Antidiabetic Activity of Calcium Bentonite in Alloxan Monohydrate-induced Diabetic Wistar Rat Models

Background: Calcium bentonite is a natural clay that has the ability to absorb toxins and metabolite excess substances and often referred to as healing clay because it is used traditionally. This study aimed to determine the ability of local calcium bentonite to absorp high blood glucose..Methods: This study was an experimental study using 20 female Wistar rats and divided into two groups consisting of Group I (control group, n=10) and Group II (calcium bentonite group, n=10). Diabetes in rats was induced by alloxan monohydrate 150 mg/kg body weight intraperitoneally. Examination of blood glucose was performed three times; in the beginning of study, 72 hours after alloxan monohydrate induction, and four days after the given interventions. Blood glucose levels in mean values were analyzed using t-independent test. Statistically significance was considered when p<0.05.Results: Oral calcium bentonite of 1g/kg body weight significantly lowered blood glucose level relatively to the control group with average value of 131.30 mg/dl (p=0.01).Conclusions: Calcium bentonite significantly lowers blood glucose levels. DOI: 10.15850/amj.v2n3.56

Rancang Bangun Aplikasi Psikotalk Berbasis Android

Advances in technology are currently happening in almost all aspects of life. Now all the desired information can be obtained using smartphone media. This is because the function of the smartphone can be used anywhere and anytime. One of the supporting factors is its relatively small size and easy to carry anywhere so that it makes it easy for users to find information. Advances and developments in this technology will certainly make it easier to present information, one of which is in the field of mental health. This study aims to design and build an android-based consulting application that connects psychologists with clients to conduct consultations in real time. This application presents a list of psychologists that can be selected according to the topic of consultation and clients can process payments and schedule consultations with psychologists through this application. This application can also provide information about the world of mental health through the information page provided. The results of this study are in the form of an android-based consulting application that can be used by psychology clients to conduct consultations with psychologists in real time through smartphone media

Association between Exclusive Breastfeeding and Child Development

Background: Child development highly correlates with child’s quality. The fastest child development period is during the first three years, also called golden period. This research was aimed to discover correlation between exclussive breastfeeding and child development in Cipacing Village Jatinangor, district of Sumedang.Methods: This research was conducted using cross-sectional method in thirteen Pos Pelayanan Terpadu (Posyandu) Cipacing Village in Jatinangor. One hundred and two children aged 12−24 months with their caregiver were recruited as respondents by using cluster sampling method. Hist ory of exclusive breastfeeding was assessed with questionnaire while child development status was assesed with Kuesioner Pra Skrining Perkembangan (KPSP) in September 2013 after informed consent was obtained. Chi-square test analysis was performed to determine correlation between exclusive breastfeeding and child development status.Results: Overall, children in Cipacing Village had non-exclusive breastfeeding history (83.3%), and only 16.7% respondents had exclusive breastfeeding history. Meanwhile, 89.2% of children had normal development status, and 10.8% had delayed development status. Statistic analysis using chi-square test in the level of 95% confidence between exclusive breastfeeding and child development showed p=0.686 and odds ratio 2.133.Conclusions: There is no significant relationship between history of exclusive breastfeeding and child development status. [AMJ.2016;3(1):79–84] DOI: 10.15850/amj.v3n1.72

Antidiabetic Activity of Calcium Bentonite in Alloxan Monohydrate-induced Diabetic Wistar Rat Models

Background: Calcium bentonite is a natural clay that has the ability to absorb toxins and metabolite excess substances and often referred to as healing clay because it is used traditionally. This study aimed to determine the ability of local calcium bentonite to absorp high blood glucose..Methods: This study was an experimental study using 20 female Wistar rats and divided into two groups consisting of Group I (control group, n=10) and Group II (calcium bentonite group, n=10). Diabetes in rats was induced by alloxan monohydrate 150 mg/kg body weight intraperitoneally. Examination of blood glucose was performed three times; in the beginning of study, 72 hours after alloxan monohydrate induction, and four days after the given interventions. Blood glucose levels in mean values were analyzed using t-independent test. Statistically significance was considered when p<0.05.Results: Oral calcium bentonite of 1g/kg body weight significantly lowered blood glucose level relatively to the control group with average value of 131.30 mg/dl (p=0.01).Conclusions: Calcium bentonite significantly lowers blood glucose levels. DOI: 10.15850/amj.v2n3.56

Analisis Kemampuan Pemahaman dan Kemampuan Komunikasi Matematis Siswa SMP Pada Materi Relasi dan Fungsi

