First images of a possible CO(+)-tail of comet P/Schwassmann-Wachmann 1 observed against the dust coma background

Comet P/Schwassmann-Wachmann 1 was observed with the 2m-Ritchey-Cretien Telescope of the Bulgarian National Observatory, Rozhen, Bulgaria, using the CCD-camera and focal reducer of the Max-Planck-Institute for Aeronomy. Images were taken in a red continuum window and in the 2-0 A(exp 2)Pi - X(exp 2)Sigma(+) band of CO(+) located in the blue part of the spectrum. The red images reveal an extended dust coma. From a comparison of the red and blue images a dust reddening of 13.2 percent per 1000 A is derived. At 642 nm the magnitude of the comet with a square diaphragm of 4.5 arcsec is 16.6. The blue images, taken in the CO(+) band, show a significantly different brightness distribution which is interpreted as presence of a CO(+) coma and tail superimposed on the continuum. A column density of several 10(exp 10) CO(+) molecules cm(exp -2) is derived. The tail thickness of 10(exp 5) km is unexpectedly small. We estimate the CO(+) production rate to about 6 x 10(exp 26) CO(+) particles s(exp -1). This value does not support the idea that the outbursts of this comet are caused by crystallization of amorphous water ice

Hydrogen-Helium Mixtures in the Interiors of Giant Planets

Equilibrium properties of hydrogen-helium mixtures under conditions similar to the interior of giant gas planets are studied by means of first principle density functional molecular dynamics simulations. We investigate the molecular and atomic fluid phase of hydrogen with and without the presence of helium for densities between $\rho=0.19$ g$$cm$^{-3}$ and $\rho=0.66$ g$$cm$^{-3}$ and temperatures from $T=500$K to $T=8000 {K}$. Helium has a crucial influence on the ionic and electronic structure of the liquid. Hydrogen molecule bonds are shortened as well as strengthened which leads to more stable hydrogen molecules compared to pure hydrogen for the same thermodynamic conditions. The {\it ab initio} treatment of the mixture enables us to investigate the validity of the widely used linear mixing approximation. We find deviations of up to 8% in energy and volume from linear mixing at constant pressure in the region of molecular dissociation.Comment: 13 pages, 18 figures, submitted to PR

Ca2+-activated K+ Channels in Murine Endothelial Cells: Block by Intracellular Calcium and Magnesium

The intermediate (IKCa) and small (SKCa) conductance Ca2+-sensitive K+ channels in endothelial cells (ECs) modulate vascular diameter through regulation of EC membrane potential. However, contribution of IKCa and SKCa channels to membrane current and potential in native endothelial cells remains unclear. In freshly isolated endothelial cells from mouse aorta dialyzed with 3 μM free [Ca2+]i and 1 mM free [Mg2+]i, membrane currents reversed at the potassium equilibrium potential and exhibited an inward rectification at positive membrane potentials. Blockers of large-conductance, Ca2+-sensitive potassium (BKCa) and strong inward rectifier potassium (Kir) channels did not affect the membrane current. However, blockers of IKCa channels, charybdotoxin (ChTX), and of SKCa channels, apamin (Ap), significantly reduced the whole-cell current. Although IKCa and SKCa channels are intrinsically voltage independent, ChTX- and Ap-sensitive currents decreased steeply with membrane potential depolarization. Removal of intracellular Mg2+ significantly increased these currents. Moreover, concomitant reduction of the [Ca2+]i to 1 μM caused an additional increase in ChTX- and Ap-sensitive currents so that the currents exhibited theoretical outward rectification. Block of IKCa and SKCa channels caused a significant endothelial membrane potential depolarization (≈11 mV) and decrease in [Ca2+]i in mesenteric arteries in the absence of an agonist. These results indicate that [Ca2+]i can both activate and block IKCa and SKCa channels in endothelial cells, and that these channels regulate the resting membrane potential and intracellular calcium in native endothelium

A quantum fluid of metallic hydrogen suggested by first-principles calculations

It is generally assumed that solid hydrogen will transform into a metallic alkali-like crystal at sufficiently high pressure. However, some theoretical models have also suggested that compressed hydrogen may form an unusual two-component (protons and electrons) metallic fluid at low temperature, or possibly even a zero-temperature liquid ground state. The existence of these new states of matter is conditional on the presence of a maximum in the melting temperature versus pressure curve (the 'melt line'). Previous measurements of the hydrogen melt line up to pressures of 44 GPa have led to controversial conclusions regarding the existence of this maximum. Here we report ab initio calculations that establish the melt line up to 200 GPa. We predict that subtle changes in the intermolecular interactions lead to a decline of the melt line above 90 GPa. The implication is that as solid molecular hydrogen is compressed, it transforms into a low-temperature quantum fluid before becoming a monatomic crystal. The emerging low-temperature phase diagram of hydrogen and its isotopes bears analogies with the familiar phases of 3He and 4He, the only known zero-temperature liquids, but the long-range Coulombic interactions and the large component mass ratio present in hydrogen would ensure dramatically different propertiesComment: See related paper: cond-mat/041040

Effects of varenicline on sympatho-vagal balance and cue reactivity during smoking withdrawal: a randomised placebo-controlled trial

