Idiomatic equivalents in terms of metaphoric transfer

The article presents a hermeneutic approach to idiomatic equivalents in terms of metaphoric transfer. Metaphor is viewed by the authors in its broad sense that can be applied to any use of words in an indirect meaning. Hence, an idiom is understood as a verbalized metaphor that reflects both the universal and specific features of a given language. Idiomatic equivalence that traditionally refers to the linguistic properties of the idiom is presented in the article as hermeneutic equivalence based on the thinking activity approach. Within the framework of such approach the idiomatic equivalence highlights the transfer from one culture to another way of thinking and thinking activity organization

New MCEQLS fuzzy AHP methodology for evaluating learning repositories: a tool for technological development of economy

The paper aims to present a new methodology to evaluate the quality of features and functionality of learning object repositories (LORs). The quality of features and functionality of LORs is analysed in terms of engaging LOR users and content producers. Thus, it can be referred to as quality-in-use of LORs. This methodology consists of creation and consequent application of methods and the model for the quality-in-use of LORs. The model of the quality-in-use of LORs is presented in this paper. The methodology for evaluating the quality-in-use of LORs is based on the general MCEQLS (Multiple Criteria Evaluation of the Quality of Learning Software) approach to evaluate the quality of learning software. The essential part of the novel methodology is the application of improved Fuzzy AHP method to establish criteria weights of the quality-in-use of LORs. It is shown that the created methodology is suitable and stable for evaluating the quality of LOR features and its functionality. A more detail presentation is given on the results of the expert evaluation of the quality-in-use of three LORs that are most popular in Lithuania against the proposed methodology. The novelty of the presented research is achieved through the innovative instrument consisting of the model of the quality-in-use of LORs and the Fuzzy AHP method. The presented methodology could serve as a technological tool for decision making in education as well as in different areas of economy. First published online: 03 Nov 201

MaGIC: a machine learning tool set and web application for monoallelic gene inference from chromatin

Background: A large fraction of human and mouse autosomal genes are subject to random monoallelic expression (MAE), an epigenetic mechanism characterized by allele-specific gene expression that varies between clonal cell lineages. MAE is highly cell-type specific and mapping it in a large number of cell and tissue types can provide insight into its biological function. Its detection, however, remains challenging. Results: We previously reported that a sequence-independent chromatin signature identifies, with high sensitivity and specificity, genes subject to MAE in multiple tissue types using readily available ChIP-seq data. Here we present an implementation of this method as a user-friendly, open-source software pipeline for monoallelic gene inference from chromatin (MaGIC). The source code for the MaGIC pipeline and the Shiny app is available at https://github.com/gimelbrantlab/magic Conclusion: The pipeline can be used by researchers to map monoallelic expression in a variety of cell types using existing models and to train new models with additional sets of chromatin marks.National Institutes of Health (U.S.) (award U54 HG007963

Biodiversity of Floodplain Soils in the European North‐East of Russia

River floodplains are unique nature landscapes. In contrast to zonal communities on watersheds, soil biota of river floodplains is studied in less degree. The research was conducted in the floodplain forests in the European North‐East of Russia and showed high diversity of soil biota in alluvial forest soils. Floodplain forest soils are inhabited by 70 species of micromycetes, 53 genera of Nematoda, 60 species of Collembola, and 110 species of large invertebrates. Alluvial meadow soils with stable moisture and temperature conditions are characterised by high species diversity of micromycetes, nematodes and large invertebrates. Collembola prefer alluvial soddy soils. Soil microorganisms, meso‐ and macro‐fauna can essentially increase taxonomic diversity and number in alluvial meadow‐boggy soils at warming autumn

Application of pile foundations in structurally unstable soils

The active development of the Asia-Pacific region is often accompanied by geotechnical problems that require a rational solution. The article presents the results of a laboratory experiment that simulates the process of slurried pile construction in sandy frozen soils. The authors present the dependence of changes in the temperature of the soil and cement-sand mortar in time, defined the maximum radius of thawing and the total duration of the process of thawing and freezing back to the natural state, given the recommendations for the design of slurried piles taking into account thermal interaction with permafrost soils. The article presents a laboratory study of the interaction of auger cast piles with frozen soil. The results of laboratory studies of the strength of cement mortars of different compositions, hardened at a negative temperature. Recommendations on the choice of the solution composition for the installation of grout-injected piles in frozen soil are given. The article presents the state of the question of designing multi-blade screw piles, reflects the relevance of the development of methods of calculation and updating the regulatory framework. The authors carried out calculations of the bearing capacity of screw piles on various calculation schemes, the results of which are compared with field tests. As a result of comparison recommendations on the choice of the reliable settlement scheme are given. The authors believe that the solution of the problems identified in the article related to the use of advanced types of pile foundations in difficult geotechnical conditions will significantly improve the reliability of structures, reduce construction time and reduce economic costs

