Load monitoring and management in elite basketball

193 p.After a systematic revision of the scholar literature about load monitoring inbasketball, we detected lack of information not only regarding the use of microtechnologybut also insufficient information about external/internal weekly trainingloads, short-term tapering models and training games among elite players. Eventually,the revision gave us directions to prepare the PhD project (see Figure 1). The mainintention of this project was to investigate team practices and match-play, in order tocontribute to scientific field of elite basketball, especially due to the fact that onlypaucity of research has focused on use of modern micro-technology. The wholeproject was divided into four parts, all of them around the same topic: external andinternal load monitoring.The first focus was on the analysis of relationship between various external(e.g. Player Load, accelerations, decelerations, jumps, changes of direction) and twointernal training load measures (e.g. RPE and sRPE). Even though these two methodsare of different construct, their complementary use is advised. In practice, it isimportant to understand the relationship between training dose (e.g. Player Load) andinternal response (i.e. RPE and sRPE).The second part also investigated both external and internal load measures butconsidering the training proximity to the match day and application of short-termtapering. In this study, for the period of three days prior to the game, progressivedecrease in training load was investigated. Moreover, use of Total Quality ofRecovery (TQR) questionnaire was presented as a marker of physical condition on thematch day. Finally, the relationship between training load and TQR scores could helpto understand the connection between accumulated training loads and players¿physical response on a match day.The third part has been focused on the external and internal training loadanalysis between three playing positions (i.e. guards, forwards and centers). In teamsports, it is well known that different playing position elicit particular physical andphysiological responses in both game and training settings, but still there is a lack ofinformation using micro-technology. Therefore, data presented in this study couldhelp coaches to better understand both external and internal training demands of eachplaying position in elite basketball.The forth part aimed to compare external load demands between match-playand two training games used in team trainings. Match-play was recorded during preseasonaltraining camp and compared with regular-stop and no-stop training games.The results from this study can help coaches who are looking for specific constraintsin training drills that can elicit similar or greater physical demands as in basketballgame.Figure 1. Doctoral project scheme.4.EXTERNAL AND INTERNALTRAINING LOAD ANALYSISREGARDING PLAYINGPOSITIONS- Three playing positions willbe considered (guards,forwards and centers)- Principal ComponentsAnalysis will be implementedin order to profile playingpositions5.EXTERNAL LOADCOMPARISON BETWEENMATCH-PLAY AND TRAININGGAMES- Physical demands frommatch-play will be compared totwo formats of 5vs5 trainingtasks- Effect size will be used forquantifying the differencesCONCLUSIONS AND APPLICATIONS- The grade of correlation between external load variables and sRPE would be used to better understandindicators of load and their inter-relationship in elite basketball- Short-term tapering models will be investigated to find an optimal amount of training load and its dailydistribution prior to the match-day- Both external and internal load variables regarding each playing position in basketball would allowprofiling their particular activity- Analysis of specific training games would provide practical information about external physical demandscompared to demands of a match-pla

DNA glycosylases as modulators of chemotherapeutic response

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. Median survival is less than two years due to several factors, including challenges in surgical removal and chemotherapy resistance, underlining the need for more effective therapeutic options. To identify genes that contribute to chemotherapy resistance, we conducted a synthetic lethal screen in a chemotherapy-resistant GBM derived cell line (T98G) with the clinical alkylator temozolomide (TMZ) and an siRNA library tailored towards “druggable” targets. This screen for TMZ-sensitizing genes indicated that a subset of genes that were over-expressed in GBM cells increased the cell’s sensitivity to TMZ when knocked down. An ubiquitin ligase, UBE3B, and a DNA glycosylase, UNG, were among the TMZ-sensitizing genes identified using the siRNA library. We demonstrate that UBE3B and UNG are sensitizing genes in the screen validation studies using unique siRNA and shRNA sequences. Although UNG is one of four human DNA glycosylases that remove uracil lesions, UNG was the only uracil removing glycosylase to sensitize GBM cells in the validation studies. Notably, analysis of archived transcription datasets revealed that over-expression of UNG was correlated with poor outcomes in glioma patients. In order to uncover functional groupings of TMZ-sensitizing proteins, we conducted in situ pathway analysis of gene candidates for synthetic lethal functions from our screen. This analysis discovered statistically significant enrichment of ontogeny clusters related to base excision repair (BER), response to DNA damage, cellular proliferation and protein modification. Interestingly, this pathway topography overlapped with TMZ-sensitizing genes identified from similar experiments in yeast and bacteria. In order to facilitate rapid in vitro identification of lesion-specific repair activity in cancer cells, we developed a novel fluorescent assay that extends the state of the art. The molecular beacon assay measures real-time DNA repair rates of specific DNA lesions by defined DNA repair proteins. These studies reveal that GBM up-regulates several TMZ-sensitizing genes that correlate with poor patient survival and inhibiting these genes may increase TMZ cytotoxicity in a tumor specific manner. These TMZ-sensitizing genes are not only potential targets for adjuvant therapy, but also represent potential biomarkers to predict TMZ response

