393 research outputs found
Long-term degradation of optical devices on the moon
Forty years ago, Apollo astronauts placed the first of several retroreflector
arrays on the lunar surface. Their continued usefulness for laser-ranging might
suggest that the lunar environment does not damage optical devices. However,
new laser ranging data reveal that the efficiency of the three Apollo reflector
arrays is now diminished by a factor of ten at all lunar phases and by an
additional factor of ten when the lunar phase is near full moon. These deficits
did not exist in the earliest years of lunar ranging, indicating that the lunar
environment damages optical equipment on the timescale of decades. Dust or
abrasion on the front faces of the corner-cube prisms may be responsible,
reducing their reflectivity and degrading their thermal performance when
exposed to face-on sunlight at full moon. These mechanisms can be tested using
laboratory simulations and must be understood before designing equipment
destined for the moon.Comment: 9 pages; 4 figures; accepted for publication in Icaru
Dynamics of vortex tangle without mutual friction in superfluid He
A recent experiment has shown that a tangle of quantized vortices in
superfluid He decayed even at mK temperatures where the normal fluid was
negligible and no mutual friction worked. Motivated by this experiment, this
work studies numerically the dynamics of the vortex tangle without the mutual
friction, thus showing that a self-similar cascade process, whereby large
vortex loops break up to smaller ones, proceeds in the vortex tangle and is
closely related with its free decay. This cascade process which may be covered
with the mutual friction at higher temperatures is just the one at zero
temperature Feynman proposed long ago. The full Biot-Savart calculation is made
for dilute vortices, while the localized induction approximation is used for a
dense tangle. The former finds the elementary scenario: the reconnection of the
vortices excites vortex waves along them and makes them kinked, which could be
suppressed if the mutual friction worked. The kinked parts reconnect with the
vortex they belong to, dividing into small loops. The latter simulation under
the localized induction approximation shows that such cascade process actually
proceeds self-similarly in a dense tangle and continues to make small vortices.
Considering that the vortices of the interatomic size no longer keep the
picture of vortex, the cascade process leads to the decay of the vortex line
density. The presence of the cascade process is supported also by investigating
the classification of the reconnection type and the size distribution of
vortices. The decay of the vortex line density is consistent with the solution
of the Vinen's equation which was originally derived on the basis of the idea
of homogeneous turbulence with the cascade process. The obtained result is
compared with the recent Vinen's theory.Comment: 16 pages, 16 figures, submitted to PR
Eureka and beyond: mining's impact on African urbanisation
This collection brings separate literatures on mining and urbanisation together at a time when both artisanal and large-scale mining are expanding in many African economies. While much has been written about contestation over land and mineral rights, the impact of mining on settlement, notably its catalytic and fluctuating effects on migration and urban growth, has been largely ignored. African nation-states’ urbanisation trends have shown considerable variation over the past half century. The current surge in ‘new’ mining countries and the slow-down in ‘old’ mining countries are generating some remarkable settlement patterns and welfare outcomes. Presently, the African continent is a laboratory of national mining experiences. This special issue on African mining and urbanisation encompasses a wide cross-section of country case studies: beginning with the historical experiences of mining in Southern Africa (South Africa, Zambia, Zimbabwe), followed by more recent mineralizing trends in comparatively new mineral-producing countries (Tanzania) and an established West African gold producer (Ghana), before turning to the influence of conflict minerals (Angola, the Democratic Republic of Congo and Sierra Leone)
Pragmatic Software Innovation
Part 2: Creating Value through Software DevelopmentInternational audienceWe understand software innovation as concerned with introducing innovation into the development of software intensive systems, i.e. systems in which software development and/or integration are dominant considerations. Innovation is key in almost any strategy for competitiveness in existing markets, for creating new markets, or for curbing rising public expenses, and software intensive systems are core elements in most such strategies. Software innovation therefore is vital for about every sector of the economy. Changes in software technologies over the last decades have opened up for experimentation, learning, and flexibility in ongoing software projects, but how can this change be used to facilitate software innovation? How can a team systematically identify and pursue opportunities to create added value in ongoing projects? In this paper, we describe Deweyan pragmatism as the philosophical foundation for Essence – a software innovation methodology – where unknown options and needs emerge as part of the development process itself. The foundation is illustrated via a simple example
