The complexity of the living entity - a new paradigm

The authors of this paper consider themselves as adepts of Adler’s theory sustaining the idea that human beings cannot authentically progress outside the acknowledgement of their feelings and interconnectedness for living and work activities as parts of the whole society. Following this point of view, the achievement of all necessities of life, inside the society, is a systemic process of consciousness supposing the freedom as an assumed responsibility. From this perspective, the humanity should switch from the knowledge based society’s concepts to those of the application of assumed responsibility where scientific knowledge becomes a must to knowing and evaluating the whole living soundness at any level (individuals, family, official entities and authorities, communities, environment). We will use the term of network effect generated by the communication for the whole living of the national academic society facing deep challenges and transformations. This way we intend to promote the re-spiritualization of the education under a national program, so that the durable change be produced and proved, from the inside to the outside of our daily societal life . Working on a model to set up a new way to measuring the soundness of any whole living, we are applying the model to determine the soundness of an university; to understand the evolution of the whole it is necessary to study the evolution and reaction of its components.peer-reviewe

Comparison of Three-Dimensional Speckle Tracking Echocardiography and Two-Dimensional Echocardiography for Evaluation of Left Atrial Size and Function in Healthy Volunteers (Results from the MAGYAR-Healthy Study)

This thesis explores the possibilities of constructing an indoor positioning system based on Bluetooth Smart technology. Two non-trainable trilateration approaches and two trainable fingerprinting were implemented and evaluated at Mobiento's offices in Stockholm, Sweden. A trilateration approach is based on finding a sought location based on known distances towards know locations, at least three locations and distances are needed. A fingerprinting approach is based on creating a radio map, which describes transmission signals within the room, towards different transmitters. A set amount of coordinates are assigned a fingerprint. These are then used as reference points for a sought location. For each major approach, trilateration and fingerprinting, a weighted approach is conducted. These approaches are evaluated in a disturbance free environment in term of accuracy, implementation and setup. In terms of accuracy, the non-weighted fingerprinting approach performs slightly better than the weighted fingerprinting approaches. Both of these are more accurate than the trilateration approaches. When it comes to implementation and setup, the trilateration algorithms impose less cost. These allow for better scalability when the indoor environment becomes larger.

Neglected Basal Cell Carcinomas in the 21st Century

Although tumors on the surface of the skin are considered to be easily recognizable, neglected advanced skin neoplasms are encountered even in the 21st century. There can be numerous causes of the delay in the diagnosis: fear of the diagnosis and the treatment, becoming accustomed to a slowly growing tumor, old age, a low social milieu, and an inadequate hygienic culture are among the factors leading some people not to seek medical advice. The treatment of such advanced neoplasms is usually challenging. The therapy of neglected cases demands an individual multidisciplinary approach and teamwork. Basal cell carcinoma (BCC), the most common cutaneous tumor, usually develops in the elderly, grows slowly, and has an extremely low metastatic potential; these factors are suggesting that BCCs might well be the “ideal candidates” for neglected tumors. Five neglected advanced cases of BCC were diagnosed in our dermatological institute between 2000 and 2009. The clinical characteristics and treatment modalities of these neoplasms are discussed, together with the possible causes of the neglect

Spreading depolarization causes reperfusion failure after cerebral ischemia

Despite successful recanalization, reperfusion failure associated with poor neurological outcomes develops in half of treated stroke patients. We explore here whether spreading depolarization (SD) is a predictor of reperfusion failure. Global forebrain ischemia/reperfusion was induced in male and female C57BL/6 mice (n = 57). SD and cerebral blood flow (CBF) changes were visualized with transcranial intrinsic optical signal and laser speckle contrast imaging. To block SD, MK801 was applied (n = 26). Neurological deficit, circle of Willis (CoW) anatomy and neuronal injury were evaluated 24 hours later. SD emerged after ischemia onset in one or both hemispheres under a perfusion threshold (CBF drop to 21.1 ± 4.6 vs. 33.6 ± 4.4%, SD vs. no SD). The failure of later reperfusion (44.4 ± 12.5%) was invariably linked to previous SD. In contrast, reperfusion was adequate (98.9 ± 7.4%) in hemispheres devoid of SD. Absence of the P1 segment of the posterior cerebral artery in the CoW favored SD occurrence and reperfusion failure. SD occurrence and reperfusion failure were associated with poor neurologic function, and neuronal necrosis 24 hours after ischemia. The inhibition of SD significantly improved reperfusion. SD occurrence during ischemia impairs later reperfusion, prognosticating poor neurological outcomes. The increased likelihood of SD occurrence is predicted by inadequate collaterals