Epidermal Growth Factor Receptor Expression and Mutational Analysis in Synovial Sarcomas and Malignant Peripheral Nerve Sheath Tumors

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140003/1/onco0459.pd

Jealousy Protest

In this article, nascent jealousy’s ultimate foundation is theorized as an adapted psychological mechanism that evolved in the environment of evolutionary adaptedness (EEA) to prepare 1-year-olds for defending against premature weaning upon the closely spaced birth of a sibling. This position rests on evidence that nascent jealousy is expressed through jealousy protest , a constellation of caregiver-directed protests and bids for exclusive attention, and evidence that its onset occurs at approximately 9 months of age. Given that the period of human gestation is 9 months, we propose that jealousy protest’s form and timing were compelled by the possibility that the end of an infant’s first year could be met by competition with a newborn sibling. That possibility placed infants at risk of malnutrition and mortality due to entailing the loss of exclusive access to mother’s milk, while infants were at an age when they were still heavily reliant on breast milk for survival. At this juncture, threat posed by the birth of a sibling was compounded by conditions of the EEA, where the sole viable source of breast milk was an infant’s mother, and her supply of milk was sufficient for sustaining only one child at a time. We conclude by offering suggestions for future research and discuss implications for the theory of parent–offspring conflict as a foundation of adaptations in children

Menopausal vasomotor symptoms and incident breast cancer risk in the Study of Women\u27s Health Across the Nation

PURPOSE: Two case-control studies reported a 50 % decreased breast cancer risk among women who experienced menopausal vasomotor symptoms (VMS), but one cohort study found no association. VMS may be triggered by declining estrogen levels during menopause, whereas elevated estrogen levels have been associated with increased breast cancer risk. VMS may thus be indicative of lower susceptibility to breast cancer. METHODS: We evaluated this relationship in the longitudinal Study of Women\u27s Health Across the Nation (SWAN), using discrete survival analysis of approximately annual data on VMS and self-reported breast cancer occurrences for up to 13 years of follow-up in 3,098 women who were pre- or early perimenopausal at enrollment. RESULTS: Over an average 11.4 years of follow-up, 129 incident breast cancer cases were self-reported, and approximately 50 % of participants experienced VMS. Symptomatic women had a reduced risk of breast cancer compared to non-symptomatic women (adjusted HR 0.63, 95 % CI 0.39, 1.00). The association was stronger in the subgroup of women who fully transitioned to postmenopause during follow-up (n = 67 cases, adjusted HR 0.45, 95 % CI 0.26, 0.77). CONCLUSION: VMS appeared to be a marker of reduced breast cancer risk. Future research is needed to understand the biology underlying this relationship