Nocturnal Observations of Thermodynamic and Kinematic Properties in a Wind Turbine Array Boundary Layer Using an Instrumented Unmanned Aerial System

Observation, simulation, and modeling have shown that wind farms have an impact on the near-surface atmospheric boundary layer as turbulent wakes generated by the turbines enhance vertical mixing. These changes alter downstream atmospheric properties. With a large portion of wind farms hosted within an agricultural context, changes to the environment can potentially have secondary impacts such as to the productivity of crops. The authors, amongst others, have demonstrated changes to relative humidity and temperature within the wind turbine array boundary layer during daylight observations made by small unmanned aerial systems (sUAS). The obtainment of permission to fly at night and higher altitudes, along with the enhancement of the sUAS instrumentation suite with fast-response 3D sonic anemometers, enabled observations during overnight hours and at altitudes above the top turbine tip height. This talk details observed changes to thermodynamic and kinematic properties during an overnight field campaign undertaken during the summer of 2019 around a utility-scale wind turbine located within a variety of crops

Novel Markers of Angiogenesis in the Setting of Cognitive Impairment and Dementia

Background: Aberrant angiogenesis may play a role in the development of Alzheimer's disease and related dementia. Objective: To explore the relationship between angiogenesis activity and evidence of neurodegeneration among older adults. Methods: Cross-sectional study of 49 older adults clinically characterized as cognitively normal, mild cognitive impairment, or early Alzheimer's disease. In addition to neuroimaging, we completed assays on peripheral blood, including: vascular endothelial growth factor, tumor necrosis factor, fibroblast growth factor, and amyloid-β peptide 40. We used advanced polychromatic flow cytometry to phenotype circulating mononuclear cells to assess angiogenesis activity. Results: Although we documented differences in cognitive performance, structural changes on neuroimaging, and burden of amyloid and tau on positron emission tomography, angiogenesis activity did not vary by group. Interestingly, VEGF levels were shown to be increased among subjects with mild cognitive impairment. In ANCOVA models controlling for age, sex, intracranial volume, and monocyte subpopulations, angiogenesis activity was correlated with increased white matter hyperintensities. Conclusion: We demonstrate a significant association between angiogenesis activity and cerebrovascular disease. To better understand the potential of angiogenesis as an intervention target, longitudinal studies are needed

Observational Practices for Urban Microclimates Using Meteorologically Instrumented Unmanned Aircraft Systems

The urban boundary layer (UBL) is one of the most important and least understood atmospheric domains and, consequently, warrants deep understanding and rigorous analysis via sophisticated experimental and numerical tools. When field experiments have been undertaken, they have primarily been accomplished with either a coarse network of in-situ sensors or slow response sensors based on timing or Doppler shifts, resulting in low resolution and decreasing performance with height. Small unmanned aircraft systems (UASs) offer an opportunity to improve on traditional UBL observational strategies that may require substantive infrastructure or prove impractical in a vibrant city, prohibitively expensive, or coarse in resolution. Multirotor UASs are compact, have the ability to take-off and land vertically, hover for long periods of time, and maneuver easily in all three spatial dimensions, making them advantageous for probing an obstacle-laden environment. Fixed-wing UASs offer an opportunity to cover vast horizontal and vertical distances, at low altitudes, in a continuous manner with high spatial resolution. Hence, fixed-wing UASs are advantageous for observing the roughness sublayer above the highest building height where traditional manned aircraft cannot safely fly. This work presents a methodology for UBL investigations using meteorologically instrumented UASs and discusses lessons learned and best practices garnered from a proof of concept field campaign that focused on the urban canopy layer and roughness sublayer of a large modern city with a high-rise urban canopy