Dietary Acrylamide Intake during Pregnancy and Fetal Growth—Results from the Norwegian Mother and Child Cohort Study (MoBa)

Background: Acrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures. Because it is widespread in food and can pass through the human placenta, concerns have been raised about potential developmental effects of dietary exposures in humans

Resonant Structure of τ→3ππ0ντ\tau\to 3\pi\pi^{0}\nu_{\tau} and τ→ωπντ\tau\to \omega\pi\nu_{\tau} Decays

The resonant structure of the four pion final state in the decay $\tau \to 3\pi\pi^0\nu_\tau$ is analyzed using 4.27 million $\tau^+\tau^-$ pairs collected by the CLEO II experiment. We search for second class currents in the decay $\tau \to \omega\pi\nu_\tau$ using spin-parity analysis and establish an upper limit on the non-vector current contribution. The mass and width of the $\rho'$ resonance are extracted from a fit to the $\tau \to \omega\pi\nu_\tau$ spectral function. A partial wave analysis of the resonant structure of the $\tau \to 3\pi\pi^0\nu_\tau$ decay is performed; the spectral decomposition of the four pion system is dominated by the $\omega\pi$ and $a_1 \pi$ final states.Comment: 34 pages postscript, also available through http://w4.lns.cornell.edu/public/CLN

Hadronic Structure in the Decay τ−→ντπ−π0π0\tau^{-}\to \nu_{\tau}\pi^{-}\pi^{0}\pi^{0} and the Sign of the Tau Neutrino Helicity

Based on a sample corresponding to 4.3 million produced tau-pair events, we have studied hadronic dynamics in the decay tau- --> nu_tau pi- pi0 pi0 in data recorded by the CLEO II detector operating at the CESR e+e- collider. The decay is dominated by the process tau --> nu_tau a_1(1260), with the a_1 meson decaying to three pions predominantly via the lowest dimensional (mainly S-wave) a_1 --> rho pi Born amplitude. From fits to the Dalitz plot and angular observables, we find significant additional contributions from amplitudes for a_1 decay to sigma pi, f_0(1370) pi and f_2(1270) pi, as well as higher dimensional a_1 --> rho pi and rho' pi amplitudes. The squared sigma pi amplitude accounts for ~15% of the total tau- --> nu_tau pi- pi0 pi0 rate in the models considered. We have searched for additional contributions from tau --> nu_tau pi'(1300). We place 90% confidence level upper limits on the branching fraction for this channel of between 1.0*10^{-4} and 1.9*10^{-4}, depending on the pi' decay mode. The pi- pi0 pi0 mass spectrum is parametrized by a Breit-Wigner form with a mass-dependent width which is specified according to the results of the Dalitz plot fits plus a coupling to an a_1 --> K* K amplitude. From a chi^2 fit, we extract the pole mass and width of the a_1, as well as the magnitude of the K* K coupling. We have also investigated the impact of a possible contribution from the a_1'(1700) meson on this spectrum. Finally, exploiting the parity-violating angular asymmetry in a_1 --> 3pi decay, we determine the signed value of the tau neutrino helicity to be h_{\nu_\tau} = -1.02 +- 0.13(stat.) +- 0.03(syst.+model), confirming the left-handedness of the tau neutrino.Comment: 44 pages, postscript file also available through http://w4.lns.cornell.edu/public/CLN

Coulomb dissociation of 16O into 4He and 12C

We measured the Coulomb dissociation of 16O into 4He and 12C at the R3B setup in a first campaign within FAIR Phase 0 at GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt. The goal was to improve the accuracy of the experimental data for the 12C(a,?)16O fusion reaction and to reach lower center-ofmass energies than measured so far. The experiment required beam intensities of 109 16O ions per second at an energy of 500 MeV/nucleon. The rare case of Coulomb breakup into 12C and 4He posed another challenge: The magnetic rigidities of the particles are so close because of the same mass-To-charge-number ratio A/Z = 2 for 16O, 12C and 4He. Hence, radical changes of the R3B setup were necessary. All detectors had slits to allow the passage of the unreacted 16O ions, while 4He and 12C would hit the detectors' active areas depending on the scattering angle and their relative energies. We developed and built detectors based on organic scintillators to track and identify the reaction products with sufficient precision

Tilted Foils Nuclear Spin Polarization and Measurement with Coulomb Excitation

Developing new experimental tools is essential to expand the possibilities of probing the structure of atomic nuclei. The better the currently known properties of nuclei can be manipulated, the more information can be extracted from data collected in nuclear reaction experiments. One property that has been controlled for many years is the nuclear spin, but this has only been viable for a certain set of isotopes with restrictions on for example specific atomic excitation schemes or half-lives. This thesis will provide details on an evaluation project using thin tilted foils after the REX-ISOLDE linac at the CERN-ISOLDE experimental facility, to polarize the spin of nuclei in-flight. The nuclear polarization is then measured with a technique based on Coulomb excitation, which is a flexible and readily available experimental method at ISOLDE with the MINIBALL spectrometer. The tilted foils technique may be beneficial to polarize the nuclear spin of short-lived radioactive beams that can be difficult by other means. The only restrictions on the accelerated ions known so far to produce polarization with tilted foils are non-zero nuclear and atomic spin. The $\beta$-NMR is an alternative, more common technique for measuring nuclear spin polarization. No such setup connected to REX-ISOLDE existed at the start of the project which prompted for the Coulomb excitation method with MINIBALL. Although, a $\beta$-NMR setup is currently under construction and testing

Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes

Insulin receptor substrate-1 (IRS-1) is tyrosine-phosphorylated in response to insulin resulting in association with and activation of phosphatidylinositol 3-kinase (PI 3-kinase), thereby initiating some of the effects of insulin. We have recently shown that the insulin-like effects of growth hormone (GH) in adipocytes can be inhibited by the selective PI 3-kinase inhibitor wortmannin (Ridderstrale, M., and Tornqvist, H. (1994) Biochem. Biophys. Res. Commun. 203, 306-310), suggesting a similar role for PI 3-kinase in GH action. Here we show that IRS-1 is tyrosine-phosphorylated in a time- and dose-dependent manner in response to GH in primary rat adipocytes. This phosphorylation coincided with the extent of interaction between IRS-1 and the 85-kDa subunit of PI 3-kinase as evidenced by coimmunoprecipitation. Stimulation with 23 nM GH increased the PI 3-kinase activity associated with IRS1 4-fold. Our data suggest that GH-induced tyrosine phosphorylation of IRS-1 and the subsequent docking of PI 3-kinase are important postreceptor events in GH action. The mechanism for the phosphorylation of IRS-1 induced by GH is unknown, but involvement of JAK2, the only known GH receptor-associated tyrosine kinase, seems possible