HARMONIC INTONATION AND IMPLICATION (ANALYSES AND COMPOSITIONS): Harmonic perception and intonation in the reception and performance of alternative tuning systems in contemporary composition

Most composers and theorists will acknowledge that some compromise is necessary when dealing with the limitations of human performance, perception, and the realities of acoustic theory. Identifying the thresholds for pitch discrimination and execution is an important point of departure for defining workable tuning schemes, and for training musicians to realise compositions in just intonation and other alternative tuning systems. The submitted paper 'HARMONIC INTONATION AND IMPLICATION (ANALYSES AND COMPOSITIONS): Harmonic perception and intonation in the reception and performance of alternative tuning systems in contemporary composition' is a phenomenological study of harmonic perception and intonation through the analysis of recordings, scores, theoretical papers, and discussion with practicing musicians. The examined repertoire covers western 'art' music of the late nineteenth to early twenty-first centuries. I approach my research from the composer's point of view though filtered through the ears and eyes of the performer, who is here considered 'expert listener'. lt is considered that intonation is a dynamic experience subject to influences beyond just intonation or equal temperament (the two poles for intonational reference)-the performance is assumed 'correct', rather than the idealised version of the composer. My goal is to relate the performance to the intentions of the composer and raise questions regarding the choice of notation, resolution of the tuning systems, the complexity of the harmonic concept, etc. and perhaps to suggest how to extend a general theory of harmony that embraces both musical practice and psychoacoustics. lt is with the understanding that harmonic implication affects intonation, but that intonation is subject to several other forces making intonation a complex system (and therefore not fully predictable)

Behavioral and Psychological Symptoms of Dementia

Behavioral and psychological symptoms of dementia (BPSD), also known as neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms and behaviors occurring in subjects with dementia. BPSD constitute a major component of the dementia syndrome irrespective of its subtype. They are as clinically relevant as cognitive symptoms as they strongly correlate with the degree of functional and cognitive impairment. BPSD include agitation, aberrant motor behavior, anxiety, elation, irritability, depression, apathy, disinhibition, delusions, hallucinations, and sleep or appetite changes. It is estimated that BPSD affect up to 90% of all dementia subjects over the course of their illness, and is independently associated with poor outcomes, including distress among patients and caregivers, long-term hospitalization, misuse of medication, and increased health care costs. Although these symptoms can be present individually it is more common that various psychopathological features co-occur simultaneously in the same patient. Thus, categorization of BPSD in clusters taking into account their natural course, prognosis, and treatment response may be useful in the clinical practice. The pathogenesis of BPSD has not been clearly delineated but it is probably the result of a complex interplay of psychological, social, and biological factors. Recent studies have emphasized the role of neurochemical, neuropathological, and genetic factors underlying the clinical manifestations of BPSD. A high degree of clinical expertise is crucial to appropriately recognize and manage the neuropsychiatric symptoms in a patient with dementia. Combination of non-pharmacological and careful use of pharmacological interventions is the recommended therapeutic for managing BPSD. Given the modest efficacy of current strategies, there is an urgent need to identify novel pharmacological targets and develop new non-pharmacological approaches to improve the adverse outcomes associated with BPSD

Foundations for a Scholarly Communications Program: Interviewing Faculty at a Small Public Liberal Arts College

INTRODUCTION Librarians at SUNY Geneseo, a small liberal arts college, conducted interviews with eighty-seven professors to learn about faculty attitudes and practices related to scholarly communications and open access. Our project can serve as a model for other small college libraries wishing to engage faculty in a discussion about scholarly communications while dealing with staff constraints and limited budgets. The interviews provided an excellent opportunity for outreach and education, and revealed faculty concerns about open access, digital scholarship, peer review, data storage and management, and co-publishing with students. DESCRIPTION OF PROJECT Interview results were shared with library staff as well as faculty, college administration, and the committee responsible for tenure and promotion decisions. Librarians were able to incorporate this knowledge into their work and make stronger connections between faculty and the library. The Scholarly Communication Team used this information to plan workshops and events aimed at faculty, and identified important topics for further professional development for librarians. We were also able to spark campus-wide conversation about scholarly communication issues. NEXT STEPS Listening to faculty concerns has proven the single best way for librarians to remain responsive and relevant in the scholarly life of the campus. As a result of this project, all library liaisons at our institution will include scholarly communication issues as a regular part of their work

Validation of a tool predicting important findings on computed tomography among Crohn’s disease patients

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/166167/1/ueg2bf00677.pd

pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion.

