Improve the Onion Routing Performance and Security with Cryptographic Algorithms

Onion Routing and Cryptographic Algorithms are two essential components of online privacy and secure data transmission. Onion Routing is a technique used to protect internet users' anonymity by routing their communication through a network of servers, while Cryptographic Algorithms are used to encrypt and decrypt data to ensure its confidentiality. As technology advances, there is a need to consider the development of new cryptographic algorithms for TOR to ensure its continued effectiveness. The combination of Onion Routing and Cryptographic Algorithms has proven to be an effective way to protect online privacy and security. This paper aims to explore the benefits of combining Onion Routing and Cryptographic Algorithms and to propose a hybrid symmetric and hashing algorithm technique to transmit data securely. By the end of this paper, researchers will have a comprehensive understanding of the Onion Routing and Cryptographic Algorithms, their implementation in TOR, and the limitations and risks associated with using such tools

Lichens: a novel and potential source as antimicrobials for human use

The use of lichens in medicine is based on the fact that they contain unique and varied biologically active substances, as antimicrobials.  Since they are natural antibiotics, their metabolites exert a wide variety of biological actions including antimycotic, antiviral, anti-inflammatory, analgesic, antipyretic, antiproliferative, and cytotoxic effects, they are considered as potential drugs. They contain a variety of secondary metabolites with strong antioxidant activity. These are substances which have high ability to scavenge toxic free radicals due their phenolic groups. These manifold activities of lichen metabolites have now been recognized, and therefore their therapeutic potential have great impact in pharma industries. The present article discusses the importance of lichens in inhibiting various types of human pathogens in addition to their chemical composition and pharmacological activities

Phytochemical screening and antimicrobial activity of Capsicum chinense Jacq.

The present study investigated on the comparative evaluation of the extraction, quantification, phytochemical and antimicrobial activity of Capsaicin from acetone and acetonitrile extracts of Capsicum chinense Jacq. The polar aprotic solvent extracts showed high amount of Capsaicin with pungency level of 1,529,500 Scoville Heat Units. The Thin layer chromatography method is providing a fingerprint of plant extract. The Capsaicin extracted in the solvents on TLC chromatogram was viewed under UV 254 nm and UV 366 nm and documented. The extraction and estimation of chlorophyll and Carotenoids were also performed for the plant sample following standard procedure. Phytochemical analysis shows that acetone and acetonitrile extract of callus, leaf, shoot, fruit and seed which shows abundant presence of alkaloids, flavonoids, phenols, saphonins etc. The acetone and acetonitrile extract showed maximum zone of inhibition of Klebsiella pneumonia and Staphylococcus aureus against the gram positive and gram negative bacteria respectively through agar well diffusion method. The acetone and acetonitrile extract was found to be more effective at different concentration against all the tested bacteria and fungi. The results revealed that the Capsaicin and other secondary metabolites present in the acetone and acetonitrile extract of Capsicum chinense would contribute for the further extraction and purification of capsaicin as an antimicrobial agent

A REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM: A NOVEL TOOL FOR IMPROVING BIOAVAILABILITY

Among all the dosages, oral is the best route of administration for its advantages but due to flow of its demerits like poor bioavailability due to first pass metabolism and unpredictable nature of gastrointestinal absorption. Moreover, oral route is cost prohibitive and inconvenient. Transdermal patches are medicated adhesive patches when it was placed on the skin layer it will deliver the drug into the blood stream through skin layer. To overcome the side effects caused by the oral route, drugs given through transdermal are preferred as transdermal patch. By employing sustained release polymers, transdermal patches can be prepared using solvent casting method. Drug excipients compatibility studies are very important to determine whether the excipients are suitable for that drug or not. These compatibility studies are very important to maintain the stability of dosage form. Evaluation studies are very important to determine the accuracy of dosage form at the same time therapeutic action also. Some of the parameters such as weight variation, physical appearance, drug content, moisture uptake, folding, endurance, swelling study and physical appearance, in vitro dissolution studies, ex vivo studies, and in vivo studies were evaluated

