270 research outputs found
Towards black hole scattering
We study black holes in three-dimensional Chern-Simons gravity with a
negative cosmological constant. In particular, we identify how the Chern-Simons
interactions between a scattering particle and a black hole project the
particle wavefunction onto a wavefunction in the black hole background. We also
analyze the set of space-times that should be allowed in the theory and the way
in which boundary conditions affect the spectrum of space-times.Comment: 12 pages, v2: reference added, typos correcte
N=4 SYM on R x S^3 and Theories with 16 Supercharges
We study N=4 SYM on R x S^3 and theories with 16 supercharges arising as its
consistent truncations. These theories include the plane wave matrix model, N=4
SYM on R x S^2 and N=4 SYM on R x S^3/Z_k, and their gravity duals were studied
by Lin and Maldacena. We make a harmonic expansion of the original N=4 SYM on R
x S^3 and obtain each of the truncated theories by keeping a part of the
Kaluza-Klein modes. This enables us to analyze all the theories in a unified
way. We explicitly construct some nontrivial vacua of N=4 SYM on R x S^2. We
perform 1-loop analysis of the original and truncated theories. In particular,
we examine states regarded as the integrable SO(6) spin chain and a
time-dependent BPS solution, which is considered to correspond to the AdS giant
graviton in the original theory.Comment: 68 pages, 12 figures, v2,v3:typos corrected and comments added. To
appear in JHE
Testing a novel large-N reduction for N=4 super Yang-Mills theory on RxS^3
Recently a novel large-N reduction has been proposed as a maximally
supersymmetric regularization of N=4 super Yang-Mills theory on RxS^3 in the
planar limit. This proposal, if it works, will enable us to study the theory
non-perturbatively on a computer, and hence to test the AdS/CFT correspondence
analogously to the recent works on the D0-brane system. We provide a nontrivial
check of this proposal by performing explicit calculations in the large-N
reduced model, which is nothing but the so-called plane wave matrix model,
around a particular stable vacuum corresponding to RxS^3. At finite temperature
and at weak coupling, we reproduce precisely the deconfinement phase transition
in the N=4 super Yang-Mills theory on RxS^3. This phase transition is
considered to continue to the strongly coupled regime, where it corresponds to
the Hawking-Page transition on the AdS side. We also perform calculations
around other stable vacua, and reproduce the phase transition in super
Yang-Mills theory on the corresponding curved space-times such as RxS^3/Z_q and
RxS^2.Comment: 24 pages, 4 figure
Tuberculose Infantil Diagnóstico - Provas Tuberculínicas
A abordagem da Tuberculose (TB) da criança é diferente da TB do adulto em aspectos da prevenção, terapêutica e do diagnóstico. Destacam-se essas particularidades da TB infantil, sendo que o maior valor predictivo para uma decisão correcta no diagnóstico da TB da criança se apoia nas
provas tuberculínicas. Estas são decisivas tanto no diagnóstico da TB doença como na TB infecção da criança, pois ambas devem ser tratadas. O autor denuncia as condições de confusão em que se realizam e interpretam provas tuberculínicas nas unidades de saúde do SNS, sobretudo no ambulatório.
As provas tuberculínicas, quer em rastreios programados quer em rastreios ocasionais, são mal interpretadas, levando com frequência ao subdiagnóstico
e subnotificação da TB doença e de TB infecção.
O autor reafirma que a única prova segura no diagnóstico da TB infecção é a Reacção de Mantoux. Esta prova deve ser considerada um acto médico e só a médicos cabe a sua interpretação. Se este acto for delegado em outros profissionais de saúde, estas devem ter orientações precisas e
tão simples como:
Independentemente da vacinação com o BCG,
1. todo o indivíduo menor de 15 anos com uma prova de Mantoux superior ou igual a 15 mm deve ser considerado infectado pelo BK e enviado
a uma consulta de Pediatria;
2. todo o indivíduo menor de 15 anos com uma reacção de Mantoux entre 10 e 14 mm deve ser enviado à consulta do médico assistente, clínico geral ou pediatra
The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system
<p>Abstract</p> <p>Background</p> <p>Previous studies have demonstrated that intrathecal administration of the substance P amino-terminal metabolite substance P<sub>1-7 </sub>(SP<sub>1-7</sub>) and its C-terminal amidated congener induced antihyperalgesic effects in diabetic mice. In this study, we studied a small synthetic dipeptide related to SP<sub>1-7 </sub>and endomorphin-2, i.e. Phe-Phe amide, using the tail-flick test and von Frey filament test in diabetic and non-diabetic mice.</p> <p>Results</p> <p>Intrathecal treatment with the dipeptide increased the tail-flick latency in both diabetic and non-diabetic mice. This effect of Phe-Phe amide was significantly greater in diabetic mice than non-diabetic mice. The Phe-Phe amide-induced antinociceptive effect in both diabetic and non-diabetic mice was reversed by the σ<sub>1 </sub>receptor agonist (+)-pentazocine. Moreover, Phe-Phe amide attenuated mechanical allodynia in diabetic mice, which was reversible by (+)-pentazocine. The expression of spinal σ1 receptor mRNA and protein did not differ between diabetic mice and non-diabetic mice. On the other hand, the expression of phosphorylated extracellular signal-regulated protein kinase 1 (ERK1) and ERK2 proteins was enhanced in diabetic mice. (+)-Pentazocine caused phosphorylation of ERK1 and ERK2 proteins in non-diabetic mice, but not in diabetic mice.</p> <p>Conclusions</p> <p>These results suggest that the spinal σ<sub>1 </sub>receptor system might contribute to diabetic mechanical allodynia and thermal hyperalgesia, which could be potently attenuated by Phe-Phe amide.</p
