An Image Based Bidirectional Reflectivity Distribution Function Experiment

The temperature dependence of Bidirectional Reflectivity Distribution Functions (BRDFs) is not well documented. For the sake of time and customer demand, current measurements are taken at room temperature, but the reflectivity of a material changes as a function of temperature. The assumption is that this change is uniform, and as such, the BRDF will retain its relative angular shape but perhaps be scaled in magnitude as a function of temperature. When BRDFs are to be used at elevated temperatures, a scaling factor is then applied. In addition, BRDF as a function of rate of change of temperature has been identified by the Directed Energy community as being of interest in optical determination of power on target. BRDF acquisition is often taken with very expensive pieces of equipment known as gonioreflectometers. The process of collecting a BRDF for a sample can take on the order of a day. To speed the collection of BRDF data, the computer graphics industry developed a technique using a series of images that contain enough information to extract the BRDF of the sample in question. This experiment begins the journey down the path towards understanding temperature dependence of BRDF through image-based BRDF measurement. With the eventual goal of temperature coupled samples, the size of the optics, used here had to be large to accommodate the size of thermally controlled samples. Much of this initial experimental set up was creating custom components to hold the large optics, the sample or the camera

Modelling of hydrological response to climate change in glacierized Central Asian catchments

The arid lowlands of Central Asia are highly dependent on the water supplied by the Tien Shan mountains. Snow and ice storage make large contributions to current runoff, particularly in summer. Two runoff models with different temporal resolutions, HBV-ETH and OEZ, were applied in three glaciated catchments of the Tien Shan mountains. Scenario runs were produced for a climate change caused by the doubling of atmospheric CO2 as predicted by the GISS global circulation model and assuming a 50% reduction of glaciation extent, as well as a complete loss of glaciation. Agreement of the results was best for runs based on 50% glaciation loss, where both models predict an increase in spring and summer runoff compared to current levels. Scenarios for complete loss of glaciation predict an increase in spring runoff levels, followed by lower runoff levels for July and August. Model predictions differ concerning the degree of reduction of late summer runoff. These scenarios are sensitive to model simulation of basin precipitation, as well as to reduction of glaciation extent

Vitamin-D Receptor Agonist Calcitriol Reduces Calcification in Vitro Through Selective Upregulation of SLC20A2 but not SLC20A1 or XPR1

Vitamin D deficiency (hypovitaminosis D) causes osteomalacia and poor long bone mineralization. In apparent contrast, hypovitaminosis D has been reported in patients with primary brain calcifications ( Fahr\u27s disease ). We evaluated the expression of two phosphate transporters which we have found to be associated with primary brain calcification (SLC20A2, whose promoter has a predicted vitamin D receptor binding site, and XPR1), and one unassociated (SLC20A1), in an in vitro model of calcification. Expression of all three genes was significantly decreased in calcifying human bone osteosarcoma (SaOs-2) cells. Further, we confirmed that vitamin D (calcitriol) reduced calcification as measured by Alizarin Red staining. Cells incubated with calcitriol under calcifying conditions specifically maintained expression of the phosphate transporter SLC20A2 at higher levels relative to controls, by RT-qPCR. Neither SLC20A1 nor XPR1 were affected by calcitriol treatment and remained suppressed. Critically, knockdown of SLC20A2 gene and protein with CRISPR technology in SaOs2 cells significantly ablated vitamin D mediated inhibition of calcification. This study elucidates the mechanistic importance of SLC20A2 in suppressing the calcification process. It also suggests that vitamin D might be used to regulate SLC20A2 gene expression, as well as reduce brain calcification which occurs in Fahr\u27s disease and normal aging

Expressivity of parameterized and data-driven representations in quality diversity search

