Residential area and physical activity : A multi-level study of 68,000 adults in Stockholm County

Aim: To determine whether there are systematic differences in physical activity between residential areas after extensive control for sociodemographic factors at the individual level. Methods: Multi-level regressions of walking/bicycling, sedentary activities, household work and exercise were carried out in a representative sample of 68,303 adults in 39 residential areas in Stockholm County, first adjusting at the individual level for country of birth, sex, age, education, occupational class and income. The type of housing was then considered at the individual level or, for walking/bicycling and exercise, at both the individual and area levels (as a measure of area density). Results: After adjustment for sociodemographic factors, differences between residential areas remained in walking/bicycling, corresponding to 0.27 SD, or 50 min/week between the most and least active areas. Forty per cent of this difference could be explained by the type of housing at the area level. For sedentary activities and household work, respectively, much of the variation that remained after adjustment for sociodemographic factors was, in turn, explained by the type of housing at the individual level, leaving a difference of 0.16 SD (80 min/week) and 0.13 SD (60 min/week), respectively. For exercise, the corresponding difference was 0.11 SD (11 min/week, not sensitive to housing). Conclusions: Area level factors may influence walking/bicycling. High area density was associated with more activity. However, high density also comes with a type of housing (apartments) that is associated with less household work and, surprisingly, more sedentary activities, introducing a challenging trade-off. The differences in exercise were smaller than for all other types of activities

Use of 16S Ribosomal DNA for Delineation of Marine Bacterioplankton Species

All of the marine bacterioplankton-derived 16S ribosomal DNA sequences previously deposited in GenBank were reanalyzed to determine the number of bacterial species in the oceanic surface waters. These sequences have been entered into the database since 1990. The rate of new additions reached a peak in 1999 and subsequently leveled off, suggesting that much of the marine microbial species richness has been sampled. When the GenBank sequences were dereplicated by using 97% similarity as a cutoff, 1,117 unique ribotypes were found. Of the unique sequences, 609 came from uncultured environmental clones and 508 came from cultured bacteria. We conclude that the apparent bacterioplankton species richness is relatively low

A Hundred Years Later. Streetcars are still rattling in Baltic Cities

A young geographer by the name of Sten De Geer mapped the cities around the Baltic Sea in an article published in 1912. As an attempt to capture the urban structure of Baltic region cities, his paper is unique. In this article, we comment on his meticulous descriptions of these cities, with a century-long perspective

The New Swedish Cyprus Expedition 2019 : excavations at Hala Sultan Tekke (The Söderberg Expedition) : preliminary results, with contributions by L. Recht, B. Placiente Robedizo, C. Eriksson, L. Andersson, M. Svensson, L. Avial Chicharro, S. Hermon, M. Polig & D. Kofel

The tenth season of excavations at the Late Bronze Age city of Hala Sultan Tekke was carried out in four areas: City Quarter 1 (CQ1), CQ4, City Wall 1 (CW1), and Area A (Tomb RR). The excavations in CQ1 provided additional information on the pre-LC IIIA occupation of the city. Stratum 3 which can be dated to the LC IIC (13th century BC) was further exposed. For the first time in the city even older phases, Strata 4 and 5, were found. These are tentatively dated to the LC I-II (15th to 14th century BC). In CQ4 numerous storage areas were exposed, which belong to a large compound. There is also evidence of production of textiles and purple dye. All remains can be associated to the most recent Stratum 1 and can be securely dated in the LC IIIA, i.e. the 12th century BC. A test trench (CW1) was opened up 150 m to the south-east of CQ4, in an area where the magnetometer survey indicated a possible city wall with moat. A c. 2.5 m-wide man-made construction consisting of small stones intermingled with larger blocks of stones was found running north-south. Built against the interior of this structure is a copper-producing workshop as indicated by much slag, ash, and remains of a furnace, which is preliminarily dated to the 13th century BC. Tomb RR, which was partly excavated in 2018 and secured, was reopened and additional burials came to light. The total number of skeletons now stands at 37; these are associated with 74 complete/intact finds of mainly pottery vessels of which some contained food remains. The pottery comprises Cypriot-produced wares and Mycenaean imports, which indicate a LC IIB-C date of the burials. Other finds include a unique Minoan female figurine and a bronze knife with ivory handle

Substituted 7‑Amino-5-thio-thiazolo[4,5‑<i>d</i>]pyrimidines as Potent and Selective Antagonists of the Fractalkine Receptor (CX₃CR1)

We have developed two parallel series, A and B, of CX₃CR1 antagonists for the treatment of multiple sclerosis. By modifying the substituents on the 7-amino-5-thio-thiazolo­[4,5-<i>d</i>]­pyrimidine core structure, we were able to achieve compounds with high selectivity for CX₃CR1 over the closely related CXCR2 receptor. The structure–activity relationships showed that a leucinol moiety attached to the core-structure in the 7-position together with α-methyl branched benzyl derivatives in the 5-position displayed promising affinity, and selectivity as well as physicochemical properties, as exemplified by compounds <b>18a</b> and <b>24h</b>. We show the preparation of the first potent and selective orally available CX₃CR1 antagonists

Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study

Purpose In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for optimizing management, and developing guidelines and clinical trials. Methods We carried out a prospective international cohort study of adult patients (≥ 18 years of age) with HA-BSI treated in intensive care units (ICUs) between June 2019 and February 2021. Results 2600 patients from 333 ICUs in 52 countries were included. 78% HA-BSI were ICU-acquired. Median Sequential Organ Failure Assessment (SOFA) score was 8 [IQR 5; 11] at HA-BSI diagnosis. Most frequent sources of infection included pneumonia (26.7%) and intravascular catheters (26.4%). Most frequent pathogens were Gram-negative bacteria (59.0%), predominantly Klebsiella spp. (27.9%), Acinetobacter spp. (20.3%), Escherichia coli (15.8%), and Pseudomonas spp. (14.3%). Carbapenem resistance was present in 37.8%, 84.6%, 7.4%, and 33.2%, respectively. Difficult-to-treat resistance (DTR) was present in 23.5% and pan-drug resistance in 1.5%. Antimicrobial therapy was deemed adequate within 24 h for 51.5%. Antimicrobial resistance was associated with longer delays to adequate antimicrobial therapy. Source control was needed in 52.5% but not achieved in 18.2%. Mortality was 37.1%, and only 16.1% had been discharged alive from hospital by day-28. Conclusions HA-BSI was frequently caused by Gram-negative, carbapenem-resistant and DTR pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy. Mortality was high, and at day-28 only a minority of the patients were discharged alive from the hospital. Prevention of antimicrobial resistance and focusing on adequate antimicrobial therapy and source control are important to optimize patient management and outcomes