Regulatory Approaches to Managing Skilled Migration: Indonesian Nurses in Japan
This article examines the Japan–Indonesia Economic Partnership Agreement, an agreement that has allowed Japan to supplement its local healthcare workforce while continuing to sidestep the thorny issue of labour and immigration policy reform and Indonesia to increase its skilled workers’ access to the Japanese labour market at a time when it was making a concerted effort to reorient migrant labour flows away from informal sector occupations. Despite the programme’s many problems, it has contributed to the use of trade agreements as a mechanism for regulating labour migration, and so to the normalisation of migrant labour as a tradable commodity rather than a discrete area of policy-making, with all the attendant risks that normalisation brings
Ab initio calculations for bromine adlayers on the Ag(100) and Au(100) surfaces: the c(2x2) structure
Ab initio total-energy density-functional methods with supercell models have
been employed to calculate the c(2x2) structure of the Br-adsorbed Ag(100) and
Au(100) surfaces. The atomic geometries of the surfaces and the preferred
bonding sites of the bromine have been determined. The bonding character of
bromine with the substrates has also been studied by analyzing the electronic
density of states and the charge transfer. The calculations show that while the
four-fold hollow-site configuration is more stable than the two-fold
bridge-site topology on the Ag(100) surface, bromine prefers the bridge site on
the Au(100) surface. The one-fold on-top configuration is the least stable
configuration on both surfaces. It is also observed that the second layer of
the Ag substrate undergoes a small buckling as a consequence of the adsorption
of Br. Our results provide a theoretical explanation for the experimental
observations that the adsorption of bromine on the Ag(100) and Au(100) surfaces
results in different bonding configurations.Comment: 10 pages, 4 figure, 5 tables, Phys. Rev. B, in pres
Late time behaviors of the expanding universe in the IIB matrix model
Recently we have studied the Lorentzian version of the IIB matrix model as a
nonperturbative formulation of superstring theory. By Monte Carlo simulation,
we have shown that the notion of time ---as well as space---emerges dynamically
from this model, and that we can uniquely extract the real-time dynamics, which
turned out to be rather surprising: after some "critical time", the SO(9)
rotational symmetry of the nine-dimensional space is spontaneously broken down
to SO(3) and the three-dimensional space starts to expand rapidly. In this
paper, we study the same model based on the classical equations of motion,
which are expected to be valid at later times. After providing a general
prescription to solve the equations, we examine a class of solutions, which
correspond to manifestly commutative space. In particular, we find a solution
with an expanding behavior that naturally solves the cosmological constant
problem.Comment: 25 pages, 3 figure
Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with an unknown molecular pathogenesis. A recent molecular focus has been the mutated neuroligin 3, neuroligin 3(R451C), in gain-of-function studies and for its role in induced impairment of synaptic function, but endoplasmic reticulum (ER) stress induced by mutated molecules also deserves investigation. We previously found two missense mutations, H246N and Y251S, in the gene-encoding synaptic cell adhesion molecule-1 (CADM1) in ASD patients, including cleavage of the mutated CADM1 and its intracellular accumulation. In this study, we found that the mutated CADM1 showed slightly reduced homophilic interactions in vitro but that most of its interactions persist. The mutated CADM1 also showed morphological abnormalities, including shorter dendrites, and impaired synaptogenesis in neurons. Wild-type CADM1 was partly localized to the ER of C2C5 cells, whereas mutated CADM1 mainly accumulated in the ER despite different sensitivities toward 4-phenyl butyric acid with chemical chaperone activity and rapamycin with promotion activity for degradation of the aggregated protein. Modeling analysis suggested a direct relationship between the mutations and the conformation alteration. Both mutated CADM1 and neuroligin 3(R451C) induced upregulation of C/EBP-homologous protein (CHOP), an ER stress marker, suggesting that in addition to the trafficking impairment, this CHOP upregulation may also be involved in ASD pathogenesis
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