BACKGROUND: Varenicline is an effective smoking cessation medication. Some concern has been raised that its use may precipitate adverse cardiovascular events although no patho-physiological mechanism potentially underlying such an effect has been reported. The aim of this study was to test the hypothesis that varenicline impacts on sympatho-vagal balance during smoking withdrawal. METHODS: In this randomised, placebo-controlled trial, muscle sympathetic nerve activity (MSNA), baroreflex sensitivity (BRS), heart rate, and blood pressure were assessed in 17 smokers four weeks before a quit attempt (baseline) and again on the third day of that quit attempt (acute smoking withdrawal). RESULTS: Regarding the primary endpoint of our study, we did not find a significant effect of varenicline compared to placebo on changes in MSNA burst incidence between baseline and acute smoking withdrawal (−3.0 ± 3.3 vs.−3.9 ± 5.0 bursts/100 heart beats; p = 0.308). However, heart rate and systolic blood pressure significantly decreased in the placebo group only, while no significant changes in these parameters were observed in the varenicline group. Exposure to smoking cues during acute withdrawal lead to a significant increase of heart rate in the placebo group, while heart rate decreased in the varenicline group, and the difference in these changes was significant between groups (+2.7 ± 1.0 vs.−1.8 ± 0.5 1/min; p = 0.002). In all 17 participants combined, a significant increase in heart rate during smoking cue exposure was detected in subjects who relapsed in the course of six weeks after the quit date compared to those who stayed abstinent (+2.5 ± 1.2 vs.−1.1 ± 0.7; p = 0.018). Six-week abstinence rates were higher in the varenicline group compared to placebo (88 vs. 22 % p = 0.015). CONCLUSION: We did not find evidence of adverse effects of varenicline on sympatho-vagal balance. Varenicline probably blunts the heart rate response to smoking cues, which may be linked to improved cessation outcome

Rotation-stimulated structures in the CN and C3 comae of comet 103P/Hartley 2 around the EPOXI encounter

In late 2010 a Jupiter Family comet 103P/Hartley 2 was a subject of an intensive world-wide investigation. On UT October 20.7 the comet approached the Earth within only 0.12 AU, and on UT November 4.6 it was visited by NASA's EPOXI spacecraft. We joined this international effort and organized an observing campaign. The images of the comet were obtained through narrowband filters using the 2-m telescope of the Rozhen National Astronomical Observatory. They were taken during 4 nights around the moment of the EPOXI encounter. Image processing methods and periodicity analysis techniques were used to reveal transient coma structures and investigate their repeatability and kinematics. We observe shells, arc-, jet- and spiral-like patterns, very similar for the CN and C3 comae. The CN features expanded outwards with the sky-plane projected velocities between 0.1 to 0.3 km/s. A corkscrew structure, observed on November 6, evolved with a much higher velocity of 0.66 km/s. Photometry of the inner coma of CN shows variability with a period of 18.32+/-0.30 h (valid for the middle moment of our run, UT 2010 Nov. 5.0835), which we attribute to the nucleus rotation. This result is fully consistent with independent determinations around the same time by other teams. The pattern of repeatability is, however, not perfect, which is understendable given the suggested excitation of the rotation state, and the variability detected in CN correlates well with the cyclic changes in HCN, but only in the active phases. The revealed coma structures, along with the snapshot of the nucleus orientation obtained by EPOXI, let us estimate the spin axis orientation. We obtained RA=122 deg, Dec=+16 deg (epoch J2000.0), neglecting at this point the rotational excitation.Comment: 9 pages, 10 figures, submitted to Astron. Astrophy

Functional Coupling of Ryanodine Receptors to KCa Channels in Smooth Muscle Cells from Rat Cerebral Arteries

The relationship between Ca2+ release (“Ca2+ sparks”) through ryanodine-sensitive Ca2+ release channels in the sarcoplasmic reticulum and KCa channels was examined in smooth muscle cells from rat cerebral arteries. Whole cell potassium currents at physiological membrane potentials (−40 mV) and intracellular Ca2+ were measured simultaneously, using the perforated patch clamp technique and a laser two-dimensional (x–y) scanning confocal microscope and the fluorescent Ca2+ indicator, fluo-3. Virtually all (96%) detectable Ca2+ sparks were associated with the activation of a spontaneous transient outward current (STOC) through KCa channels. A small number of sparks (5 of 128) were associated with currents smaller than 6 pA (mean amplitude, 4.7 pA, at −40 mV). Approximately 41% of STOCs occurred without a detectable Ca2+ spark. The amplitudes of the Ca2+ sparks correlated with the amplitudes of the STOCs (regression coefficient 0.8; P < 0.05). The half time of decay of Ca2+ sparks (56 ms) was longer than the associated STOCs (9 ms). The mean amplitude of the STOCs, which were associated with Ca2+ sparks, was 33 pA at −40 mV. The mean amplitude of the “sparkless” STOCs was smaller, 16 pA. The very significant increase in KCa channel open probability (>104-fold) during a Ca2+ spark is consistent with local Ca2+ during a spark being in the order of 1–100 μM. Therefore, the increase in fractional fluorescence (F/Fo) measured during a Ca2+ spark (mean 2.04 F/Fo or ∼310 nM Ca2+) appears to significantly underestimate the local Ca2+ that activates KCa channels. These results indicate that the majority of ryanodine receptors that cause Ca2+ sparks are functionally coupled to KCa channels in the surface membrane, providing direct support for the idea that Ca2+ sparks cause STOCs