During adaptive immune responses, CD8(+) T cells with low TCR affinities are released early into the circulation before high-affinity clones become dominant at later time points. How functional avidity maturation is orchestrated in lymphoid tissue and how low-affinity cells contribute to host protection remains unclear. In this study, we used intravital imaging of reactive lymph nodes (LNs) to show that T cells rapidly attached to dendritic cells irrespective of TCR affinity, whereas one day later, the duration of these stable interactions ceased progressively with lowering peptide major histocompatibility complex (pMHC) affinity. This correlated inversely BATF (basic leucine zipper transcription factor, ATF-like) and IRF4 (interferon-regulated factor 4) induction and timing of effector differentiation, as low affinity-primed T cells acquired cytotoxic activity earlier than high affinity-primed ones. After activation, low-affinity effector CD8(+) T cells accumulated at efferent lymphatic vessels for egress, whereas high affinity-stimulated CD8(+) T cells moved to interfollicular regions in a CXCR3-dependent manner for sustained pMHC stimulation and prolonged expansion. The early release of low-affinity effector T cells led to rapid target cell elimination outside reactive LNs. Our data provide a model for affinity-dependent spatiotemporal orchestration of CD8(+) T cell activation inside LNs leading to functional avidity maturation and uncover a role for low-affinity effector T cells during early microbial containment

Phenotyping the brain, the face, and their genetic interaction over development

The development of the brain and the face is intimately coordinated through a continuous physical and molecular interaction during morphogenesis. Understanding how dynamic spatio-temporal regulation of gene expression patterns guide this process is crucial to reveal mechanisms that may have contributed to human evolution

Efficient Bayesian-based Multi-View Deconvolution

Light sheet fluorescence microscopy is able to image large specimen with high resolution by imaging the sam- ples from multiple angles. Multi-view deconvolution can significantly improve the resolution and contrast of the images, but its application has been limited due to the large size of the datasets. Here we present a Bayesian- based derivation of multi-view deconvolution that drastically improves the convergence time and provide a fast implementation utilizing graphics hardware.Comment: 48 pages, 20 figures, 1 table, under review at Nature Method

Vimentin Intermediate Filaments Mediate Cell Morphology on Viscoelastic Substrates

The ability of cells to take and change shape is a fundamental feature underlying development, wound repair, and tissue maintenance. Central to this process is physical and signaling interactions between the three cytoskeletal polymeric networks: F-actin, microtubules, and intermediate filaments (IFs). Vimentin is an IF protein that is essential to the mechanical resilience of cells and regulates cross-talk among the cytoskeleton, but its role in how cells sense and respond to the surrounding extracellular matrix is largely unclear. To investigate vimentin’s role in substrate sensing, we designed polyacrylamide hydrogels that mimic the elastic and viscoelastic nature of in vivo tissues. Using wild-type and vimentin-null mouse embryonic fibroblasts, we show that vimentin enhances cell spreading on viscoelastic substrates, even though it has little effect in the limit of purely elastic substrates. Our results provide compelling evidence that vimentin modulates how cells sense and respond to their environment and thus plays a key role in cell mechanosensing

PhOTO Zebrafish: A Transgenic Resource for In Vivo Lineage Tracing during Development and Regeneration

Background: Elucidating the complex cell dynamics (divisions, movement, morphological changes, etc.) underlying embryonic development and adult tissue regeneration requires an efficient means to track cells with high fidelity in space and time. To satisfy this criterion, we developed a transgenic zebrafish line, called PhOTO, that allows photoconvertible optical tracking of nuclear and membrane dynamics in vivo. Methodology: PhOTO zebrafish ubiquitously express targeted blue fluorescent protein (FP) Cerulean and photoconvertible FP Dendra2 fusions, allowing for instantaneous, precise targeting and tracking of any number of cells using Dendra2 photoconversion while simultaneously monitoring global cell behavior and morphology. Expression persists through adulthood, making the PhOTO zebrafish an excellent tool for studying tissue regeneration: after tail fin amputation and photoconversion of a ~100µm stripe along the cut area, marked differences seen in how cells contribute to the new tissue give detailed insight into the dynamic process of regeneration. Photoconverted cells that contributed to the regenerate were separated into three distinct populations corresponding to the extent of cell division 7 days after amputation, and a subset of cells that divided the least were organized into an evenly spaced, linear orientation along the length of the newly regenerating fin. Conclusions/Significance: PhOTO zebrafish have wide applicability for lineage tracing at the systems-level in the early embryo as well as in the adult, making them ideal candidate tools for future research in development, traumatic injury and regeneration, cancer progression, and stem cell behavior

Імуногістохімічне виявлення судинного епітеліального ростового фактору в корі великих півкуль головного мозку при порушеннях кровообігу

Порушення кровопостачання мозку – одне з актуальних питань сучасної медицини, що обумовлено, як тяжкістю наслідків кожного конкретного випадку хвороби, так і рівнем показників захворюваності, що сягають пандемії, а смертність від цієї патології становить понад 20% і займає друге місце після серцево-судинних захворювань. Сьогодні зміни при ішемії мозку розглядаються як складний багатовекторний процес зі специфічною кінетикою на перебіг якого можна впливати, а не як одноманітну подію, як вважалось ще 20 років тому