Enhancing Care Transitions for Older People through Interprofessional Simulation: A Mixed Method Evaluation

Introduction: The educational needs of the health and social care workforce for delivering effective integrated care are important. This paper reports on the development, pilot and evaluation of an interprofessional simulation course, which aimed to support integrated care models for care transitions for older people from hospital to home. Theory and methods: The course development was informed by a literature review and a scoping exercise with the health and social care workforce. The course ran six times and was attended by health and social care professionals from hospital and community (n=49). The evaluation aimed to elicit staff perceptions of their learning about care transfers of older people and to explore application of learning into practice and perceived outcomes. The study used a sequential mixed method design with questionnaires completed pre (n=44) and post (n=47) course and interviews (n=9) 2-5 months later. Results:Participants evaluated interprofessional simulation as a successful strategy. Post-course, participants identified learning points and at the interviews, similar themes with examples of application in practice were: Understanding individual needs and empathy; Communicating with patients and families; Interprofessional working; Working across settings to achieve effective care transitions. Conclusions and discussion:An interprofessional simulation course successfully brought together health and social care professionals across settings to develop integrated care skills and improve care transitions for older people with complex needs from hospital to home

Thermoanalysis of ablation materials

Thermal analysis on pyrolysis of charring ablator material

The Carboxyl-Terminal Segment of Apolipoprotein A-V Undergoes a Lipid-Induced Conformational Change

Apolipoprotein (apo) A-V is a 343-residue, multidomain protein that plays an important role in regulation of plasma triglyceride homeostasis. Primary sequence analysis revealed a unique tetraproline sequence (Pro293-Pro296) near the carboxyl terminus of the protein. A peptide corresponding to the 48-residue segment beyond the tetraproline motif was generated from a recombinant apoA-V precursor wherein Pro295 was replaced by Met. Cyanogen bromide cleavage of the precursor protein, followed by negative affinity chromatography, yielded a purified peptide. Nondenaturing polyacrylamide gel electrophoresis verified that apoA-V(296-343) solubilizes phospholipid vesicles, forming a relatively heterogeneous population of reconstituted high-density lipoprotein with Stokes’ diameters\u3e17 nm. At the same time, apoA-V(296-343) failed to bind a spherical lipoprotein substrate in vitro. Far-UV circular dichroism spectroscopy revealed the peptide is unstructured in buffer yet adopts significant R-helical secondary structure in the presence of the lipid mimetic solvent trifluoroethanol (TFE; 50% v/v). Heteronuclear multidemensional NMR spectroscopy experiments were conducted with uniformly 15N- and 15N/13C-labeled peptide in 50% TFE. Peptide backbone assignment and secondary structure prediction using TALOSþ reveal the peptide adopts R-helix secondary structure from residues 309 to 334. In TFE, apoA-V(296-343) adopts an extended amphipathic R-helix, consistent with a role in lipoprotein binding as a component of full-length apoA-V

Development of computer software to analyze entire LANDSAT scenes and to summarize classification results of variable-size polygons

The Forest Pest Management Division (FPMD) of the Pennsylvania Bureau of Forestry has the responsibility for conducting annual surveys of the State's forest lands to accurately detect, map, and appraise forest insect infestations. A standardized, timely, and cost-effective method of accurately surveying forests and their condition should enhance the probability of suppressing infestations. The repetitive and synoptic coverage provided by LANDSAT (formerly ERTS) makes such satellite-derived data potentially attractive as a survey medium for monitoring forest insect damage over large areas. Forest Pest Management Division personnel have expressed keen interest in LANDSAT data and have informally cooperated with NASA/Goddard Space Flight Center (GSFC) since 1976 in the development of techniques to facilitate their use. The results of this work indicate that it may be feasible to use LANDSAT digital data to conduct annual surveys of insect defoliation of hardwood forests

Neutron spectroscopic factors of Ni isotopes from transfer reactions

177 neutron spectroscopic factors for nickel isotopes have been extracted by performing a systematic analysis of the angular distributions measured from (d,p) transfer reactions. A subset of the extracted spectroscopic factors are compared to predictions of large-basis shell models in the full pf model space using the GXPF1A effective interaction, and the (f5/2, p3/2, p1/2, g9/2) model space using the JJ4PNA interaction. For ground states, the predicted spectroscopic factors using the GXPF1A effective interaction in the full pf model space agree very well with the experimental values, while predictions based on several other effective interactions and model spaces are about 30% higher than the experimental values. For low-energy excited states (<3.5 MeV), the agreement between the extracted spectroscopic factors and shell model calculations is not better than a factor of two.Comment: 18 pages, 4 figures, 2 tables. accepted for publication in PR

Assessing Mediating Effect of Motivation Types on Competition Intervention For Physically Inactive Adults

Competition has been widely used as the behaviour change technique for physical activity intervention (Peng, Crouse, & Lin, 2012), this approach might push someone motivation to achieve the desired behaviour. Therefore, the objective of this study was to assess the mediating effects of the motivation on the competition intervention effectiveness. An experimental research was conducted where participants were randomly allocated into one of two groups (control and competition group). For calculating the motivation types, Behavioural Regulation in Exercise Questionnaire (BREQ-2) was administered. The results revealed that motivation was not found to mediate the effect of competition intervention

Planetary Science Goals for the Spitzer Warm Era

The overarching goal of planetary astronomy is to deduce how the present collection of objects found in our Solar System were formed from the original material present in the proto-solar nebula. As over two hundred exo-planetary systems are now known, and multitudes more are expected, the Solar System represents the closest and best system which we can study, and the only one in which we can clearly resolve individual bodies other than planets. In this White Paper we demonstrate how to use Spitzer Space Telescope InfraRed Array Camera Channels 1 and 2 (3.6 and 4.5 µm) imaging photometry with large dedicated surveys to advance our knowledge of Solar System formation and evolution. There are a number of vital, key projects to be pursued using dedicated large programs that have not been pursued during the five years of Spitzer cold operations. We present a number of the largest and most important projects here; more will certainly be proposed once the warm era has begun, including important observations of newly discovered objects

The role of neutrophils in pregnancy, term and preterm labour

Neutrophils are surveillance cells, and the first to react and migrate to sites of inflammation and infection following a chemotactic gradient. Neutrophils play a key role in both sterile inflammation and infection, performing a wide variety of effector functions such as degranulation, phagocytosis, ROS production and release of neutrophil extracellular traps (NETs). Healthy term labour requires a sterile pro-inflammatory process, whereas one of the most common causes of spontaneous preterm birth is microbial driven. Peripheral neutrophilia has long been described during pregnancy, and evidence exists demonstrating neutrophils infiltrating the cervix, uterus and foetal membranes during both term and preterm deliveries. Their presence supports a role in tissue remodelling via their effector functions. In this review, we describe the effector functions of neutrophils. We summarise the evidence to support their role in healthy pregnancy and labour and describe their potential contribution to microbial driven preterm birth