State sampling dependence of the Hopfield network inference
The fully connected Hopfield network is inferred based on observed
magnetizations and pairwise correlations. We present the system in the glassy
phase with low temperature and high memory load. We find that the inference
error is very sensitive to the form of state sampling. When a single state is
sampled to compute magnetizations and correlations, the inference error is
almost indistinguishable irrespective of the sampled state. However, the error
can be greatly reduced if the data is collected with state transitions. Our
result holds for different disorder samples and accounts for the previously
observed large fluctuations of inference error at low temperatures.Comment: 4 pages, 1 figure, further discussions added and relevant references
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An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal
Promising therapeutic approaches for eradicating HIV include transcriptional activation of provirus from latently infected cells using latency-reversing agents (LRAs) and immune-mediated clearance to purge reservoirs. Accurate detection of cells capable of producing viral antigens and virions, and the measurement of clearance of infected cells, is essential to assessing therapeutic efficacy. Here, we apply enhanced methodology extending the sensitivity limits for the rapid detection of subfemtomolar HIV gag p24 capsid protein in CD4+ T cells from ART-suppressed HIV+ individuals, and we show viral protein induction following treatment with LRAs. Importantly, we demonstrate that clinical administration of histone deacetylase inhibitors (HDACis; vorinostat and panobinostat) induced HIV gag p24, and ex vivo stimulation produced sufficient viral antigen to elicit immune-mediated cell killing using anti-gp120/CD3 bispecific antibody. These findings extend beyond classical nucleic acid endpoints, which are confounded by the predominance of mutated, defective proviruses and, of paramount importance, enable assessment of cells making HIV protein that can now be targeted by immunological approaches
Particle acceleration mechanisms
We review the possible mechanisms for production of non-thermal electrons
which are responsible for non-thermal radiation in clusters of galaxies. Our
primary focus is on non-thermal Bremsstrahlung and inverse Compton scattering,
that produce hard X-ray emission. We briefly review acceleration mechanisms and
point out that in most astrophysical situations, and in particular for the
intracluster medium, shocks, turbulence and plasma waves play a crucial role.
We consider two scenarios for production of non-thermal radiation. The first is
hard X-ray emission due to non-thermal Bremsstrahlung by nonrelativistic
particles. Non-thermal tails are produced by accelerating electrons from the
background plasma with an initial Maxwellian distribution. However, these tails
are accompanied by significant heating and they are present for a short time of
<10^6 yr, which is also the time that the tail will be thermalised. Such
non-thermal tails, even if possible, can only explain the hard X-ray but not
the radio emission which needs GeV or higher energy electrons. For these and
for production of hard X-rays by the inverse Compton model, we need the second
scenario where there is injection and subsequent acceleration of relativistic
electrons. It is shown that a steady state situation, for example arising from
secondary electrons produced from cosmic ray proton scattering by background
protons, will most likely lead to flatter than required electron spectra or it
requires a short escape time of the electrons from the cluster. An episodic
injection of relativistic electrons, presumably from galaxies or AGN, and/or
episodic generation of turbulence and shocks by mergers can result in an
electron spectrum consistent with observations but for only a short period of
less than one billion years.Comment: 22 pages, 5 figures, accepted for publication in Space Science
Reviews, special issue "Clusters of galaxies: beyond the thermal view",
Editor J.S. Kaastra, Chapter 11; work done by an international team at the
International Space Science Institute (ISSI), Bern, organised by J.S.
Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke
Towards an understanding of neuroscience for science educators
Advances in neuroscience have brought new insights to the development of cognitive functions. These data are of considerable interest to educators concerned with how students learn. This review documents some of the recent findings in neuroscience, which is richer in describing cognitive functions than affective aspects of learning. A brief overview is presented here of the techniques used to generate data from imaging and how these findings have the possibility to inform educators. There are implications for considering the impact of neuroscience at all levels of education – from the classroom teacher and practitioner to policy. This relatively new cross-disciplinary area of research implies a need for educators and scientists to engage with each other. What questions are emerging through such dialogues between educators and scientists are likely to shed light on, for example, reward, motivation, working memory, learning difficulties, bilingualism and child development. The sciences of learning are entering a new paradigm
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