IODINE AND THE THYROID : III. THE SPECIFIC ACTION OF IODINE IN ACCELERATING AMPHIBIAN METAMORPHOSIS.

1. Amphibian metamorphosis depends upon the amount of iodine secured by the larvæ; the greater the quantity the more rapid the differentiation. 2. Bromine is physiologically inert when fed even in large quantities to frog larvæ, hence it cannot be substituted for iodine. Bromine feeding has no effect on the thyroid. 3. Iodine is the active constituent of the thyroid gland, in the Anura at any rate, and functions within the body by stimulating intracellular oxidations; it is apparently specific in its action. 4. The basal metabolism of patients suffering from athyreosis, whose metabolism is 40 per cent below normal, is very likely held at this figure and prevented from sinking lower to the death point by the introduction of iodine into the body through food and water. 5. The thyroid gland is an organ the function of which is the extraction from the circulation, storage, and supplying to the organism, under the pressure of its needs, the small quantities of iodine taken into the body. The chief function of this gland then is the utilization of iodine in small quantities

Sulphate Retention following Bilateral Adrenal Extirpation

Previous experiments by the senior writer have clearly shown that the cause of death following adrenal removal is an acid intoxication probably due to phosphoric and unknown organic acids. In the absence of the hormone of the adrenal cortex, the kidney fails to function properly with the result that marked acid and nitrogen retention occurs. In our previous work on the acid-base equilibrium the acid values of the serum protein, bicarbonate, chloride, and phosphorus were calculated. Total acid was taken as the sum of all the determined acids. Organic acid was calculated by subtracting total acid from total base and included the sulphate ion

Apollo experience report guidance and control systems: Primary guidance, navigation, and control system development

The primary guidance, navigation, and control systems for both the lunar module and the command module are described. Development of the Apollo primary guidance systems is traced from adaptation of the Polaris Mark II system through evolution from Block I to Block II configurations; the discussion includes design concepts used, test and qualification programs performed, and major problems encountered. The major subsystems (inertial, computer, and optical) are covered. Separate sections on the inertial components (gyroscopes and accelerometers) are presented because these components represent a major contribution to the success of the primary guidance, navigation, and control system

Membrane Insertion for the Detection of Lipopolysaccharides: Exploring the Dynamics of Amphiphile-in-Lipid Assays

Shiga toxin-producing Escherichia coli is an important cause of foodborne illness, with cases attributable to beef, fresh produce and other sources. Many serotypes of the pathogen cause disease, and differentiating one serotype from another requires specific identification of the O antigen located on the lipopolysaccharide (LPS) molecule. The amphiphilic structure of LPS poses a challenge when using classical detection methods, which do not take into account its lipoglycan biochemistry. Typically, detection of LPS requires heat or chemical treatment of samples and relies on bioactivity assays for the conserved lipid A portion of the molecule. Our goal was to develop assays to facilitate the direct and discriminative detection of the entire LPS molecule and its O antigen in complex matrices using minimal sample processing. To perform serogroup identification of LPS, we used a method called membrane insertion on a waveguide biosensor, and tested three serogroups of LPS. The membrane insertion technique allows for the hydrophobic association of LPS with a lipid bilayer, where the exposed O antigen can be targeted for specific detection. Samples of beef lysate were spiked with LPS to perform O antigen specific detection of LPS from E. coli O157. To validate assay performance, we evaluated the biophysical interactions of LPS with lipid bilayers both in- and outside of a flow cell using fluorescence microscopy and fluorescently doped lipids. Our results indicate that membrane insertion allows for the qualitative and reliable identification of amphiphilic LPS in complex samples like beef homogenates. We also demonstrated that LPS-induced hole formation does not occur under the conditions of the membrane insertion assays. Together, these findings describe for the first time the serogroup-specific detection of amphiphilic LPS in complex samples using a membrane insertion assay, and highlight the importance of LPS molecular conformations in detection architectures

Cube law, condition factor and weight-length relationships: history, meta-analysis and recommendations

This study presents a historical review, a meta-analysis, and recommendations for users about weight–length relationships, condition factors and relative weight equations. The historical review traces the developments of the respective concepts. The meta-analysis explores 3929 weight–length relationships of the type W = aLb for 1773 species of fishes. It shows that 82% of the variance in a plot of log a over b can be explained by allometric versus isometric growth patterns and by different body shapes of the respective species. Across species median b = 3.03 is significantly larger than 3.0, thus indicating a tendency towards slightly positive-allometric growth (increase in relative body thickness or plumpness) in most fishes. The expected range of 2.5 < b < 3.5 is confirmed. Mean estimates of b outside this range are often based on only one or two weight–length relationships per species. However, true cases of strong allometric growth do exist and three examples are given. Within species, a plot of log a vs b can be used to detect outliers in weight–length relationships. An equation to calculate mean condition factors from weight–length relationships is given as Kmean = 100aLb−3. Relative weight Wrm = 100W/(amLbm) can be used for comparing the condition of individuals across populations, where am is the geometric mean of a and bm is the mean of b across all available weight–length relationships for a given species. Twelve recommendations for proper use and presentation of weight–length relationships, condition factors and relative weight are given

Quantum Gravity in the Lab: Teleportation by Size and Traversable Wormholes, Part II

In [1] we discussed how quantum gravity may be simulated using quantum devices and gave a specific proposal -- teleportation by size and the phenomenon of size-winding. Here we elaborate on what it means to do 'Quantum Gravity in the Lab' and how size-winding connects to bulk gravitational physics and traversable wormholes. Perfect size-winding is a remarkable, fine-grained property of the size wavefunction of an operator; we show from a bulk calculation that this property must hold for quantum systems with a nearly-AdS_2 bulk. We then examine in detail teleportation by size in three systems: the Sachdev-Ye-Kitaev model, random matrices, and spin chains, and discuss prospects for realizing these phenomena in near-term quantum devices.Comment: 50 pages, 14 figures, Part II of arXiv:1911.0631

Quantum Gravity in the Lab: Teleportation by Size and Traversable Wormholes

With the long-term goal of studying models of quantum gravity in the lab, we propose holographic teleportation protocols that can be readily executed in table-top experiments. These protocols exhibit similar behavior to that seen in the recent traversable wormhole constructions of [1,2]: information that is scrambled into one half of an entangled system will, following a weak coupling between the two halves, unscramble into the other half. We introduce the concept of teleportation by size to capture how the physics of operator-size growth naturally leads to information transmission. The transmission of a signal through a semi-classical holographic wormhole corresponds to a rather special property of the operator-size distribution we call size winding. For more general systems (which may not have a clean emergent geometry), we argue that imperfect size winding is a generalization of the traversable wormhole phenomenon. In addition, a form of signalling continues to function at high temperature and at large times for generic chaotic systems, even though it does not correspond to a signal going through a geometrical wormhole, but rather to an interference effect involving macroscopically different emergent geometries. Finally, we outline implementations feasible with current technology in two experimental platforms: Rydberg atom arrays and trapped ions.Comment: 33 pages, 5 figures. This paper has a companion paper (Part II) by the same author