EXERCÍCIO FÍSICO E Diabetes mellitus TIPO 2

Um estilo de vida sedentrio deve ser considerado um importante fator de risco capaz de ser modificado para indivduos com diabetes mellitus (DM) tipo 2, j que atividade fsica regular oferece mltiplos benefcios que incluem melhora da sensibilidade insulina e do controle glicmico, aumento do condicionamento cardiorespiratrio e reduo do risco de mortalidade cardiovascular. Entretanto, o estabelecimento de programas de treinamentos e de guias prticos para o manejo adequado na diabetes tipo 2 no tm sido sugeridos num consenso nico. Dessa forma, o presente estudo selecionou publicaes realizadas a partir de dados Pubmed, objetivando discutir informaes que esto sendo descritas na literatura de forma a reforar bases que representem uma resposta adaptativa s demandas do treinamento, apoiando uma positiva funo da atividade fsica no cuidado da diabetes tipo 2

Programa Justicia SÍ, Un Modelo de Gestión para la Reestructuración del Poder Judicial del Ecuador basado en Tecnología de la Información e Inclusión Social

Justicia Sí es un programa de reestructuración destinado a conseguir una mayor inclusión social y transparencia de los procedimientos judiciales, reforzando los principios democráticos de la República del Ecuador para garantizar la justicia a todos los ciudadanos mediante los más avanzados mecanismos de tecnología de la información y de la gestión de proyectos. Actualmente, el sistema judicial de Ecuador está poco informatizado, los procesos son físicos y de difícil gestión, perjudicando la elaboración de los indicadores de eficiencia de la gestión y del trabajo de los jueces. Además, se crea una sensación de inseguridad en el ciudadano al no tener el conocimiento sobre lo que ocurre en el sector judicial. Por lo tanto, este programa se estructuró en tres ejes principales: Transformación de Recursos Humanos, Desmaterialización y Sistematización de la Justicia y Nueva infraestructura Predial y TICS para la Justicia. El enfoque principal de este trabajo es la sistematización y la desmaterialización de la justicia con el uso de las TICS. Para la ejecución del Programa Justicia Sí se contará con una coordinación que gerencia todos sus proyectos e iniciativas de forma integrada para implementar las mejores prácticas para el desarrollo y entrenamiento de todos los jueces y funcionarios del poder Judicial de Ecuador, incluidos los abogados y ciudadanos que son usuarios del sistema judicial.Sociedad Argentina de Informática e Investigación Operativ

Impact of Resistance to Fluconazole on Virulence and Morphological Aspects of Cryptococcus neoformans and Cryptococcus gattii Isolates

Cryptococcus spp. are responsible for around one million cases of meningitis every year. Fluconazole (FLU) is commonly used in the treatment of cryptococcosis, mainly in immunocompromised patients and the resistance is usually reported after long periods of treatment. In this study, the morphological characterization and virulence profile of FLU-susceptible and FLU-resistant clinical and environmental isolates of C. neoformans and C. gattii were performed both in vitro and in vivo using the Galleria mellonella model. FLU-susceptible isolates from C. neoformans were significantly more virulent than the FLU-resistant isolates. FLU-susceptible C. gattii isolates showed a different virulence profile from C. neoformans isolates where only the environmental isolate, CL, was more virulent compared with the resistant isolates. Cell morphology and capsule size were analyzed and the FLU-resistant isolates did not change significantly compared with the most sensitive isolates. Growth at 37°C was also evaluated and in both species, the resistant isolates showed a reduced growth at this temperature, indicating that FLU resistance can affect their growth. Based on the results obtained is possible suggest that FLU resistance can influence the morphology of the isolates and consequently changed the virulence profiles. The most evident results were observed for C. neoformans showing that the adaptation of isolates to antifungal selective pressure influenced the loss of virulence

Epiisopilosine alkaloid has activity against schistosoma mansoni in mice without acute toxicity

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPSchistosomiasis is a disease caused by parasites of the genus Schistosoma, currently affecting more than 200 million people. Among the various species of this parasite that infect humans, S. mansoni is the most common. Pharmacological treatment is limited135119CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP404134/2012-22014/02282-76, 2016/18023-5, 2016/22488-3The authors are grateful to Phytobios Pesquisa Desenvolvimento e Inovação LTDA.,company of the Centroflora Group, for its support during the realization of this research. SMA is grateful to Conselho Nacional de Desenvolvimento Científico e Tecnológico

Sandpiles with height restrictions

We study stochastic sandpile models with a height restriction in one and two dimensions. A site can topple if it has a height of two, as in Manna's model, but, in contrast to previously studied sandpiles, here the height (or number of particles per site), cannot exceed two. This yields a considerable simplification over the unrestricted case, in which the number of states per site is unbounded. Two toppling rules are considered: in one, the particles are redistributed independently, while the other involves some cooperativity. We study the fixed-energy system (no input or loss of particles) using cluster approximations and extensive simulations, and find that it exhibits a continuous phase transition to an absorbing state at a critical value zeta_c of the particle density. The critical exponents agree with those of the unrestricted Manna sandpile.Comment: 10 pages, 14 figure

Proanthocyanidin Polymer-Rich Fraction of Stryphnodendron adstringens Promotes in Vitro and in Vivo Cancer Cell Death via Oxidative Stress

Cervical cancer is the fourth most common cancer that affects women, mainly through human papilloma virus (HPV) infection with high-risk HPV16 and HPV18. The present study investigated the in vitro anticancer activity and mechanism of action of a proanthocyanidin polymer-rich fraction of Stryphnodendron adstringens (F2) in cervical cancer cell lines, including HeLa (HPV18-positive), SiHa (HPV16-positive), and C33A (HPV-negative) cells, and also evaluated in vivo anticancer activity. In vitro, cell viability was determined by the MTT assay. Cell migration was determined by the wound healing assay. The mechanism of action was investigated by performing ultrastructural analysis and evaluating reactive oxygen species (ROS) production, mitochondrial metabolism, lipoperoxidation, BCL-2 family expression, caspase expression, and DNA and cell membrane integrity. In vivo activity was evaluated using the murine Ehrlich solid tumor model. F2 time- and dose-dependently reduced cell viability and significantly inhibited the migration of cervical cancer cells. HeLa and SiHa cells treated with F2 (IC50) exhibited intense oxidative stress (i.e., increase in ROS and decrease in antioxidant species) and mitochondrial damage (i.e., mitochondrial membrane potential depolarization and a reduction of intracellular levels of adenosine triphosphate). Increases in the Bax/BCL-2 ratio and caspase 9 and caspase 3 expression, were observed, with DNA damage that was sufficient to trigger mitochondria-dependent apoptosis. Cell membrane disruption was observed in C33A cells (IC50 and IC90) and HeLa and SiHa cells (IC90), indicating progress to late apoptosis/necrosis. The inhibition of ROS production by N-acetylcysteine significantly suppressed oxidative stress in all three cell lines. In vivo, F2 significantly reduced tumor volume and weight of the Ehrlich solid tumor, and significantly increased lipoperoxidation, indicating that F2 also induces oxidative stress in the in vivo model. These findings indicate that the proanthocyanidin polymer-rich fraction of S. adstringens may be a potential chemotherapeutic candidate for cancer treatment

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

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