Kemampuan siswa diukur dari pemahaman siswa terhadap materi yang diajarkanoleh guru, siswa dapat mengerjakan soal/menjawab soal-soal tergantung dari seberapa besar kemampuan siswa memahami materi tersebut, jika siswa mengisi soal yang diberikan masih kurang tepat bahkan salah, itu artinya pemahaman dan kemampuan komunikasi siswa masih kurang. Analisis yang saya lakukan adalah mamahami manfaat dari kemampuan pemahaman serta kemampuan komunikasi matematis siswa pada materi relasi dan fungsi. Penelitian ini dilakukan di SMP Negeri 1 Margaasih, pada semester ganjil tahun ajaran 2018/2019 di kota Bandung, populasi dari kegiatana adalah semua peserta didik kelas VIII dengan jumlah sampel 30 siwa. Instrument penelitian berupa soal tes kemampuan dari pemahaman dan komunkasi matematis, metode yang digunakan yaitu penelitian kualitatif. Sedangkan untuk penilaiannya dilakukan secara reduksi, penyajian data dan kesimpulan. Dari hasil analisis yang diperoleh maka dapat disimpulkan bahwa siswa masih sulit mengisi soal dari kemampuan pemahaman dan komunikasi matematis

Olahraga Rutin Untuk Meningkatkan Imunitas Pasien Hipertensi Selama Masa Pandemi COVID-19

Hipertensi merupakan salah satu komorbid yang paling banyak ditemukan pada Coronavirus disease-19 (COVID-19) dan berasosiasi dengan prognostik buruk dari infeksi tersebut. Olahraga rutin ternyata dapat meningkatkan imunitas tubuh, sehingga dapat berperan dalam pencegahan infeksi COVID-19 selain efeknya terhadap penurunan tekanan darah. Olahraga tipe aerobik dengan intensitas sedang 30-60 menit, dengan cara tetap melakukan pembatasan jarak, ataupun dengan teknik home exercise dan virtual dengan daring, dapat dilakukan oleh penderita hipertensi dalam meningkatkan imunitas selama masa pandemi &nbsp;COVID-19

Effect of Dietary Sodium on α, β, and γ Epithelial Sodium Channel (ENaC) Gene Expression in Kidney Tubules of Wistar Rats

Hypertension is a condition of persistently high blood pressure. It is currently a big health issue as its prevalence is high in Indonesia and its complications are numerous and deadly. Salt intake is one of the modifiable factors of hypertension. According to a study by Indonesian Ministry of Health, salt consumption in Indonesia is almost two times greater than the recommended salt diet from WHO. Sodium reabsorption in kidney plays a role in regulating blood pressure. Epithelial sodium channel (ENaC) is one of the structures that function in sodium reabsorption in kidney tubules. This study was conducted at the Central Laboratory and Animal Laboratory of the Faculty of Medicine Universitas Padjadjaran from June to Desember 2018. The aim of this study was to analyze the effect of high sodium diet on the expression of ENaC gene in kidney tubules of rats. Twelve Rattus norvegicus wistar rats were divided into two groups of control and treatment. Treatment group was given daily 2 mL NaCl solution treatment using gavage for 8 weeks. The expression of ENaC α, β, and γ was obtained by running tissue samples from kidney cortex and medulla in polymerase chain reaction and electrophoresis. The result showed that there was an insignificant decrease in ENaC α, β, and γ gene expressions in both kidney cortex and medulla of the treatment group when compared to control groupThis study concludes that ENaC gene expression is not significantly affected by high sodium diet.Pengaruh Diet Tinggi Natrium terhadap Perubahan Ekspresi Gen Epithelial Sodium Channel (ENaC) pada Tubulus Ginjal TikusHipertensi merupakan kondisi tekanan darah tinggi dalam waktu lama. Prevalensi dan komplikasi hipertensi menyebabkan hipertensi menjadi isu kesehatan yang cukup besar. Jumlah asupan garam merupakan faktor hipertensi yang dapat dimodifikasi. Berdasar studi Kementrian Kesehatan Indonesia, konsumsi garam di Indonesia rerata dua kali lipat lebih banyak daripada rekomendasi WHO. Reabsorpsi natrium pada ginjal berperan penting pada regulasi tekanan darah. Fungsi ini diperankan oleh epithelial sodium channel (ENaC) yang berfungsi untuk reabsorpsi natrium. Penelitian ini dilakukan di Laboratorium Sentral dan Laboratorium Hewan Fakultas Kedokteran pada Juni–Desember 2018. Tujuan penelitian ini menganalisis efek diet tinggi natrium pada ekspresi gen dari ENaC di tubulus ginjal pada tikus. Duabelas ekor tikus Rattus norvegicus dibagi menjadi dua kelompok, yaitu kontrol dan perlakuan. Kelompok perlakuan diberikan 2 mL larutan NaCl setiap hari selama 8 minggu. Larutan diberikan melalui paksa (gavage). Ekspresi gen ENaC α, β, γ dari korteks dan medula ginjal diamplifikasi dengan PCR dan dideteksi dengan elektroforesis. Pita protein dari gel elektroforesis dinilai intensitasnya dengan software ImageJ. Hasil dari elektroforesis menunjukkan penurunan ekspresi gen ENaC α, β, γ di korteks dan medulla pada kelompok perlakuan dibanding dengan kontrol. Studi ini menyimpulkan ekspresi gen ENaC pada korteks dan medulla ginjal tidak signifikan dipengaruhi oleh diet tinggi natrium

