe the critical RF magnetic field. The electric and magnetic field configuration of the Quadrupole Resonator are dependent on the excited mode. It is shown how this can be used to distinguish between electric and magnetic losses.Comment: 6 pages, g figure

Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study

BACKGROUND: For virtually every patient with colorectal cancer (CRC), hematoxylin-eosin (HE)-stained tissue slides are available. These images contain quantitative information, which is not routinely used to objectively extract prognostic biomarkers. In the present study, we investigated whether deep convolutional neural networks (CNNs) can extract prognosticators directly from these widely available images. METHODS AND FINDINGS: We hand-delineated single-tissue regions in 86 CRC tissue slides, yielding more than 100,000 HE image patches, and used these to train a CNN by transfer learning, reaching a nine-class accuracy of >94% in an independent data set of 7,180 images from 25 CRC patients. With this tool, we performed automated tissue decomposition of representative multitissue HE images from 862 HE slides in 500 stage I-IV CRC patients in the The Cancer Genome Atlas (TCGA) cohort, a large international multicenter collection of CRC tissue. Based on the output neuron activations in the CNN, we calculated a "deep stroma score," which was an independent prognostic factor for overall survival (OS) in a multivariable Cox proportional hazard model (hazard ratio [HR] with 95% confidence interval [CI]: 1.99 [1.27-3.12], p = 0.0028), while in the same cohort, manual quantification of stromal areas and a gene expression signature of cancer-associated fibroblasts (CAFs) were only prognostic in specific tumor stages. We validated these findings in an independent cohort of 409 stage I-IV CRC patients from the "Darmkrebs: Chancen der Verhütung durch Screening" (DACHS) study who were recruited between 2003 and 2007 in multiple institutions in Germany. Again, the score was an independent prognostic factor for OS (HR 1.63 [1.14-2.33], p = 0.008), CRC-specific OS (HR 2.29 [1.5-3.48], p = 0.0004), and relapse-free survival (RFS; HR 1.92 [1.34-2.76], p = 0.0004). A prospective validation is required before this biomarker can be implemented in clinical workflows. CONCLUSIONS: In our retrospective study, we show that a CNN can assess the human tumor microenvironment and predict prognosis directly from histopathological images

Familial clustering of Leiomyomatosis peritonealis disseminata: an unknown genetic syndrome?

BACKGROUND: Leiomyomatosis peritonealis disseminata (LPD) is defined as the occurrence of multiple tumorous intraabdominal lesions, which are myomatous nodules. LPD is a rare disease with only about 100 cases reported. The usual course of LPD is benign with the majority of the patients being premenopausal females. Only two cases involving men have been reported, no syndrome or familial occurrence of LPD has been described. CASE PRESENTATION: We describe a Caucasian-American family in which six members (three men) are diagnosed with Leiomyomatosis peritonealis disseminata (LPD) and three deceased family members most likely had LPD (based on the autopsy reports). Furthermore we describe the association of LPD with Raynaud's syndrome and Prurigo nodularis. CONCLUSION: Familial clustering of Leiomyomatosis peritonealis disseminata (LPD) has not been reported so far. The etiology of LPD is unknown and no mode of inheritance is known. We discuss possible modes of inheritance in the presented case, taking into account the possibility of a genetic syndrome. Given the similarity to other genetic syndromes with leiomyomatosis and skin alterations, we describe possible similar genetic pathomechanisms

200-GeV ISA with room temperature magnets

A conceptual design study of 200-GeV proton intersecting storage accclerators with room temperature magnets is presented. The key to this study was thc desire to keep the electric power consumptiom to an acceptable level (40 MW). The design has been optimized by choosing small-gap (4 cm) aluminum coil dipoles operating at about 15 kG. The luminosity of this machine is limited to about 10/sup 32/ cm-/sup -2/ sec/sup -1/ by transverse space-charg e effects. An order of magnitude higher luminositics can be obtained by adding a booster of modest cost. A novel vacuum system using distributed Ti-sublimation pumps results in considerable savings. A cost comparison with a high-luminosity superconducting machine is given. (auth

Perceiving societal pressure to be happy is linked to poor well-being, especially in happy nations

Happiness is a valuable experience, and societies want their citizens to be happy. Although this societal commitment seems laudable, overly emphasizing positivity (versus negativity) may create an unattainable emotion norm that ironically compromises individual well-being. In this multi-national study (40 countries; 7443 participants), we investigate how societal pressure to be happy and not sad predicts emotional, cognitive and clinical indicators of well-being around the world, and examine how these relations differ as a function of countries’ national happiness levels (collected from the World Happiness Report). Although detrimental well-being associations manifest for an average country, the strength of these relations varies across countries. People’s felt societal pressure to be happy and not sad is particularly linked to poor well-being in countries with a higher World Happiness Index. Although the cross-sectional nature of our work prohibits causal conclusions, our findings highlight the correlational link between social emotion valuation and individual well-being, and suggest that high national happiness levels may have downsides for some.info:eu-repo/semantics/publishedVersio

Corrosion challenges towards a sustainable society

A global transition towards more sustainable, affordable and reliable energy systems is being stimulated by the Paris Agreement and the United Nation's 2030 Agenda for Sustainable Development. This poses a challenge for the corrosion industry, as building climate-resilient energy systems and infrastructures brings with it a long-term direction, so as a result the long-term behaviour of structural materials (mainly metals and alloys) becomes a major prospect. With this in mind "Corrosion Challenges Towards a Sustainable Society" presents a series of cases showing the importance of corrosion protection of metals and alloys in the development of energy production to further understand the science of corrosion, and bring the need for research and the consequences of corrosion into public and political focus. This includes emphasis on the limitation of greenhouse gas emissions, on the lifetime of infrastructures, implants, cultural heritage artefacts, and a variety of other topics