A (Partial and Principled) Defense of Sentences of Life Imprisonment

There has been more than a five-fold increase in the number of life sentences in the United States over the past four decades. One in seven prisoners in the United States is serving a life (or virtual) life sentence. This amounts to over 200,000 prisoners. The increase has occurred against the backdrop of near universal condemnation by scholars and public policy advocates – many of whom are now advocating for the abolition of life sentences. Arguments that life sentences are not an effective deterrent or means of protecting the community have some merit. Yet, we argue that in a limited range of circumstances, penalties of life imprisonment are appropriate. The proportionality principle commands that the devastating consequences of certain crimes are punishable by a permanent loss of liberty. Any lesser form of punishment fails to acknowledge the suffering inflicted by the crime and the loss experienced by the victim. First-degree murder mandates no lesser punishment. The reforms in this Article, while justifying some life terms and enhancing the integrity of the sentencing system, would paradoxically reduce the number of prisoners sentenced to life imprisonment in the United States by over 60% given that life terms for all other offenses should be abolished. The same rationale that justifies life imprisonment for first-degree murder also requires that lesser forms of punishments are imposed for all other crimes – life in prison is too harsh given the seriousness of all other offenses

THE CRUELTY OF SUPERMAX DETENTION AND THE CASE FOR A HARD-TIME SENTENCING DISCOUNT: A PRAGMATIC SOLUTION TO A MORAL SHORTCOMING

THE CRUELTY OF SUPERMAX DETENTION AND THE CASE FOR A HARD-TIME SENTENCING DISCOUNT: A PRAGMATIC SOLUTION TO A MORAL SHORTCOMIN

Библиографија Растка Васића

The bibliography, written in Serbian language, was created according to the chronological principle, which is a common method for personal bibliographies, while bibliographic units within each year are organized according to the alphabetical principle. The ISBD (M) (International Standard Book Description (monograph) and ISBD (CP) standards were used. The first part is devoted to his archaeological works, while the second part deals with author’s literary novels and stories

The Increased Exposure to Coronavirus (COVID-19) for Prisoners Justifies Early Release: And the Wider Implications of This for Sentencing—Reducing Most Prison Terms Due to the Harsh Incidental Consequences of Prison

The risk of coronavirus (COVID-19) spreading in prisons is especially acute. This has resulted in an unprecedented number of prisoners being released across the world – including many prisoners in the United States. From the health, social, and political perspectives, this is a sound approach. This is especially the situation in relation to older prisoners and those who have not been imprisoned for serious sexual and violent offenses. Despite the large number of prisoners that are being released, the United States will still have the largest prison population on earth—and by a large margin. However, the coronavirus pandemic and the response to it has considerably wider implications for the broader criminal justice system. In particular, it brings into focus a large number of other unintended adverse consequences experienced by prisoners. These include being deprived of the right to procreate; materially increasing the risk that they will be assaulted or raped in prison; and suffering a considerable reduction in their lifetime earnings. The familial relationships of most prisoners are also normally materially impaired. The adverse incidental harms associated with prison and the impact that this should have on sentencing law is an under-researched area of law. This Article fills that gap in the literature: we argue that sentences for most offenders should be reduced to accommodate the incidental hardships experienced by prisoners. The result would be a large reduction in the United States prison and jail population, without an increase in the crime rate

Analysis of Printing Substrate, Ink Age and Number of IR Drying Influence on Electrical Resistance of Conductive Inks

As a result of availability of new technologies, functional printing as a segment has become one of the most interesting directions of research and development in graphic technology. Conductive inks are not a novelty and they already have broad possibilities in production of everyday products. There is still a big market for the broadening of their use, as well as a possibility of further enhancing their properties. This paper analyzes the influence of printing substrate, age of ink and the number of IR drying on the electrical resistance of the conductive inks. In the paper, subject of analysis was the change of electrical resistance in the line that was 9 cm long and 10 typographic points wide. The semi-automated screen-printing machine was used for printing. Three types of printing substrates were used; uncoated, coated and recycled paper. Two types of inks were used; newly opened ink and ink that was out of date for half year. After the printing, prints were dried using the IR dryer. Prints were dried once, and then additional three times. After the first and last drying, multimeter was used to measure electrical resistance of the lines. Analysis of the data shows that the older ink produces prints with higher electrical resistance. There are also notable differences in the electrical resistance based on the printing substrate

Selfie

Razvoj fotografije se općenito i tehnički i sintaktičko-semantički u velikoj mjeri veže uz razvoj portretne fotografije. Pri tome posebnu ulogu ima autoportret koji se u fotografiji javlja već pojavom dagerotipije. Pojava digitalnih fotografskih aparata pogotovo onih integriranih u mobilne telefone, ali i GoPro i sličnih fotografskih aparata te objavljivanje fotografija na društvenim mrežama, autoportret, nazvan selfie, dovode jednog od najzastupljenijih fotografskih motiva koji utječe na razvoj novih pristupa komunikacije fotografijom. U radu se analiziraju tehnički, sintaktički i semantički aspekti selfie fotografije prvenstveno temeljem autorskih selfie fotografija