Implementasi Penggunaan Digital Marketing Pada UMKM Di Credit Union Madani Kotabumi Tangerang

Pengabdian ini bertujuan untuk mengimplementasikan penggunaan digital marketing pada UMKM di Credit Union Madani Kotabumi Tangerang. Dimana masih kurangnya pemahaman mengenai penggunaan digital marketing diantaranya sebagai berikut: Belum memanfaatkan media tekhnologi dalam pengembangan usahanya, Kegunaan digital marketing dalam perluasan usaha masih belum memadai, Kurangnya informasi mengenai Digital Marketing, Adanya motivasi dalam meningkatkan target penjualan dibidang digital marketing. Peserta yang terdiri dari mitra credit union merupakan pelaku usaha di bidang kuliner serta jasa. Kegiatan Pengabdian Masyarakat (Abdimas) yang dilaksanakan oleh 3 (tiga) prodi sekaligus, yaitu: Prodi Manajemen, Prodi Akuntansi, dan Prodi Ilmu Administrasi Niaga. Implemetasi dilakukan pertama adalah pengenalan digital marketing, pemasaran dan tujuan dari digital marketing. Pengenalan produk-poduk digital marketing sampai penggunaan digital marketing di market&nbsp; place

Potential Molecular Interaction of Nutmeg's (Myristica Fragrans) Active Compound via Activation of Caspase-3

Myristica fragrans Houtt (belongs to the Myristicaceae family) is a Maluku Island (Indonesia) native plant. The seed of M. fragrans (Nutmeg) has been used for medicinal benefits. M. fragrans also has anti-cancer properties. The goal of this research was to use computer-aided drug design to investigate the in silico molecular docking of selected nutmeg compounds against Caspase-3. Molecular docking using Malegro Virtual Docker (MVD) software Ver 5.5 was performed to investigate binding complicated models to offer information on critical drug-receptor interactions. The most potent ligand was Licarin B, which had a docking score of -103.07 kcal/mol. The Licarin B structure formed several hydrogen bonds with Trp214 and Phe250. These findings imply that the nutmeg seed contains a prospective compound that could be a great anti-cancer agent

The Potency of NTHi lic1A Gene as a Biomarker in Determining The Severity of Post-Viral Acute Rhinosinusitis

BACKGROUND: The lic1A gene is an important virulence factor for non-typeable H. influenzae (NTHi), which allows its translocation from the nasopharynx into the sinonasal cavity and modulates more severe inflammatory processes. This study is aimed for identifying the potential correlation between the NTHi lic1A gene expressions and the severity of post-viral acute rhinosinusitis.METHODS: Sixty patients who were diagnosed with post-viral acute rhinosinusitis, were recruited from an ENT clinic in a referral hospital, in Bandung, West Java, Indonesia. All patients underwent a historical assessment and ENT examination. The nasal specimen was taken from the patient’s middle meatal. The NTHi lic1A gene expression was detected using Polymerase Chain Reaction (PCR).RESULTS: We observed that eight patients had the NTHi lic1A (+), with a strong correlation toward the dominant symptoms (nasal obstruction and discharge). In addition, the symptom’s duration of the NTHi lic1A (+) was twice longer than patients with the NTHi lic1A (-). Its severity was significantly more different between the two groups (p=0.034).CONCLUSION: Taken together, the presence of the NTHi lic1A gene is significantly associated with the severity of the disease and the symptom’s duration. Thus, the NTHi lic1A gene could potentially be a good marker for assessing the severity of post-viral acute rhinosinusitis cases in the future.KEYWORDS: H. influenzae, rhinosinusitis, nasal obstruction, virulence factor