Poloxamers for Surface Modification of Hydrophobic Drug Carriers and Their Effects on Drug Delivery

Tri-block copolymer poloxamers are successfully employed for reducing adsorption of proteinous molecules onto hydrophobic surfaces, which will protect them from quick engulfing by macrophages. For sustained systemic circulation of hydrophobic drug carriers, particle surfaces need suitable modification for avoiding phagocytosis and this can be successfully done by poloxamers. They can affect the drug release profile, which makes them a very promising agent for targeted delivery. This review discusses the structure, characteristics and advantages of poloxamers. Poloxamer adsorption onto hydrophobic surfaces and adlayer thickness, relative phagocytic uptake and drug release profiles of coated drug loaded particles have been described in detail

On the existence of the generalized Gauss composition of means

The paper deals with the generalized Gauss composition of arbitrary means. We give sufficient conditions for the existence of this generalized Gauss composition. Finally, we show that these conditions cannot be improved or changed. Keywords: means, power means, Gauss composition of means, Archimedean composition of mean

On very porosity and spaces of generalized uniformly distributed sequences.

In the paper the porosity structure of sets of generalized uniformly distributed sequences is investigated in the Baire's space