An interesting case of Phocomelia

Authors present a very rare case of tetra-phocomelia evaluated by antenatal ultrasonography. It is a condition seen in 0.62 per 100,000 live births. This is a congenital chromosomal abnormality involving the musculoskeletal system. Primi gravida with spontaneous conception after a long period of infertility underwent early anomaly scan. Patient was not aware of the last menstrual period hence; NT scan was missed. Routine early anomaly scan done between 16-18 weeks of pregnancy diagnosed a fetus with Tetra-Phocomelia. Due to the lack of associated symptoms or significant history, our case did not fit into any specific syndrome and appears to be the result of a sporadic, non-hereditary limb deficiency involving all four limb buds.  Second opinion obtained from a fetal medicine consultant who confirmed the diagnosis. Hence, decided for mid trimester termination and fetus was expelled after 8 hours. Fetus was not sent for pathological analysis. Tetra-phocomelia is a rare congenital anomaly and it may be associated with other deformity also. 1st case of phocomelia was described after the intake of thalidomide. In this condition hands and feet are seen as small flippers of a seal. The differential diagnosis includes sporadic phocomelia, Holt-Oram syndrome, thrombocytopenia-absent radius syndrome (TAR syndrome), Robert’s syndrome, and thalidomide-induced phocomelia. Here authors are presenting a rare case of Phocomelia where there is no history of drug intake or family history. This has to differentiate from thrombocytopenia-absent radius syndrome (TAR syndrome), sporadic phocomelia, Holt-Oram syndrome, Robert’s syndrome, and thalidomide-induced phocomelia

Coverage Issues in Wireless Ad-Hoc Sensor Networks

Wireless Ad-Hoc sensor networks have a broad range of applications in the military,vigilance, environment monitoring, and healthcare fields. Coverage of the sensor networks describes how well an area is monitored. The coverage problem has been studied extensively, especially when combined with connectivity and well-organized. Coverage is a typical problem in the wireless sensor networks to fulfil issued sensing tasks. In general, sensing analysis represents how well an area is monitored by sensors. The quality of the sensor network can be reflected by levels of coverage and connectivity that it offers. The coverage issues have been studied extensively, especially when combined with connectivity and energy efficiency. Constructing a connected fully covered, and energy efficient sensor network is valuable for real world applications due to limited resources of sensor nodes. The survey recent contributions addressing energy efficient coverage problems in the context of static WASNs, networks in which sensor nodes do not move once they are deployed and present in some detail of the algorithms, assumptions, and results. A comprehensive comparison among these approaches is given from perspective of design objectives, assumptions, algorithm attributes and related results

Standardization of the method for estimation of ethambutol in pharmaceutical preparations and biological fluid

A simple column chromatographic method for determination of ethambutol (EMB) in pharmaceutical preparations containing EMB in combination with other anti-TB drugs is presented. The method involved extraction of EMB into an organic solvent. followed by basification and column chromatographic separation on Amberlite CG 50 (100-200 mesh) and elution with suitable eluants and estimation at a wavelength of 270 nm. The assay was linear from 25 to 400 μg/ml. The relative standard deviations of intra and inter day assays were lower than 5%. Ethambutol was recovered from human urine quantitatively and stable for a period of atleast one week in urine stored at-20°C

Piperine Modulates High Fat Diet - Induced Renal Damage by Regulating Kim-1 and Igf-1 Beta Signaling Molecules in Male Wistar Rats

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia and other symptoms which ultimately cause various other complications like retinopathy , micro angioplasty and nephropathy . piperine shows antidiabetic activity by improving insulin level, signifying its usage in the management of hyperglycemia. IGF-1 is the insulin-like growth factor receptor . KIM-1 has proved to be an outstanding early indicator of kidney injury in the rats. Induction of type 2 diabetes to male wistar albino rats , they were divided into four groups , one group were treated with piperine , fasting blood glucose was analysed. Biochemical analysis and mRNA expression analysis of KIM-1 and IGF-1 by RT-PCR is done. Fasting blood glucose and the serum insulin was elevated in diabetes induced rats . piperine-treated animals exhibited a significant decrease in the level of FBG and serum insulin from the above study, it could show that piperine possesses antidiabetic activity