Introduction to “Binary Binds”: Deconstructing Sex and Gender Dichotomies in Archaeological Practice

YesGender archaeology has made significant strides toward deconstructing the hegemony of binary categorizations. Challenging dichotomies such as man/woman, sex/gender, and biology/culture, approaches informed by poststructuralist, feminist, and queer theories have moved beyond essentialist and universalist identity constructs to more nuanced configurations. Despite the theoretical emphasis on context, multiplicity, and fluidity, binary starting points continue to streamline the spectrum of variability that is recognized, often reproducing normative assumptions in the evidence. The contributors to this special issue confront how sex, gender, and sexuality categories condition analytical visibility, aiming to develop approaches that respond to the complexity of theory in archaeological practice. The papers push the ontological and epistemological boundaries of bodies, personhood, and archaeological possibility, challenging a priori assumptions that contain how sex, gender, and sexuality categories are constituted and related to each other. Foregrounding intersectional approaches that engage with ambiguity, variability, and difference, this special issue seeks to “de-contain” categories, assumptions, and practices from “binding” our analytical gaze toward only certain kinds of persons and knowledges, in interpretations of the past and practices in the present

Modelling of a soft sensor for exteroception and proprioception in a pneumatically actuated soft robot

© Springer Nature Switzerland AG 2019. Soft sensors are crucial to enable feedback in soft robots. Soft capacitive sensing is a reliable technology that can be embedded into soft pneumatic robots for obtaining proprioceptive and exteroceptive feedback. In this paper, we model a soft capacitive sensor that measures both the actuated state as well as applied external forces. We develop a Finite Element Model using a multiphysics software (COMSOL®). Using this model, we investigate the change in capacitance with the application of external force, for a range of different internal pressures and strains. We hope this study is helpful in understanding the coupling of internal inputs and external stimuli on the feedback obtained from the sensors and help us design better sensory systems for soft robots

Queering Queer Theory in Management and Organization Studies: Notes toward queering heterosexuality

This article suggests new possibilities for queer theory in management and organization studies. Management and organization studies has tended to use queer theory as a conceptual resource for studying the workplace experience of ‘minorities’ such as gay men, lesbians and those identifying as bisexual or transgender, often focusing on how heteronormativity shapes the discursive constitution of sexualities and genders coded as such. This deployment is crucial and apposite but it can limit the analytical reach of queer theory, neglecting other objects of analysis like heterosexuality. Potentially, MOS queer theory scholarship could be vulnerable to criticism about overlooking queer theory as a productive site for acknowledging both heterosexuality’s coercive aspects and its non-normative forms. The principal contribution of our article is therefore twofold. First, it proposes a queering of queer theory in management and organization studies, whereby scholars are alert to and question the potential normativities that such research can produce, opening up a space for exploring how heterosexuality can be queered. Second, we show how queering heterosexuality can be another site where queer theory and politics come together in the management and organization studies field, through a shared attempt to undermine sexual and gender binaries and challenge normative social relations. The article concludes by outlining the political implications of queering heterosexuality for generating modes of organizing in which heterosexuality can be experienced as non-normative and how this might rupture and dismantle heteronormativity

Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes

Hypoxia is a common and prominent feature of the microenvironment at sites of bacteria-associated inflammation in inflammatory bowel disease. The prolyl-hydroxylases (PHD1/2/3) and the asparaginyl-hydroxylase factor-inhibiting HIF are oxygen-sensing enzymes that regulate adaptive responses to hypoxia through controlling the activity of HIF and NF-κB–dependent transcriptional pathways. Previous studies have demonstrated that the pan-hydroxylase inhibitor dimethyloxalylglycine (DMOG) is effective in the alleviation of inflammation in preclinical models of inflammatory bowel disease, at least in part, through suppression of IL-1β–induced NF-κB activity. TLR-dependent signaling in immune cells, such as monocytes, which is important in bacteria-driven inflammation, shares a signaling pathway with IL-1β. In studies into the effect of pharmacologic hydroxylase inhibition on TLR-induced inflammation in monocytes, we found that DMOG selectively triggers cell death in cultured THP-1 cells and primary human monocytes at concentrations well tolerated in other cell types. DMOG-induced apoptosis was independent of increased caspase-3/7 activity but was accompanied by reduced expression of the inhibitor of apoptosis protein 1 (cIAP1). Based on these data, we hypothesize that pharmacologic inhibition of the HIF-hydroxylases selectively targets monocytes for cell death and that this may contribute to the anti-inflammatory activity of HIF-hydroxylase inhibitors