Algorithms and the Foundations of Software technolog

Re-establishing glacier monitoring in Kyrgyzstan and Uzbekistan, Central Asia

Glacier mass loss is among the clearest indicators of atmospheric warming. The observation of these changes is one of the major objectives of the international climate monitoring strategy developed by the Global Climate Observing System (GCOS). Long-term glacier mass balance measurements are furthermore the basis for calibrating and validating models simulating future runoff of glacierised catchments. This is essential for Central Asia, which is one of the driest continental regions of the Northern Hemisphere. In the highly populated regions, water shortage due to decreased glacierisation potentially leads to pronounced political instability, drastic ecological changes and endangered food security. As a consequence of the collapse of the former Soviet Union, however, many valuable glacier monitoring sites in the Tien Shan and Pamir Mountains were abandoned. In recent years, multinational actors have re-established a set of important in situ measuring sites to continue the invaluable long-term data series. This paper introduces the applied monitoring strategy for selected glaciers in the Kyrgyz and Uzbek Tien Shan and Pamir, highlights the existing and the new measurements on these glaciers, and presents an example for how the old and new data can be combined to establish multi-decadal mass balance time series. This is crucial for understanding the impact of climate change on glaciers in this region

Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury

Olfactory ensheathing cell (OEC) transplantation is a promising strategy for treating spinal cord injury (SCI), as has been demonstrated in experimental SCI models and naturally occurring SCI in dogs. However, the presence of chondroitin sulphate proteoglycans within the extracellular matrix of the glial scar can inhibit efficient axonal repair and limit the therapeutic potential of OECs. Here we have used lentiviral vectors to genetically modify canine OECs to continuously deliver mammalian chondroitinase ABC at the lesion site in order to degrade the inhibitory chondroitin sulphate proteoglycans in a rodent model of spinal cord injury. We demonstrate that these chondroitinase producing canine OECs survived at 4 weeks following transplantation into the spinal cord lesion and effectively digested chondroitin sulphate proteoglycans at the site of injury. There was evidence of sprouting within the corticospinal tract rostral to the lesion and an increase in the number of corticospinal axons caudal to the lesion, suggestive of axonal regeneration. Our results indicate that delivery of the chondroitinase enzyme can be achieved with the genetically modified OECs to increase axon growth following SCI. The combination of these two promising approaches is a potential strategy for promoting neural regeneration following SCI in veterinary practice and human patients

Preventing Prostate Biopsy Complications: to Augment or to Swab?

Aims for Improvement The aim of this study was to determine the antibiotic prophylaxis associated with the fewest infectious complications following prostate biopsy Determining the safest method allows the Jefferson Department of Urology to modify its biopsy protocol and improve the rate of post-biopsy complication

Distribution of motor unit potential velocities in short static and prolonged dynamic contractions at low forces: use of the within-subject’s skewness and standard deviation variables

Behaviour of motor unit potential (MUP) velocities in relation to (low) force and duration was investigated in biceps brachii muscle using a surface electrode array. Short static tests of 3.8 s (41 subjects) and prolonged dynamic tests (prolonged tests) of 4 min (30 subjects) were performed as position tasks, applying forces up to 20% of maximal voluntary contraction (MVC). Four variables, derived from the inter-peak latency technique, were used to describe changes in the surface electromyography signal: the mean muscle fibre conduction velocity (CV), the proportion between slow and fast MUPs expressed as the within-subject skewness of MUP velocities, the within-subject standard deviation of MUP velocities [SD-peak velocity (PV)], and the amount of MUPs per second (peak frequency = PF). In short static tests and the initial phase of prolonged tests, larger forces induced an increase of the CV and PF, accompanied with the shift of MUP velocities towards higher values, whereas the SD-PV did not change. During the first 1.5–2 min of the prolonged lower force levels tests (unloaded, and loaded 5 and 10% MVC) the CV and SD-PV slightly decreased and the MUP velocities shifted towards lower values; then the three variables stabilized. The PF values did not change in these tests. However, during the prolonged higher force (20% MVC) test, the CV decreased and MUP velocities shifted towards lower values without stabilization, while the SD-PV broadened and the PF decreased progressively. It is argued that these combined results reflect changes in both neural regulatory strategies and muscle membrane state