In Vivo Clonal Analysis Reveals Random Monoallelic Expression in Lymphocytes That Traces Back to Hematopoietic Stem Cells

Funding Information: This work has received funding from the FCT (Fundação para a Ciência e a Tecnologia) under grants PTDC/BEX-BCM/5900/2014 and IF/ 1823 01721/2014/CP1252/CT0005, and European Union’s Horizon 2020 research and innovation programme under grant agreement No. 752806. NK received a fellowship (PD/BD/114164/2016) from FCT. Publisher Copyright: Copyright © 2022 Kubasova, Alves-Pereira, Gupta, Vinogradova, Gimelbrant and Barreto.Evaluating the epigenetic landscape in the stem cell compartment at the single-cell level is essential to assess the cells’ heterogeneity and predict their fate. Here, using a genome-wide transcriptomics approach in vivo, we evaluated the allelic expression imbalance in the progeny of single hematopoietic cells (HSCs) as a read-out of epigenetic marking. After 4 months of extensive proliferation and differentiation, we found that X-chromosome inactivation (XCI) is tightly maintained in all single-HSC derived hematopoietic cells. In contrast, the vast majority of the autosomal genes did not show clonal patterns of random monoallelic expression (RME). However, a persistent allele-specific autosomal transcription in HSCs and their progeny was found in a rare number of cases, none of which has been previously reported. These data show that: 1) XCI and RME in the autosomal chromosomes are driven by different mechanisms; 2) the previously reported high frequency of genes under RME in clones expanded in vitro (up to 15%) is not found in clones undergoing multiple differentiation steps in vivo; 3) prior to differentiation, HSCs have stable patterns of autosomal RME. We propose that most RME patterns in autosomal chromosomes are erased and established de novo during cell lineage differentiation.publishersversionpublishe

Comprehensive analysis of draft genomes of two closely related pseudomonas syringae phylogroup 2b strains infecting mono- and dicotyledon host plants

Comparison of the prophage region in Pseudomonas syringae strain SM (A) with the corresponding regions in strains 1845 (B) and 2507 (C) using MAUVE software (Darling et al. 2010). (PNG 2118 kb

Light-Induced Manipulation of Passive and Active Microparticles

We consider sedimented at a solid wall particles that are immersed in water containing small additives of photosensitive ionic surfactants. It is shown that illumination with an appropriate wavelength, a beam intensity profile, shape and size could lead to a variety of dynamic, both unsteady and steady-state, configurations of particles. These dynamic, well-controlled and switchable particle patterns at the wall are due to an emerging diffusio-osmotic flow that takes its origin in the adjacent to the wall electrostatic diffuse layer, where the concentration gradients of surfactant are induced by light. The conventional nonporous particles are passive and can move only with already generated flow. However, porous colloids actively participate themselves in the flow generation mechanism at the wall, which also sets their interactions that can be very long ranged. This light-induced diffusio-osmosis opens novel avenues to manipulate colloidal particles and assemble them to various patterns. We show in particular how to create and split optically the confined regions of particles of tunable size and shape, where well controlled flow-induced forces on the colloids could result in their cristalline packing, formation of dilute lattices of well-separated particles, and other states.Comment: 11 pages, 14 figure

Legal Protection of Sami Traditional Livelihoods from the Adverse Impacts of Mining: A Comparison of the Level of Protection Enjoyed by Sami in Their Four Home States

As a consequence of the growing global need for minerals, extractive industries are continuously expanding. In the North, together with several environmental problems such as climate change, this poses a real threat to the traditional livelihoods of Sami people. The article examines how the rights of Sami indigenous people are protected against adverse impacts of mining activities. The relevant national legislation is analyzed in all the four countries where Sami are present. It is specifically examined how the main mining act in each country protects the right of Sami people to their traditional livelihoods. Finally, the article sheds light on the actual effectiveness of the legal regulation. This is done by analyzing the results of interviews conducted with relevant actors and stakeholders in the mining industry.Keywords: indigenous peoples; Sami rights; mining(Published: March 2015)Citation: T. Koivurova et al. “Legal Protection of Sami Traditional Livelihoods from the Adverse Impacts of Mining: A Comparison of the Level of Protection Enjoyed by Sami in Their Four Home States.” Arctic Review on Law and Politics, Vol. 6, No. 1, 2015, pp. 11-51. http://dx.doi.org/10.3402/arctic.v6.7